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0  structures 5923  species 0  interactions 23607  sequences 108  architectures

Family: Mem_trans (PF03547)

Summary: Membrane transport protein

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Membrane transport protein Provide feedback

This family includes auxin efflux carrier proteins and other transporter proteins from all domains of life.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR004776

This entry represents a mostly uncharacterised family of membrane transport proteins found in eukaryotes, bacteria and archaea. Most characterised members of this family are the PIN components of auxin efflux systems from plants. These carriers are saturable, auxin-specific, and localized to the basal ends of auxin transport-competent cells [ PUBMED:16054428 , PUBMED:15564124 ]. Plants typically posses several of these proteins, each displaying a unique tissue-specific expression pattern. They are expressed in almost all plant tissues including vascular tissues and roots, and influence many processes including the establishment of embryonic polarity, plant growth, apical hook formation in seedlings and the photo- and gravitrophic responses. These plant proteins are typically 600-700 amino acyl residues long and exhibit 8-12 transmembrane segments.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan CPA_AT (CL0064), which has the following description:

This Clan contains transporter proteins that belong to the CPA superfamily and AT superfamily according to TCDB [1].

The clan contains the following 13 members:

Asp-Al_Ex Cons_hypoth698 DUF819 Glt_symporter KdgT Lys_export Mem_trans Na_H_antiport_1 Na_H_Exchanger OAD_beta SBF SBF_like Sbt_1

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(18)
Full
(23607)
Representative proteomes UniProt
(82143)
RP15
(2876)
RP35
(11550)
RP55
(22613)
RP75
(37517)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(18)
Full
(23607)
Representative proteomes UniProt
(82143)
RP15
(2876)
RP35
(11550)
RP55
(22613)
RP75
(37517)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(18)
Full
(23607)
Representative proteomes UniProt
(82143)
RP15
(2876)
RP35
(11550)
RP55
(22613)
RP75
(37517)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: TIGRFAMs & Pfam-B_5261 (Release 7.5)
Previous IDs: Auxin_eff;
Type: Family
Sequence Ontology: SO:0100021
Author: TIGRFAMs, Griffiths-Jones SR
Number in seed: 18
Number in full: 23607
Average length of the domain: 210.50 aa
Average identity of full alignment: 11 %
Average coverage of the sequence by the domain: 82.65 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.7 25.7
Trusted cut-off 25.7 25.7
Noise cut-off 25.6 25.6
Model length: 387
Family (HMM) version: 20
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0XYD3 View 3D Structure Click here
A0A0P0YAS0 View 3D Structure Click here
A0A0R0EQ77 View 3D Structure Click here
A0A0R0EXB6 View 3D Structure Click here
A0A0R0FPG2 View 3D Structure Click here
A0A0R0I0D7 View 3D Structure Click here
A0A0R0ICB3 View 3D Structure Click here
A0A0R0IJY3 View 3D Structure Click here
A0A0R0ILJ6 View 3D Structure Click here
A0A0R0JAB1 View 3D Structure Click here
A0A1D6F3U6 View 3D Structure Click here
A0A1D6F6S1 View 3D Structure Click here
A0A1D6GB07 View 3D Structure Click here
A0A1D6H6N4 View 3D Structure Click here
A0A1D6I4D2 View 3D Structure Click here
A0A1D6I789 View 3D Structure Click here
A0A1D6IAQ8 View 3D Structure Click here
A0A1D6J6R5 View 3D Structure Click here
A0A1D6KJT2 View 3D Structure Click here
A0A1D6KJT2 View 3D Structure Click here
A0A1D6MNE9 View 3D Structure Click here
A0A1D6N9F1 View 3D Structure Click here
A0A1D6NE27 View 3D Structure Click here
A0A1D6P5D8 View 3D Structure Click here
A0A1D8PGN3 View 3D Structure Click here
A0A1D8PTH4 View 3D Structure Click here
A2AWR3 View 3D Structure Click here
A4HWX7 View 3D Structure Click here
A4HY96 View 3D Structure Click here
B2D1S1 View 3D Structure Click here
B4FSJ4 View 3D Structure Click here
B4FSJ4 View 3D Structure Click here
B6T254 View 3D Structure Click here
B7EM10 View 3D Structure Click here
B9G4Z8 View 3D Structure Click here
C0PGY4 View 3D Structure Click here
D3ZWM3 View 3D Structure Click here
D5A7J3 View 3D Structure Click here
D5A7J3 View 3D Structure Click here
E7FDX1 View 3D Structure Click here
E9QEQ9 View 3D Structure Click here
E9QEQ9 View 3D Structure Click here
F4HWB6 View 3D Structure Click here
F4HWB6 View 3D Structure Click here
I1J898 View 3D Structure Click here
I1J8B4 View 3D Structure Click here
I1JMS6 View 3D Structure Click here
I1K2H7 View 3D Structure Click here
I1KJ54 View 3D Structure Click here
I1KJK8 View 3D Structure Click here
I1KQK9 View 3D Structure Click here
I1L2S6 View 3D Structure Click here
I1L4N1 View 3D Structure Click here
I1L6W5 View 3D Structure Click here
I1LIC5 View 3D Structure Click here
I1LIE1 View 3D Structure Click here
I1LVK8 View 3D Structure Click here
I1MAE5 View 3D Structure Click here
I1MI30 View 3D Structure Click here
I1MMV2 View 3D Structure Click here
I1N3Y1 View 3D Structure Click here
I1N4A8 View 3D Structure Click here
I1N7B8 View 3D Structure Click here
I1ND75 View 3D Structure Click here
I3RWV5 View 3D Structure Click here
I3RWW1 View 3D Structure Click here
I3RWW3 View 3D Structure Click here
K7KEN1 View 3D Structure Click here
K7KY67 View 3D Structure Click here
K7L183 View 3D Structure Click here
K7L348 View 3D Structure Click here
K7LC37 View 3D Structure Click here
K7LDB3 View 3D Structure Click here
K7LEW8 View 3D Structure Click here
K7LFZ2 View 3D Structure Click here
K7LKA4 View 3D Structure Click here
K7LY06 View 3D Structure Click here
K7LY07 View 3D Structure Click here
K7MBW3 View 3D Structure Click here
K7MBW3 View 3D Structure Click here
K7MGQ0 View 3D Structure Click here
K7MLV7 View 3D Structure Click here
K7MTX9 View 3D Structure Click here
K7N4N4 View 3D Structure Click here
K7V280 View 3D Structure Click here
M9PFK5 View 3D Structure Click here
M9PFK5 View 3D Structure Click here
M9WU84 View 3D Structure Click here
O14197 View 3D Structure Click here
P0AA49 View 3D Structure Click here
P0AA49 View 3D Structure Click here
P0C0X5 View 3D Structure Click here
P38355 View 3D Structure Click here
P53932 View 3D Structure Click here
P54072 View 3D Structure Click here
Q0IQA5 View 3D Structure Click here
Q0IZR4 View 3D Structure Click here
Q0JI87 View 3D Structure Click here
Q0JJV0 View 3D Structure Click here
Q0JJV0 View 3D Structure Click here
Q0MWY1 View 3D Structure Click here
Q0MWY2 View 3D Structure Click here
Q2FVZ8 View 3D Structure Click here
Q4CM80 View 3D Structure Click here
Q4CP58 View 3D Structure Click here
Q4CW11 View 3D Structure Click here
Q4DDT5 View 3D Structure Click here
Q4DPM3 View 3D Structure Click here
Q4DRE6 View 3D Structure Click here
Q58437 View 3D Structure Click here
Q58437 View 3D Structure Click here
Q59TZ9 View 3D Structure Click here
Q5JLM1 View 3D Structure Click here
Q5JLM1 View 3D Structure Click here
Q5KQI0 View 3D Structure Click here
Q5SMQ9 View 3D Structure Click here
Q5VP70 View 3D Structure Click here
Q5VQY3 View 3D Structure Click here
Q651V6 View 3D Structure Click here
Q67UL3 View 3D Structure Click here
Q6L5F6 View 3D Structure Click here
Q6YZX7 View 3D Structure Click here
Q6ZIB5 View 3D Structure Click here
Q6ZIB5 View 3D Structure Click here
Q7Z3F1 View 3D Structure Click here
Q7Z3F1 View 3D Structure Click here
Q8RWZ6 View 3D Structure Click here
Q940Y5 View 3D Structure Click here
Q99252 View 3D Structure Click here
Q9C6B8 View 3D Structure Click here
Q9C999 View 3D Structure Click here
Q9C9K4 View 3D Structure Click here
Q9C9K5 View 3D Structure Click here
Q9FFD0 View 3D Structure Click here
Q9FFD0 View 3D Structure Click here
Q9FKY4 View 3D Structure Click here
Q9LFP6 View 3D Structure Click here
Q9LU77 View 3D Structure Click here
Q9LZN2 View 3D Structure Click here
Q9S7Z8 View 3D Structure Click here
Q9SHL8 View 3D Structure Click here
Q9SQH6 View 3D Structure Click here