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15  structures 7025  species 0  interactions 11830  sequences 87  architectures

Family: Anth_synt_I_N (PF04715)

Summary: Anthranilate synthase component I, N terminal region

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Anthranilate synthase component I, N terminal region Provide feedback

Anthranilate synthase ( EC:4.1.3.27) catalyses the first step in the biosynthesis of tryptophan. Component I catalyses the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family (PF00425). This region is involved in feedback inhibition by tryptophan [1]. This family also contains a region of Para-aminobenzoate synthase component I (EC 4.1.3.-).

Literature references

  1. Spraggon G, Kim C, Nguyen-Huu X, Yee MC, Yanofsky C, Mills SE; , Proc Natl Acad Sci U S A 2001;98:6021-6026.: The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan. PUBMED:11371633 EPMC:11371633

  2. Dosselaere F, Vanderleyden J; , Crit Rev Microbiol 2001;27:75-131.: A metabolic node in action: chorismate-utilizing enzymes in microorganisms. PUBMED:11450855 EPMC:11450855


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR006805

Anthranilate synthase catalyses the first step in the biosynthesis of tryptophan. Component I catalyses the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family ( INTERPRO ). This region is involved in feedback inhibition by tryptophan [ PUBMED:11371633 ]. This family also contains a region of Para-aminobenzoate synthase component I.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(46)
Full
(11830)
Representative proteomes UniProt
(54437)
RP15
(1625)
RP35
(5651)
RP55
(11680)
RP75
(20063)
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HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(46)
Full
(11830)
Representative proteomes UniProt
(54437)
RP15
(1625)
RP35
(5651)
RP55
(11680)
RP75
(20063)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(46)
Full
(11830)
Representative proteomes UniProt
(54437)
RP15
(1625)
RP35
(5651)
RP55
(11680)
RP75
(20063)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: DOMO:DM04829;
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Kerrison ND
Number in seed: 46
Number in full: 11830
Average length of the domain: 143.9 aa
Average identity of full alignment: 22 %
Average coverage of the sequence by the domain: 26.43 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.0 23.0
Trusted cut-off 23.0 23.0
Noise cut-off 22.9 22.9
Model length: 142
Family (HMM) version: 16
Download: download the raw HMM for this family

Species distribution

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Anth_synt_I_N domain has been found. There are 15 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A077ZBW7 View 3D Structure Click here
A0A0D2EXH1 View 3D Structure Click here
A0A0D2GUR2 View 3D Structure Click here
A0A0H3GS28 View 3D Structure Click here
A0A0H3GZZ4 View 3D Structure Click here
A0A0R0EQ27 View 3D Structure Click here
A0A0R0F675 View 3D Structure Click here
A0A0R0IAS6 View 3D Structure Click here
A0A175WBT2 View 3D Structure Click here
A0A175WCG4 View 3D Structure Click here
A0A1C1CPX1 View 3D Structure Click here
A0A1C1CXQ7 View 3D Structure Click here
A0A1D6GDZ9 View 3D Structure Click here
A0A1D6LA98 View 3D Structure Click here
A0A1D6LNP0 View 3D Structure Click here
A0A1D8PMB0 View 3D Structure Click here
A0A1D8PS03 View 3D Structure Click here
A0A1I9LMN9 View 3D Structure Click here
A0QX93 View 3D Structure Click here
A2XNK3 View 3D Structure Click here
B4F8P4 View 3D Structure Click here
C0NHA0 View 3D Structure Click here
C0NZX2 View 3D Structure Click here
C1GXG6 View 3D Structure Click here
C1H2L2 View 3D Structure Click here
F2RB79 View 3D Structure Click here
I1NF54 View 3D Structure Click here
K0ET36 View 3D Structure Click here
K0EXX8 View 3D Structure Click here
K7LKM5 View 3D Structure Click here
K7MPL4 View 3D Structure Click here
O25869 View 3D Structure Click here
O27692 View 3D Structure Click here
O28669 View 3D Structure Click here
O66849 View 3D Structure Click here
O94277 View 3D Structure Click here
O94582 View 3D Structure Click here
P00895 View 3D Structure Click here
P00898 View 3D Structure Click here
P00899 View 3D Structure Click here