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34  structures 582  species 0  interactions 11636  sequences 271  architectures

Family: AIG1 (PF04548)

Summary: AIG1 family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

AIG1 family Provide feedback

Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.

Literature references

  1. Reuber TL, Ausubel FM; , Plant Cell 1996;8:241-249.: Isolation of Arabidopsis genes that differentiate between resistance responses mediated by the RPS2 and RPM1 disease resistance genes. PUBMED:8742710 EPMC:8742710


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR006703

This entry represents the AIG1-type G domain.

The P-loop guanosine triphosphatases (GTPases) control a multitude of biological processes, ranging from cell division, cell cycling, and signal transduction, to ribosome assembly and protein synthesis. GTPases exert their control by interchanging between an inactive GDP-bound state and an active GTP-bound state, thereby acting as molecular switches. The common denominator of GTPases is the highly conserved guanine nucleotide-binding (G) domain that is responsible for binding and hydrolysis of guanine nucleotides.

The TRAFAC (translation factor related) class AIG1/Toc34/Toc159-like paraseptin GTPase family contains the following subfamilies [ PUBMED:11916378 ]:

  • The GTPases of immunity-associated protein (GIMAP)/immune-associated nucleotide-binding protein (IAN) subfamily is conserved among vertebrates and angiosperm plants and has been postulated to regulate apoptosis, particularly in context with diseases such as cancer, diabetes, and infections. The function of GIMAP/IAN GTPases has been linked to self defense in plants and to the development of T cells in vertebrates [ PUBMED:15474311 , PUBMED:21059949 ].
  • Plant-specific Toc (translocon at the outer envelope membrane of chloroplasts) proteins. Toc proteins function as integral components of the chloroplast protein import machinery. The Toc translocon contains the two membrane-bound GTPases Toc33/34 and Toc 159, which expose their G domains to the cytosol and recognise and then deliver precursor proteins through the translocation pore Toc75 [ PUBMED:17337454 , PUBMED:18400179 ].

The GIMAP/IAN GTPases contain a avrRpt2 induced gene 1 (AIG1)-type G domain that exhibits the five motifs G1-G5 characteristic for GTP/GDP-binding proteins. In addition, the AIG-type G domain contains a unique, highly conserved, hydrophobic motif between G3 and G4. It has a divergent version of the guanine recognition motif (G4) at the end of the core strand 5 and an additional helix alpha6 at the C terminus. The AIG1-type G domain contains a central beta-sheet sandwiched by two layers of alpha-helices.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan P-loop_NTPase (CL0023), which has the following description:

AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].

The clan contains the following 243 members:

6PF2K AAA AAA-ATPase_like AAA_10 AAA_11 AAA_12 AAA_13 AAA_14 AAA_15 AAA_16 AAA_17 AAA_18 AAA_19 AAA_2 AAA_21 AAA_22 AAA_23 AAA_24 AAA_25 AAA_26 AAA_27 AAA_28 AAA_29 AAA_3 AAA_30 AAA_31 AAA_32 AAA_33 AAA_34 AAA_35 AAA_5 AAA_6 AAA_7 AAA_8 AAA_9 AAA_PrkA ABC_ATPase ABC_tran ABC_tran_Xtn Adeno_IVa2 Adenylsucc_synt ADK AFG1_ATPase AIG1 APS_kinase Arf ArsA_ATPase ATP-synt_ab ATP_bind_1 ATP_bind_2 ATPase ATPase_2 Bac_DnaA BCA_ABC_TP_C Beta-Casp bpMoxR Cas_Csn2 Cas_St_Csn2 CbiA CBP_BcsQ CDC73_C CENP-M CFTR_R CLP1_P CMS1 CoaE CobA_CobO_BtuR CobU cobW CPT CSM2 CTP_synth_N Cytidylate_kin Cytidylate_kin2 DAP3 DBINO DEAD DEAD_2 DLIC DNA_pack_C DNA_pack_N DNA_pol3_delta DNA_pol3_delta2 DnaB_C dNK DO-GTPase1 DO-GTPase2 DUF1611 DUF1726 DUF2075 DUF2326 DUF2478 DUF257 DUF2791 DUF2813 DUF3584 DUF463 DUF5906 DUF6079 DUF815 DUF853 DUF87 DUF927 Dynamin_N Dynein_heavy Elong_Iki1 ELP6 ERCC3_RAD25_C Exonuc_V_gamma FeoB_N Fer4_NifH Flavi_DEAD FTHFS FtsK_SpoIIIE G-alpha Gal-3-0_sulfotr GBP GBP_C GTP_EFTU Gtr1_RagA Guanylate_kin GvpD HDA2-3 Helicase_C Helicase_C_2 Helicase_C_4 Helicase_RecD Herpes_Helicase Herpes_ori_bp Herpes_TK HSA HydF_dimer HydF_tetramer Hydin_ADK IIGP IPPT IPT iSTAND IstB_IS21 KAP_NTPase KdpD Kinase-PPPase Kinesin KTI12 LAP1C Lon_2 LpxK MCM MeaB MEDS Mg_chelatase Microtub_bd MipZ MMR_HSR1 MMR_HSR1_C MobB MukB Mur_ligase_M MutS_V Myosin_head NACHT NAT_N NB-ARC NOG1 NTPase_1 NTPase_P4 OPA1_C ORC3_N P-loop_TraG ParA Parvo_NS1 PAXNEB PduV-EutP PhoH PIF1 Ploopntkinase1 Ploopntkinase2 Ploopntkinase3 Podovirus_Gp16 Polyoma_lg_T_C Pox_A32 PPK2 PPV_E1_C PRK PSY3 Rad17 Rad51 Ras RecA ResIII RHD3 RhoGAP_pG1_pG2 RHSP RNA12 RNA_helicase Roc RsgA_GTPase RuvB_N SbcCD_C SecA_DEAD Septin Sigma54_activ_2 Sigma54_activat SKI SMC_N SNF2-rel_dom Spore_III_AA Spore_IV_A SRP54 SRPRB SulA Sulfotransfer_1 Sulfotransfer_2 Sulfotransfer_3 Sulfotransfer_4 Sulfotransfer_5 Sulphotransf SWI2_SNF2 T2SSE T4SS-DNA_transf Terminase_1 Terminase_3 Terminase_6N Terminase_GpA Thymidylate_kin TIP49 TK TniB Torsin TraG-D_C tRNA_lig_kinase TrwB_AAD_bind TsaE UvrB UvrD-helicase UvrD_C UvrD_C_2 Viral_helicase1 VirC1 VirE YqeC Zeta_toxin Zot

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(32)
Full
(11636)
Representative proteomes UniProt
(20214)
RP15
(1631)
RP35
(4853)
RP55
(10877)
RP75
(13774)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(32)
Full
(11636)
Representative proteomes UniProt
(20214)
RP15
(1631)
RP35
(4853)
RP55
(10877)
RP75
(13774)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(32)
Full
(11636)
Representative proteomes UniProt
(20214)
RP15
(1631)
RP35
(4853)
RP55
(10877)
RP75
(13774)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_1846 (release 7.5)
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 32
Number in full: 11636
Average length of the domain: 184.80 aa
Average identity of full alignment: 25 %
Average coverage of the sequence by the domain: 45.65 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.0 27.0
Noise cut-off 26.9 26.9
Model length: 212
Family (HMM) version: 18
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the AIG1 domain has been found. There are 34 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A096RKK3 View 3D Structure Click here
A0A096TUW0 View 3D Structure Click here
A0A0G2KE99 View 3D Structure Click here
A0A0G2KEF2 View 3D Structure Click here
A0A0G2KIU3 View 3D Structure Click here
A0A0G2KPB1 View 3D Structure Click here
A0A0G2KUY7 View 3D Structure Click here
A0A0G2KXL4 View 3D Structure Click here
A0A0G2L1M8 View 3D Structure Click here
A0A0G2L7C5 View 3D Structure Click here
A0A0G2L7C5 View 3D Structure Click here
A0A0G2L7C5 View 3D Structure Click here
A0A0J9YJF6 View 3D Structure Click here
A0A0P0WAT9 View 3D Structure Click here
A0A0P0Y7V1 View 3D Structure Click here
A0A0R0IRU4 View 3D Structure Click here
A0A0R4IHF7 View 3D Structure Click here
A0A0R4IJU8 View 3D Structure Click here
A0A0R4IW29 View 3D Structure Click here
A0A0R4IW29 View 3D Structure Click here
A0A0R4IYQ6 View 3D Structure Click here
A0A0R4IYU8 View 3D Structure Click here
A0A0R4J4G5 View 3D Structure Click here
A0A140LFW6 View 3D Structure Click here
A0A140LFW6 View 3D Structure Click here
A0A140LG59 View 3D Structure Click here
A0A140LGH1 View 3D Structure Click here
A0A140LGH1 View 3D Structure Click here
A0A140LGH1 View 3D Structure Click here
A0A140LGJ1 View 3D Structure Click here
A0A140LH15 View 3D Structure Click here
A0A1D5NSA9 View 3D Structure Click here
A0A1D6FUE3 View 3D Structure Click here
A0A1D6GDQ7 View 3D Structure Click here
A0A1D6JVK1 View 3D Structure Click here
A0A1D6K830 View 3D Structure Click here
A0A1D6LIW1 View 3D Structure Click here
A0A1D6PF59 View 3D Structure Click here
A0A1D6Q388 View 3D Structure Click here
A0A2R8PYG4 View 3D Structure Click here
A0A2R8PYT4 View 3D Structure Click here
A0A2R8Q083 View 3D Structure Click here
A0A2R8Q1R3 View 3D Structure Click here
A0A2R8Q2F9 View 3D Structure Click here
A0A2R8Q3G3 View 3D Structure Click here
A0A2R8Q4S4 View 3D Structure Click here
A0A2R8Q4S4 View 3D Structure Click here
A0A2R8Q6A2 View 3D Structure Click here
A0A2R8Q6I9 View 3D Structure Click here
A0A2R8Q813 View 3D Structure Click here
A0A2R8Q9V6 View 3D Structure Click here
A0A2R8QCG5 View 3D Structure Click here
A0A2R8QD03 View 3D Structure Click here
A0A2R8QEE2 View 3D Structure Click here
A0A2R8QEP8 View 3D Structure Click here
A0A2R8QF17 View 3D Structure Click here
A0A2R8QF90 View 3D Structure Click here
A0A2R8QGG4 View 3D Structure Click here
A0A2R8QK87 View 3D Structure Click here
A0A2R8QLW1 View 3D Structure Click here
A0A2R8QMS4 View 3D Structure Click here
A0A2R8QMV1 View 3D Structure Click here
A0A2R8QNH6 View 3D Structure Click here
A0A2R8QP20 View 3D Structure Click here
A0A2R8QSB3 View 3D Structure Click here
A0A2R8QSW6 View 3D Structure Click here
A0A2R8QSW6 View 3D Structure Click here
A0A2R8QTD1 View 3D Structure Click here
A0A2R8QU83 View 3D Structure Click here
A0A2R8RJF7 View 3D Structure Click here
A0A2R8RMP9 View 3D Structure Click here
A0A2R8RQ40 View 3D Structure Click here
A0A2R8RQL5 View 3D Structure Click here
A0A2R8RTY2 View 3D Structure Click here
A0A2R8RY56 View 3D Structure Click here
A0A368UHT3 View 3D Structure Click here
A8WFZ9 View 3D Structure Click here
A8WG18 View 3D Structure Click here
B0BMZ3 View 3D Structure Click here
B0S5W4 View 3D Structure Click here
B0S637 View 3D Structure Click here
B0UXS4 View 3D Structure Click here
B3DIJ3 View 3D Structure Click here
B6T438 View 3D Structure Click here
B8JLT8 View 3D Structure Click here
E7EYK5 View 3D Structure Click here
E7EYK5 View 3D Structure Click here
E7EYM3 View 3D Structure Click here
E7F536 View 3D Structure Click here
E7FA02 View 3D Structure Click here
E7FA55 View 3D Structure Click here
E7FBP5 View 3D Structure Click here
E7FCE6 View 3D Structure Click here
E7FDG9 View 3D Structure Click here
E7FG49 View 3D Structure Click here
E9PW74 View 3D Structure Click here
E9QFE2 View 3D Structure Click here
E9QG14 View 3D Structure Click here
E9QG14 View 3D Structure Click here
E9QH87 View 3D Structure Click here
E9QHM5 View 3D Structure Click here
E9QHM5 View 3D Structure Click here
F1Q4P8 View 3D Structure Click here
F1Q6X7 View 3D Structure Click here
F1Q8X3 View 3D Structure Click here
F1QFC1 View 3D Structure Click here
F1QJF8 View 3D Structure Click here
F1QNL4 View 3D Structure Click here
F1QNL7 View 3D Structure Click here
F1QUG6 View 3D Structure Click here
F1QUG6 View 3D Structure Click here
F1QUU6 View 3D Structure Click here
F1QV70 View 3D Structure Click here
F1QVS2 View 3D Structure Click here
F1QVS3 View 3D Structure Click here
F1R3F6 View 3D Structure Click here
F1R7T3 View 3D Structure Click here
F1R857 View 3D Structure Click here
F1RBS9 View 3D Structure Click here
F1RBS9 View 3D Structure Click here
F4HT21 View 3D Structure Click here
F4JKW7 View 3D Structure Click here
F8W2W4 View 3D Structure Click here
G3X987 View 3D Structure Click here
H0WEU1 View 3D Structure Click here
H0WEU1 View 3D Structure Click here
H0WEU1 View 3D Structure Click here
I1JK18 View 3D Structure Click here
I1KFT9 View 3D Structure Click here
I1LIY4 View 3D Structure Click here
I1LZT2 View 3D Structure Click here
I1MU33 View 3D Structure Click here
I1N8J5 View 3D Structure Click here
K7DYB1 View 3D Structure Click here
K7DYH3 View 3D Structure Click here
K7KQN4 View 3D Structure Click here
K7KYF6 View 3D Structure Click here
K7LST1 View 3D Structure Click here
K7MJN0 View 3D Structure Click here
K7VKG7 View 3D Structure Click here
O23680 View 3D Structure Click here
O81025 View 3D Structure Click here
O81283 View 3D Structure Click here
P0DJR0 View 3D Structure Click here
P54120 View 3D Structure Click here
P70224 View 3D Structure Click here
Q0DKN6 View 3D Structure Click here
Q10PB3 View 3D Structure Click here
Q38906 View 3D Structure Click here
Q3LF76 View 3D Structure Click here
Q3ZAV4 View 3D Structure Click here
Q4KLG2 View 3D Structure Click here
Q4KLG2 View 3D Structure Click here
Q4KLG2 View 3D Structure Click here
Q54DC6 View 3D Structure Click here
Q552Z6 View 3D Structure Click here
Q5BK45 View 3D Structure Click here
Q5EAR1 View 3D Structure Click here
Q5FVN6 View 3D Structure Click here
Q6P9H5 View 3D Structure Click here
Q6S5G3 View 3D Structure Click here
Q6YVY1 View 3D Structure Click here
Q75LI9 View 3D Structure Click here
Q75N62 View 3D Structure Click here
Q75N62 View 3D Structure Click here
Q75N62 View 3D Structure Click here
Q8BWF2 View 3D Structure Click here
Q8K349 View 3D Structure Click here
Q8K3K9 View 3D Structure Click here
Q8K3L6 View 3D Structure Click here
Q8ND71 View 3D Structure Click here
Q8ND71 View 3D Structure Click here
Q8ND71 View 3D Structure Click here
Q8NHV1 View 3D Structure Click here
Q8R379 View 3D Structure Click here
Q8WWP7 View 3D Structure Click here
Q94LU7 View 3D Structure Click here
Q96F15 View 3D Structure Click here
Q99JY3 View 3D Structure Click here
Q99MI6 View 3D Structure Click here
Q9C8U2 View 3D Structure Click here
Q9C8U4 View 3D Structure Click here
Q9C8U5 View 3D Structure Click here
Q9C8U6 View 3D Structure Click here
Q9C8U7 View 3D Structure Click here
Q9C8U8 View 3D Structure Click here
Q9C8V0 View 3D Structure Click here
Q9C8V2 View 3D Structure Click here
Q9LUS2 View 3D Structure Click here
Q9LVT3 View 3D Structure Click here
Q9NUV9 View 3D Structure Click here
Q9SLF3 View 3D Structure Click here
Q9T0F2 View 3D Structure Click here
Q9T0F3 View 3D Structure Click here
Q9T0F4 View 3D Structure Click here
Q9UG22 View 3D Structure Click here
R4GDV0 View 3D Structure Click here
R4GDV0 View 3D Structure Click here
X1WBF3 View 3D Structure Click here
X1WBF3 View 3D Structure Click here
X1WBF3 View 3D Structure Click here
X1WBQ3 View 3D Structure Click here
X1WCF0 View 3D Structure Click here
X1WCF0 View 3D Structure Click here
X1WDF8 View 3D Structure Click here
X1WDF8 View 3D Structure Click here
X1WDF8 View 3D Structure Click here
X1WE97 View 3D Structure Click here
X1WE97 View 3D Structure Click here
X1WFE5 View 3D Structure Click here