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9  structures 170  species 0  interactions 9423  sequences 112  architectures

Family: GRAS (PF03514)

Summary: GRAS domain family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

GRAS domain family Provide feedback

Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development [1]. Mutation of the SCARECROW (SCR) gene results in a radial pattern defect, loss of a ground tissue layer, in the root. The PAT1 protein is involved in phytochrome A signal transduction [2]. A sequence, structure and evolutionary analysis showed that the GRAS family emerged in bacteria and belongs to the Rossmann-fold, AdoMET (SAM)-dependent methyltransferase superfamily [3]. All bacterial, and a subset of plant GRAS proteins, are predicted to be active and function as small-molecule methylases. Several plant GRAS proteins lack one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. Although GRAS proteins are implicated to function as transcriptional factors, the above analysis suggests that they instead might either modify or bind small molecules [3].

Literature references

  1. Pysh LD, Wysocka-Diller JW, Camilleri C, Bouchez D, Benfey PN; , Plant J 1999;18:111-119.: The GRAS gene family in Arabidopsis: sequence characterization and basic expression analysis of the SCARECROW-LIKE genes. PUBMED:10341448 EPMC:10341448

  2. Bolle C, Koncz C, Chua NH; , Genes Dev 2000;14:1269-1278.: PAT1, a new member of the GRAS family, is involved in phytochrome A signal transduction. PUBMED:10817761 EPMC:10817761

  3. Zhang D, Iyer LM, Aravind L;, Bioinformatics. 2012;28:2407-2411.: Bacterial GRAS domain proteins throw new light on gibberellic acid response mechanisms. PUBMED:22829623 EPMC:22829623

  4. Hofmann NR;, Plant Cell. 2016;28:993-994.: A Structure for Plant-Specific Transcription Factors: The GRAS Domain Revealed. PUBMED:27095838 EPMC:27095838

  5. Hirsch S, Oldroyd GE;, Plant Signal Behav. 2009;4:698-700.: GRAS-domain transcription factors that regulate plant development. PUBMED:19820314 EPMC:19820314


This tab holds annotation information from the InterPro database.

InterPro entry IPR005202

Sequence analysis of the products of the GRAS (GAI, RGA, SCR) gene family indicates that they share a variable N terminus and a highly conserved C terminus that contains five recognizable motifs [ PUBMED:10341448 ]. Proteins in the GRAS family are major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development [ PUBMED:10341448 ]. Mutation of the SCARECROW (SCR) gene results in a radial pattern defect, loss of a ground tissue layer, in the root. The PAT1 protein is involved in phytochrome A signal transduction [ PUBMED:10817761 ].

A sequence, structure and evolutionary analysis showed that the GRAS family emerged in bacteria and belongs to the Rossmann-fold, AdoMET (SAM)-dependent methyltransferase superfamily [ PUBMED:22829623 ]. All bacterial, and a subset of plant GRAS proteins, are predicted to be active and function as small-molecule methylases. Several plant GRAS proteins lack one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. Although GRAS proteins are implicated to function as transcriptional factors, the above analysis suggests that they instead might either modify or bind small molecules [ PUBMED:22829623 ].

    Some proteins known to belong to the GRAS family are listed below:
  • Arabidopsis thaliana SCARECROW (SCR) protein. It regulates asymetric cell divisions of cortex/endodermal initial cells during root development.
  • Arabidopsis thaliana SCARECROW-LIKE (SCL) protein.
  • Arabidopsis thaliana GIBBERELLIN-ACID INSENSITIVE (GAI) and REPRESSOR OF GA1 (RGA), two closely related proteins involved in gibberellin signaling.
  • Arabidopsis thaliana SHORT ROOT (SHR) protein. It is necessary for cell division and endodermis specification.
  • Arabidopsis thaliana PAT1 protein. It inhibits light signaling via the phytochrome A (phyA).
  • LATERAL SUPPRESSOR (LS), a protein from tomato that controls the formation of lateral branches during vegetative development.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan NADP_Rossmann (CL0063), which has the following description:

A class of redox enzymes are two domain proteins. One domain, termed the catalytic domain, confers substrate specificity and the precise reaction of the enzyme. The other domain, which is common to this class of redox enzymes, is a Rossmann-fold domain. The Rossmann domain binds nicotinamide adenine dinucleotide (NAD+) and it is this cofactor that reversibly accepts a hydride ion, which is lost or gained by the substrate in the redox reaction. Rossmann domains have an alpha/beta fold, which has a central beta sheet, with approximately five alpha helices found surrounding the beta sheet.The strands forming the beta sheet are found in the following characteristic order 654123. The inter sheet crossover of the stands in the sheet form the NAD+ binding site [1]. In some more distantly relate Rossmann domains the NAD+ cofactor is replaced by the functionally similar cofactor FAD.

The clan contains the following 206 members:

2-Hacid_dh_C 3Beta_HSD 3HCDH_N 3HCDH_RFF adh_short adh_short_C2 ADH_zinc_N ADH_zinc_N_2 AdoHcyase_NAD AdoMet_MTase AlaDh_PNT_C Amino_oxidase ApbA AviRa B12-binding Bac_GDH Bin3 Bmt2 CbiJ CheR CMAS CmcI CoA_binding CoA_binding_2 CoA_binding_3 Cons_hypoth95 CoV_ExoN CoV_Methyltr_2 DAO DapB_N DFP DNA_methylase DOT1 DRE2_N DREV DUF1442 DUF1611_N DUF166 DUF1776 DUF2431 DUF268 DUF2855 DUF3410 DUF364 DUF43 DUF5129 DUF5130 DUF6094 DUF938 DXP_reductoisom DXPR_C Eco57I ELFV_dehydrog Eno-Rase_FAD_bd Eno-Rase_NADH_b Enoyl_reductase Epimerase F420_oxidored FAD_binding_2 FAD_binding_3 FAD_oxidored Fibrillarin FMO-like FmrO FtsJ fvmX7 G6PD_N GCD14 GDI GDP_Man_Dehyd GFO_IDH_MocA GIDA GidB GLF Glu_dehyd_C Glyco_hydro_4 Glyco_tran_WecG GMC_oxred_N Gp_dh_N GRAS GRDA HcgC HI0933_like HIM1 IlvN ISPD_C K_oxygenase KR LCM Ldh_1_N LpxI_N Lycopene_cycl Malic_M Mannitol_dh MCRA Met_10 Methyltr_RsmB-F Methyltr_RsmF_N Methyltrans_Mon Methyltrans_SAM Methyltransf_10 Methyltransf_11 Methyltransf_12 Methyltransf_14 Methyltransf_15 Methyltransf_16 Methyltransf_17 Methyltransf_18 Methyltransf_19 Methyltransf_2 Methyltransf_20 Methyltransf_21 Methyltransf_22 Methyltransf_23 Methyltransf_24 Methyltransf_25 Methyltransf_28 Methyltransf_29 Methyltransf_3 Methyltransf_30 Methyltransf_31 Methyltransf_32 Methyltransf_33 Methyltransf_34 Methyltransf_4 Methyltransf_5 Methyltransf_7 Methyltransf_8 Methyltransf_9 Methyltransf_PK MethyltransfD12 MetW Mg-por_mtran_C MOLO1 Mqo MT-A70 MTS Mur_ligase N2227 N6-adenineMlase N6_Mtase N6_N4_Mtase NAD_binding_10 NAD_binding_2 NAD_binding_3 NAD_binding_4 NAD_binding_5 NAD_binding_7 NAD_binding_8 NAD_binding_9 NAD_Gly3P_dh_N NAS NmrA NNMT_PNMT_TEMT NodS OCD_Mu_crystall Orbi_VP4 PALP PARP_regulatory PCMT PDH PglD_N Polysacc_syn_2C Polysacc_synt_2 Pox_MCEL Pox_mRNA-cap Prenylcys_lyase PrmA PRMT5 Pyr_redox Pyr_redox_2 Pyr_redox_3 Reovirus_L2 RmlD_sub_bind Rossmann-like rRNA_methylase RrnaAD Rsm22 RsmJ Sacchrp_dh_NADP SAM_MT SE Semialdhyde_dh Shikimate_DH Spermine_synth TehB THF_DHG_CYH_C Thi4 ThiF TPM_phosphatase TPMT TrkA_N TRM TRM13 TrmK tRNA_U5-meth_tr Trp_halogenase TylF Ubie_methyltran UDPG_MGDP_dh_N UPF0020 UPF0146 Urocanase V_cholerae_RfbT XdhC_C YjeF_N

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(30)
Full
(9423)
Representative proteomes UniProt
(15361)
RP15
(847)
RP35
(5320)
RP55
(7977)
RP75
(10367)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(30)
Full
(9423)
Representative proteomes UniProt
(15361)
RP15
(847)
RP35
(5320)
RP55
(7977)
RP75
(10367)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(30)
Full
(9423)
Representative proteomes UniProt
(15361)
RP15
(847)
RP35
(5320)
RP55
(7977)
RP75
(10367)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_393 (release 7.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A
Number in seed: 30
Number in full: 9423
Average length of the domain: 330.50 aa
Average identity of full alignment: 28 %
Average coverage of the sequence by the domain: 63.98 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.4 21.4
Trusted cut-off 21.5 21.5
Noise cut-off 21.3 21.2
Model length: 374
Family (HMM) version: 16
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the GRAS domain has been found. There are 9 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A060CVG2 View 3D Structure Click here
A0A060CVM9 View 3D Structure Click here
A0A060CY61 View 3D Structure Click here
A0A060CZ17 View 3D Structure Click here
A0A060CZR1 View 3D Structure Click here
A0A060D4L7 View 3D Structure Click here
A0A060D4M4 View 3D Structure Click here
A0A060D570 View 3D Structure Click here
A0A060D6F1 View 3D Structure Click here
A0A060D6K6 View 3D Structure Click here
A0A060D7B7 View 3D Structure Click here
A0A060D7Z4 View 3D Structure Click here
A0A0N7KKZ7 View 3D Structure Click here
A0A0N7KLR4 View 3D Structure Click here
A0A0N7KTJ8 View 3D Structure Click here
A0A0P0VG96 View 3D Structure Click here
A0A0P0W075 View 3D Structure Click here
A0A0P0WB67 View 3D Structure Click here
A0A0P0WC33 View 3D Structure Click here
A0A0P0WRA8 View 3D Structure Click here
A0A0P0WX06 View 3D Structure Click here
A0A0P0X4E3 View 3D Structure Click here
A0A0P0X7S9 View 3D Structure Click here
A0A0P0XYI1 View 3D Structure Click here
A0A0P0XYU0 View 3D Structure Click here
A0A0P0XYX6 View 3D Structure Click here
A0A0P0XZ16 View 3D Structure Click here
A0A0P0XZ47 View 3D Structure Click here
A0A0P0Y2H3 View 3D Structure Click here
A0A0P0Y6V0 View 3D Structure Click here
A0A0P0Y6W1 View 3D Structure Click here
A0A0P0Y795 View 3D Structure Click here
A0A0R0EMS0 View 3D Structure Click here
A0A0R0ENH4 View 3D Structure Click here
A0A0R0F237 View 3D Structure Click here
A0A0R0F2C2 View 3D Structure Click here
A0A0R0FVT7 View 3D Structure Click here
A0A0R0FYG5 View 3D Structure Click here
A0A0R0G3S3 View 3D Structure Click here
A0A0R0G4D4 View 3D Structure Click here
A0A0R0G6U9 View 3D Structure Click here
A0A0R0GEN3 View 3D Structure Click here
A0A0R0GY58 View 3D Structure Click here
A0A0R0GY58 View 3D Structure Click here
A0A0R0H4U7 View 3D Structure Click here
A0A0R0H9X9 View 3D Structure Click here
A0A0R0HGV4 View 3D Structure Click here
A0A0R0HH94 View 3D Structure Click here
A0A0R0HMZ5 View 3D Structure Click here
A0A0R0HWZ0 View 3D Structure Click here
A0A0R0I7H8 View 3D Structure Click here
A0A0R0I7X7 View 3D Structure Click here
A0A0R0IHU3 View 3D Structure Click here
A0A0R0IZK3 View 3D Structure Click here
A0A0R0IZK3 View 3D Structure Click here
A0A0R0JYL3 View 3D Structure Click here
A0A0R0KPV6 View 3D Structure Click here
A0A1D6DVQ3 View 3D Structure Click here
A0A1D6E9S7 View 3D Structure Click here
A0A1D6EAN3 View 3D Structure Click here
A0A1D6EIU2 View 3D Structure Click here
A0A1D6EXP9 View 3D Structure Click here
A0A1D6F055 View 3D Structure Click here
A0A1D6F535 View 3D Structure Click here
A0A1D6F535 View 3D Structure Click here
A0A1D6FKW5 View 3D Structure Click here
A0A1D6GIN1 View 3D Structure Click here
A0A1D6HFA6 View 3D Structure Click here
A0A1D6HTM0 View 3D Structure Click here
A0A1D6I0J2 View 3D Structure Click here
A0A1D6IIN9 View 3D Structure Click here
A0A1D6IIN9 View 3D Structure Click here
A0A1D6IJF0 View 3D Structure Click here
A0A1D6IJT5 View 3D Structure Click here
A0A1D6IJT5 View 3D Structure Click here
A0A1D6IQZ0 View 3D Structure Click here
A0A1D6IXR1 View 3D Structure Click here
A0A1D6JCC1 View 3D Structure Click here
A0A1D6JN21 View 3D Structure Click here
A0A1D6JN21 View 3D Structure Click here
A0A1D6K5G0 View 3D Structure Click here
A0A1D6KE60 View 3D Structure Click here
A0A1D6KEM4 View 3D Structure Click here
A0A1D6KJV7 View 3D Structure Click here
A0A1D6L9Y8 View 3D Structure Click here
A0A1D6LHS7 View 3D Structure Click here
A0A1D6LJ67 View 3D Structure Click here
A0A1D6M1N2 View 3D Structure Click here
A0A1D6M4M4 View 3D Structure Click here
A0A1D6M6V4 View 3D Structure Click here
A0A1D6M7J8 View 3D Structure Click here
A0A1D6MWL2 View 3D Structure Click here
A0A1D6MWL2 View 3D Structure Click here
A0A1D6MWT0 View 3D Structure Click here
A0A1D6N495 View 3D Structure Click here
A0A1D6N743 View 3D Structure Click here
A0A1D6NHK5 View 3D Structure Click here
A0A1D6NWE2 View 3D Structure Click here
A0A1D6NX76 View 3D Structure Click here
A0A1D6P0V6 View 3D Structure Click here
A0A1D6P4Z1 View 3D Structure Click here
A0A1D6PDQ1 View 3D Structure Click here
A0A1D6PF45 View 3D Structure Click here
A0A1D6PIF4 View 3D Structure Click here
A0A1D6PN07 View 3D Structure Click here
A0A1D6PN07 View 3D Structure Click here
A0A1D6PN38 View 3D Structure Click here
A0A1D6PTF1 View 3D Structure Click here
A0A1D6QHE2 View 3D Structure Click here
A0A368UHK0 View 3D Structure Click here
B6SV05 View 3D Structure Click here
B6SWF9 View 3D Structure Click here
B7F9I5 View 3D Structure Click here
B7ZYK9 View 3D Structure Click here
B9FY68 View 3D Structure Click here
C0HI72 View 3D Structure Click here
C0P581 View 3D Structure Click here
C0P5D5 View 3D Structure Click here
C0P6K9 View 3D Structure Click here
C0PD56 View 3D Structure Click here
C0PG95 View 3D Structure Click here
C0PGA9 View 3D Structure Click here
C0PHC4 View 3D Structure Click here
C0PLA4 View 3D Structure Click here
C4J9P5 View 3D Structure Click here
C6TJ61 View 3D Structure Click here
E3NYP4 View 3D Structure Click here
I1J7R8 View 3D Structure Click here
I1J8X5 View 3D Structure Click here
I1J9E7 View 3D Structure Click here
I1JAF3 View 3D Structure Click here
I1JCS2 View 3D Structure Click here
I1JJH1 View 3D Structure Click here
I1JJQ8 View 3D Structure Click here
I1JKU2 View 3D Structure Click here
I1JLK0 View 3D Structure Click here
I1JW83 View 3D Structure Click here
I1JWI2 View 3D Structure Click here
I1JZ90 View 3D Structure Click here
I1K082 View 3D Structure Click here
I1K0D0 View 3D Structure Click here
I1KD93 View 3D Structure Click here
I1KEE1 View 3D Structure Click here
I1KHC2 View 3D Structure Click here
I1KRT7 View 3D Structure Click here
I1KYG8 View 3D Structure Click here
I1L013 View 3D Structure Click here
I1LCF0 View 3D Structure Click here
I1LDM9 View 3D Structure Click here
I1LG67 View 3D Structure Click here
I1LH59 View 3D Structure Click here
I1LHP0 View 3D Structure Click here
I1LIM7 View 3D Structure Click here
I1LIN3 View 3D Structure Click here
I1LK06 View 3D Structure Click here
I1LK07 View 3D Structure Click here
I1LK10 View 3D Structure Click here
I1LL90 View 3D Structure Click here
I1LMC8 View 3D Structure Click here
I1LP80 View 3D Structure Click here
I1LPE1 View 3D Structure Click here
I1LPE8 View 3D Structure Click here
I1LQP3 View 3D Structure Click here
I1LQP5 View 3D Structure Click here
I1LU93 View 3D Structure Click here
I1LW54 View 3D Structure Click here
I1LXB0 View 3D Structure Click here
I1LYM4 View 3D Structure Click here
I1M3G4 View 3D Structure Click here
I1M4X6 View 3D Structure Click here
I1M578 View 3D Structure Click here
I1M692 View 3D Structure Click here
I1MAD8 View 3D Structure Click here
I1MD47 View 3D Structure Click here
I1MFQ0 View 3D Structure Click here
I1MGF6 View 3D Structure Click here
I1MK09 View 3D Structure Click here
I1MNH6 View 3D Structure Click here
I1MNY6 View 3D Structure Click here
I1MPJ5 View 3D Structure Click here
I1MQZ7 View 3D Structure Click here
I1MUM2 View 3D Structure Click here
I1MUR1 View 3D Structure Click here
I1MVL1 View 3D Structure Click here
I1MZE2 View 3D Structure Click here
I1N0D2 View 3D Structure Click here
I1N309 View 3D Structure Click here
I1NGX2 View 3D Structure Click here
K7K2L0 View 3D Structure Click here
K7K6Y4 View 3D Structure Click here
K7KCY7 View 3D Structure Click here
K7KGE2 View 3D Structure Click here
K7KM36 View 3D Structure Click here
K7KPG8 View 3D Structure Click here
K7KUH0 View 3D Structure Click here
K7KUM7 View 3D Structure Click here
K7L0W9 View 3D Structure Click here
K7L1H1 View 3D Structure Click here
K7L1X9 View 3D Structure Click here
K7L6R7 View 3D Structure Click here
K7LBN1 View 3D Structure Click here
K7LGC3 View 3D Structure Click here
K7LGU1 View 3D Structure Click here
K7LHB2 View 3D Structure Click here
K7LPM8 View 3D Structure Click here
K7LPN1 View 3D Structure Click here
K7LQP7 View 3D Structure Click here
K7LTB4 View 3D Structure Click here
K7LTB7 View 3D Structure Click here
K7LUN8 View 3D Structure Click here
K7M2U4 View 3D Structure Click here
K7M3F6 View 3D Structure Click here
K7M3F9 View 3D Structure Click here
K7M9D7 View 3D Structure Click here
K7MBA5 View 3D Structure Click here
K7MLZ6 View 3D Structure Click here
K7MTY7 View 3D Structure Click here
K7MXH7 View 3D Structure Click here
K7TE25 View 3D Structure Click here
K7TQL6 View 3D Structure Click here
K7TU12 View 3D Structure Click here
K7TYB9 View 3D Structure Click here
K7U8D1 View 3D Structure Click here
K7U8D6 View 3D Structure Click here
K7UES9 View 3D Structure Click here
K7UIJ3 View 3D Structure Click here
K7UKW8 View 3D Structure Click here
K7UPJ5 View 3D Structure Click here
K7V297 View 3D Structure Click here
K7V627 View 3D Structure Click here
K7V9G6 View 3D Structure Click here
K7VD41 View 3D Structure Click here
K7VY97 View 3D Structure Click here
O23210 View 3D Structure Click here
O80933 View 3D Structure Click here
O81316 View 3D Structure Click here
P0C883 View 3D Structure Click here
P0C884 View 3D Structure Click here
Q06F07 View 3D Structure Click here
Q0DW05 View 3D Structure Click here
Q0IVV5 View 3D Structure Click here
Q10QK3 View 3D Structure Click here
Q2QNA3 View 3D Structure Click here
Q2QYF3 View 3D Structure Click here
Q2RB59 View 3D Structure Click here
Q2V2T9 View 3D Structure Click here
Q3EDH0 View 3D Structure Click here
Q53K16 View 3D Structure Click here
Q53MB0 View 3D Structure Click here
Q53MB2 View 3D Structure Click here
Q53MB4 View 3D Structure Click here
Q5N9X3 View 3D Structure Click here
Q688G4 View 3D Structure Click here
Q69VG1 View 3D Structure Click here
Q6AUP1 View 3D Structure Click here
Q6AUW2 View 3D Structure Click here
Q6AVK7 View 3D Structure Click here
Q6F368 View 3D Structure Click here
Q6H6L0 View 3D Structure Click here
Q6H6L3 View 3D Structure Click here
Q75I13 View 3D Structure Click here
Q7G7J6 View 3D Structure Click here
Q7X7C0 View 3D Structure Click here
Q7XJM8 View 3D Structure Click here
Q7XLZ1 View 3D Structure Click here
Q7XQP2 View 3D Structure Click here
Q7XT28 View 3D Structure Click here
Q84MM9 View 3D Structure Click here
Q84MQ9 View 3D Structure Click here
Q84PD5 View 3D Structure Click here
Q84Q92 View 3D Structure Click here
Q8GT03 View 3D Structure Click here
Q8GVE1 View 3D Structure Click here
Q8GXW1 View 3D Structure Click here
Q8H125 View 3D Structure Click here
Q8H2X8 View 3D Structure Click here
Q8RZQ6 View 3D Structure Click here
Q9C8Y3 View 3D Structure Click here
Q9CAN3 View 3D Structure Click here
Q9FHZ1 View 3D Structure Click here
Q9FL03 View 3D Structure Click here
Q9FUZ7 View 3D Structure Click here
Q9FYR7 View 3D Structure Click here
Q9LDL7 View 3D Structure Click here
Q9LF53 View 3D Structure Click here
Q9LPR8 View 3D Structure Click here
Q9LQT8 View 3D Structure Click here
Q9LRW3 View 3D Structure Click here
Q9LTI5 View 3D Structure Click here
Q9LWU9 View 3D Structure Click here
Q9M000 View 3D Structure Click here
Q9M0M5 View 3D Structure Click here
Q9M384 View 3D Structure Click here
Q9S7H5 View 3D Structure Click here
Q9SCR0 View 3D Structure Click here
Q9SDQ3 View 3D Structure Click here
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