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0  structures 64  species 0  interactions 3877  sequences 106  architectures

Family: Candida_ALS (PF05792)

Summary: Candida agglutinin-like (ALS)

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Candida agglutinin-like (ALS) Provide feedback

This family consists of several agglutinin-like proteins from different Candida species. ALS genes of Candida albicans encode a family of cell-surface glycoproteins with a three-domain structure. Each Als protein has a relatively conserved N-terminal domain, a central domain consisting of a tandemly repeated motif of variable number, and a serine-threonine-rich C-terminal domain that is relatively variable across the family. The ALS family exhibits several types of variability that indicate the importance of considering strain and allelic differences when studying ALS genes and their encoded proteins [1]. Fungal adhesins, which include sexual agglutinins, virulence factors, and flocculins, are surface proteins that mediate cell-cell and cell-environment interactions. It is possible that both the serine/threonine-rich domain and the cysteine residues in the C-terminal and DIPSY PF11763 participate in anchoring the terminal domains inside the wall, so that only the inner part of Map4p, including the repeat region, is sticking out as a fold-back loop then able to act in adhesing [3].

Literature references

  1. Hoyer LL, Hecht JE; , Yeast 2001;18:49-60.: The ALS5 gene of Candida albicans and analysis of the Als5p N-terminal domain. PUBMED:11124701 EPMC:11124701

  2. Sharifmoghadam MR, Bustos-Sanmamed P, Valdivieso MH; , FEBS Lett. 2006;580:4457-4462.: The fission yeast Map4 protein is a novel adhesin required for mating. PUBMED:16857197 EPMC:16857197

  3. Linder T, Gustafsson CM; , Fungal Genet Biol. 2007; [Epub ahead of print]: Molecular phylogenetics of ascomycotal adhesins-A novel family of putative cell-surface adhesive proteins in fission yeasts. PUBMED:17870620 EPMC:17870620


This tab holds annotation information from the InterPro database.

InterPro entry IPR008440

Adhesive properties in fungi are conveyed by a group of cell-surface proteins called adhesins (sometimes also referred to as agglutinins or flocculins). Several fungal adhesins have been described to date, including the the Candida albicans Als (agglutinin-like sequence) proteins [PUBMED:17870620]. Als proteins are cell-surface glycoproteins and have a three-domain structure. Each Als protein has a relatively conserved N-terminal domain, a central domain consisting of a tandemly repeated motif of variable number, and a serine-threonine-rich C-terminal domain that is relatively variable across the family. The Als family exhibits several types of variability that indicate the importance of considering strain and allelic differences when studying als genes and their encoded proteins [PUBMED:11124701].

This entry represents the tandem repeat found in the central domain of the Als proteins.

Gene Ontology

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Domain organisation

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Alignments

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(451)
Full
(3877)
Representative proteomes UniProt
(6800)
NCBI
(10007)
Meta
(0)
RP15
(228)
RP35
(628)
RP55
(1269)
RP75
(3780)
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PP/heatmap 1 View               

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(451)
Full
(3877)
Representative proteomes UniProt
(6800)
NCBI
(10007)
Meta
(0)
RP15
(228)
RP35
(628)
RP55
(1269)
RP75
(3780)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(451)
Full
(3877)
Representative proteomes UniProt
(6800)
NCBI
(10007)
Meta
(0)
RP15
(228)
RP35
(628)
RP55
(1269)
RP75
(3780)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_7578 (release 8.0)
Previous IDs: none
Type: Repeat
Sequence Ontology: SO:0001068
Author: Moxon SJ
Number in seed: 451
Number in full: 3877
Average length of the domain: 32.40 aa
Average identity of full alignment: 38 %
Average coverage of the sequence by the domain: 34.59 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild --amino -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 11.0
Trusted cut-off 25.5 11.0
Noise cut-off 24.7 10.9
Model length: 32
Family (HMM) version: 14
Download: download the raw HMM for this family

Species distribution

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