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4  structures 1593  species 0  interactions 1618  sequences 10  architectures

Family: Iron_traffic (PF04362)

Summary: Bacterial Fe(2+) trafficking

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Bacterial Fe(2+) trafficking Provide feedback

This is a family of bacterial Fe(2+) trafficking proteins.

Literature references

  1. Wasinger VC, Humphery-Smith I; , FEMS Microbiol Lett 1998;169:375-382.: Small genes/gene-products in Escherichia coli K-12. PUBMED:9868784 EPMC:9868784

  2. Link AJ, Robison K, Church GM; , Electrophoresis 1997;18:1259-1313.: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12. PUBMED:9298646 EPMC:9298646

  3. Osborne MJ, Siddiqui N, Landgraf D, Pomposiello PJ, Gehring K; , Protein Sci 2005;14:1673-1678.: The solution structure of the oxidative stress-related protein YggX from Escherichia coli. PUBMED:15883188 EPMC:15883188


This tab holds annotation information from the InterPro database.

InterPro entry IPR007457

The protein represented by this entry, YggX, serves to protect Fe-S clusters from oxidative damage [PUBMED:11416172]. The effect is two-fold: proteins that rely on Fe-S clusters do not become inactivated, and the release of free iron and hydrogen peroxide--a DNA damaging agent--is prevented. These observations are consistent with the hypothesis that YggX chelates free iron, and recent experiments show that YggX can indeed bind Fe(II) in vitro and in vivo [PUBMED:12670952]. Furthermore, YggX has a positive effect on the action of at least one Fe(II)-responsive protein. The combined actions of YggX is reminiscent of iron trafficking proteins [PUBMED:12033438], and YggX is therefore proposed to play a role in Fe(II) trafficking [PUBMED:12670952]. In Escherichia coli, YggX was shown to be under the transcriptional control of the redox-sensing SoxRS system [PUBMED:14594836].

Gene Ontology

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Domain organisation

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(101)
Full
(1618)
Representative proteomes UniProt
(5657)
NCBI
(4331)
Meta
(383)
RP15
(346)
RP35
(964)
RP55
(1645)
RP75
(2667)
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(101)
Full
(1618)
Representative proteomes UniProt
(5657)
NCBI
(4331)
Meta
(383)
RP15
(346)
RP35
(964)
RP55
(1645)
RP75
(2667)
Alignment:
Format:
Order:
Sequence:
Gaps:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(101)
Full
(1618)
Representative proteomes UniProt
(5657)
NCBI
(4331)
Meta
(383)
RP15
(346)
RP35
(964)
RP55
(1645)
RP75
(2667)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.