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1  structure 218  species 0  interactions 7108  sequences 77  architectures

Family: CCT (PF06203)

Summary: CCT motif

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

CCT motif Provide feedback

This short motif is found in a number of plant proteins. It is rich in basic amino acids and has been called a CCT motif after Co, Col and Toc1 [1]. The CCT motif is about 45 amino acids long and contains a putative nuclear localisation signal within the second half of the CCT motif [1]. Toc1 mutants have been identified in this region.

Literature references

  1. Strayer C, Oyama T, Schultz TF, Raman R, Somers DE, Mas P, Panda S, Kreps JA, Kay SA; , Science 2000;289:768-771.: Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog. PUBMED:10926537 EPMC:10926537


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR010402

The CCT (CONSTANS, CO-like, and TOC1) domain is a highly conserved basic module of ~43 amino acids, which is found near the C terminus of plant proteins often involved in light signal transduction. The CCT domain is found in association with other domains, such as the B-box zinc finger, the GATA-type zinc finger, the ZIM motif or the response regulatory domain. The CCT domain contains a putative nuclear localisation signal within the second half of the CCT motif and has been shown to be involved in nuclear localization and probably also has a role in protein-protein interaction [ PUBMED:10926537 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan CCT (CL0281), which has the following description:

This clan includes the CCT motif as well as a related motif that is similar to the first half of the CCT motif.

The clan contains the following 2 members:

CCT Jas_motif

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(88)
Full
(7108)
Representative proteomes UniProt
(12631)
RP15
(781)
RP35
(3766)
RP55
(5931)
RP75
(7940)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(88)
Full
(7108)
Representative proteomes UniProt
(12631)
RP15
(781)
RP35
(3766)
RP55
(5931)
RP75
(7940)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(88)
Full
(7108)
Representative proteomes UniProt
(12631)
RP15
(781)
RP35
(3766)
RP55
(5931)
RP75
(7940)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_314 (release 9.0)
Previous IDs: none
Type: Motif
Sequence Ontology: SO:0001067
Author: Bateman A
Number in seed: 88
Number in full: 7108
Average length of the domain: 43.60 aa
Average identity of full alignment: 52 %
Average coverage of the sequence by the domain: 10.92 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 28.4 28.4
Trusted cut-off 28.4 28.4
Noise cut-off 28.3 28.3
Model length: 44
Family (HMM) version: 16
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the CCT domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0VDS9 View 3D Structure Click here
A0A0P0VFH3 View 3D Structure Click here
A0A0P0WZZ8 View 3D Structure Click here
A0A0P0XB35 View 3D Structure Click here
A0A0P0XQF3 View 3D Structure Click here
A0A0P0XY51 View 3D Structure Click here
A0A0P0XZB5 View 3D Structure Click here
A0A0P0Y3U1 View 3D Structure Click here
A0A0P0Y5X8 View 3D Structure Click here
A0A0P0Y8R4 View 3D Structure Click here
A0A0R0GQG6 View 3D Structure Click here
A0A0R0HEE4 View 3D Structure Click here
A0A0R0IW01 View 3D Structure Click here
A0A0R0KBW5 View 3D Structure Click here
A0A0R4J3G9 View 3D Structure Click here
A0A178WDK9 View 3D Structure Click here
A0A1D6E763 View 3D Structure Click here
A0A1D6E9U3 View 3D Structure Click here
A0A1D6ETT5 View 3D Structure Click here
A0A1D6F3U4 View 3D Structure Click here
A0A1D6F525 View 3D Structure Click here
A0A1D6FGI9 View 3D Structure Click here
A0A1D6GI61 View 3D Structure Click here
A0A1D6GPR9 View 3D Structure Click here
A0A1D6GUV7 View 3D Structure Click here
A0A1D6GY69 View 3D Structure Click here
A0A1D6H0V3 View 3D Structure Click here
A0A1D6H2A1 View 3D Structure Click here
A0A1D6HCU0 View 3D Structure Click here
A0A1D6HD83 View 3D Structure Click here
A0A1D6HIW9 View 3D Structure Click here
A0A1D6HJB4 View 3D Structure Click here
A0A1D6I9R1 View 3D Structure Click here
A0A1D6INK3 View 3D Structure Click here
A0A1D6JN96 View 3D Structure Click here
A0A1D6K8A4 View 3D Structure Click here
A0A1D6KB12 View 3D Structure Click here
A0A1D6KKF2 View 3D Structure Click here
A0A1D6KTW4 View 3D Structure Click here
A0A1D6KZF6 View 3D Structure Click here
A0A1D6L1R1 View 3D Structure Click here
A0A1D6LEN2 View 3D Structure Click here
A0A1D6LNQ5 View 3D Structure Click here
A0A1D6N7N8 View 3D Structure Click here
A0A1D6NEV9 View 3D Structure Click here
A0A1D6NP38 View 3D Structure Click here
A0A1D6NY20 View 3D Structure Click here
A0A1D6NZ62 View 3D Structure Click here
A0A1D6Q4M1 View 3D Structure Click here
A0A1D6Q542 View 3D Structure Click here
A0A1D6QJY6 View 3D Structure Click here
A0A1D6QT42 View 3D Structure Click here
A0A1P8AYU7 View 3D Structure Click here
A0A1X7YG15 View 3D Structure Click here
B4FE60 View 3D Structure Click here
B4FFD4 View 3D Structure Click here
B6SZU8 View 3D Structure Click here
B6TFB2 View 3D Structure Click here
B7EN35 View 3D Structure Click here
B7ZZT6 View 3D Structure Click here
B8A2Q1 View 3D Structure Click here
B9MSS5 View 3D Structure Click here
C0P687 View 3D Structure Click here
C0P6E9 View 3D Structure Click here
C0PI33 View 3D Structure Click here
C0PJC1 View 3D Structure Click here
C0SV91 View 3D Structure Click here
C6TN62 View 3D Structure Click here
D0EP03 View 3D Structure Click here
D0EP04 View 3D Structure Click here
D0EP05 View 3D Structure Click here
E3VJR1 View 3D Structure Click here
E5RQA1 View 3D Structure Click here
F4ISV4 View 3D Structure Click here
I1JH98 View 3D Structure Click here
I1JHH0 View 3D Structure Click here
I1JQH3 View 3D Structure Click here
I1JU45 View 3D Structure Click here
I1JV86 View 3D Structure Click here
I1JV87 View 3D Structure Click here
I1JWS5 View 3D Structure Click here
I1JYH9 View 3D Structure Click here
I1K9S5 View 3D Structure Click here
I1K9S6 View 3D Structure Click here
I1KCV3 View 3D Structure Click here
I1KL59 View 3D Structure Click here
I1KPD5 View 3D Structure Click here
I1KQ52 View 3D Structure Click here
I1KQX6 View 3D Structure Click here
I1LCF1 View 3D Structure Click here
I1LEW9 View 3D Structure Click here
I1LGE6 View 3D Structure Click here
I1LVL9 View 3D Structure Click here
I1LWY2 View 3D Structure Click here
I1MB13 View 3D Structure Click here
I1MB79 View 3D Structure Click here
I1MID6 View 3D Structure Click here
I1MKC2 View 3D Structure Click here
I1MLC5 View 3D Structure Click here
I1MLR4 View 3D Structure Click here
I1MSL3 View 3D Structure Click here
I1N4U7 View 3D Structure Click here
I1N6I8 View 3D Structure Click here
I1N7H8 View 3D Structure Click here
I1N7Y1 View 3D Structure Click here
I1NCR4 View 3D Structure Click here
I1NFI8 View 3D Structure Click here
K7K589 View 3D Structure Click here
K7K8I7 View 3D Structure Click here
K7K9Y2 View 3D Structure Click here
K7KH59 View 3D Structure Click here
K7KMI1 View 3D Structure Click here
K7KRL4 View 3D Structure Click here
K7KS13 View 3D Structure Click here
K7KUW6 View 3D Structure Click here
K7KZQ2 View 3D Structure Click here
K7L0J7 View 3D Structure Click here
K7L771 View 3D Structure Click here
K7LGY4 View 3D Structure Click here
K7LHH0 View 3D Structure Click here
K7LJ76 View 3D Structure Click here
K7LPS6 View 3D Structure Click here
K7LTJ5 View 3D Structure Click here
K7LYE4 View 3D Structure Click here
K7LZK3 View 3D Structure Click here
K7M1Z5 View 3D Structure Click here
K7M2U8 View 3D Structure Click here
K7M3A2 View 3D Structure Click here
K7MDZ5 View 3D Structure Click here
K7MKY0 View 3D Structure Click here
K7N1D6 View 3D Structure Click here
K7N4M3 View 3D Structure Click here
K7TS29 View 3D Structure Click here
K7U1I6 View 3D Structure Click here
K7UJZ2 View 3D Structure Click here
K7VBR1 View 3D Structure Click here
K7VNP3 View 3D Structure Click here
K7W7Y8 View 3D Structure Click here
K7WBK7 View 3D Structure Click here
O22800 View 3D Structure Click here
O23379 View 3D Structure Click here
O50055 View 3D Structure Click here
O82112 View 3D Structure Click here
O82117 View 3D Structure Click here
O82118 View 3D Structure Click here
O82256 View 3D Structure Click here
Q0D3B6 View 3D Structure Click here
Q0D3T5 View 3D Structure Click here
Q0DD26 View 3D Structure Click here
Q0DFE5 View 3D Structure Click here
Q0DNU1 View 3D Structure Click here
Q0IX46 View 3D Structure Click here
Q10F25 View 3D Structure Click here
Q10N34 View 3D Structure Click here
Q10S06 View 3D Structure Click here
Q1PFY3 View 3D Structure Click here
Q1PFY7 View 3D Structure Click here
Q2QYZ4 View 3D Structure Click here
Q39057 View 3D Structure Click here
Q53RJ0 View 3D Structure Click here
Q5Q0A4 View 3D Structure Click here
Q5QMF4 View 3D Structure Click here
Q5VRH5 View 3D Structure Click here
Q5Z4U5 View 3D Structure Click here
Q5Z857 View 3D Structure Click here
Q67ZF8 View 3D Structure Click here
Q689G6 View 3D Structure Click here
Q689G9 View 3D Structure Click here
Q6I5J7 View 3D Structure Click here
Q6K9C5 View 3D Structure Click here
Q6LA42 View 3D Structure Click here
Q6Z1G2 View 3D Structure Click here
Q6Z2L0 View 3D Structure Click here
Q6Z433 View 3D Structure Click here
Q6Z438 View 3D Structure Click here
Q7XC67 View 3D Structure Click here
Q7XQH7 View 3D Structure Click here
Q8GXL7 View 3D Structure Click here
Q8H1G0 View 3D Structure Click here
Q8L500 View 3D Structure Click here
Q8L602 View 3D Structure Click here
Q8LG76 View 3D Structure Click here
Q8RWD0 View 3D Structure Click here
Q93WK5 View 3D Structure Click here
Q940T9 View 3D Structure Click here
Q949T9 View 3D Structure Click here
Q94KJ2 View 3D Structure Click here
Q96502 View 3D Structure Click here
Q9C7E8 View 3D Structure Click here
Q9C9A9 View 3D Structure Click here
Q9FDX8 View 3D Structure Click here
Q9FHH8 View 3D Structure Click here
Q9FJD8 View 3D Structure Click here
Q9LDL9 View 3D Structure Click here
Q9LJ44 View 3D Structure Click here
Q9LKL2 View 3D Structure Click here
Q9LRH6 View 3D Structure Click here
Q9LU68 View 3D Structure Click here
Q9LUA9 View 3D Structure Click here
Q9LVG4 View 3D Structure Click here
Q9M9B3 View 3D Structure Click here
Q9SK53 View 3D Structure Click here
Q9SSE5 View 3D Structure Click here
Q9SUE8 View 3D Structure Click here

trRosetta Structure

The structural model below was generated by the Baker group with the trRosetta software using the Pfam UniProt multiple sequence alignment.

The InterPro website shows the contact map for the Pfam SEED alignment. Hovering or clicking on a contact position will highlight its connection to other residues in the alignment, as well as on the 3D structure.

Improved protein structure prediction using predicted inter-residue orientations. Jianyi Yang, Ivan Anishchenko, Hahnbeom Park, Zhenling Peng, Sergey Ovchinnikov, David Baker Proceedings of the National Academy of Sciences Jan 2020, 117 (3) 1496-1503; DOI: 10.1073/pnas.1914677117;