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0  structures 1314  species 0  interactions 4008  sequences 64  architectures

Family: PEX11 (PF05648)

Summary: Peroxisomal biogenesis factor 11 (PEX11)

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Peroxisomal biogenesis factor 11". More...

Peroxisomal biogenesis factor 11 Edit Wikipedia article

Peroxisomal biogenesis factor 11 (PEX11)
Identifiers
SymbolPEX11
PfamPF05648
InterProIPR008733
Membranome191

Peroxisomal biogenesis factor 11 (PEX11) are peroxisomal membrane proteins which promote peroxisome division in eukaryotic cells.[1]

Human proteins from this family

PEX11A; PEX11B; PEX11G;

References

This article incorporates text from the public domain Pfam and InterPro: IPR008733


This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Peroxisomal biogenesis factor 11 (PEX11) Provide feedback

This family consists of several peroxisomal biogenesis factor 11 (PEX11) proteins from several eukaryotic species. The PEX11 peroxisomal membrane proteins promote peroxisome division in multiple eukaryotes.

Literature references

  1. Li X, Baumgart E, Dong GX, Morrell JC, Jimenez-Sanchez G, Valle D, Smith KD, Gould SJ; , Mol Cell Biol 2002;22:8226-8240.: PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation. PUBMED:12417726 EPMC:12417726


This tab holds annotation information from the InterPro database.

InterPro entry IPR008733

This family consists of several peroxisomal biogenesis factor 11 (PEX11) proteins from several eukaryotic species. The PEX11 peroxisomal membrane proteins promote peroxisome division in multiple eukaryotes [ PUBMED:12417726 ]. PEX11 genes in rice have diversification not only in sequences but also in expression patterns under normal and various stress conditions [ PUBMED:18291602 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(47)
Full
(4008)
Representative proteomes UniProt
(7094)
RP15
(717)
RP35
(1838)
RP55
(3080)
RP75
(4254)
Jalview View  View  View  View  View  View  View 
HTML View  View           
PP/heatmap 1 View           

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(47)
Full
(4008)
Representative proteomes UniProt
(7094)
RP15
(717)
RP35
(1838)
RP55
(3080)
RP75
(4254)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(47)
Full
(4008)
Representative proteomes UniProt
(7094)
RP15
(717)
RP35
(1838)
RP55
(3080)
RP75
(4254)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_2629 (release 8.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Moxon SJ
Number in seed: 47
Number in full: 4008
Average length of the domain: 207.30 aa
Average identity of full alignment: 18 %
Average coverage of the sequence by the domain: 78.51 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.8 23.8
Trusted cut-off 23.8 23.8
Noise cut-off 23.7 23.7
Model length: 223
Family (HMM) version: 16
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0B4K701 View 3D Structure Click here
A0A1D6LK73 View 3D Structure Click here
A0A1D6PC95 View 3D Structure Click here
A0A1D8PQD7 View 3D Structure Click here
A0A2R8QCF7 View 3D Structure Click here
A1Z891 View 3D Structure Click here
A3QJY9 View 3D Structure Click here
A4HTS1 View 3D Structure Click here
A4I3V7 View 3D Structure Click here
A4IBQ8 View 3D Structure Click here
A4IBQ9 View 3D Structure Click here
B6SGC2 View 3D Structure Click here
B6TV18 View 3D Structure Click here
B6UD14 View 3D Structure Click here
B6ZK00 View 3D Structure Click here
D4AEJ6 View 3D Structure Click here
E9AH26 View 3D Structure Click here
I1L5H9 View 3D Structure Click here
I1L6Q5 View 3D Structure Click here
I1LP17 View 3D Structure Click here
I1M8F2 View 3D Structure Click here
I1MXU8 View 3D Structure Click here
O62103 View 3D Structure Click here
O70597 View 3D Structure Click here
O75192 View 3D Structure Click here
O80845 View 3D Structure Click here
O96011 View 3D Structure Click here
Q02969 View 3D Structure Click here
Q0P453 View 3D Structure Click here
Q10333 View 3D Structure Click here
Q10MN2 View 3D Structure Click here
Q10MN3 View 3D Structure Click here
Q10SM7 View 3D Structure Click here
Q12462 View 3D Structure Click here
Q4CR48 View 3D Structure Click here
Q4CY44 View 3D Structure Click here
Q4D1W2 View 3D Structure Click here
Q4D418 View 3D Structure Click here
Q4D8L7 View 3D Structure Click here
Q4DC12 View 3D Structure Click here
Q4E4Q2 View 3D Structure Click here
Q4KM24 View 3D Structure Click here
Q54H86 View 3D Structure Click here
Q5VRJ8 View 3D Structure Click here
Q6P6M5 View 3D Structure Click here
Q7JZE1 View 3D Structure Click here
Q7XU74 View 3D Structure Click here
Q84JW1 View 3D Structure Click here
Q86AC7 View 3D Structure Click here
Q86AC7 View 3D Structure Click here
Q96HA9 View 3D Structure Click here
Q9FZF1 View 3D Structure Click here
Q9LQ73 View 3D Structure Click here
Q9STY0 View 3D Structure Click here
Q9Z210 View 3D Structure Click here
Q9Z211 View 3D Structure Click here

Family Structural Model

The structural model below was generated by the Baker group with the trRosetta software using the Pfam UniProt multiple sequence alignment.

The InterPro website shows the contact map for the Pfam SEED alignment. Hovering or clicking on a contact position will highlight its connection to other residues in the alignment, as well as on the 3D structure.

Improved protein structure prediction using predicted inter-residue orientations. Jianyi Yang, Ivan Anishchenko, Hahnbeom Park, Zhenling Peng, Sergey Ovchinnikov, David Baker Proceedings of the National Academy of Sciences Jan 2020, 117 (3) 1496-1503; DOI: 10.1073/pnas.1914677117;