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0  structures 1300  species 0  interactions 1512  sequences 25  architectures

Family: TMEM208_SND2 (PF05620)

Summary: SRP-independent targeting protein 2/TMEM208

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SRP-independent targeting protein 2/TMEM208 Provide feedback

This family includes SRP-independent targeting protein 2 (SND2) from yeast and transmembrane protein 208 (TMEM208) from mammals. Both are localized to the endoplasmic reticulum (ER) [1, 2]. SND2 works together with SND1 and SND3 in an alternative targeting route to the ER [1]. TMEM208 regulates both ER stress and autophagy. It contains three predicted transmembrane regions [2]. SND2 also known as Env10 in Saccharomyces cerevisiae, and its homologue as Mug69 in Schizosaccharomyces pombe. They were identified as proteins involved in vacuolar processing and morphology [3] and meiosis [4] respectively.

Literature references

  1. Aviram N, Ast T, Costa EA, Arakel EC, Chuartzman SG, Jan CH, Hassdenteufel S, Dudek J, Jung M, Schorr S, Zimmermann R, Schwappach B, Weissman JS, Schuldiner M;, Nature. 2016;540:134-138.: The SND proteins constitute an alternative targeting route to the endoplasmic reticulum. PUBMED:27905431 EPMC:27905431

  2. Zhao Y, Hu J, Miao G, Qu L, Wang Z, Li G, Lv P, Ma D, Chen Y;, PLoS One. 2013;8:e64228.: Transmembrane protein 208: a novel ER-localized protein that regulates autophagy and ER stress. PUBMED:23691174 EPMC:23691174

  3. Ricarte F, Menjivar R, Chhun S, Soreta T, Oliveira L, Hsueh T, Serranilla M, Gharakhanian E;, PLoS One. 2011;6:e23696.: A genome-wide immunodetection screen in S. cerevisiae uncovers novel genes involved in lysosomal vacuole function and morphology. PUBMED:21912603 EPMC:21912603

  4. Martin-Castellanos C, Blanco M, Rozalen AE, Perez-Hidalgo L, Garcia AI, Conde F, Mata J, Ellermeier C, Davis L, San-Segundo P, Smith GR, Moreno S;, Curr Biol. 2005;15:2056-2062.: A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events. PUBMED:16303567 EPMC:16303567


This tab holds annotation information from the InterPro database.

InterPro entry IPR008506

This family includes SRP-independent targeting protein 2 (SND2) from yeast and transmembrane protein 208 (TMEM208) from mammals. Both are localized to the endoplasmic reticulum (ER) [ PUBMED:27905431 , PUBMED:23691174 ]. SND2 works together with SND1 and SND3 in an alternative targeting route to the ER [ PUBMED:27905431 ]. TMEM208 regulates both ER stress and autophagy [ PUBMED:23691174 ].

SND2 was previously known as Env10 in Saccharomyces cerevisiae, and its homologue as Mug69 in Schizosaccharomyces pombe. They were identified as proteins involved in vacuolar processing and morphology [ PUBMED:21912603 ] and meiosis [ PUBMED:16303567 ], respectively.

Domain organisation

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Alignments

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  Seed
(149)
Full
(1512)
Representative proteomes UniProt
(2628)
RP15
(316)
RP35
(731)
RP55
(1188)
RP75
(1598)
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available

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Format an alignment

  Seed
(149)
Full
(1512)
Representative proteomes UniProt
(2628)
RP15
(316)
RP35
(731)
RP55
(1188)
RP75
(1598)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(149)
Full
(1512)
Representative proteomes UniProt
(2628)
RP15
(316)
RP35
(731)
RP55
(1188)
RP75
(1598)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

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Curation View help on the curation process

Seed source: Pfam-B_9014 (release 8.0)
Previous IDs: DUF788;
Type: Family
Sequence Ontology: SO:0100021
Author: Moxon SJ , El-Gebali S
Number in seed: 149
Number in full: 1512
Average length of the domain: 153.40 aa
Average identity of full alignment: 27 %
Average coverage of the sequence by the domain: 83.75 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.9 22.9
Trusted cut-off 23.0 22.9
Noise cut-off 22.7 22.7
Model length: 168
Family (HMM) version: 13
Download: download the raw HMM for this family

Species distribution

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