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13  structures 1360  species 0  interactions 1711  sequences 42  architectures

Family: BOP1NT (PF08145)

Summary: BOP1NT (NUC169) domain

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This is the Wikipedia entry entitled "BOP1". More...

BOP1 Edit Wikipedia article

Aliases BOP1, block of proliferation 1
External IDs MGI: 1334460 HomoloGene: 6612 GeneCards: BOP1
Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for BOP1
Genomic location for BOP1
Band No data available Start 144,262,102 bp[1]
End 144,291,370 bp[1]
RNA expression pattern
PBB GE BOP1 212563 at fs.png

PBB GE BOP1 216397 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 8: 144.26 – 144.29 Mb Chr 8: 76.45 – 76.48 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Ribosome biogenesis protein BOP1 is a protein that in humans is encoded by the BOP1 gene.[5][6]


It is a WD40 repeat-containing nucleolar protein involved in rRNA processing, thereby controlling the cell cycle.[7] It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA. The Pes1-Bop1 complex has several components: BOP1, GRWD1, PES1, ORC6L, and RPL3 and is involved in ribosome biogenesis and altered chromosome segregation. The overexpression of BOP1 increases the percentage of multipolar spindles in human cells. Deregulation of the BOP1 pathway may contribute to colorectal tumourigenesis in humans.[8] Elevated levels of Bop1 induces Bop1/WDR12 and Bop1/Pes1 subcomplexes and the assembly and integrity of the PeBoW complex is highly sensitive to changes in Bop1 protein levels.[9]

Nop7p-Erb1p-Ytm1p, found in yeast, is potentially the homologous complex of Pes1-Bop1-WDR12 as it is involved in the control of ribosome biogenesis and S phase entry. The integrity of the PeBoW complex is required for ribosome biogenesis and cell proliferation in mammalian cells.[10] In Giardia, the species specific cytoskeleton protein, beta-giardin, interacts with Bop1.[7]


Symbol BOP1NT
Pfam PF08145
InterPro IPR012953

BOP1 contains a conserved N-terminal domain, BOP1NT.


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000261236 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022557 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Mar 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. PMID 8590280. doi:10.1093/dnares/2.4.167. 
  6. ^ "Entrez Gene: BOP1 block of proliferation 1". 
  7. ^ a b Kim J, Goo SY, Chung HJ, Yang HW, Yong TS, Lee KH, Park SJ (January 2006). "Interaction of beta-giardin with the Bop1 protein in Giardia lamblia". Parasitol. Res. 98 (2): 138–44. PMID 16362343. doi:10.1007/s00436-005-0040-8. 
  8. ^ Killian A, Sarafan-Vasseur N, Sesboüé R, Le Pessot F, Blanchard F, Lamy A, Laurent M, Flaman JM, Frébourg T (September 2006). "Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis". Genes Chromosomes Cancer. 45 (9): 874–81. PMID 16804918. doi:10.1002/gcc.20351. 
  9. ^ Rohrmoser M, Hölzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D (May 2007). "Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit". Mol. Cell. Biol. 27 (10): 3682–94. PMC 1899993Freely accessible. PMID 17353269. doi:10.1128/MCB.00172-07. 
  10. ^ Hölzel M, Rohrmoser M, Schlee M, Grimm T, Harasim T, Malamoussi A, Gruber-Eber A, Kremmer E, Hiddemann W, Bornkamm GW, Eick D (August 2005). "Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation". J. Cell Biol. 170 (3): 367–78. PMC 2171466Freely accessible. PMID 16043514. doi:10.1083/jcb.200501141. 

External links

Further reading

This article incorporates text from the public domain Pfam and InterPro IPR012953

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

BOP1NT (NUC169) domain Provide feedback

This N terminal domain is found in BOP1-like WD40 proteins [1].

Literature references

  1. Staub E, Fiziev P, Rosenthal A, Hinzmann B; , Bioessays 2004;26:567-581.: Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire. PUBMED:15112237 EPMC:15112237

Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR012953

This domain is found in the N-terminal region of BOP1-like WD40 proteins. Bop1 is a nucleolar protein involved in rRNA processing, thereby controlling the cell cycle [ PUBMED:16362343 ]. It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA.

Gene Ontology

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Domain organisation

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Seed source: Staub E
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Staub E , Bateman A , Mistry J
Number in seed: 96
Number in full: 1711
Average length of the domain: 244.20 aa
Average identity of full alignment: 46 %
Average coverage of the sequence by the domain: 34.20 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 29.6 29.6
Trusted cut-off 30.2 29.9
Noise cut-off 29.5 29.5
Model length: 259
Family (HMM) version: 14
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Species distribution

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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the BOP1NT domain has been found. There are 13 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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