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49  structures 567  species 0  interactions 20608  sequences 722  architectures

Family: Kazal_2 (PF07648)

Summary: Kazal-type serine protease inhibitor domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Kazal domain". More...

Kazal domain Edit Wikipedia article

Kazal-type serine protease inhibitor domain
PDB 2b0u EBI.jpg
the structure of the follistatin:activin complex
Identifiers
SymbolKazal_1
PfamPF00050
InterProIPR002350
PROSITEPDOC00254
SCOPe3sgb / SUPFAM
Kazal-type serine protease inhibitor domain
PDB 1lr9 EBI.jpg
structure of fs1, the heparin-binding domain of follistatin
Identifiers
SymbolKazal_2
PfamPF07648
InterProIPR011497
PROSITEPDOC00254
SCOPe3sgb / SUPFAM

The Kazal domain is an evolutionary conserved protein domain usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors.

In animals, serine protease inhibitors that act via their Kazal domain are grouped under the MEROPS inhibitor family I1, clan IA.[1][2]

Kazal 1

Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulfide bonds. Alignment also includes a single domain from transporters in the OATP/PGT family P46721.

Peptide proteinase inhibitors can be found as single domain proteins or as single or multiple domains within proteins; these are referred to as either simple or compound inhibitors, respectively. In many cases they are synthesised as part of a larger precursor protein, either as a prepropeptide or as an N-terminal domain associated with an inactive peptidase or zymogen. This domain prevents access of the substrate to the active site. Removal of the N-terminal inhibitor domain either by interaction with a second peptidase or by autocatalytic cleavage activates the zymogen. Other inhibitors interact direct with proteinases using a simple noncovalent lock and key mechanism; while yet others use a conformational change-based trapping mechanism that depends on their structural and thermodynamic properties.

This family of Kazal inhibitors, belongs to MEROPS inhibitor family I1, clan IA. They inhibit serine peptidases of the S1 family (INTERPRO).[3] The members are primarily metazoan, but includes exceptions in the alveolata (apicomplexa), stramenopiles, higher plants and bacteria.

Kazal inhibitors, which inhibit a number of serine proteases (such as trypsin and elastase), belong to family of proteins that includes pancreatic secretory trypsin inhibitor; avian ovomucoid; acrosin inhibitor; and elastase inhibitor. These proteins contain between 1 and 7 Kazal-type inhibitor repeats.[4][5]

The structure of the Kazal repeat includes a large quantity of extended chain, 2 short alpha-helices and a 3-stranded anti-parallel beta sheet.[4] The inhibitor makes 11 contacts with its enzyme substrate: unusually, 8 of these important residues are hypervariable.[5] Altering the enzyme-contact residues, and especially that of the active site bond, affects the strength of inhibition and specificity of the inhibitor for particular serine proteases.[5][6] The presence of this Pfam domain is usually indicative of serine protease inhibitors, however, Kazal-like domains are also seen in the extracellular part of agrins which are not known to be proteinase inhibitors.

Human proteins with Kazal 1 domains:

Kazal 2

This domain is usually indicative of serine protease inhibitors that belong to Merops inhibitor families: I1, I2, I17 and I31. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays and have a central alpha-helix, a short two-stranded antiparallel beta-sheet and several disulphide bonds.[7][8][9] The amino terminal segment of this domain binds to the active site of its target proteases, thus inhibiting their function.

Human proteins with Kazal 2 domains:

References

  1. ^ MEROPS family I1
  2. ^ InterProIPR001239
  3. ^ Rawlings ND, Tolle DP, Barrett AJ (March 2004). "Evolutionary families of peptidase inhibitors". Biochem. J. 378 (Pt 3): 705–16. doi:10.1042/BJ20031825. PMC 1224039. PMID 14705960.
  4. ^ a b Williamson MP; Marion D; Wüthrich K (March 1984). "Secondary structure in the solution conformation of the proteinase inhibitor IIA from bull seminal plasma by nuclear magnetic resonance". J. Mol. Biol. 173 (3): 341–59. doi:10.1016/0022-2836(84)90125-6. PMID 6699915.
  5. ^ a b c Laskowski M, Kato I, Ardelt W, Cook J, Denton A, Empie MW, Kohr WJ, Park SJ, Parks K, Schatzley BL (January 1987). "Ovomucoid third domains from 100 avian species: isolation, sequences, and hypervariability of enzyme-inhibitor contact residues". Biochemistry. 26 (1): 202–21. doi:10.1021/bi00375a028. PMID 3828298.
  6. ^ Empie MW, Laskowski M (May 1982). "Thermodynamics and kinetics of single residue replacements in avian ovomucoid third domains: effect on inhibitor interactions with serine proteinases". Biochemistry. 21 (10): 2274–84. doi:10.1021/bi00539a002. PMID 7046785.
  7. ^ Schlott B, Wöhnert J, Icke C, Hartmann M, Ramachandran R, Gührs KH, Glusa E, Flemming J, Görlach M, Grosse F, Ohlenschläger O (April 2002). "Interaction of Kazal-type inhibitor domains with serine proteinases: biochemical and structural studies". J. Mol. Biol. 318 (2): 533–46. doi:10.1016/S0022-2836(02)00014-1. PMID 12051857.
  8. ^ Stubbs MT, Morenweiser R, Stürzebecher J, Bauer M, Bode W, Huber R, Piechottka GP, Matschiner G, Sommerhoff CP, Fritz H, Auerswald EA (August 1997). "The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition". J. Biol. Chem. 272 (32): 19931–7. doi:10.1074/jbc.272.32.19931. PMID 9242660.
  9. ^ van de Locht A, Lamba D, Bauer M, Huber R, Friedrich T, Kröger B, Höffken W, Bode W (November 1995). "Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin". EMBO J. 14 (21): 5149–57. PMC 394622. PMID 7489704.
This article incorporates text from the public domain Pfam and InterPro: IPR002350
This article incorporates text from the public domain Pfam and InterPro: IPR011497

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Kazal-type serine protease inhibitor domain Provide feedback

Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002350

Canonical serine proteinase inhibitors are distributed in a wide range of organisms from all kingdoms of life and play crucial role in various physiological mechanisms [ PUBMED:6996568 ]. They interact from the canonical proteinase-inhibitor binding loop, where P1 residue has a predominant role (the residue at the P1 position contributing the carbonyl portion to the reactive-site peptide bond). These so-called canonical inhibitors bind to their cognate enzymes in the same manner as a good substrate, but are cleaved extremely slowly. Kazal-type inhibitors represent the most studied canonical proteinase inhibitors. Kazal inhibitors are extremely variable at their reactive sites. However, some regularity prevails such as the presence of lysine at position P1 indicating strong inhibition of trypsin [ PUBMED:10708867 ].

The Kazal inhibitor has six cysteine residues engaged in disulfide bonds arranged as shown in the following schematic representation:

                       +------------------+
                       |                  |
                       *******************|***
        xxxxxxxxCxxxxxxCx#xxxxxCxxxxxxxxxxCxxCxxxxxxxxxxxxxxxxxC
                |              |             |                 |
                |              +-------------|-----------------+
                +----------------------------+

'C': conserved cysteine involved in a disulfide bond.
'#': active site residue.
'*': position of the pattern.

The structure of classical Kazal domains consists of a central alpha helix, which is inserted between two beta-strands and a third that is toward the C terminus [ PUBMED:6752426 ]. The reactive site P1 and the conformation of the reactive site loop is structurally highly conserved, similar to the canonical conformation of small serine proteinase inhibitors.

This entry represents the Kazal domain.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Kazal (CL0005), which has the following description:

Kazal domains are found in both serine protease inhibitors and extracellular regions of agrins. The structure of the Kazal domain is a small alpha/beta fold. Typically the Kazal domain consists of 2 short-helices and a 3-stranded anti-parallel sheet. The fold is contains several disulphide bonds.

The clan contains the following 3 members:

Kazal_1 Kazal_2 Kazal_3

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(40)
Full
(20608)
Representative proteomes UniProt
(37232)
RP15
(3648)
RP35
(8315)
RP55
(18658)
RP75
(24507)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(40)
Full
(20608)
Representative proteomes UniProt
(37232)
RP15
(3648)
RP35
(8315)
RP55
(18658)
RP75
(24507)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(40)
Full
(20608)
Representative proteomes UniProt
(37232)
RP15
(3648)
RP35
(8315)
RP55
(18658)
RP75
(24507)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Manual
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD
Number in seed: 40
Number in full: 20608
Average length of the domain: 47.20 aa
Average identity of full alignment: 30 %
Average coverage of the sequence by the domain: 13.52 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.8 11.0
Trusted cut-off 22.8 11.0
Noise cut-off 22.7 10.9
Model length: 49
Family (HMM) version: 17
Download: download the raw HMM for this family

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Kazal_2 domain has been found. There are 49 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A096MK67 View 3D Structure Click here
A0A0A0MPH1 View 3D Structure Click here
A0A0G2JWY3 View 3D Structure Click here
A0A0G2JZ40 View 3D Structure Click here
A0A0G2JZ40 View 3D Structure Click here
A0A0G2JZ40 View 3D Structure Click here
A0A0G2JZU6 View 3D Structure Click here
A0A0G2JZU6 View 3D Structure Click here
A0A0G2K0K9 View 3D Structure Click here
A0A0G2K946 View 3D Structure Click here
A0A0G2K9W9 View 3D Structure Click here
A0A0H2UKS1 View 3D Structure Click here
A0A0N4SU37 View 3D Structure Click here
A0A0N4SUD8 View 3D Structure Click here
A0A0R4IBD9 View 3D Structure Click here
A0A0R4ICL4 View 3D Structure Click here
A0A0R4IKU3 View 3D Structure Click here
A0A0R4IKU3 View 3D Structure Click here
A0A0R4IU08 View 3D Structure Click here
A0A0R4IW35 View 3D Structure Click here
A0A2R8Q7K1 View 3D Structure Click here
A0A2R8Q8S3 View 3D Structure Click here
A0A2R8QE24 View 3D Structure Click here
A0A2R8QHY9 View 3D Structure Click here
A0A2R8QJ36 View 3D Structure Click here
A0A2R8QJ36 View 3D Structure Click here
A0A2R8RXR5 View 3D Structure Click here
A1A6Q4 View 3D Structure Click here
A2ASQ1 View 3D Structure Click here
A2ASQ1 View 3D Structure Click here
A2ASQ1 View 3D Structure Click here
A2ASQ1 View 3D Structure Click here
A2ASQ1 View 3D Structure Click here
A2ASQ1 View 3D Structure Click here
A2ASQ1 View 3D Structure Click here
A2ASQ1 View 3D Structure Click here
A2RT60 View 3D Structure Click here
A4IG14 View 3D Structure Click here
A4IG14 View 3D Structure Click here
A9JRB3 View 3D Structure Click here
B0BN16 View 3D Structure Click here
B0S6Y8 View 3D Structure Click here
B0S6Y8 View 3D Structure Click here
B0V1B1 View 3D Structure Click here
B3DH26 View 3D Structure Click here
B3DJD4 View 3D Structure Click here
D3ZA76 View 3D Structure Click here
D3ZJ81 View 3D Structure Click here
D3ZKF5 View 3D Structure Click here
D3ZUT1 View 3D Structure Click here
D3ZZM7 View 3D Structure Click here
E7EDQ9 View 3D Structure Click here
E7F2I7 View 3D Structure Click here
E7F9M2 View 3D Structure Click here
E7FET3 View 3D Structure Click here
E7FFX7 View 3D Structure Click here
E9PVD9 View 3D Structure Click here
F1M6V6 View 3D Structure Click here
F1M9B2 View 3D Structure Click here
F1Q5M5 View 3D Structure Click here
F1Q6U6 View 3D Structure Click here
F1QSU6 View 3D Structure Click here
F1QSU6 View 3D Structure Click here
F1R074 View 3D Structure Click here
F1R074 View 3D Structure Click here
F1R074 View 3D Structure Click here
F1R074 View 3D Structure Click here
F1R074 View 3D Structure Click here
F1R074 View 3D Structure Click here
F1R074 View 3D Structure Click here
F1R074 View 3D Structure Click here
F1R074 View 3D Structure Click here
G3V0H7 View 3D Structure Click here
G5EG68 View 3D Structure Click here
G5EG68 View 3D Structure Click here
G5EG68 View 3D Structure Click here
G5EG68 View 3D Structure Click here
G5EG68 View 3D Structure Click here
G5EG68 View 3D Structure Click here
G5EG68 View 3D Structure Click here
G5EG68 View 3D Structure Click here
I3ISY9 View 3D Structure Click here
I3ISY9 View 3D Structure Click here
L7N264 View 3D Structure Click here
M0QWR8 View 3D Structure Click here
M9PF81 View 3D Structure Click here
O00468 View 3D Structure Click here
O00468 View 3D Structure Click here
O00468 View 3D Structure Click here
O00468 View 3D Structure Click here
O00468 View 3D Structure Click here
O00468 View 3D Structure Click here
O00468 View 3D Structure Click here
O00468 View 3D Structure Click here
O35913 View 3D Structure Click here
O88397 View 3D Structure Click here
O95633 View 3D Structure Click here
O95633 View 3D Structure Click here
O95980 View 3D Structure Click here
O95980 View 3D Structure Click here
O95980 View 3D Structure Click here
O97176 View 3D Structure Click here
O97176 View 3D Structure Click here
P19883 View 3D Structure Click here
P19883 View 3D Structure Click here
P19883 View 3D Structure Click here
P21674 View 3D Structure Click here
P21674 View 3D Structure Click here
P21674 View 3D Structure Click here
P25304 View 3D Structure Click here
P25304 View 3D Structure Click here
P25304 View 3D Structure Click here
P25304 View 3D Structure Click here
P25304 View 3D Structure Click here
P25304 View 3D Structure Click here
P25304 View 3D Structure Click here
P25304 View 3D Structure Click here
P34714 View 3D Structure Click here
P46720 View 3D Structure Click here
P46721 View 3D Structure Click here
P47931 View 3D Structure Click here
P47931 View 3D Structure Click here
P47931 View 3D Structure Click here
P70502 View 3D Structure Click here
P70663 View 3D Structure Click here
P83105 View 3D Structure Click here
P83110 View 3D Structure Click here
Q00910 View 3D Structure Click here
Q08629 View 3D Structure Click here
Q0E9E0 View 3D Structure Click here
Q12841 View 3D Structure Click here
Q16270 View 3D Structure Click here
Q1LV73 View 3D Structure Click here
Q2PMI2 View 3D Structure Click here
Q2PMI4 View 3D Structure Click here
Q2PMI4 View 3D Structure Click here
Q2PMI4 View 3D Structure Click here
Q3S1M5 View 3D Structure Click here
Q3S1M5 View 3D Structure Click here
Q5STE3 View 3D Structure Click here
Q61129 View 3D Structure Click here
Q61581 View 3D Structure Click here
Q62288 View 3D Structure Click here
Q62356 View 3D Structure Click here
Q62632 View 3D Structure Click here
Q6DBR1 View 3D Structure Click here
Q6GMI0 View 3D Structure Click here
Q6IE50 View 3D Structure Click here
Q6MZW2 View 3D Structure Click here
Q6PFE7 View 3D Structure Click here
Q6PFE7 View 3D Structure Click here
Q6ZQN7 View 3D Structure Click here
Q86NV3 View 3D Structure Click here
Q86NV3 View 3D Structure Click here
Q86NV3 View 3D Structure Click here
Q86UG4 View 3D Structure Click here
Q8BFR2 View 3D Structure Click here
Q8BGD4 View 3D Structure Click here
Q8BJ66 View 3D Structure Click here
Q8BKV0 View 3D Structure Click here
Q8BLY1 View 3D Structure Click here
Q8C0X7 View 3D Structure Click here
Q8CD91 View 3D Structure Click here
Q8IYR6 View 3D Structure Click here
Q8IYR6 View 3D Structure Click here
Q8IZJ3 View 3D Structure Click here
Q8K078 View 3D Structure Click here
Q8N475 View 3D Structure Click here
Q8R3L5 View 3D Structure Click here
Q8SY02 View 3D Structure Click here
Q8WX77 View 3D Structure Click here
Q91YY5 View 3D Structure Click here
Q924H6 View 3D Structure Click here
Q92563 View 3D Structure Click here
Q92743 View 3D Structure Click here
Q92959 View 3D Structure Click here
Q95011 View 3D Structure Click here
Q95011 View 3D Structure Click here
Q95011 View 3D Structure Click here
Q95011 View 3D Structure Click here
Q95011 View 3D Structure Click here
Q95011 View 3D Structure Click here
Q95011 View 3D Structure Click here
Q95011 View 3D Structure Click here
Q95011 View 3D Structure Click here
Q95011 View 3D Structure Click here
Q95011 View 3D Structure Click here
Q95ZT3 View 3D Structure Click here
Q96BD0 View 3D Structure Click here
Q96I82 View 3D Structure Click here
Q99J94 View 3D Structure Click here
Q99N01 View 3D Structure Click here
Q99N02 View 3D Structure Click here
Q99PW7 View 3D Structure Click here
Q99PW7 View 3D Structure Click here
Q9BQ16 View 3D Structure Click here
Q9D236 View 3D Structure Click here
Q9D5W6 View 3D Structure Click here
Q9EP96 View 3D Structure Click here
Q9EPT5 View 3D Structure Click here
Q9EPZ7 View 3D Structure Click here
Q9EQC7 View 3D Structure Click here
Q9EQC7 View 3D Structure Click here
Q9ER58 View 3D Structure Click here
Q9ERB5 View 3D Structure Click here
Q9H2Y9 View 3D Structure Click here
Q9H3U7 View 3D Structure Click here
Q9H4F8 View 3D Structure Click here
Q9JJL3 View 3D Structure Click here
Q9NPD5 View 3D Structure Click here
Q9NQ38 View 3D Structure Click here
Q9NYB5 View 3D Structure Click here
Q9QXZ6 View 3D Structure Click here
Q9QYE2 View 3D Structure Click here
Q9QYM9 View 3D Structure Click here
Q9QYM9 View 3D Structure Click here
Q9QYV1 View 3D Structure Click here
Q9QYV1 View 3D Structure Click here
Q9QZK5 View 3D Structure Click here
Q9QZX8 View 3D Structure Click here
Q9R118 View 3D Structure Click here
Q9UIG8 View 3D Structure Click here
Q9UIK5 View 3D Structure Click here
Q9UIK5 View 3D Structure Click here
Q9VCR3 View 3D Structure Click here
Q9VDG1 View 3D Structure Click here
Q9VLB3 View 3D Structure Click here
Q9VNL6 View 3D Structure Click here
Q9VNL6 View 3D Structure Click here
Q9VP16 View 3D Structure Click here
Q9VSK1 View 3D Structure Click here
Q9VSK1 View 3D Structure Click here
Q9VSK1 View 3D Structure Click here
Q9VSK1 View 3D Structure Click here
Q9VSK1 View 3D Structure Click here
Q9VSK1 View 3D Structure Click here
Q9VSK1 View 3D Structure Click here
Q9VSK1 View 3D Structure Click here
Q9VUD8 View 3D Structure Click here
Q9VUJ2 View 3D Structure Click here
Q9VUJ2 View 3D Structure Click here
Q9VYH7 View 3D Structure Click here
Q9VYH7 View 3D Structure Click here
Q9VYH8 View 3D Structure Click here
Q9W269 View 3D Structure Click here
Q9W271 View 3D Structure Click here
Q9WUW3 View 3D Structure Click here
Q9Y6L6 View 3D Structure Click here
Q9YHV4 View 3D Structure Click here
Q9YHV4 View 3D Structure Click here
Q9YHV4 View 3D Structure Click here
Q9Z0J1 View 3D Structure Click here
Q9Z0J1 View 3D Structure Click here
Q9Z0J1 View 3D Structure Click here