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21  structures 412  species 0  interactions 9424  sequences 259  architectures

Family: SOCS_box (PF07525)

Summary: SOCS box

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

SOCS box Provide feedback

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.

Literature references

  1. Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ; , Trends Biochem Sci 2002;27:235-241.: The SOCS box: a tale of destruction and degradation. PUBMED:12076535 EPMC:12076535


This tab holds annotation information from the InterPro database.

InterPro entry IPR001496

The SOCS box was first identified in SH2-domain-containing proteins of the suppressor of cytokines signalling (SOCS) family [ PUBMED:9202125 ] but was later also found in:

  • the WSB (WD-40-repeat-containing proteins with a SOCS box) family,
  • the SSB (SPRY domain-containing proteins with a SOCS box) family,
  • the ASB (ankyrin-repeat-containing proteins with a SOCS box) family,
  • and ras and ras-like GTPases [ PUBMED:9419338 ].

The SOCS box found in these proteins is an about 50 amino acid C-terminal domain composed of two blocks of well-conserved residues separated by between 2 and 10 non-conserved residues [ PUBMED:9419338 ]. The C-terminal conserved region is an L/P-rich sequence of unknown function, whereas the N-terminal conserved region is a consensus BC box [ PUBMED:9869640 ], which binds to the Elongin BC complex [ PUBMED:9869640 , PUBMED:10051596 ]. It has been demonstrated that this association couple bound proteins to the ubiquitination or proteasomal compartments [ PUBMED:10051596 , PUBMED:15601820 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan SOCS_box (CL0642), which has the following description:

This superfamily includes the SOCS-box domain and the VHL-box domain [1].

The clan contains the following 2 members:

SOCS_box VHL_C

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(379)
Full
(9424)
Representative proteomes UniProt
(15789)
RP15
(1386)
RP35
(3326)
RP55
(8275)
RP75
(10940)
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HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(379)
Full
(9424)
Representative proteomes UniProt
(15789)
RP15
(1386)
RP35
(3326)
RP55
(8275)
RP75
(10940)
Alignment:
Format:
Order:
Sequence:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(379)
Full
(9424)
Representative proteomes UniProt
(15789)
RP15
(1386)
RP35
(3326)
RP55
(8275)
RP75
(10940)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: [1]
Previous IDs: Clip; SOCS_Clip;
Type: Domain
Sequence Ontology: SO:0000417
Author: Studholme DJ
Number in seed: 379
Number in full: 9424
Average length of the domain: 38.10 aa
Average identity of full alignment: 37 %
Average coverage of the sequence by the domain: 9.52 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.5 23.5
Trusted cut-off 23.5 23.5
Noise cut-off 23.4 23.4
Model length: 37
Family (HMM) version: 18
Download: download the raw HMM for this family

Species distribution

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Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SOCS_box domain has been found. There are 21 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JZ15 View 3D Structure Click here
A0A0G2K9S1 View 3D Structure Click here
A0A0R4IA11 View 3D Structure Click here
A0A0R4IAA4 View 3D Structure Click here
A0A0R4IFZ8 View 3D Structure Click here
A0A0R4IHQ5 View 3D Structure Click here
A0A140LGI6 View 3D Structure Click here
A0A286Y9U7 View 3D Structure Click here
A0A2R8PZ70 View 3D Structure Click here
A0A2R8Q1K5 View 3D Structure Click here
A0A2R8Q6H6 View 3D Structure Click here
A0A2R8RQU2 View 3D Structure Click here
A1Z6E0 View 3D Structure Click here
A2CEZ8 View 3D Structure Click here
A4IG40 View 3D Structure Click here
A6NK59 View 3D Structure Click here
A9LDR6 View 3D Structure Click here
B0BMX8 View 3D Structure Click here
B0BMZ0 View 3D Structure Click here
B0EVP5 View 3D Structure Click here
B0EVP6 View 3D Structure Click here
B0EVP7 View 3D Structure Click here
B0EVQ1 View 3D Structure Click here
B0R1B6 View 3D Structure Click here
B0S5W3 View 3D Structure Click here
B0S7L8 View 3D Structure Click here
B3DM89 View 3D Structure Click here
B5DEZ7 View 3D Structure Click here
B5DF08 View 3D Structure Click here
B5DF17 View 3D Structure Click here
B5DF38 View 3D Structure Click here
B5DF78 View 3D Structure Click here
B5DF97 View 3D Structure Click here
B8JKT2 View 3D Structure Click here
D3ZEJ6 View 3D Structure Click here
D3ZJN4 View 3D Structure Click here
D3ZS84 View 3D Structure Click here
D3ZU92 View 3D Structure Click here
D3ZUE4 View 3D Structure Click here
D3ZVT6 View 3D Structure Click here
D4A8E5 View 3D Structure Click here
E7F166 View 3D Structure Click here
E7FDH8 View 3D Structure Click here
E7FFH0 View 3D Structure Click here
E9QDL8 View 3D Structure Click here
F1M6U5 View 3D Structure Click here
F1M9V9 View 3D Structure Click here
F1Q4U7 View 3D Structure Click here
F1Q993 View 3D Structure Click here
F1QB63 View 3D Structure Click here
F1QBD5 View 3D Structure Click here
F1QCR9 View 3D Structure Click here
F1QKK3 View 3D Structure Click here
F1QY53 View 3D Structure Click here
F6NLA2 View 3D Structure Click here
F7EPG5 View 3D Structure Click here
H0WF25 View 3D Structure Click here
M9PHY7 View 3D Structure Click here
O14508 View 3D Structure Click here
O14512 View 3D Structure Click here
O14544 View 3D Structure Click here
O35716 View 3D Structure Click here
O35717 View 3D Structure Click here
O54927 View 3D Structure Click here
O54928 View 3D Structure Click here
O54929 View 3D Structure Click here
O70512 View 3D Structure Click here
O75159 View 3D Structure Click here
O88582 View 3D Structure Click here
O88838 View 3D Structure Click here
P0C0E4 View 3D Structure Click here
P0C927 View 3D Structure Click here
Q08BW5 View 3D Structure Click here
Q12829 View 3D Structure Click here
Q1LX92 View 3D Structure Click here
Q1RLP4 View 3D Structure Click here
Q32Q00 View 3D Structure Click here
Q4KLY9 View 3D Structure Click here
Q4V8W1 View 3D Structure Click here
Q5M877 View 3D Structure Click here
Q5RGR4 View 3D Structure Click here
Q5U2S6 View 3D Structure Click here
Q62225 View 3D Structure Click here
Q66HE3 View 3D Structure Click here
Q68EL0 View 3D Structure Click here
Q6AYC9 View 3D Structure Click here
Q6DBS3 View 3D Structure Click here
Q6Y2E6 View 3D Structure Click here
Q6ZVZ8 View 3D Structure Click here
Q70X92 View 3D Structure Click here
Q7JVF1 View 3D Structure Click here
Q7T2B1 View 3D Structure Click here
Q7T2F6 View 3D Structure Click here
Q7T386 View 3D Structure Click here
Q7ZUC6 View 3D Structure Click here
Q8C6Y6 View 3D Structure Click here
Q8CHM6 View 3D Structure Click here
Q8IR80 View 3D Structure Click here
Q8K0L0 View 3D Structure Click here
Q8R5B6 View 3D Structure Click here
Q8VBX0 View 3D Structure Click here
Q8VHA6 View 3D Structure Click here
Q8VHP8 View 3D Structure Click here
Q8VHP9 View 3D Structure Click here
Q8VHQ2 View 3D Structure Click here
Q8VHQ4 View 3D Structure Click here
Q8VHS5 View 3D Structure Click here
Q8VHS6 View 3D Structure Click here
Q8WWX0 View 3D Structure Click here
Q8WXH4 View 3D Structure Click here
Q8WXH5 View 3D Structure Click here
Q8WXH6 View 3D Structure Click here
Q8WXI3 View 3D Structure Click here
Q8WXJ9 View 3D Structure Click here
Q8WXK1 View 3D Structure Click here
Q8WXK3 View 3D Structure Click here
Q8WXK4 View 3D Structure Click here
Q91ZA6 View 3D Structure Click here
Q91ZT7 View 3D Structure Click here
Q91ZT8 View 3D Structure Click here
Q91ZT9 View 3D Structure Click here
Q91ZU0 View 3D Structure Click here
Q91ZU1 View 3D Structure Click here
Q965N7 View 3D Structure Click here
Q96A44 View 3D Structure Click here
Q96BD6 View 3D Structure Click here
Q96DX5 View 3D Structure Click here
Q96NS5 View 3D Structure Click here
Q96Q27 View 3D Structure Click here
Q96S21 View 3D Structure Click here
Q99619 View 3D Structure Click here
Q9BR09 View 3D Structure Click here
Q9CQ31 View 3D Structure Click here
Q9D0S4 View 3D Structure Click here
Q9D1A4 View 3D Structure Click here
Q9D5L7 View 3D Structure Click here
Q9D738 View 3D Structure Click here
Q9GYM5 View 3D Structure Click here
Q9H672 View 3D Structure Click here
Q9H765 View 3D Structure Click here
Q9JLY0 View 3D Structure Click here
Q9NSE2 View 3D Structure Click here
Q9NWX5 View 3D Structure Click here
Q9NYS7 View 3D Structure Click here
Q9QX78 View 3D Structure Click here
Q9VA06 View 3D Structure Click here
Q9VMV0 View 3D Structure Click here
Q9W089 View 3D Structure Click here
Q9W112 View 3D Structure Click here
Q9WV71 View 3D Structure Click here
Q9WV72 View 3D Structure Click here
Q9WV74 View 3D Structure Click here
Q9Y574 View 3D Structure Click here
Q9Y575 View 3D Structure Click here
Q9Y576 View 3D Structure Click here
Q9Y6I7 View 3D Structure Click here