Summary: Otx1 transcription factor
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Otx1 transcription factor Provide feedback
No Pfam abstract.
This tab holds annotation information from the InterPro database.
InterPro entry IPR013851
Otx proteins constitute a class of vertebrate homeodomain-containing transcription factors that have been shown to be essential for anterior head formation, including brain morphogenesis. They are orthologous to the product of the Drosophila head gap gene, orthodenticle (Otd), and appear to play similar roles in both, since the developmental abnormalities caused by disruption of these transcription factors in one, can be recovered by substitution of the factor(s) from the other. Such studies have provided strong evidence that there exists a conserved genetic programme for insect and mammalian brain development, which presumably arose in a more primitive common ancestor [ PUBMED:10199636 , PUBMED:10440864 ].
Two vertebrate orthodenticle-related transcription factors have been indentified, Otx1 and Otx2, which have sizes of 355 and 289 residues respectively. They contain a bicoid-like homeodomain, which features a conserved lysine residue at position 9 of the DNA recognition helix, which is thought to confer high-affinity binding to TAATCC/T elements on DNA [ PUBMED:10375352 ]. Otd-like transcription factors have also been found in zebrafish and certain lamprey species.
This entry represents a conserved region found in the C-terminal region of these proteins.
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Cellular component | nucleus (GO:0005634) |
Molecular function | DNA-binding transcription factor activity (GO:0003700) |
Biological process | multicellular organism development (GO:0007275) |
Domain organisation
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Alignments
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Seed (16) |
Full (751) |
Representative proteomes | UniProt (1635) |
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RP15 (43) |
RP35 (224) |
RP55 (653) |
RP75 (896) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
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Seed (16) |
Full (751) |
Representative proteomes | UniProt (1635) |
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RP15 (43) |
RP35 (224) |
RP55 (653) |
RP75 (896) |
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Raw Stockholm | |||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
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Trees
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Curation and family details
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Curation
Seed source: | PRINTS |
Previous IDs: | none |
Type: | Family |
Sequence Ontology: | SO:0100021 |
Author: |
Griffiths-Jones SR |
Number in seed: | 16 |
Number in full: | 751 |
Average length of the domain: | 89.00 aa |
Average identity of full alignment: | 58 % |
Average coverage of the sequence by the domain: | 29.25 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 92 | ||||||||||||
Family (HMM) version: | 15 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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