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862  structures 8873  species 0  interactions 131949  sequences 1306  architectures

Family: Pyr_redox_2 (PF07992)

Summary: Pyridine nucleotide-disulphide oxidoreductase

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The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Pyridine nucleotide-disulphide oxidoreductase Provide feedback

This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.

Literature references

  1. Mande SS, Sarfaty S, Allen MD, Perham RN, Hol WG; , Structure 1996;4:277-286.: Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase. PUBMED:8805537 EPMC:8805537


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR023753

FAD flavoproteins belonging to the family of pyridine nucleotide-disulphide oxidoreductases (glutathione reductase, trypanothione reductase, lipoamide dehydrogenase, mercuric reductase, thioredoxin reductase, alkyl hydroperoxide reductase) share sequence similarity with a number of other flavoprotein oxidoreductases, in particular with ferredoxin-NAD+ reductases involved in oxidative metabolism of a variety of hydrocarbons (rubredoxin reductase, putidaredoxin reductase, terpredoxin reductase, ferredoxin-NAD+ reductase components of benzene 1,2-dioxygenase, toluene 1,2-dioxygenase, chlorobenzene dioxygenase, biphenyl dioxygenase), NADH oxidase and NADH peroxidase [ PUBMED:2319593 , PUBMED:1404382 , PUBMED:2067578 ]. Comparison of the crystal structures of human glutathione reductase and Escherichia coli thioredoxin reductase reveals different locations of their active sites, suggesting that the enzymes diverged from an ancestral FAD/NAD(P)H reductase and acquired their disulphide reductase activities independently [ PUBMED:2067578 ].

Despite functional similarities, oxidoreductases of this family show no sequence similarity with adrenodoxin reductases [ PUBMED:2924777 ] and flavoprotein pyridine nucleotide cytochrome reductases (FPNCR) [ PUBMED:1748631 ]. Assuming that disulphide reductase activity emerged later, during divergent evolution, the family can be referred to as FAD-dependent pyridine nucleotide reductases, FADPNR.

To date, 3D structures of glutathione reductase [ PUBMED:3656429 ], thioredoxin reductase [ PUBMED:2067578 ], mercuric reductase [ PUBMED:2067577 ], lipoamide dehydrogenase [ PUBMED:1880807 ], trypanothione reductase [ PUBMED:1924336 ] and NADH peroxidase [ PUBMED:1942054 ] have been solved. The enzymes share similar tertiary structures based on a doubly-wound alpha/beta fold, but the relative orientations of their FAD- and NAD(P)H-binding domains may vary significantly. By contrast with the FPNCR family, the folds of the FAD- and NAD(P)H-binding domains are similar, suggesting that the domains evolved by gene duplication [ PUBMED:7411611 ].

This entry describes the FAD binding domain which has a nested NADH binding domain and is found in both class I and class II oxidoreductases.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan NADP_Rossmann (CL0063), which has the following description:

A class of redox enzymes are two domain proteins. One domain, termed the catalytic domain, confers substrate specificity and the precise reaction of the enzyme. The other domain, which is common to this class of redox enzymes, is a Rossmann-fold domain. The Rossmann domain binds nicotinamide adenine dinucleotide (NAD+) and it is this cofactor that reversibly accepts a hydride ion, which is lost or gained by the substrate in the redox reaction. Rossmann domains have an alpha/beta fold, which has a central beta sheet, with approximately five alpha helices found surrounding the beta sheet.The strands forming the beta sheet are found in the following characteristic order 654123. The inter sheet crossover of the stands in the sheet form the NAD+ binding site [1]. In some more distantly relate Rossmann domains the NAD+ cofactor is replaced by the functionally similar cofactor FAD.

The clan contains the following 206 members:

2-Hacid_dh_C 3Beta_HSD 3HCDH_N 3HCDH_RFF adh_short adh_short_C2 ADH_zinc_N ADH_zinc_N_2 AdoHcyase_NAD AdoMet_MTase AlaDh_PNT_C Amino_oxidase ApbA AviRa B12-binding Bac_GDH Bin3 Bmt2 CbiJ CheR CMAS CmcI CoA_binding CoA_binding_2 CoA_binding_3 Cons_hypoth95 CoV_ExoN CoV_Methyltr_2 DAO DapB_N DFP DNA_methylase DOT1 DRE2_N DREV DUF1442 DUF1611_N DUF166 DUF1776 DUF2431 DUF268 DUF2855 DUF3410 DUF364 DUF43 DUF5129 DUF5130 DUF6094 DUF938 DXP_reductoisom DXPR_C Eco57I ELFV_dehydrog Eno-Rase_FAD_bd Eno-Rase_NADH_b Enoyl_reductase Epimerase F420_oxidored FAD_binding_2 FAD_binding_3 FAD_oxidored Fibrillarin FMO-like FmrO FtsJ fvmX7 G6PD_N GCD14 GDI GDP_Man_Dehyd GFO_IDH_MocA GIDA GidB GLF Glu_dehyd_C Glyco_hydro_4 Glyco_tran_WecG GMC_oxred_N Gp_dh_N GRAS GRDA HcgC HI0933_like HIM1 IlvN ISPD_C K_oxygenase KR LCM Ldh_1_N LpxI_N Lycopene_cycl Malic_M Mannitol_dh MCRA Met_10 Methyltr_RsmB-F Methyltr_RsmF_N Methyltrans_Mon Methyltrans_SAM Methyltransf_10 Methyltransf_11 Methyltransf_12 Methyltransf_14 Methyltransf_15 Methyltransf_16 Methyltransf_17 Methyltransf_18 Methyltransf_19 Methyltransf_2 Methyltransf_20 Methyltransf_21 Methyltransf_22 Methyltransf_23 Methyltransf_24 Methyltransf_25 Methyltransf_28 Methyltransf_29 Methyltransf_3 Methyltransf_30 Methyltransf_31 Methyltransf_32 Methyltransf_33 Methyltransf_34 Methyltransf_4 Methyltransf_5 Methyltransf_7 Methyltransf_8 Methyltransf_9 Methyltransf_PK MethyltransfD12 MetW Mg-por_mtran_C MOLO1 Mqo MT-A70 MTS Mur_ligase N2227 N6-adenineMlase N6_Mtase N6_N4_Mtase NAD_binding_10 NAD_binding_2 NAD_binding_3 NAD_binding_4 NAD_binding_5 NAD_binding_7 NAD_binding_8 NAD_binding_9 NAD_Gly3P_dh_N NAS NmrA NNMT_PNMT_TEMT NodS OCD_Mu_crystall Orbi_VP4 PALP PARP_regulatory PCMT PDH PglD_N Polysacc_syn_2C Polysacc_synt_2 Pox_MCEL Pox_mRNA-cap Prenylcys_lyase PrmA PRMT5 Pyr_redox Pyr_redox_2 Pyr_redox_3 Reovirus_L2 RmlD_sub_bind Rossmann-like rRNA_methylase RrnaAD Rsm22 RsmJ Sacchrp_dh_NADP SAM_MT SE Semialdhyde_dh Shikimate_DH Spermine_synth TehB THF_DHG_CYH_C Thi4 ThiF TPM_phosphatase TPMT TrkA_N TRM TRM13 TrmK tRNA_U5-meth_tr Trp_halogenase TylF Ubie_methyltran UDPG_MGDP_dh_N UPF0020 UPF0146 Urocanase V_cholerae_RfbT XdhC_C YjeF_N

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(64)
Full
(131949)
Representative proteomes UniProt
(553772)
RP15
(16505)
RP35
(60035)
RP55
(127881)
RP75
(218186)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(64)
Full
(131949)
Representative proteomes UniProt
(553772)
RP15
(16505)
RP35
(60035)
RP55
(127881)
RP75
(218186)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(64)
Full
(131949)
Representative proteomes UniProt
(553772)
RP15
(16505)
RP35
(60035)
RP55
(127881)
RP75
(218186)
Raw Stockholm Download     Download   Download        
Gzipped Download     Download   Download        

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Manual
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD , Eberhardt R
Number in seed: 64
Number in full: 131949
Average length of the domain: 287.90 aa
Average identity of full alignment: 18 %
Average coverage of the sequence by the domain: 58.34 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null --hand HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.1 26.1
Trusted cut-off 26.1 26.1
Noise cut-off 26.0 26.0
Model length: 295
Family (HMM) version: 16
Download: download the raw HMM for this family

Species distribution

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Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Pyr_redox_2 domain has been found. There are 862 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2K0G3 View 3D Structure Click here
A0A0P0WIG6 View 3D Structure Click here
A0A0P0XUU0 View 3D Structure Click here
A0A0R0EH76 View 3D Structure Click here
A0A0R0EVI7 View 3D Structure Click here
A0A0R0FAD6 View 3D Structure Click here
A0A0R0H3V8 View 3D Structure Click here
A0A0R0H8E2 View 3D Structure Click here
A0A0R0HAR3 View 3D Structure Click here
A0A0R0HR30 View 3D Structure Click here
A0A0R0I177 View 3D Structure Click here
A0A0R0I3F1 View 3D Structure Click here
A0A0R0IGG0 View 3D Structure Click here
A0A0R0JMI0 View 3D Structure Click here
A0A0R0JZ96 View 3D Structure Click here
A0A0R0JZ96 View 3D Structure Click here
A0A0R0KBX5 View 3D Structure Click here
A0A0R4IGI3 View 3D Structure Click here
A0A0R4IPH8 View 3D Structure Click here
A0A0R4IXT5 View 3D Structure Click here
A0A0R4J365 View 3D Structure Click here
A0A0R4J5Z5 View 3D Structure Click here
A0A143ZVU1 View 3D Structure Click here
A0A144A323 View 3D Structure Click here
A0A144A3W0 View 3D Structure Click here
A0A1D6FI70 View 3D Structure Click here
A0A1D6FLZ4 View 3D Structure Click here
A0A1D6G2B5 View 3D Structure Click here
A0A1D6G6H2 View 3D Structure Click here
A0A1D6G8Y4 View 3D Structure Click here
A0A1D6HHM8 View 3D Structure Click here
A0A1D6HI32 View 3D Structure Click here
A0A1D6HP35 View 3D Structure Click here
A0A1D6IF39 View 3D Structure Click here
A0A1D6IFU8 View 3D Structure Click here
A0A1D6ILW6 View 3D Structure Click here
A0A1D6ILW6 View 3D Structure Click here
A0A1D6JPH3 View 3D Structure Click here
A0A1D6LPC7 View 3D Structure Click here
A0A1D6LXK7 View 3D Structure Click here
A0A1D6LYX0 View 3D Structure Click here
A0A1D6MBZ9 View 3D Structure Click here
A0A1D6MSE3 View 3D Structure Click here
A0A1D6N9U7 View 3D Structure Click here
A0A1D6NFK0 View 3D Structure Click here
A0A1D6PWC0 View 3D Structure Click here
A0A1D6QNR8 View 3D Structure Click here
A0A1D8PDU9 View 3D Structure Click here
A0A1D8PH88 View 3D Structure Click here
A0A1D8PI22 View 3D Structure Click here
A0A1D8PLS0 View 3D Structure Click here
A0A1D8PLT0 View 3D Structure Click here
A0A1D8PLT2 View 3D Structure Click here
A0A1D8PQ66 View 3D Structure Click here
A0A1X7YHU3 View 3D Structure Click here
A0A2R8QMQ0 View 3D Structure Click here
A0A2R8RQT4 View 3D Structure Click here
A2BGE5 View 3D Structure Click here
A4HSF7 View 3D Structure Click here
A4HSY5 View 3D Structure Click here
A4HVY7 View 3D Structure Click here
A4I1Z7 View 3D Structure Click here
A4I4P1 View 3D Structure Click here
A4I769 View 3D Structure Click here
A4I8F6 View 3D Structure Click here
A4I8U6 View 3D Structure Click here
A4I9J7 View 3D Structure Click here
A4IDV2 View 3D Structure Click here
A8MS68 View 3D Structure Click here
B0BMT9 View 3D Structure Click here
B4FMX6 View 3D Structure Click here
B4FQ13 View 3D Structure Click here
B4FQK0 View 3D Structure Click here
B8A028 View 3D Structure Click here
C0P4M0 View 3D Structure Click here
C4J4E4 View 3D Structure Click here
C6TNF9 View 3D Structure Click here
D3ZF03 View 3D Structure Click here
D4AA14 View 3D Structure Click here
E7F3F1 View 3D Structure Click here
E7FB58 View 3D Structure Click here
E7FFC4 View 3D Structure Click here
E7FGD0 View 3D Structure Click here
E9AHL8 View 3D Structure Click here
F1Q6Z6 View 3D Structure Click here
F1QYT2 View 3D Structure Click here
F2Z4R3 View 3D Structure Click here
F4JJJ3 View 3D Structure Click here
F4JLP5 View 3D Structure Click here
F8W3A6 View 3D Structure Click here
I1J8A4 View 3D Structure Click here
I1JD78 View 3D Structure Click here
I1JF43 View 3D Structure Click here
I1JGA5 View 3D Structure Click here
I1JHD9 View 3D Structure Click here
I1K526 View 3D Structure Click here
I1K5W8 View 3D Structure Click here
I1KF65 View 3D Structure Click here
I1KLC9 View 3D Structure Click here
I1KLE3 View 3D Structure Click here
I1KMS8 View 3D Structure Click here
I1KPF0 View 3D Structure Click here
I1L899 View 3D Structure Click here
I1L9Y6 View 3D Structure Click here
I1LKM5 View 3D Structure Click here
I1LLL3 View 3D Structure Click here
I1LRK6 View 3D Structure Click here
I1LRK7 View 3D Structure Click here
I1MAK3 View 3D Structure Click here
I1MBC1 View 3D Structure Click here
I1MC49 View 3D Structure Click here
I1MEA0 View 3D Structure Click here
I1MGG7 View 3D Structure Click here
I1MLW5 View 3D Structure Click here
I1MMU1 View 3D Structure Click here
I1MNX4 View 3D Structure Click here
I1MRP6 View 3D Structure Click here
I1MRV6 View 3D Structure Click here
I1MZY7 View 3D Structure Click here
I6Y4U4 View 3D Structure Click here
J7SF87 View 3D Structure Click here
K7L482 View 3D Structure Click here
K7L561 View 3D Structure Click here
K7L567 View 3D Structure Click here
K7LCH3 View 3D Structure Click here
K7LNQ6 View 3D Structure Click here
K7LQ40 View 3D Structure Click here
K7M1Q3 View 3D Structure Click here
K7US39 View 3D Structure Click here
K7V323 View 3D Structure Click here
K7VC17 View 3D Structure Click here
K7VD90 View 3D Structure Click here
K8F7V7 View 3D Structure Click here
M9NFH8 View 3D Structure Click here
O05204 View 3D Structure Click here
O07255 View 3D Structure Click here
O08749 View 3D Structure Click here
O14121 View 3D Structure Click here
O17953 View 3D Structure Click here
O43090 View 3D Structure Click here
O50431 View 3D Structure Click here
O59710 View 3D Structure Click here
O62133 View 3D Structure Click here
O80874 View 3D Structure Click here
O81413 View 3D Structure Click here
O89000 View 3D Structure Click here
P00393 View 3D Structure Click here
P09622 View 3D Structure Click here
P09624 View 3D Structure Click here
P09832 View 3D Structure Click here
P09832 View 3D Structure Click here
P0A9P0 View 3D Structure Click here
P22570 View 3D Structure Click here
P27306 View 3D Structure Click here
P32340 View 3D Structure Click here
P37127 View 3D Structure Click here
P37127 View 3D Structure Click here
P38816 View 3D Structure Click here
P40215 View 3D Structure Click here
P42593 View 3D Structure Click here
P47791 View 3D Structure Click here
P48640 View 3D Structure Click here
P48641 View 3D Structure Click here
P48642 View 3D Structure Click here
P56522 View 3D Structure Click here
P70619 View 3D Structure Click here
P78965 View 3D Structure Click here
P95160 View 3D Structure Click here
P95200 View 3D Structure Click here
P9WHH1 View 3D Structure Click here
P9WIQ3 View 3D Structure Click here
P9WJI1 View 3D Structure Click here
P9WJJ1 View 3D Structure Click here
P9WN19 View 3D Structure Click here
Q07500 View 3D Structure Click here
Q0DG35 View 3D Structure Click here
Q0E3X3 View 3D Structure Click here
Q0JKD0 View 3D Structure Click here
Q12680 View 3D Structure Click here
Q12882 View 3D Structure Click here
Q18164 View 3D Structure Click here
Q18213 View 3D Structure Click here
Q18213 View 3D Structure Click here
Q19910 View 3D Structure Click here
Q1JPL4 View 3D Structure Click here
Q2FVL8 View 3D Structure Click here
Q2FVP8 View 3D Structure Click here
Q2FY51 View 3D Structure Click here
Q2FZV7 View 3D Structure Click here
Q2FZW0 View 3D Structure Click here
Q2G0I4 View 3D Structure Click here
Q2G0U1 View 3D Structure Click here
Q2G1R5 View 3D Structure Click here
Q2G2A3 View 3D Structure Click here
Q2G2I0 View 3D Structure Click here
Q2RAB3 View 3D Structure Click here
Q39242 View 3D Structure Click here
Q39243 View 3D Structure Click here
Q3TMV7 View 3D Structure Click here
Q3TMV7 View 3D Structure Click here
Q3TY86 View 3D Structure Click here
Q41219 View 3D Structure Click here
Q46811 View 3D Structure Click here
Q46820 View 3D Structure Click here
Q4CL55 View 3D Structure Click here
Q4CQ18 View 3D Structure Click here
Q4CQX3 View 3D Structure Click here
Q4CT43 View 3D Structure Click here
Q4CX42 View 3D Structure Click here
Q4CX43 View 3D Structure Click here
Q4CYV7 View 3D Structure Click here
Q4D003 View 3D Structure Click here
Q4D2Y5 View 3D Structure Click here
Q4D2Y6 View 3D Structure Click here
Q4D9I1 View 3D Structure Click here
Q4DCU2 View 3D Structure Click here
Q4DD33 View 3D Structure Click here
Q4DFA7 View 3D Structure Click here
Q4DKB3 View 3D Structure Click here
Q4DLM3 View 3D Structure Click here
Q4DWL8 View 3D Structure Click here
Q4DYH0 View 3D Structure Click here
Q4DZ00 View 3D Structure Click here
Q54DK1 View 3D Structure Click here
Q54EW8 View 3D Structure Click here
Q54GF3 View 3D Structure Click here
Q54H36 View 3D Structure Click here
Q54H36 View 3D Structure Click here
Q54KG7 View 3D Structure Click here
Q54M28 View 3D Structure Click here
Q54NS8 View 3D Structure Click here
Q54NS9 View 3D Structure Click here
Q54UU8 View 3D Structure Click here
Q55CD9 View 3D Structure Click here
Q55FT1 View 3D Structure Click here
Q58053 View 3D Structure Click here
Q59NQ5 View 3D Structure Click here
Q59RQ6 View 3D Structure Click here
Q5AEC9 View 3D Structure Click here
Q5AG89 View 3D Structure Click here
Q5QLT6 View 3D Structure Click here
Q5W745 View 3D Structure Click here
Q61578 View 3D Structure Click here
Q652L6 View 3D Structure Click here
Q655G1 View 3D Structure Click here
Q66I16 View 3D Structure Click here
Q68FS6 View 3D Structure Click here
Q68FS6 View 3D Structure Click here
Q69PS6 View 3D Structure Click here
Q69Y16 View 3D Structure Click here
Q6ERP0 View 3D Structure Click here
Q6NYG8 View 3D Structure Click here
Q6P6R2 View 3D Structure Click here
Q6PBT5 View 3D Structure Click here
Q6PBT5 View 3D Structure Click here
Q6TNU6 View 3D Structure Click here
Q6YZ09 View 3D Structure Click here
Q6ZFU6 View 3D Structure Click here
Q6ZJ08 View 3D Structure Click here
Q70G58 View 3D Structure Click here
Q7KVK5 View 3D Structure Click here
Q84PW3 View 3D Structure Click here
Q86AE2 View 3D Structure Click here
Q8BUE4 View 3D Structure Click here
Q8CHR6 View 3D Structure Click here
Q8GWA1 View 3D Structure Click here
Q8GXR9 View 3D Structure Click here
Q8H5X6 View 3D Structure Click here
Q8I302 View 3D Structure Click here
Q8I5A0 View 3D Structure Click here
Q8IAZ6 View 3D Structure Click here
Q8IBP8 View 3D Structure Click here
Q8S3R1 View 3D Structure Click here
Q8S3R2 View 3D Structure Click here
Q8S5T1 View 3D Structure Click here
Q8T137 View 3D Structure Click here
Q8W3L1 View 3D Structure Click here
Q8WU10 View 3D Structure Click here
Q92375 View 3D Structure Click here
Q93379 View 3D Structure Click here
Q93WJ8 View 3D Structure Click here
Q94BV7 View 3D Structure Click here
Q94CN9 View 3D Structure Click here
Q960D4 View 3D Structure Click here
Q96NN9 View 3D Structure Click here
Q9ASP4 View 3D Structure Click here
Q9BRQ8 View 3D Structure Click here
Q9C102 View 3D Structure Click here
Q9C574 View 3D Structure Click here
Q9CA67 View 3D Structure Click here
Q9GRX6 View 3D Structure Click here
Q9JM53 View 3D Structure Click here
Q9LFA3 View 3D Structure Click here
Q9LK94 View 3D Structure Click here
Q9LV03 View 3D Structure Click here
Q9LXP4 View 3D Structure Click here
Q9M5K2 View 3D Structure Click here
Q9M5K3 View 3D Structure Click here
Q9R112 View 3D Structure Click here
Q9SKT7 View 3D Structure Click here
Q9SR59 View 3D Structure Click here
Q9U1X0 View 3D Structure Click here
Q9U229 View 3D Structure Click here
Q9VIP2 View 3D Structure Click here
Q9VIP2 View 3D Structure Click here
Q9VJ03 View 3D Structure Click here
Q9VNT5 View 3D Structure Click here
Q9VQ79 View 3D Structure Click here
Q9VVL7 View 3D Structure Click here
Q9VZF6 View 3D Structure Click here
Q9W374 View 3D Structure Click here
Q9Y6N5 View 3D Structure Click here
Q9Z0X1 View 3D Structure Click here