# STOCKHOLM 1.0 #=GF ID GcpE #=GF AC PF04551.16 #=GF DE GcpE protein #=GF AU Bateman A;0000-0002-6982-4660 #=GF SE Pfam-B_1482 (release 7.5) #=GF GA 32.00 32.00; #=GF TC 32.30 32.20; #=GF NC 31.90 31.80; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 1521767 #=GF RT Sequence and characterization of the gcpE gene of Escherichia #=GF RT coli. #=GF RA Baker J, Franklin DB, Parker J; #=GF RL FEMS Microbiol Lett 1992;73:175-180. #=GF RN [2] #=GF RM 11274098 #=GF RT GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate #=GF RT pathway of isoprenoid biosynthesis in Escherichia coli. #=GF RA Altincicek B, Kollas AK, Sanderbrand S, Wiesner J, Hintz M, Beck #=GF RA E, Jomaa H; #=GF RL J Bacteriol 2001;183:2411-2416. #=GF DR INTERPRO; IPR004588; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC In a variety of organisms, including plants and several #=GF CC eubacteria, isoprenoids are synthesised by the #=GF CC mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) #=GF CC pathway. Although different enzymes of this pathway have been #=GF CC described, the terminal biosynthetic steps of the MEP pathway #=GF CC have not been fully elucidated. GcpE gene of Escherichia coli is #=GF CC involved in this pathway [2]. #=GF SQ 7795 #=GS A0A495IDV5_9MICO/14-357 AC A0A495IDV5.1 #=GS H1HKA0_9BACT/13-607 AC H1HKA0.1 #=GS A0A370I2S5_9NOCA/22-365 AC A0A370I2S5.1 #=GS D7BN44_ARCHD/25-367 AC D7BN44.1 #=GS A0A1T0CMK2_9GAMM/12-354 AC A0A1T0CMK2.1 #=GS A0A1G8RE36_9RHOB/17-360 AC A0A1G8RE36.1 #=GS A0A1M6I4M2_9CLOT/5-349 AC A0A1M6I4M2.1 #=GS A0A1D3RIJ7_PLAMA/126-881 AC A0A1D3RIJ7.1 #=GS A0A367YX76_9ACTN/23-366 AC A0A367YX76.1 #=GS A0A160F594_9BACI/10-352 AC A0A160F594.1 #=GS A0A5N5RN30_9BIFI/33-376 AC A0A5N5RN30.1 #=GS A0A1B8QLA3_9GAMM/12-354 AC A0A1B8QLA3.1 #=GS A0A0M1J772_9GAMM/15-121 AC A0A0M1J772.1 #=GS A0A1H9UCR0_9ACTN/21-364 AC A0A1H9UCR0.1 #=GS A0A0Q8EYF5_9GAMM/22-410 AC A0A0Q8EYF5.1 #=GS A0A367EQE3_9ACTN/21-364 AC A0A367EQE3.1 #=GS A0A372JKH4_9ACTN/20-363 AC A0A372JKH4.1 #=GS A0A095T7J8_9GAMM/12-355 AC A0A095T7J8.1 #=GS W2BVP5_9FIRM/2-347 AC W2BVP5.1 #=GS L1MLI4_9BACT/11-337 AC L1MLI4.1 #=GS D7VMV2_9SPHI/519-663 AC D7VMV2.1 #=GS A0A380BPC4_SPOPA/10-352 AC A0A380BPC4.1 #=GS W4J2X7_PLAFP/121-409 AC W4J2X7.1 #=GS E7MM66_9FIRM/6-348 AC E7MM66.1 #=GS W0HQX9_9GAMM/12-355 AC W0HQX9.1 #=GS A0A0M1JDU8_9GAMM/14-259 AC A0A0M1JDU8.1 #=GS A0A1R1SSS9_9ACTN/28-371 AC A0A1R1SSS9.1 #=GS A0A1Y4CH97_9BACT/16-437 AC A0A1Y4CH97.1 #=GS A0A1C2DGT5_9RHIZ/14-402 AC A0A1C2DGT5.1 #=GS A0A2H9VPJ3_9SPHI/25-310 AC A0A2H9VPJ3.1 #=GS A0A558NLA6_9GAMM/12-353 AC A0A558NLA6.1 #=GS A0A0Q6K4V4_9SPHN/14-357 AC A0A0Q6K4V4.1 #=GS G4M8Q1_9BURK/39-427 AC G4M8Q1.1 #=GS A0A2K3V1G6_9DEIO/6-394 AC A0A2K3V1G6.1 #=GS A0A4R5VFX8_9RHOB/17-360 AC A0A4R5VFX8.1 #=GS F9MTD6_9FIRM/5-347 AC F9MTD6.1 #=GS R6CQG7_9BACE/11-301 AC R6CQG7.1 #=GS E0E181_9FIRM/8-350 AC E0E181.1 #=GS A0A4U1C132_9SPHI/508-654 AC A0A4U1C132.1 #=GS A0A0C1IDK1_9BACT/16-303 AC A0A0C1IDK1.1 #=GS A0A222SFG0_9CHLB/473-670 AC A0A222SFG0.1 #=GS A0A1H3X5Q6_ALKAM/1-340 AC A0A1H3X5Q6.1 #=GS A0A2T4DTW2_9BACT/452-641 AC A0A2T4DTW2.1 #=GS A0A074LPF3_9BACL/7-349 AC A0A074LPF3.1 #=GS A0A1E3HB06_9RHIZ/1-256 AC A0A1E3HB06.1 #=GS A0A658JYP0_9CLOT/2-345 AC A0A658JYP0.1 #=GS D2MQD3_9FIRM/6-348 AC D2MQD3.1 #=GS A0A517TX11_9BACT/8-372 AC A0A517TX11.1 #=GS S2ZT56_9ACTN/22-365 AC S2ZT56.1 #=GS A0A553GNJ8_9BACT/19-315 AC A0A553GNJ8.1 #=GS A0A1Y5YCN8_KIBAR/1-221 AC A0A1Y5YCN8.1 #=GS A0A0U5BA34_9MICO/14-357 AC A0A0U5BA34.1 #=GS A0A0H0XS25_9SPHN/15-358 AC A0A0H0XS25.1 #=GS A0A1G6L2N6_9BACT/15-301 AC A0A1G6L2N6.1 #=GS A0A5C6RNI9_9FLAO/409-629 AC A0A5C6RNI9.1 #=GS A0A0S2FDQ6_9GAMM/22-410 AC A0A0S2FDQ6.1 #=GS A0A1H2EI44_9ACTO/22-364 AC A0A1H2EI44.1 #=GS A0A432W8L0_9GAMM/12-355 AC A0A432W8L0.1 #=GS M1E5M4_9FIRM/3-343 AC M1E5M4.1 #=GS A0A0S9BXQ4_9MICC/22-365 AC A0A0S9BXQ4.1 #=GS A0A3R6AE58_9FIRM/6-348 AC A0A3R6AE58.1 #=GS A0A368XBX7_9BACI/9-351 AC A0A368XBX7.1 #=GS A0A5B2ZE84_9GAMM/12-400 AC A0A5B2ZE84.1 #=GS A0A5B2XRT4_9PSEU/21-364 AC A0A5B2XRT4.1 #=GS A0A4R2IAZ5_9GAMM/16-404 AC A0A4R2IAZ5.1 #=GS ISPG_HAEDU/12-355 AC Q7VME2.1 #=GS A0A6B2S5U6_9ACTN/21-364 AC A0A6B2S5U6.1 #=GS M7Y865_9BACT/438-650 AC M7Y865.1 #=GS A0A1D9P114_9FIRM/7-349 AC A0A1D9P114.1 #=GS F4GVB7_PUSST/24-416 AC F4GVB7.1 #=GS A0A1B2HUY6_9PSEU/20-363 AC A0A1B2HUY6.1 #=GS A0A0F2C647_9MICO/21-364 AC A0A0F2C647.1 #=GS F6EWT9_SPHCR/19-362 AC F6EWT9.1 #=GS A0A3M8R1V0_9PROT/12-354 AC A0A3M8R1V0.1 #=GS A0A545AK74_9ACTN/22-364 AC A0A545AK74.1 #=GS A0A0W7Y526_9BACI/10-352 AC A0A0W7Y526.1 #=GS C7LXX9_ACIFD/14-357 AC C7LXX9.1 #=GS F3SF46_9PROT/15-358 AC F3SF46.1 #=GS A0A1X8WPV7_LEPIR/455-653 AC A0A1X8WPV7.1 #=GS E1ZCS3_CHLVA/488-673 AC E1ZCS3.1 #=GS A0A415DQC7_9BACT/397-605 AC A0A415DQC7.1 #=GS A0A2A8IMJ1_9BACI/10-352 AC A0A2A8IMJ1.1 #=GS R5P6X5_9BACT/12-358 AC R5P6X5.1 #=GS A0A1I5RQH6_9BACT/472-691 AC A0A1I5RQH6.1 #=GS A0A1Q2CDH1_9ACTN/21-363 AC A0A1Q2CDH1.1 #=GS A0A239FTH7_9SPHN/14-357 AC A0A239FTH7.1 #=GS X7YAL1_MYCKA/1-340 AC X7YAL1.1 #=GS A0A2G5D1J6_AQUCA/85-727 AC A0A2G5D1J6.1 #=GS V5BIW6_9GAMM/9-397 AC V5BIW6.1 #=GS A0A653JYJ7_9BURK/48-435 AC A0A653JYJ7.1 #=GS K9UIW8_CHAP6/26-399 AC K9UIW8.1 #=GS U1MSV6_9MICO/20-363 AC U1MSV6.1 #=GS A0A399F2R8_9DEIN/8-396 AC A0A399F2R8.1 #=GS A0A5J5KXW2_9MICC/22-365 AC A0A5J5KXW2.1 #=GS A0A0D0N808_KITGR/22-365 AC A0A0D0N808.1 #=GS A0A3P1V8J5_9ACTO/25-368 AC A0A3P1V8J5.1 #=GS R9KV90_9ACTN/33-377 AC R9KV90.1 #=GS K5ZG93_9BACT/408-606 AC K5ZG93.1 #=GS A0A1X6WV01_9MICO/44-387 AC A0A1X6WV01.1 #=GS A0A4Q7S425_9RHIZ/15-403 AC A0A4Q7S425.1 #=GS A0A2T0TAF8_9PSEU/23-366 AC A0A2T0TAF8.1 #=GS V4LEX8_EUTSA/88-730 AC V4LEX8.1 #=GS A0A4Q2RBG3_9RHIZ/30-418 AC A0A4Q2RBG3.1 #=GS R6GX79_9FIRM/6-349 AC R6GX79.1 #=GS A0A221R404_9MICC/22-365 AC A0A221R404.1 #=GS A0A0M9GK76_9PSED/12-353 AC A0A0M9GK76.1 #=GS A0A1M6IBV5_9ACTN/22-365 AC A0A1M6IBV5.1 #=GS V1CQF7_9FIRM/2-352 AC V1CQF7.1 #=GS A0A1Y0FU09_9GAMM/12-354 AC A0A1Y0FU09.1 #=GS A0A1I2J962_9CLOT/6-348 AC A0A1I2J962.1 #=GS A8PLR4_9COXI/15-403 AC A8PLR4.1 #=GS W8KHN0_9GAMM/12-400 AC W8KHN0.1 #=GS A0A0F3IKZ3_9GAMM/9-397 AC A0A0F3IKZ3.1 #=GS A0A2H5XWZ6_9BACT/27-369 AC A0A2H5XWZ6.1 #=GS C7R3D3_JONDD/23-366 AC C7R3D3.1 #=GS A0A2H5XEU0_9BACT/20-362 AC A0A2H5XEU0.1 #=GS A0A0E0CN07_9ORYZ/90-733 AC A0A0E0CN07.1 #=GS A0A4R3VRV5_9SPHI/25-316 AC A0A4R3VRV5.1 #=GS A0A1B9ARX7_9BACI/10-352 AC A0A1B9ARX7.1 #=GS A0A5J5GNE2_9RHOB/17-360 AC A0A5J5GNE2.1 #=GS A0A5C8IBK9_9MICO/15-358 AC A0A5C8IBK9.1 #=GS A0A291QGM1_9ACTN/21-364 AC A0A291QGM1.1 #=GS A0A1X1CYM0_9GAMM/12-355 AC A0A1X1CYM0.1 #=GS A0A0J8Y7C5_9ENTR/12-354 AC A0A0J8Y7C5.1 #=GS A0A4U1CGU3_9SPHI/26-646 AC A0A4U1CGU3.1 #=GS A0A2P7S5K5_9RHIZ/14-402 AC A0A2P7S5K5.1 #=GS A0A4U9JL89_9SPHI/515-658 AC A0A4U9JL89.1 #=GS H4F908_9RHIZ/15-403 AC H4F908.1 #=GS A0A482MEZ9_9CAUD/12-354 AC A0A482MEZ9.1 #=GS R6NHB0_9CLOT/6-348 AC R6NHB0.1 #=GS B9HQ97_POPTR/87-729 AC B9HQ97.2 #=GS R7EYU3_9BACT/10-535 AC R7EYU3.1 #=GS A0A3G9K5R4_9ACTN/18-361 AC A0A3G9K5R4.1 #=GS A0A0M2WCH6_9BURK/23-410 AC A0A0M2WCH6.1 #=GS A0A1G8AS09_9MICO/20-363 AC A0A1G8AS09.1 #=GS A0A317ZGS1_9BACT/533-676 AC A0A317ZGS1.1 #=GS A0A1I3WVL9_9ALTE/12-354 AC A0A1I3WVL9.1 #=GS A0A2T5C2T6_9BACT/20-313 AC A0A2T5C2T6.1 #=GS A0A2T5HJ15_9PSED/12-354 AC A0A2T5HJ15.1 #=GS B3QS38_CHLT3/453-674 AC B3QS38.1 #=GS A0A087BK87_9BIFI/29-372 AC A0A087BK87.1 #=GS A0A372ITS4_9BACT/9-397 AC A0A372ITS4.1 #=GS A0A433UMR0_ANAVA/28-401 AC A0A433UMR0.1 #=GS A0A1Y4WQH8_9FIRM/2-344 AC A0A1Y4WQH8.1 #=GS A9BMV3_DELAS/25-413 AC A9BMV3.1 #=GS C6HXA9_9BACT/8-350 AC C6HXA9.1 #=GS J5KDN6_PASMD/1-76 AC J5KDN6.1 #=GS A0A2L0PNQ0_VITS1/9-397 AC A0A2L0PNQ0.2 #=GS U1KS67_9GAMM/12-355 AC U1KS67.1 #=GS A0A5D6USY6_9BACT/17-645 AC A0A5D6USY6.1 #=GS A0A318URH6_9SPHI/26-648 AC A0A318URH6.1 #=GS A0A5Q3L2G4_9BACT/8-372 AC A0A5Q3L2G4.1 #=GS K6U9Q2_9CLOT/6-348 AC K6U9Q2.1 #=GS A0A0F0KCT7_9MICO/14-357 AC A0A0F0KCT7.1 #=GS A0A1Y1RM68_9MICC/22-365 AC A0A1Y1RM68.1 #=GS A0A5R9QSF4_9BACT/19-330 AC A0A5R9QSF4.1 #=GS A0A0M2XZC4_9SPHI/28-315 AC A0A0M2XZC4.1 #=GS E9SYB7_RHOHA/25-368 AC E9SYB7.1 #=GS A0A090K4K0_9GAMM/12-355 AC A0A090K4K0.1 #=GS A0A1Y0CV36_9GAMM/13-355 AC A0A1Y0CV36.1 #=GS A0A1R3VQT1_9GAMM/13-401 AC A0A1R3VQT1.1 #=GS A0A0Q6F9M5_9ACTN/22-365 AC A0A0Q6F9M5.1 #=GS A0A4D7QKK1_9PROT/13-401 AC A0A4D7QKK1.1 #=GS M3BZK2_STRMB/1-165 AC M3BZK2.1 #=GS A0A316C8V6_PSESE/14-402 AC A0A316C8V6.1 #=GS A0A1I5TID2_9FIRM/7-349 AC A0A1I5TID2.1 #=GS A0A1M6N8L6_9RHOB/17-360 AC A0A1M6N8L6.1 #=GS Q13X28_PARXL/33-421 AC Q13X28.1 #=GS ISPG_DEIRA/28-416 AC Q9RXC9.1 #=GS A0A561EVZ2_9ACTN/22-365 AC A0A561EVZ2.1 #=GS A0A1S9PDY9_9SPHI/537-683 AC A0A1S9PDY9.1 #=GS A0A453P0V0_AEGTS/79-254 AC A0A453P0V0.1 #=GS A0A399RFJ7_9RHOB/17-360 AC A0A399RFJ7.1 #=GS A0A445IDB6_GLYSO/89-731 AC A0A445IDB6.1 #=GS A0A0Q4C8Y9_9SPHN/15-358 AC A0A0Q4C8Y9.1 #=GS A0A1W6B6Q4_9GAMM/12-355 AC A0A1W6B6Q4.1 #=GS A0A1H7U124_STRJI/1-75 AC A0A1H7U124.1 #=GS A0A3L7E1Y6_9GAMM/12-354 AC A0A3L7E1Y6.1 #=GS A0A0H4W791_9BORD/24-416 AC A0A0H4W791.1 #=GS A0A518D4V1_9BACT/7-370 AC A0A518D4V1.1 #=GS A0A2K8SIW9_9NOSO/1-353 AC A0A2K8SIW9.1 #=GS A0A1G8CU00_9BACI/10-352 AC A0A1G8CU00.1 #=GS A0A2N1I4G4_9GAMM/12-355 AC A0A2N1I4G4.1 #=GS A0A505D520_9ACTN/331-381 AC A0A505D520.1 #=GS A0A3N1UQF5_9DELT/10-352 AC A0A3N1UQF5.1 #=GS A0A0B2AAK2_9MICO/14-357 AC A0A0B2AAK2.1 #=GS A0A5R9LWI7_9ACTN/21-364 AC A0A5R9LWI7.1 #=GS A0A1G6NNI2_9MICO/23-365 AC A0A1G6NNI2.1 #=GS H8L0R0_FRAAD/22-410 AC H8L0R0.1 #=GS A0A2W2JCT3_9ACTN/6-349 AC A0A2W2JCT3.1 #=GS A0A150X6F0_9BACT/437-647 AC A0A150X6F0.1 #=GS A0A4Y6U7E4_9PROT/15-358 AC A0A4Y6U7E4.1 #=GS A0A419V3A4_9BACL/10-352 AC A0A419V3A4.1 #=GS N6X2Y6_9RHOO/18-406 AC N6X2Y6.1 #=GS A0A5C7ET87_9PROT/11-399 AC A0A5C7ET87.1 #=GS C6WV27_METML/8-402 AC C6WV27.1 #=GS W7JBQ5_PLAFA/475-816 AC W7JBQ5.1 #=GS V6KDS7_STRNV/1-202 AC V6KDS7.1 #=GS A0A0A8K0H2_9RHIZ/9-397 AC A0A0A8K0H2.1 #=GS A0A0V8QJF0_9FIRM/6-348 AC A0A0V8QJF0.1 #=GS A0A4V3BMG0_9RHOO/16-404 AC A0A4V3BMG0.1 #=GS F9ZHB2_9PROT/13-401 AC F9ZHB2.1 #=GS A0A2N0VJJ4_9BACT/10-397 AC A0A2N0VJJ4.1 #=GS A0A453P0T5_AEGTS/1-283 AC A0A453P0T5.1 #=GS A0A4R7T4S1_9ACTN/21-364 AC A0A4R7T4S1.1 #=GS A0A0Q7WYF9_9RHIZ/14-402 AC A0A0Q7WYF9.1 #=GS A0A4Q7USQ2_9PSEU/21-364 AC A0A4Q7USQ2.1 #=GS 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