# STOCKHOLM 1.0
#=GF ID   Utp14
#=GF AC   PF04615.14
#=GF DE   Utp14 protein
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Wood V;0000-0001-6330-7526
#=GF SE   Pfam-B_5404 (release 7.4)
#=GF GA   30.20 30.20;
#=GF TC   30.30 30.50;
#=GF NC   29.40 30.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cut_ga HMM metaseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12068309
#=GF RT   A large nucleolar U3 ribonucleoprotein required for 18S
#=GF RT   ribosomal RNA biogenesis. 
#=GF RA   Dragon F, Gallagher JE, Compagnone-Post PA, Mitchell BM,
#=GF RA   Porwancher KA, Wehner KA, Wormsley S, Settlage RE, Shabanowitz
#=GF RA   J, Osheim Y, Beyer AL, Hunt DF, Baserga SJ; 
#=GF RL   Nature 2002;0:0-0.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This protein is found to be part of a large ribonucleoprotein
#=GF CC   complex containing the U3 snoRNA [1]. Depletion of the Utp
#=GF CC   proteins impedes production of the 18S rRNA, indicating that
#=GF CC   they are part of the active pre-rRNA processing complex. This
#=GF CC   large RNP complex has been termed the small subunit (SSU)
#=GF CC   processome [1].
#=GF SQ   11
#=GS EBB23708.1/8-255   DE [subseq from] hypothetical protein GOS_266940 [marine metagenome]
#=GS EBC79621.1/10-166  DE [subseq from] hypothetical protein GOS_12969 [marine metagenome]
#=GS ECK31577.1/1-228   DE [subseq from] hypothetical protein GOS_4332066 [marine metagenome]
#=GS ECK31578.1/2-154   DE [subseq from] hypothetical protein GOS_4332067 [marine metagenome]
#=GS EBL20133.1/113-366 DE [subseq from] hypothetical protein GOS_8607894 [marine metagenome]
#=GS EBO00920.1/2-181   DE [subseq from] hypothetical protein GOS_8151973 [marine metagenome]
#=GS ECA93193.1/2-200   DE [subseq from] hypothetical protein GOS_6392882 [marine metagenome]
#=GS ECD57559.1/3-271   DE [subseq from] hypothetical protein GOS_6400618 [marine metagenome]
#=GS ECB28981.1/34-151  DE [subseq from] hypothetical protein GOS_4961653 [marine metagenome]
#=GS ECS03515.1/17-117  DE [subseq from] hypothetical protein GOS_6314278 [marine metagenome]
#=GS EBS09850.1/40-79   DE [subseq from] hypothetical protein GOS_7491465 [marine metagenome]
EBB23708.1/8-255           ------------------------------------...................--...--------------------------------------..---------------....GKKLVSSAPLPRLVKARVNRGAAYESTSASVTEWQATVKKNRERATLSF-LDQErkKAPKMNSLAALAADFAPADDFERRVADKLREKGVATGEDVERGEDLAMHALDPEEARERRGRLAKMRSLLFKHELKAKRVKAIKSKTFHRHNRKTGARVRLLGED.GNPEeeDDGEGGGG--EggdGAEARREYLRAQERMLLKHKNTSRWAKRAI........RKGLAH-LPGTKEAIAEQLRIGNELRRKIAGKgaAGDGGDG--...--------------........-...-------------------.............----------------------------------------------------------...------------...........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.----------------------..-----..---------------------.....------.-------.......-------.------.....------.---------------------..-------------------------------------
EBC79621.1/10-166          ------------------------------------...................--...--------------------------------------..---------------....------------------------------------------------------..---------------------------------------------------------------------------------------------------------.----..-----------...------------------------------........--------------------------------..---------...--------------........-...-------------------.............----------------------------------------------------------...------------...........-----------------------------------------------------------------------------------------------------------------------------------------------------------------GEELSQRDLLSRAF.AGDDVVGEFETDKNAEVTGELP..-KIDVpkQMPGWGGWAEDQAKRGPPK--.....-WQLEAeRKAKREQqka.lkaRRDADLK.HVVISE.....RYDKKV.AGFNVEHLPHGFDSKAVYEGS..MRMPLGPDANTDKSFRDMTRPAVLKAAGTVIRPMTFP
ECK31577.1/1-228           ------------------------------------...................--...--------------------------------------..---------------....------------------------------------------------------..----------------------------------------------------------------KMRSLMFYEERKRHQVNKIKSKKFRKIHKKAQAREKEKEME.LLRE..TDPELAKE---...-LDEKEAMKRMEERMTLQHKNTSKWARAQL........RRGKGM-DTDARKALTEQILIGNKLRRKQMGE..--DVSEDDD...CSDAGDETNIE---........S...LKREAEKVLQDVDND----.............-EEKEEREKTGLFKMAFMQKGMETQRLRARQEAEDLLRELKEEDEDSDDDSDESCSHD...DNEDDNKGAEVKagdptdtshiqG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.----------------------..-----..---------------------.....------.-------.......-------.------.....------.---------------------..-------------------------------------
ECK31578.1/2-154           ------------------------------------...................--...--------------------------------------..---------------....------------------------------------------------------..---------------------------------------------------------------------------------------------------------.----..-----------...------------------------------........--------------------------------..---------...--------------........-...-------------------.............----------------------------------------------------------...------------...........---------------------------------------------------------------------------------------------------------------------------------------------------------------------AQDKLVKMAFaAPEDTEEEFRKEKQALIDRDDPnkNGEEK..DAKGWGSWAGAGTKLPKKK-R.....KTSAKM.SAPEKKPsv...nrRADADKP.TVIINE.....KRVKKL.TKFKLAAVPYPFTSAEQYERA..MSGAIGSGWNTTKAFKELTRAEVLTRAGKIIMPASK-
EBL20133.1/113-366         -------------GSDDEADSDQYEDLSRMLDDDHAdeggkqtggqsagssdrmlRAvglTSRRARERTEARDEADFAA---EGGALSIDALVGSLKDseGFGQLRRDIASLTRTaghrAARAQLDAPLERSDQRRVERQAATSAAHHDVSGWQAAVDRHRNAEKMQYPLDRE..ARVAGASTLSLSAPRAPGSELEKAMASLLETHGLGDEQAVTKGEALELAEVDEEEVRKRTLELRRMRDLLFHHERKLKRASKNKSKAYRKAHKKAKA--------.----..-----------...------------------------------........--------------------------------..---------...--------------........-...-------------------.............----------------------------------------------------------...------------...........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.----------------------..-----..---------------------.....------.-------.......-------.------.....------.---------------------..-------------------------------------
EBO00920.1/2-181           ------------------------------------...................--...--------------------------------------..---------------....------------------------------------------------------..--------------------------------------------------------EQKYTEMGRLKSLLFKQEIKNRRVAKIKSKLYHKLKKKERERDEDKLKQ.YMME..VDPEAAKA---...-YQQKEDLRQVEERLRARHGTGTKYAKNLK........-RFRGMDDKDTRDAYHQAVLDRQALTQRKERA..NQDSSASDD...SDSDLSESELK---........-...-----EKACARMEQEAESD............cEMSASDSERSNGVKMDFSQKAKQK----------------------------------...------------...........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.----------------------..-----..---------------------.....------.-------.......-------.------.....------.---------------------..-------------------------------------
ECA93193.1/2-200           ------------------------------------...................--...--------------------------------------..---------------....------------------------------------------------------..---------------------------------------------------------------------------------------------------------.----..-DPELYAQ---...-MQEEAATDRVRERMSLKHRSTSAFARKML........QH--AHGDKGMRQAYNESLALGSELKDKIEGR.iAGDGSDGEDgggSSDSLDDSEGEDDDdddgeegsRsggKKKGKKKKVAALAAKALHAanilegdkegfdsGDTEVQGKYKKLFDMDFMRRAQVGQRERARQEAQDVLRELEDMEEGEDSESDTDGAKDknkE-----------...........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.----------------------..-----..---------------------.....------.-------.......-------.------.....------.---------------------..-------------------------------------
ECD57559.1/3-271           ------------------------------------...................--...--------------------------------------..---------------....------------------------------------------------------..-------------------------------------------------------------------------------------------RRRESAKDDSDETEdMMRR..LDPEAAAA---...-AEEKEALERMKERMTLRHGNASKWARATLgskkkllsNQGTGEQGAATRRAVAAQLRLGDELKRKAEGRdeRGEREDDDS...SSASSSSSDDDDDDee....egEegeEDSAKRKAVEAAQALIVGIsrde.....negaERSKGKKASKGLMGMKFMQKAVQKQREAARLEAEALLKELKETPGDAFTDDAHDDGMGsgdKKTKKRKGL-RF...........EEDSGDDDDDEEERR--GGKGSSGAAYHGENDSEDVEASKEAK------------------------------------------------------------------------------------------------------------------------------------.----------------------..-----..---------------------.....------.-------.......-------.------.....------.---------------------..-------------------------------------
ECB28981.1/34-151          ------------------------------------...................--...--------------------------------------..---------------....------------------------------------------------------..---------------------------------------------------------------------------------------------------------.----..-----------...------------------------------........--------------------------------..---------...--------------........-...-------------------.............----------------------------------------------------------...------------...........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.----------------------..-----..--AGWGSWTGLGAAGPSRRQRa..reRAERRE.REA---RrqaalaaRRDAATGgAAMISE.....RKQRAV.AKHQPRAAPYPFASVERYEAAqaAAAPVGRAWLTEQAAAKARRPLVATRPGLIVQPLRR-
ECS03515.1/17-117          ------------------------------------...................--...--------------------------------------..---------------....------------------------------------------------------..---------------------------------------------------------------------------------------------------------.----..-----------...------------------------------........--------------------------------..---------...--------------........-...-------------------.............----------------------------------------------------------...------------...........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.----------------------..-----..---GWNEWAGAGVKDTRYAEKvaqaeKFKRDKiEELRQK-.......RADQRLR.GVVLNQgdeagGRDKKFaHKYMLKQLPHPYQSTEQLNRV..MDQPVGREWTTIQSHKRLI------------------
EBS09850.1/40-79           ------------------------------------...................--...--------------------------------------..---------------....------------------------------------------------------..------------------------------------------------------QAAKRMAEMKKMRDLLFYHEAKAKRVAKIKSRSYRKVHKK-----------.----..-----------...------------------------------........--------------------------------..---------...--------------........-...-------------------.............----------------------------------------------------------...------------...........-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.----------------------..-----..---------------------.....------.-------.......-------.------.....------.---------------------..-------------------------------------
#=GC PP_cons               .............22222233333333333332222...................11...6788899***********7...689************9..9***********888....7888999*******************************************8888..999999999999******************************************899999*******************************9***99*9998888.7888..87787777..2...5788999*********************99........7789778***********************99..655555566...55555555555333........1...2233356666666555555.............777789999************999*****************98888877774444443...345455555545...........365544443333333..33333333333333333323322222......................................................................................................................5689899*******.88********************..34455..998**********99996645.....666655.4444432.......****999.99***9.....999999.*******************99..99***************99**************9866
#=GC RF                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...................xx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxx..xxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxx...xxxxxxxxxxxxxx........x...xxxxxxxxxxxxxxxxxxx.............xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxx...........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxx..xxxxx..xxxxxxxxxxxxxxxxxxxxx.....xxxxxx.xxxxxxx.......xxxxxxx.xxxxxx.....xxxxxx.xxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
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