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1980  structures 1488  species 0  interactions 16658  sequences 274  architectures

Family: Tubulin_C (PF03953)

Summary: Tubulin C-terminal domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Tubulin C-terminal domain Provide feedback

This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).

Literature references

  1. Nogales E, Wolf SG, Downing KH; , Nature 1998;391:199-203.: Structure of the alphabeta tubulin dimer by electron crystallography. PUBMED:9428769 EPMC:9428769

  2. Nogales E, Downing KH, Amos LA, Lowe J; , Nat Struct Biol 1998;5:451-458.: Tubulin and FtsZ form a distinct family of GTPases. PUBMED:9628483 EPMC:9628483

  3. Lowe J, Amos LA; , Nature 1998;391:203-206.: Crystal structure of the bacterial cell-division protein FtsZ [see comments] PUBMED:9428770 EPMC:9428770


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR018316

This domain is found in the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. These proteins are GTPases and are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea. This is the C-terminal domain.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Tubulin_C (CL0442), which has the following description:

This superfamily is characterised by being at the C-terminus of the GTPase-binding region of tubulins.

The clan contains the following 2 members:

FtsZ_C Tubulin_C

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(34)
Full
(16658)
Representative proteomes UniProt
(39950)
RP15
(3553)
RP35
(7899)
RP55
(13660)
RP75
(17888)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(34)
Full
(16658)
Representative proteomes UniProt
(39950)
RP15
(3553)
RP35
(7899)
RP55
(13660)
RP75
(17888)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(34)
Full
(16658)
Representative proteomes UniProt
(39950)
RP15
(3553)
RP35
(7899)
RP55
(13660)
RP75
(17888)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: tubulin_C;
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A , Sonnhammer ELL , Griffiths-Jones SR
Number in seed: 34
Number in full: 16658
Average length of the domain: 122.70 aa
Average identity of full alignment: 45 %
Average coverage of the sequence by the domain: 27.97 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.6 26.6
Trusted cut-off 26.6 26.7
Noise cut-off 26.3 26.5
Model length: 126
Family (HMM) version: 19
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Tubulin_C domain has been found. There are 1980 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A096SSY4 View 3D Structure Click here
A0A0H2UHM7 View 3D Structure Click here
A0A0R0FGR2 View 3D Structure Click here
A0A0R0H6V5 View 3D Structure Click here
A0A0R0IHF9 View 3D Structure Click here
A0A0R0JYY8 View 3D Structure Click here
A0A0R4IPH2 View 3D Structure Click here
A0A0R4IXC8 View 3D Structure Click here
A0A143ZWL7 View 3D Structure Click here
A0A1D6FLZ8 View 3D Structure Click here
A0A1D6GL69 View 3D Structure Click here
A0A1D6JI52 View 3D Structure Click here
A0A1D6LHB5 View 3D Structure Click here
A0A1D8PC97 View 3D Structure Click here
A0A1D8PMD4 View 3D Structure Click here
A0A1D8PTV4 View 3D Structure Click here
A0A2R8RVU0 View 3D Structure Click here
A0A368UHL7 View 3D Structure Click here
A0A381MCS3 View 3D Structure Click here
A0A381MS01 View 3D Structure Click here
A2AQ07 View 3D Structure Click here
A4HTR0 View 3D Structure Click here
A4HTR1 View 3D Structure Click here
A4HZJ3 View 3D Structure Click here
A4I1D7 View 3D Structure Click here
A6NHL2 View 3D Structure Click here
A6NNZ2 View 3D Structure Click here
B4F7C2 View 3D Structure Click here
B4F946 View 3D Structure Click here
B4FTM1 View 3D Structure Click here
B6SPX4 View 3D Structure Click here
B6TF38 View 3D Structure Click here
B8A516 View 3D Structure Click here
B8A518 View 3D Structure Click here
B9DGT7 View 3D Structure Click here
B9DHQ0 View 3D Structure Click here
C0P664 View 3D Structure Click here
C0PH85 View 3D Structure Click here
D3ZRL5 View 3D Structure Click here
E7F244 View 3D Structure Click here
E7FC32 View 3D Structure Click here
E9AGK7 View 3D Structure Click here
E9AGW9 View 3D Structure Click here
F1LUM5 View 3D Structure Click here
F1LUW9 View 3D Structure Click here
F1QKY8 View 3D Structure Click here
F1QQ90 View 3D Structure Click here
F1R4K1 View 3D Structure Click here
G5EDD4 View 3D Structure Click here
G5EF01 View 3D Structure Click here
H2L2E8 View 3D Structure Click here
I1J752 View 3D Structure Click here
I1J9I1 View 3D Structure Click here
I1JLU8 View 3D Structure Click here
I1JRY0 View 3D Structure Click here
I1JT28 View 3D Structure Click here
I1JV03 View 3D Structure Click here
I1K2I1 View 3D Structure Click here
I1K2Y0 View 3D Structure Click here
I1K3X9 View 3D Structure Click here
I1K5C2 View 3D Structure Click here
I1K7J4 View 3D Structure Click here
I1K9J7 View 3D Structure Click here
I1KPA1 View 3D Structure Click here
I1KRC0 View 3D Structure Click here
I1KSD0 View 3D Structure Click here
I1L0G9 View 3D Structure Click here
I1LDR2 View 3D Structure Click here
I1LEC4 View 3D Structure Click here
I1LH27 View 3D Structure Click here
I1MC39 View 3D Structure Click here
I1MG61 View 3D Structure Click here
I1ML11 View 3D Structure Click here
I1MNV2 View 3D Structure Click here
I1MY33 View 3D Structure Click here
I1N898 View 3D Structure Click here
I1N8P5 View 3D Structure Click here
I1NCI3 View 3D Structure Click here
I1NG45 View 3D Structure Click here
I1NGT9 View 3D Structure Click here
K7KXN7 View 3D Structure Click here
K7VKH1 View 3D Structure Click here
M0R8B6 View 3D Structure Click here
O17921 View 3D Structure Click here
O18154 View 3D Structure Click here
O49068 View 3D Structure Click here
P02557 View 3D Structure Click here
P04350 View 3D Structure Click here
P04688 View 3D Structure Click here
P04689 View 3D Structure Click here
P05213 View 3D Structure Click here
P05214 View 3D Structure Click here
P05219 View 3D Structure Click here
P06603 View 3D Structure Click here
P06604 View 3D Structure Click here
P06605 View 3D Structure Click here
P06606 View 3D Structure Click here
P07437 View 3D Structure Click here
P08841 View 3D Structure Click here
P09733 View 3D Structure Click here
P09734 View 3D Structure Click here
P0DPH7 View 3D Structure Click here
P0DPH8 View 3D Structure Click here
P11139 View 3D Structure Click here
P12411 View 3D Structure Click here
P12456 View 3D Structure Click here
P12459 View 3D Structure Click here
P12460 View 3D Structure Click here
P14640 View 3D Structure Click here
P14641 View 3D Structure Click here
P18025 View 3D Structure Click here
P18026 View 3D Structure Click here
P22275 View 3D Structure Click here
P23257 View 3D Structure Click here
P23258 View 3D Structure Click here
P24636 View 3D Structure Click here
P25295 View 3D Structure Click here
P28551 View 3D Structure Click here
P28752 View 3D Structure Click here
P29511 View 3D Structure Click here
P29513 View 3D Structure Click here
P29514 View 3D Structure Click here
P29515 View 3D Structure Click here
P29516 View 3D Structure Click here
P29517 View 3D Structure Click here
P32255 View 3D Structure Click here
P32256 View 3D Structure Click here
P33627 View 3D Structure Click here
P34475 View 3D Structure Click here
P34690 View 3D Structure Click here
P37832 View 3D Structure Click here
P38557 View 3D Structure Click here
P38558 View 3D Structure Click here
P41937 View 3D Structure Click here
P42271 View 3D Structure Click here
P45960 View 3D Structure Click here
P46265 View 3D Structure Click here
P52274 View 3D Structure Click here
P52275 View 3D Structure Click here
P53378 View 3D Structure Click here
P61857 View 3D Structure Click here
P68363 View 3D Structure Click here
P68366 View 3D Structure Click here
P68368 View 3D Structure Click here
P68369 View 3D Structure Click here
P68370 View 3D Structure Click here
P68371 View 3D Structure Click here
P68372 View 3D Structure Click here
P68373 View 3D Structure Click here
P69897 View 3D Structure Click here
P83887 View 3D Structure Click here
P83888 View 3D Structure Click here
P85108 View 3D Structure Click here
P91873 View 3D Structure Click here
P91910 View 3D Structure Click here
P99024 View 3D Structure Click here
Q02245 View 3D Structure Click here
Q0WV25 View 3D Structure Click here
Q10PW2 View 3D Structure Click here
Q13509 View 3D Structure Click here
Q13885 View 3D Structure Click here
Q18817 View 3D Structure Click here
Q19490 View 3D Structure Click here
Q20221 View 3D Structure Click here
Q24560 View 3D Structure Click here
Q2TFP1 View 3D Structure Click here
Q3KRE8 View 3D Structure Click here
Q3UX10 View 3D Structure Click here
Q3ZCM7 View 3D Structure Click here
Q40665 View 3D Structure Click here
Q41782 View 3D Structure Click here
Q41783 View 3D Structure Click here
Q41784 View 3D Structure Click here
Q41785 View 3D Structure Click here
Q41807 View 3D Structure Click here
Q41808 View 3D Structure Click here
Q41874 View 3D Structure Click here
Q43594 View 3D Structure Click here
Q43695 View 3D Structure Click here
Q43697 View 3D Structure Click here
Q4CLA1 View 3D Structure Click here
Q4DKP7 View 3D Structure Click here
Q4DLN2 View 3D Structure Click here
Q4DQP2 View 3D Structure Click here
Q4DTQ7 View 3D Structure Click here
Q4QQV0 View 3D Structure Click here
Q4QRB4 View 3D Structure Click here
Q53M52 View 3D Structure Click here
Q54TA6 View 3D Structure Click here
Q55AR3 View 3D Structure Click here
Q56WH1 View 3D Structure Click here
Q56YW9 View 3D Structure Click here
Q5XIF6 View 3D Structure Click here
Q68FR8 View 3D Structure Click here
Q6AY56 View 3D Structure Click here
Q6AYZ1 View 3D Structure Click here
Q6DC49 View 3D Structure Click here
Q6GQM1 View 3D Structure Click here
Q6IQJ2 View 3D Structure Click here
Q6NW90 View 3D Structure Click here
Q6NWJ5 View 3D Structure Click here
Q6NWK7 View 3D Structure Click here
Q6P5M9 View 3D Structure Click here
Q6P972 View 3D Structure Click here
Q6P9T8 View 3D Structure Click here
Q6P9V9 View 3D Structure Click here
Q6PC95 View 3D Structure Click here
Q6PE34 View 3D Structure Click here
Q6PEY2 View 3D Structure Click here
Q6TNP9 View 3D Structure Click here
Q6ZLZ9 View 3D Structure Click here
Q71U36 View 3D Structure Click here
Q75GI3 View 3D Structure Click here
Q76FS2 View 3D Structure Click here
Q76FS3 View 3D Structure Click here
Q7TMM9 View 3D Structure Click here
Q7ZVM5 View 3D Structure Click here
Q8H7U1 View 3D Structure Click here
Q8IAN7 View 3D Structure Click here
Q8IFP3 View 3D Structure Click here
Q8IK81 View 3D Structure Click here
Q8MST5 View 3D Structure Click here
Q8VCK3 View 3D Structure Click here
Q922F4 View 3D Structure Click here
Q9ASR0 View 3D Structure Click here
Q9BQE3 View 3D Structure Click here
Q9BUF5 View 3D Structure Click here
Q9BVA1 View 3D Structure Click here
Q9CWF2 View 3D Structure Click here
Q9D6F9 View 3D Structure Click here
Q9D6T1 View 3D Structure Click here
Q9ERD7 View 3D Structure Click here
Q9H4B7 View 3D Structure Click here
Q9JJZ2 View 3D Structure Click here
Q9NRH3 View 3D Structure Click here
Q9NY65 View 3D Structure Click here
Q9UJT0 View 3D Structure Click here
Q9VED6 View 3D Structure Click here
Q9VRX3 View 3D Structure Click here