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2  structures 1091  species 0  interactions 1917  sequences 17  architectures

Family: Calcipressin (PF04847)

Summary: Calcipressin

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This is the Wikipedia entry entitled "Calcipressin". More...

Calcipressin Edit Wikipedia article

PDB 1wey EBI.jpg
solution structure of rrm domain in calcipressin 1
Symbol Calcipressin
Pfam PF04847
Pfam clan CL0221
InterPro IPR006931

In molecular biology, the calcipressin family of proteins negatively regulate calcineurin by direct binding. They are essential for the survival of T helper type 1 cells. Calcipressin 1 is a phosphoprotein that increases its capacity to inhibit calcineurin when phosphorylated at the conserved FLISPP motif, this phosphorylation also controls the half-life of calcipressin 1 by accelerating its degradation.[1]

In humans, the Calcipressins family of proteins is derived from three genes. Calcipressin 1 is also known as modulatory calcineurin-interacting protein 1 (MCIP1), Adapt78 and Down syndrome critical region 1 (DSCR1). Calcipressin 2 is variously known as MCIP2, ZAKI-4 and DSCR1-like 1. Calcipressin 3 is also called MCIP3 and DSCR1-like 2.[2]


  1. ^ Genesca L, Aubareda A, Fuentes JJ, Estivill X, De La Luna S, Perez-Riba M (September 2003). "Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life". Biochem. J. 374 (Pt 2): 567–75. doi:10.1042/BJ20030267. PMC 1223619Freely accessible. PMID 12809556. 
  2. ^ Parry RV, June CH (September 2003). "Calcium-independent calcineurin regulation". Nat. Immunol. 4 (9): 821–3. doi:10.1038/ni0903-821. PMID 12942079. 

This article incorporates text from the public domain Pfam and InterPro IPR006931

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Calcipressin Provide feedback

Calcipressin is also known as calcineurin-binding protein, since it inhibits calcineurin-mediated transcriptional modulation by binding to calcineurin's catalytic domain [1].

Literature references

  1. Ermak G, Harris CD, Davies KJ; , FASEB J 2002;16:814-824.: The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress. PUBMED:12039863 EPMC:12039863

Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR006931

Calcipressins (RCANs) are a novel family of calcineurin regulators that have been suggested as key factors contributing to Down syndrome in humans. Three human calcipressins have been identified, calcipressin 1-3. Calcipressin 1 is also known as modulatory calcineurin-interacting protein 1 (MCIP1), Adapt78 and Down syndrome critical region 1 (DSCR1). Calcipressin 2 is variously known as MCIP2, ZAKI-4 and DSCR1-like 1. Calcipressin 3 is also called MCIP3 and DSCR1-like 2 [ PUBMED:12942079 ]. Calcipressins contain an N-terminal RNA recognition motif (RRM), a highly conserved SP repeat domain containing the phosphorylation site by GSK-3, a well-known PxIxIT motif responsible for docking many substrates to calcineurin, and a C-terminal TxxP motif [ PUBMED:19273587 ].

Calcineurin is a calcium-responsive enzyme that dephosphorylates the nuclear factor of activated T cells (NFAT). In doing so, it promotes its nuclear translocation and uniquely links calcium signalling to transcriptional regulation [ PUBMED:12942079 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan RRM (CL0221), which has the following description:

This clan contains families that are related to the RNA recognition motif domains. However, not all these families are RNA binding.

The clan contains the following 32 members:

BRAP2 Calcipressin DbpA DUF1743 DUF1866 DUF4523 GlcNAc-1_reg GUCT Limkain-b1 Nup35_RRM Nup35_RRM_2 PHM7_cyt RL RNA_bind RRM_1 RRM_2 RRM_3 RRM_5 RRM_7 RRM_8 RRM_9 RRM_occluded RRM_Rrp7 SET_assoc Smg4_UPF3 Spo7_2_N Tap-RNA_bind Transposase_22 U1snRNP70_N xRRM XS YlmH_RBD


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Curation and family details

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Seed source: Pfam-B_4547 (release 7.6)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Mifsud W
Number in seed: 6
Number in full: 1917
Average length of the domain: 177.40 aa
Average identity of full alignment: 37 %
Average coverage of the sequence by the domain: 72.94 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.5 23.5
Trusted cut-off 23.5 24.4
Noise cut-off 23.4 23.4
Model length: 186
Family (HMM) version: 14
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Species distribution

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Archea Archea Eukaryota Eukaryota
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Calcipressin domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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