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0  structures 154  species 0  interactions 2912  sequences 65  architectures

Family: Calmodulin_bind (PF07887)

Summary: Calmodulin binding protein-like

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Calmodulin binding protein-like Provide feedback

The members of this family are putative or actual calmodulin binding proteins expressed by various plant species. Some members (for example, Q8H6T7), are known to be involved in the induction of plant defence responses [1]. However, their precise function in this regards is as yet unknown.

Literature references

  1. Ali GS, Reddy VS, Lindgren PB, Jakobek JL, Reddy AS; , Plant Mol Biol 2003;51:803-815.: Differential expression of genes encoding calmodulin-binding proteins in response to bacterial pathogens and inducers of defense responses. PUBMED:12777041 EPMC:12777041


This tab holds annotation information from the InterPro database.

InterPro entry IPR012416

CALMODULIN-BINDING PROTEIN60 (CBP60) family from plants have been known to be involved in both biotic and abiotic stress responses [ PUBMED:22466450 ]. Some members (for example, SWISSPROT ), are known to be involved in the induction of plant defence responses [ PUBMED:12777041 ]. In Arabidopsis, CBP60s have eight members, including CBP60g and SARD1, which encode positive regulators of plant immunity that promote production of salicylic acid (SA) and affect expression of SA-dependent and SA-independent defense genes [ PUBMED:20921422 , PUBMED:24134885 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(60)
Full
(2912)
Representative proteomes UniProt
(4070)
RP15
(217)
RP35
(1443)
RP55
(2420)
RP75
(3167)
Jalview View  View  View  View  View  View  View 
HTML View  View           
PP/heatmap 1 View           

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(60)
Full
(2912)
Representative proteomes UniProt
(4070)
RP15
(217)
RP35
(1443)
RP55
(2420)
RP75
(3167)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(60)
Full
(2912)
Representative proteomes UniProt
(4070)
RP15
(217)
RP35
(1443)
RP55
(2420)
RP75
(3167)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_4579 (release 14.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Fenech M
Number in seed: 60
Number in full: 2912
Average length of the domain: 250.30 aa
Average identity of full alignment: 39 %
Average coverage of the sequence by the domain: 49.12 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.2 27.2
Trusted cut-off 27.4 27.2
Noise cut-off 26.8 27.1
Model length: 292
Family (HMM) version: 13
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0VZX9 View 3D Structure Click here
A0A0P0W533 View 3D Structure Click here
A0A0P0XF72 View 3D Structure Click here
A0A0P0Y229 View 3D Structure Click here
A0A0P0Y516 View 3D Structure Click here
A0A0P0Y591 View 3D Structure Click here
A0A0P0Y5G3 View 3D Structure Click here
A0A0P0Y5H7 View 3D Structure Click here
A0A0P0Y5K5 View 3D Structure Click here
A0A0P0Y5T7 View 3D Structure Click here
A0A0P0YBV0 View 3D Structure Click here
A0A0R0KNR6 View 3D Structure Click here
A0A1D6E9U4 View 3D Structure Click here
A0A1D6F486 View 3D Structure Click here
A0A1D6GE14 View 3D Structure Click here
A0A1D6GTM5 View 3D Structure Click here
A0A1D6H296 View 3D Structure Click here
A0A1D6HAV3 View 3D Structure Click here
A0A1D6K023 View 3D Structure Click here
A0A1D6KQ92 View 3D Structure Click here
A0A1D6LK64 View 3D Structure Click here
A0A1D6MLY1 View 3D Structure Click here
A0A1D6MYW1 View 3D Structure Click here
A0A1D6Q3C3 View 3D Structure Click here
C0P4B9 View 3D Structure Click here
C0PGN9 View 3D Structure Click here
C0SV51 View 3D Structure Click here
C0SVV6 View 3D Structure Click here
F4IPM3 View 3D Structure Click here
F4JR57 View 3D Structure Click here
F4K2R6 View 3D Structure Click here
I1JR66 View 3D Structure Click here
I1K5M7 View 3D Structure Click here
I1KLD8 View 3D Structure Click here
I1KQ96 View 3D Structure Click here
I1L2E3 View 3D Structure Click here
I1L4A9 View 3D Structure Click here
I1LB64 View 3D Structure Click here
I1LVT0 View 3D Structure Click here
I1MEA5 View 3D Structure Click here
I1MST1 View 3D Structure Click here
I1NBS5 View 3D Structure Click here
I1NBS6 View 3D Structure Click here
K7KGL0 View 3D Structure Click here
K7KMN1 View 3D Structure Click here
K7L0L5 View 3D Structure Click here
K7L565 View 3D Structure Click here
K7MCM7 View 3D Structure Click here
K7MKS1 View 3D Structure Click here
K7TJS3 View 3D Structure Click here
K7UQ53 View 3D Structure Click here
K7UQ53 View 3D Structure Click here
Q0DN31 View 3D Structure Click here
Q0IR76 View 3D Structure Click here
Q0J2S0 View 3D Structure Click here
Q0WVV6 View 3D Structure Click here
Q2QNS0 View 3D Structure Click here
Q2QNS2 View 3D Structure Click here
Q2QNS3 View 3D Structure Click here
Q2QZV8 View 3D Structure Click here
Q6ETN1 View 3D Structure Click here
Q6YU05 View 3D Structure Click here
Q7XRM0 View 3D Structure Click here
Q943R3 View 3D Structure Click here
Q9C9T2 View 3D Structure Click here
Q9FKL6 View 3D Structure Click here

trRosetta Structure

The structural model below was generated by the Baker group with the trRosetta software using the Pfam UniProt multiple sequence alignment.

The InterPro website shows the contact map for the Pfam SEED alignment. Hovering or clicking on a contact position will highlight its connection to other residues in the alignment, as well as on the 3D structure.

Improved protein structure prediction using predicted inter-residue orientations. Jianyi Yang, Ivan Anishchenko, Hahnbeom Park, Zhenling Peng, Sergey Ovchinnikov, David Baker Proceedings of the National Academy of Sciences Jan 2020, 117 (3) 1496-1503; DOI: 10.1073/pnas.1914677117;