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15  structures 1518  species 0  interactions 6898  sequences 149  architectures

Family: Glyco_transf_90 (PF05686)

Summary: Glycosyl transferase family 90

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Glycosyl transferase family 90 Provide feedback

This family of glycosyl transferases are specifically (mannosyl) glucuronoxylomannan/galactoxylomannan -beta 1,2-xylosyltransferases, EC:2.4.2.-.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR006598

The CAP10 domain is found in glycosyltransferases from animals, plants and fungi. Rumi is a Drosophila protein with a CAP10 domain that functions as a protein O-glucosyltransferase. In human and mouse, three potential homologues exist: one with a high degree of identity to Drosophila Rumi (52%), and two others with lower degrees of identity but including a CAP10 domain (KDELC1 and KDELC2) [ PUBMED:21949356 ]. Rumi catalyzes the transfer of glucose and/or xylose from UDP-glucose and UDP-xylose, respectively, to a serine within the consensus Cys-Xaa-Ser-Xaa-Pro-Cys) in epidermal growth factor repeats, such as those found in coagulation factors F7, F9 and NOTCH proteins. Notch signaling is regulated by Notch glucosylation and glucosylation is required for the correct folding and cleavage of Notch [ PUBMED:18243100 , PUBMED:21490058 ].

CAP10 from Cryptococcus neoformans encodes a xylosyltransferase [ PUBMED:24751576 ]. This pathogenic fungus, which most commonly affects the central nervous system and causes fatal meningoencephalitis primarily in patients with AIDS, produces a thick extracellular polysaccharide capsule which is well recognised as a virulence factor. The CAP10 domain is required for capsule formation and virulence [ PUBMED:10482503 ]. The capsule is primarily made of two xylose-containing polysaccharides, glucuronoxylomannan and galactoxylomannan, and the glycosyltransferase transfers xylose to alpha-1,3-dimannoside in a beta-1,2-linkage [ PUBMED:17430900 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(19)
Full
(6898)
Representative proteomes UniProt
(12651)
RP15
(1260)
RP35
(3191)
RP55
(5386)
RP75
(7465)
Jalview View  View  View  View  View  View  View 
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(19)
Full
(6898)
Representative proteomes UniProt
(12651)
RP15
(1260)
RP35
(3191)
RP55
(5386)
RP75
(7465)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(19)
Full
(6898)
Representative proteomes UniProt
(12651)
RP15
(1260)
RP35
(3191)
RP55
(5386)
RP75
(7465)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_6682 (Release 8.0) & Pfam-B_7101 (Release 8.0)
Previous IDs: DUF821;
Type: Family
Sequence Ontology: SO:0100021
Author: Moxon SJ
Number in seed: 19
Number in full: 6898
Average length of the domain: 270.00 aa
Average identity of full alignment: 20 %
Average coverage of the sequence by the domain: 52.89 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 24.0 24.0
Trusted cut-off 24.0 24.0
Noise cut-off 23.9 23.9
Model length: 396
Family (HMM) version: 15
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Glyco_transf_90 domain has been found. There are 15 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0WD91 View 3D Structure Click here
A0A0P0WHZ2 View 3D Structure Click here
A0A0R0E3S8 View 3D Structure Click here
A0A0R0E3W6 View 3D Structure Click here
A0A0R0EEY4 View 3D Structure Click here
A0A0R0EF60 View 3D Structure Click here
A0A0R0FC25 View 3D Structure Click here
A0A0R0FS80 View 3D Structure Click here
A0A0R0FSE2 View 3D Structure Click here
A0A0R0FZI0 View 3D Structure Click here
A0A0R0G0F4 View 3D Structure Click here
A0A0R0G0X7 View 3D Structure Click here
A0A0R0G1T6 View 3D Structure Click here
A0A0R0G205 View 3D Structure Click here
A0A0R0G2A6 View 3D Structure Click here
A0A0R0J6L5 View 3D Structure Click here
A0A0R0KIM0 View 3D Structure Click here
A0A0R0KKY4 View 3D Structure Click here
A0A0R0KMU8 View 3D Structure Click here
A0A178VAW3 View 3D Structure Click here
A0A1D6E4Q6 View 3D Structure Click here
A0A1D6NV87 View 3D Structure Click here
A5PLC1 View 3D Structure Click here
B4FL50 View 3D Structure Click here
B4FZJ0 View 3D Structure Click here
B4G0G0 View 3D Structure Click here
B5DFA5 View 3D Structure Click here
F4I232 View 3D Structure Click here
F4IH50 View 3D Structure Click here
F4IH52 View 3D Structure Click here
G3V9D0 View 3D Structure Click here
G5E897 View 3D Structure Click here
I1JA60 View 3D Structure Click here
I1L6L7 View 3D Structure Click here
I1LLK2 View 3D Structure Click here
I1MZZ5 View 3D Structure Click here
K7KC52 View 3D Structure Click here
K7L079 View 3D Structure Click here
K7LDT0 View 3D Structure Click here
K7MIC4 View 3D Structure Click here