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0  structures 1368  species 0  interactions 4468  sequences 57  architectures

Family: Lung_7-TM_R (PF06814)

Summary: Lung seven transmembrane receptor

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Lung seven transmembrane receptor Provide feedback

This family represents a conserved region with eukaryotic lung seven transmembrane receptors and related proteins.

Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR009637

This entry represents a group of transmembrane proteins, including mammalian lung seven transmembrane receptor GPR107 and GPR108. GPR107 localizes to the trans-Golgi network and is essential for retrograde transport [ PUBMED:25031321 ]. This entry also includes proteins from fungi and plants [ PUBMED:17454009 ]. The plant proteins in this entry, including CAND6 and CAND7, are predicted to be G-protein coupled receptors [ PUBMED:18671868 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan GPCR_A (CL0192), which has the following description:

This clan contains various seven-transmembrane receptors and related proteins. A major member is Pfam:PF00001, members of which have been considered to be typical members of the rhodopsin superfamily. Many members of this clan are Caenorhabditis proteins, suggesting great expansion of the relevant families in these nematode worms.

The clan contains the following 45 members:

7TM-7TMR_HD 7tm_1 7tm_2 7tm_3 7tm_4 7TM_GPCR_Sra 7TM_GPCR_Srab 7TM_GPCR_Srb 7TM_GPCR_Srbc 7TM_GPCR_Srd 7TM_GPCR_Srh 7TM_GPCR_Sri 7TM_GPCR_Srj 7TM_GPCR_Srsx 7TM_GPCR_Srt 7TM_GPCR_Sru 7TM_GPCR_Srv 7TM_GPCR_Srw 7TM_GPCR_Srx 7TM_GPCR_Srz 7TM_GPCR_Str 7TMR-DISM_7TM Bac_rhodopsin Ceramidase Dicty_CAR DUF1182 DUF3522 DUF621 Frizzled Git3 GpcrRhopsn4 GPR_Gpa2_C Heliorhodopsin HisKA_7TM HlyIII Lung_7-TM_R Ocular_alb Per1 Pombe_5TM Serpentine_r_xa SID-1_RNA_chan Sre Srg TAS2R V1R

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(14)
Full
(4468)
Representative proteomes UniProt
(8237)
RP15
(751)
RP35
(2153)
RP55
(3641)
RP75
(4823)
Jalview View  View  View  View  View  View  View 
HTML View  View           
PP/heatmap 1 View           

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(14)
Full
(4468)
Representative proteomes UniProt
(8237)
RP15
(751)
RP35
(2153)
RP55
(3641)
RP75
(4823)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(14)
Full
(4468)
Representative proteomes UniProt
(8237)
RP15
(751)
RP35
(2153)
RP55
(3641)
RP75
(4823)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_4367 (release 10.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Vella Briffa B
Number in seed: 14
Number in full: 4468
Average length of the domain: 253.80 aa
Average identity of full alignment: 26 %
Average coverage of the sequence by the domain: 54.87 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.2 25.2
Trusted cut-off 25.2 25.2
Noise cut-off 25.1 25.1
Model length: 295
Family (HMM) version: 15
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0VA50 View 3D Structure Click here
A0A0R4IBK1 View 3D Structure Click here
A0A1D6E6A6 View 3D Structure Click here
A0A1D6ENT7 View 3D Structure Click here
A0A1D6ER19 View 3D Structure Click here
A0A1D6ER19 View 3D Structure Click here
A0A1D6ETZ5 View 3D Structure Click here
A0A1D6F6H5 View 3D Structure Click here
A0A1D6I586 View 3D Structure Click here
A0A1D6IJJ6 View 3D Structure Click here
A0A1D6K209 View 3D Structure Click here
A0A1D6K209 View 3D Structure Click here
A0A1D6NW37 View 3D Structure Click here
A0A1D6PAY3 View 3D Structure Click here
A0A1D8PGD2 View 3D Structure Click here
A0A2R8QA85 View 3D Structure Click here
A0A2R8QEN4 View 3D Structure Click here
B0G155 View 3D Structure Click here
B4FA55 View 3D Structure Click here
B4FG64 View 3D Structure Click here
B4FVK4 View 3D Structure Click here
B4FYY6 View 3D Structure Click here
B4G274 View 3D Structure Click here
B7F9V1 View 3D Structure Click here
C4J4N6 View 3D Structure Click here
D3ZWZ9 View 3D Structure Click here
D4A017 View 3D Structure Click here
D4A7B6 View 3D Structure Click here
F1Q5U9 View 3D Structure Click here
F4IM73 View 3D Structure Click here
F4JY11 View 3D Structure Click here
I1JDK6 View 3D Structure Click here
I1JPF9 View 3D Structure Click here
I1KHD9 View 3D Structure Click here
I1KUJ7 View 3D Structure Click here
I1L8N5 View 3D Structure Click here
I1L8N6 View 3D Structure Click here
I1LXH8 View 3D Structure Click here
I1LYX4 View 3D Structure Click here
I1MDR1 View 3D Structure Click here
I1MK24 View 3D Structure Click here
K7L1C5 View 3D Structure Click here
K7MYX2 View 3D Structure Click here
K7TQN5 View 3D Structure Click here
K7VBB3 View 3D Structure Click here
O04088 View 3D Structure Click here
O13989 View 3D Structure Click here
P32857 View 3D Structure Click here
P38745 View 3D Structure Click here
Q0DZH4 View 3D Structure Click here
Q10LU2 View 3D Structure Click here
Q18024 View 3D Structure Click here
Q22938 View 3D Structure Click here
Q2R2X1 View 3D Structure Click here
Q54F03 View 3D Structure Click here
Q54LQ7 View 3D Structure Click here
Q54YI0 View 3D Structure Click here
Q5VW38 View 3D Structure Click here
Q5VW38 View 3D Structure Click here
Q69P89 View 3D Structure Click here
Q6L517 View 3D Structure Click here
Q6P6V6 View 3D Structure Click here
Q7XM97 View 3D Structure Click here
Q8BKU8 View 3D Structure Click here
Q8BUV8 View 3D Structure Click here
Q8BXN9 View 3D Structure Click here
Q8GYD0 View 3D Structure Click here
Q8I5P8 View 3D Structure Click here
Q8NBN3 View 3D Structure Click here
Q8S1S0 View 3D Structure Click here
Q91WD0 View 3D Structure Click here
Q96K49 View 3D Structure Click here
Q9C5T6 View 3D Structure Click here
Q9C9E6 View 3D Structure Click here
Q9FHX6 View 3D Structure Click here
Q9LZ39 View 3D Structure Click here
Q9NPR9 View 3D Structure Click here
Q9SNM0 View 3D Structure Click here
Q9VQ34 View 3D Structure Click here
Q9W366 View 3D Structure Click here
Q9Y7Y9 View 3D Structure Click here

trRosetta Structure

The structural model below was generated by the Baker group with the trRosetta software using the Pfam UniProt multiple sequence alignment.

The InterPro website shows the contact map for the Pfam SEED alignment. Hovering or clicking on a contact position will highlight its connection to other residues in the alignment, as well as on the 3D structure.

Improved protein structure prediction using predicted inter-residue orientations. Jianyi Yang, Ivan Anishchenko, Hahnbeom Park, Zhenling Peng, Sergey Ovchinnikov, David Baker Proceedings of the National Academy of Sciences Jan 2020, 117 (3) 1496-1503; DOI: 10.1073/pnas.1914677117;