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8  structures 415  species 0  interactions 6994  sequences 48  architectures

Family: Band_3_cyto (PF07565)

Summary: Band 3 cytoplasmic domain

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This is the Wikipedia entry entitled "Bicarbonate transporter proteins". More...

Bicarbonate transporter proteins Edit Wikipedia article

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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Band 3 cytoplasmic domain Provide feedback

This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk). [1]

Literature references

  1. Zhang D, Kiyatkin A, Bolin JT, Low PS; , Blood 2000;96:2925-2933.: Crystallographic structure and functional interpretation of the cytoplasmic domain of erythrocyte membrane band 3. PUBMED:11049968 EPMC:11049968


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR013769

This entry contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk) [ PUBMED:11049968 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan PTase-anion_tr (CL0340), which has the following description:

The families here are the cytoplasmic regions of anion transporter proteins.

The clan contains the following 2 members:

Band_3_cyto PTS_EIIA_2

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(14)
Full
(6994)
Representative proteomes UniProt
(11888)
RP15
(640)
RP35
(2083)
RP55
(5775)
RP75
(7993)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(14)
Full
(6994)
Representative proteomes UniProt
(11888)
RP15
(640)
RP35
(2083)
RP55
(5775)
RP75
(7993)
Alignment:
Format:
Order:
Sequence:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(14)
Full
(6994)
Representative proteomes UniProt
(11888)
RP15
(640)
RP35
(2083)
RP55
(5775)
RP75
(7993)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_1004 (release 3.0)
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 14
Number in full: 6994
Average length of the domain: 214.20 aa
Average identity of full alignment: 42 %
Average coverage of the sequence by the domain: 24.92 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 34.3 34.3
Trusted cut-off 34.3 34.3
Noise cut-off 34.1 34.2
Model length: 262
Family (HMM) version: 15
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Band_3_cyto domain has been found. There are 8 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2KM71 View 3D Structure Click here
A0A0R4IUL4 View 3D Structure Click here
A0A286YA89 View 3D Structure Click here
A0A2R8PYB9 View 3D Structure Click here
A0A2R8Q9J0 View 3D Structure Click here
A0A2R8QJJ4 View 3D Structure Click here
A0A494BA31 View 3D Structure Click here
A0A494BA31 View 3D Structure Click here
B0S7B8 View 3D Structure Click here
B3WFV9 View 3D Structure Click here
B3WFV9 View 3D Structure Click here
D1FTM8 View 3D Structure Click here
D1FTM8 View 3D Structure Click here
E7FGE7 View 3D Structure Click here
E9Q3M5 View 3D Structure Click here
F1Q5R4 View 3D Structure Click here
F1QGN4 View 3D Structure Click here
F1R0Y5 View 3D Structure Click here
O88343 View 3D Structure Click here
P02730 View 3D Structure Click here
P04919 View 3D Structure Click here
P04920 View 3D Structure Click here
P13808 View 3D Structure Click here
P16283 View 3D Structure Click here
P23347 View 3D Structure Click here
P23348 View 3D Structure Click here
P23562 View 3D Structure Click here
P48751 View 3D Structure Click here
Q2Y0W8 View 3D Structure Click here
Q58QG8 View 3D Structure Click here
Q5DTL9 View 3D Structure Click here
Q6RI88 View 3D Structure Click here
Q6RVG2 View 3D Structure Click here
Q6U841 View 3D Structure Click here
Q7ZZJ7 View 3D Structure Click here
Q7ZZJ7 View 3D Structure Click here
Q80ZA5 View 3D Structure Click here
Q8BTY2 View 3D Structure Click here
Q8IPI3 View 3D Structure Click here
Q8JZR6 View 3D Structure Click here
Q8K4V2 View 3D Structure Click here
Q8K4V2 View 3D Structure Click here
Q96Q91 View 3D Structure Click here
Q96Q91 View 3D Structure Click here
Q9BY07 View 3D Structure Click here
Q9JI66 View 3D Structure Click here
Q9R1N3 View 3D Structure Click here
Q9R1N3 View 3D Structure Click here
Q9VT48 View 3D Structure Click here
Q9Y6M7 View 3D Structure Click here
Q9Y6M7 View 3D Structure Click here
Q9Y6R1 View 3D Structure Click here