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3  structures 1505  species 0  interactions 3846  sequences 250  architectures

Family: FTP (PF07504)

Summary: Fungalysin/Thermolysin Propeptide Motif

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The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Fungalysin/Thermolysin Propeptide Motif Provide feedback

This motif is found in both the bacterial M4 peptidase propeptide and the fungal M36 propeptide. Its exact function is not clear, but it is likely to either inhibit the peptidase, so as to prevent its premature activation, or has a chaperone activity. Both of these roles have been ascribed to the M4 and M36 propeptides ([1] [2]).

Literature references

  1. Tang B, Nirasawa S, Kitaoka M, Marie-Claire C, Hayashi K; , Biochem Biophys Res Commun 2003;301:1093-1098.: General function of N-terminal propeptide on assisting protein folding and inhibiting catalytic activity based on observations with a chimeric thermolysin-like protease. PUBMED:12589825 EPMC:12589825

  2. Markaryan A, Lee JD, Sirakova TD, Kolattukudy PE; , J Bacteriol 1996;178:2211-2215.: Specific inhibition of mature fungal serine proteinases and metalloproteinases by their propeptides. PUBMED:8636020 EPMC:8636020


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR011096

The fungalysin/thermolysin propeptide (FTP) domain is found in both the bacterial M4 peptidase propeptide and the fungal M36 propeptide. Its exact function is not clear, but it is likely to either inhibit the peptidase, so as to prevent its premature activation, or to have a chaperone activity. Both of these roles have been ascribed to the M4 and M36 propeptides [ PUBMED:12589825 , PUBMED:8636020 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Cystatin (CL0121), which has the following description:

This superfamily includes cystatins and cathelicidins [1]. The cystatin superfamily comprises cysteine protease inhibitors that play key regulatory roles in protein degradation processes. The progenitor of this superfamily was most probably intracellular and lacked a signal peptide and disulfide bridges, much like the extant Giardia cystatin. A primordial gene duplication produced two ancestral eukaryotic lineages, cystatins and stefins. Stefins - included in Pfam:PF00031 - remain encoded by a single or a small number of genes throughout the eukaryotes, whereas the cystatins have undergone a more complex and dynamic evolution through numerous gene and domain duplications [2].

The clan contains the following 13 members:

Cathelicidins Cystatin DUF3889 DUF5590 FTP Latexin Monellin PP1 Spp-24 SQAPI Staphopain_pro YebF YPEB

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(144)
Full
(3846)
Representative proteomes UniProt
(16396)
RP15
(469)
RP35
(1598)
RP55
(3811)
RP75
(6812)
Jalview View  View  View  View  View  View  View 
HTML View  View           
PP/heatmap 1 View           

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(144)
Full
(3846)
Representative proteomes UniProt
(16396)
RP15
(469)
RP35
(1598)
RP55
(3811)
RP75
(6812)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(144)
Full
(3846)
Representative proteomes UniProt
(16396)
RP15
(469)
RP35
(1598)
RP55
(3811)
RP75
(6812)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Yeats C
Previous IDs: none
Type: Motif
Sequence Ontology: SO:0001067
Author: Bateman A , Yeats C , Rawlings ND
Number in seed: 144
Number in full: 3846
Average length of the domain: 48.9 aa
Average identity of full alignment: 26 %
Average coverage of the sequence by the domain: 6.83 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.0 21.0
Trusted cut-off 21.0 21.0
Noise cut-off 20.9 20.9
Model length: 51
Family (HMM) version: 16
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the FTP domain has been found. There are 3 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A1C4M2 View 3D Structure Click here
A1DBW0 View 3D Structure Click here
A2Q7V4 View 3D Structure Click here
A4QWP8 View 3D Structure Click here
B2WKX9 View 3D Structure Click here
B8NC58 View 3D Structure Click here
B8NMK3 View 3D Structure Click here
C4JR56 View 3D Structure Click here
C4JX59 View 3D Structure Click here
C5FIK0 View 3D Structure Click here
C5FJ19 View 3D Structure Click here
C5FNU8 View 3D Structure Click here
C5FX29 View 3D Structure Click here
C5FYJ8 View 3D Structure Click here
C7Z3B7 View 3D Structure Click here
D4AL88 View 3D Structure Click here
D4AQG5 View 3D Structure Click here
D4AX35 View 3D Structure Click here
D4AYW3 View 3D Structure Click here
D4B1S5 View 3D Structure Click here
E3QKL1 View 3D Structure Click here
E4UQ65 View 3D Structure Click here
E4UUL6 View 3D Structure Click here
E4UVK2 View 3D Structure Click here
E4UYA3 View 3D Structure Click here
E4V5B2 View 3D Structure Click here
E4ZJL4 View 3D Structure Click here
K0EZU8 View 3D Structure Click here
P14756 View 3D Structure Click here
P23224 View 3D Structure Click here
P24153 View 3D Structure Click here
P39899 View 3D Structure Click here
P46075 View 3D Structure Click here
P68736 View 3D Structure Click here
Q0CFJ0 View 3D Structure Click here
Q0UC19 View 3D Structure Click here
Q0V671 View 3D Structure Click here
Q2FUX4 View 3D Structure Click here
Q2U1G7 View 3D Structure Click here
Q2U1N5 View 3D Structure Click here