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0  structures 660  species 0  interactions 968  sequences 2  architectures

Family: Cad (PF03596)

Summary: Cadmium resistance transporter

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This is the Wikipedia entry entitled "Cadmium resistance transporter". More...

Cadmium resistance transporter Edit Wikipedia article

Cadmium Resistance Protein

The cadmium resistance (CadD) protein family (TC# 2.A.77) belongs to the Lysine exporter (LysE) superfamily.[1] CadD members facilitate the export of cationic compounds such as cadmium ions.[2]


Currently, many sequenced proteins comprise the CadD family. Two are close orthologues in two Staphylococcus species that have been reported to function in cadmium resistance, a fourth has been reported to function in quaternary ammonium cation export, and the fourth is a distant open reading frame (ORF) in Staphylococcus aureus.[3] These proteins are found in Gram-positive bacteria. Their mode of energy coupling has not been investigated, but is hypothesized to include a proton antiport mechanism. This family is distantly related to members of the LysE family (TC #2.A.75) and the RhtB family (TC #2.A.76). These three families, which are included in the LysE superfamily, all consist of proteins of similar sizes (about 200 residues) and topologies (6 putative transmembrane α-helical segments; 5 experimentally determined TMSs).[4]

General Transport Reaction

The probable reaction catalyzed by these proteins is:[2]

Cationic compound (in) + nH+ (out) → Cationic compound (out) + nH+ (in).

Further reading


  1. ^ Tsu BV, Saier MH (2015-01-01). "The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis". PLOS One. 10 (10): e0137184. doi:10.1371/journal.pone.0137184. PMC 4608589. PMID 26474485.
  2. ^ a b "2.A.77 The Cadmium Resistance (CadD) Family". Transporter Classification Database. Retrieved 2016-02-25.
  3. ^ Crupper SS, Worrell V, Stewart GC, Iandolo JJ (July 1999). "Cloning and expression of cadD, a new cadmium resistance gene of Staphylococcus aureus". Journal of Bacteriology. 181 (13): 4071–5. PMC 93898. PMID 10383976.
  4. ^ Cao Y, Jin X, Levin EJ, Huang H, Zong Y, Quick M, Weng J, Pan Y, Love J, Punta M, Rost B, Hendrickson WA, Javitch JA, Rajashankar KR, Zhou M (May 2011). "Crystal structure of a phosphorylation-coupled saccharide transporter". Nature. 473 (7345): 50–4. doi:10.1038/nature09939. PMC 3201810. PMID 21471968.

As of 25 February 2016, this article is derived in whole or in part from Transporter Classification Database. The copyright holder has licensed the content in a manner that permits reuse under CC BY-SA 3.0 and GFDL. All relevant terms must be followed. The original text was at "2.A.77 The Cadmium Resistance (CadD) Family".

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Cadmium resistance transporter Provide feedback

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Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR004676

These proteins are members of the Cadmium Resistance (CadD) family. The CadD family includes two close orthologues in two Staphylococcus species that have been reported to function in cadmium resistance [ PUBMED:10383976 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan LysE (CL0292), which has the following description:

This clan includes a diverse range of transporter families [1].

The clan contains the following 19 members:

BacA Cad Colicin_V DsbD DsbD_2 DUF475 DUF6044 FTR1 HupE_UreJ HupE_UreJ_2 LysE MarC Mntp NicO OFeT_1 SfLAP TauE TerC UPF0016


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This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: TIGRFAMs
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: TIGRFAMs, Griffiths-Jones SR
Number in seed: 4
Number in full: 968
Average length of the domain: 184.30 aa
Average identity of full alignment: 33 %
Average coverage of the sequence by the domain: 87.86 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.2 26.2
Trusted cut-off 27.1 26.3
Noise cut-off 26.1 26.1
Model length: 192
Family (HMM) version: 15
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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trRosetta Structure

The structural model below was generated by the Baker group with the trRosetta software using the Pfam UniProt multiple sequence alignment.

The InterPro website shows the contact map for the Pfam SEED alignment. Hovering or clicking on a contact position will highlight its connection to other residues in the alignment, as well as on the 3D structure.

Improved protein structure prediction using predicted inter-residue orientations. Jianyi Yang, Ivan Anishchenko, Hahnbeom Park, Zhenling Peng, Sergey Ovchinnikov, David Baker Proceedings of the National Academy of Sciences Jan 2020, 117 (3) 1496-1503; DOI: 10.1073/pnas.1914677117;