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841  structures 7993  species 0  interactions 117856  sequences 1425  architectures

Family: ADH_N (PF08240)

Summary: Alcohol dehydrogenase GroES-like domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Alcohol dehydrogenase GroES-like domain Provide feedback

This is the catalytic domain of alcohol dehydrogenases. Many of them contain an inserted zinc binding domain. This domain has a GroES-like structure [1-2].

Literature references

  1. Murzin AG; , Curr Opin Struct Biol 1996;6:386-394.: Structural classification of proteins: new superfamilies. PUBMED:8804825 EPMC:8804825

  2. Taneja B, Mande SC; , Protein Eng 1999;12:815-818.: Conserved structural features and sequence patterns in the GroES fold family. PUBMED:10556240 EPMC:10556240


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR013154

This is the catalytic domain of alcohol dehydrogenases ( EC ). Many of them contain an inserted zinc binding domain. This domain has a GroES-like structure; a name derived from the superfamily of proteins with a GroES fold. Proteins with a GroES fold structure have a highly conserved hydrophobic core and a glycyl-aspartate dipeptide which is thought to maintain the fold [ PUBMED:10556240 , PUBMED:8804825 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan GroES (CL0296), which has the following description:

This superfamily includes the GroES protein as well as the N-terminal GroES-like domain from Alcohol dehydrogenase.

The clan contains the following 3 members:

ADH_N ADH_N_2 Cpn10

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(66)
Full
(117856)
Representative proteomes UniProt
(428713)
RP15
(11781)
RP35
(47891)
RP55
(106527)
RP75
(186291)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(66)
Full
(117856)
Representative proteomes UniProt
(428713)
RP15
(11781)
RP35
(47891)
RP55
(106527)
RP75
(186291)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(66)
Full
(117856)
Representative proteomes UniProt
(428713)
RP15
(11781)
RP35
(47891)
RP55
(106527)
RP75
(186291)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_7 (Release17.0)
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 66
Number in full: 117856
Average length of the domain: 100.50 aa
Average identity of full alignment: 25 %
Average coverage of the sequence by the domain: 24.12 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.1 21.1
Trusted cut-off 21.1 21.1
Noise cut-off 21.0 21.0
Model length: 109
Family (HMM) version: 14
Download: download the raw HMM for this family

Species distribution

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Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the ADH_N domain has been found. There are 841 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A089QRB9 View 3D Structure Click here
A0A0P0VRW1 View 3D Structure Click here
A0A0P0W8W7 View 3D Structure Click here
A0A0P0W924 View 3D Structure Click here
A0A0P0WKK9 View 3D Structure Click here
A0A0P0XBM6 View 3D Structure Click here
A0A0R0EAL6 View 3D Structure Click here
A0A0R0F139 View 3D Structure Click here
A0A0R0FW40 View 3D Structure Click here
A0A0R0G330 View 3D Structure Click here
A0A0R0G967 View 3D Structure Click here
A0A0R0GTU4 View 3D Structure Click here
A0A0R0GXI0 View 3D Structure Click here
A0A0R0H054 View 3D Structure Click here
A0A0R0H2V7 View 3D Structure Click here
A0A0R0HA20 View 3D Structure Click here
A0A0R0I1N1 View 3D Structure Click here
A0A0R0IEK0 View 3D Structure Click here
A0A0R0IIS7 View 3D Structure Click here
A0A0R0IL09 View 3D Structure Click here
A0A0R0ITF2 View 3D Structure Click here
A0A0R0ITG0 View 3D Structure Click here
A0A0R0ITL5 View 3D Structure Click here
A0A0R0JL19 View 3D Structure Click here
A0A0R0KFA8 View 3D Structure Click here
A0A0R0KM05 View 3D Structure Click here
A0A0R0LIV3 View 3D Structure Click here
A0A0R4J2H4 View 3D Structure Click here
A0A0R4J2R3 View 3D Structure Click here
A0A0R4J364 View 3D Structure Click here
A0A0R4J4D2 View 3D Structure Click here
A0A0R4J4U4 View 3D Structure Click here
A0A1D5RMB0 View 3D Structure Click here
A0A1D6DYL5 View 3D Structure Click here
A0A1D6HNQ2 View 3D Structure Click here
A0A1D6HP90 View 3D Structure Click here
A0A1D6I3Z8 View 3D Structure Click here
A0A1D6I3Z9 View 3D Structure Click here
A0A1D6I5W8 View 3D Structure Click here
A0A1D6I5X9 View 3D Structure Click here
A0A1D6I7Z1 View 3D Structure Click here
A0A1D6J5A6 View 3D Structure Click here
A0A1D6JJP0 View 3D Structure Click here
A0A1D6JR64 View 3D Structure Click here
A0A1D6JR65 View 3D Structure Click here
A0A1D6KC47 View 3D Structure Click here
A0A1D6KC48 View 3D Structure Click here
A0A1D6KL30 View 3D Structure Click here
A0A1D6LDQ8 View 3D Structure Click here
A0A1D6QBR6 View 3D Structure Click here
A0A1D8PDC5 View 3D Structure Click here
A0A1D8PH64 View 3D Structure Click here
A0A1D8PH67 View 3D Structure Click here
A0A1D8PIM0 View 3D Structure Click here
A0A1D8PNH7 View 3D Structure Click here
A0A1D8PP43 View 3D Structure Click here
A0A1D8PQE3 View 3D Structure Click here
A0A1D8PS45 View 3D Structure Click here
A0A1D8PSE7 View 3D Structure Click here
A0A1D8PSF7 View 3D Structure Click here
A0A1D8PSZ0 View 3D Structure Click here
A0A1D8PTL3 View 3D Structure Click here
A0A1D8PU61 View 3D Structure Click here
A0A1D8PUB4 View 3D Structure Click here
A0A286Y901 View 3D Structure Click here
A0A286YBD8 View 3D Structure Click here
A1L4Y2 View 3D Structure Click here
A1L4Y4 View 3D Structure Click here
A4HS24 View 3D Structure Click here
A4HUG8 View 3D Structure Click here
A4HVK0 View 3D Structure Click here
A4I076 View 3D Structure Click here
A4I0D8 View 3D Structure Click here
A4I4G0 View 3D Structure Click here
A4I8R5 View 3D Structure Click here
A4IE56 View 3D Structure Click here
A5PN39 View 3D Structure Click here
B0BNC9 View 3D Structure Click here
B0G100 View 3D Structure Click here
B0G101 View 3D Structure Click here
B2GUZ6 View 3D Structure Click here
B4FAJ0 View 3D Structure Click here
B4FBW5 View 3D Structure Click here
B4FJW4 View 3D Structure Click here
B4FPE6 View 3D Structure Click here
B4FR97 View 3D Structure Click here
B4G1G0 View 3D Structure Click here
B6SUD1 View 3D Structure Click here
B6TEK2 View 3D Structure Click here
B6TXY3 View 3D Structure Click here
B6U7D8 View 3D Structure Click here
B7Z0M7 View 3D Structure Click here
C6T942 View 3D Structure Click here
C6TB56 View 3D Structure Click here
C6THI3 View 3D Structure Click here
C6TID4 View 3D Structure Click here
C6TLX4 View 3D Structure Click here
D3ZT84 View 3D Structure Click here
D4A264 View 3D Structure Click here
E7EYZ5 View 3D Structure Click here
E9AG46 View 3D Structure Click here
E9Q5Z6 View 3D Structure Click here
F1Q713 View 3D Structure Click here
F1QP54 View 3D Structure Click here
F4I3C3 View 3D Structure Click here
I1J7B3 View 3D Structure Click here
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I1JEV3 View 3D Structure Click here
I1JIQ4 View 3D Structure Click here
I1JP95 View 3D Structure Click here
I1JY29 View 3D Structure Click here
I1JYD9 View 3D Structure Click here
I1K548 View 3D Structure Click here
I1KB52 View 3D Structure Click here
I1KKE1 View 3D Structure Click here
I1KXG0 View 3D Structure Click here
I1KZ26 View 3D Structure Click here
I1L3S5 View 3D Structure Click here
I1L4T5 View 3D Structure Click here
I1L8I0 View 3D Structure Click here
I1LNP4 View 3D Structure Click here
I1LP48 View 3D Structure Click here
I1LV40 View 3D Structure Click here
I1LVH0 View 3D Structure Click here
I1M4P9 View 3D Structure Click here
I1M7A9 View 3D Structure Click here
I1MA91 View 3D Structure Click here
I1MAE6 View 3D Structure Click here
I1MC17 View 3D Structure Click here
I1ME21 View 3D Structure Click here
I1MLW9 View 3D Structure Click here
I1MQ30 View 3D Structure Click here
I1MY52 View 3D Structure Click here
I1N1G8 View 3D Structure Click here
I1N1Z5 View 3D Structure Click here
I1N2X1 View 3D Structure Click here
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I1N9X0 View 3D Structure Click here
I1NE10 View 3D Structure Click here
I6Y231 View 3D Structure Click here
K7KDL1 View 3D Structure Click here
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M0R3N4 View 3D Structure Click here
O07721 View 3D Structure Click here
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O53146 View 3D Structure Click here
O53533 View 3D Structure Click here
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O65621 View 3D Structure Click here
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O69693 View 3D Structure Click here
O74489 View 3D Structure Click here
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O94038 View 3D Structure Click here
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P00325 View 3D Structure Click here
P00326 View 3D Structure Click here
P00329 View 3D Structure Click here
P00330 View 3D Structure Click here
P00331 View 3D Structure Click here
P00332 View 3D Structure Click here
P00333 View 3D Structure Click here
P04707 View 3D Structure Click here
P06525 View 3D Structure Click here
P06757 View 3D Structure Click here
P07246 View 3D Structure Click here
P07327 View 3D Structure Click here
P07913 View 3D Structure Click here
P08319 View 3D Structure Click here
P0A9S3 View 3D Structure Click here
P11766 View 3D Structure Click here
P12711 View 3D Structure Click here
P25377 View 3D Structure Click here
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P26646 View 3D Structure Click here
P27250 View 3D Structure Click here
P27867 View 3D Structure Click here
P28304 View 3D Structure Click here
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P28474 View 3D Structure Click here
P32771 View 3D Structure Click here
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P36624 View 3D Structure Click here
P38105 View 3D Structure Click here
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P38230 View 3D Structure Click here
P39346 View 3D Structure Click here
P39400 View 3D Structure Click here
P39451 View 3D Structure Click here
P39713 View 3D Structure Click here
P39714 View 3D Structure Click here
P39945 View 3D Structure Click here
P40394 View 3D Structure Click here
P41682 View 3D Structure Click here
P42734 View 3D Structure Click here
P46415 View 3D Structure Click here
P47199 View 3D Structure Click here
P48523 View 3D Structure Click here
P52048 View 3D Structure Click here
P72043 View 3D Structure Click here
P75691 View 3D Structure Click here
P77280 View 3D Structure Click here
P77316 View 3D Structure Click here
P77360 View 3D Structure Click here
P77539 View 3D Structure Click here
P78870 View 3D Structure Click here
P93629 View 3D Structure Click here
P94996 View 3D Structure Click here
P95185 View 3D Structure Click here
P96202 View 3D Structure Click here
P96285 View 3D Structure Click here
P96826 View 3D Structure Click here
P9WQB9 View 3D Structure Click here
P9WQC1 View 3D Structure Click here
P9WQC3 View 3D Structure Click here
P9WQC5 View 3D Structure Click here
P9WQC7 View 3D Structure Click here
P9WQE9 View 3D Structure Click here
Q00796 View 3D Structure Click here
Q02971 View 3D Structure Click here
Q02972 View 3D Structure Click here
Q04894 View 3D Structure Click here
Q07786 View 3D Structure Click here
Q07993 View 3D Structure Click here
Q08257 View 3D Structure Click here
Q0DWH1 View 3D Structure Click here
Q0IQT2 View 3D Structure Click here
Q0ITW6 View 3D Structure Click here
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Q0J0N7 View 3D Structure Click here
Q0J0P9 View 3D Structure Click here
Q0J6T3 View 3D Structure Click here
Q0JA75 View 3D Structure Click here
Q0JDV3 View 3D Structure Click here
Q0V7W6 View 3D Structure Click here
Q10A46 View 3D Structure Click here
Q10PS6 View 3D Structure Click here
Q10QN9 View 3D Structure Click here
Q10QP0 View 3D Structure Click here
Q17334 View 3D Structure Click here
Q17335 View 3D Structure Click here
Q21702 View 3D Structure Click here
Q21703 View 3D Structure Click here
Q23624 View 3D Structure Click here
Q2FVQ0 View 3D Structure Click here
Q2FW62 View 3D Structure Click here
Q2G0G1 View 3D Structure Click here
Q2G1B9 View 3D Structure Click here
Q2G1C4 View 3D Structure Click here
Q2G2C5 View 3D Structure Click here
Q2G2C7 View 3D Structure Click here
Q2R114 View 3D Structure Click here
Q2R8Z5 View 3D Structure Click here
Q336S6 View 3D Structure Click here
Q337Y2 View 3D Structure Click here
Q3MIE4 View 3D Structure Click here
Q3UNZ8 View 3D Structure Click here
Q43264 View 3D Structure Click here
Q4CNS6 View 3D Structure Click here
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Q4CXB5 View 3D Structure Click here
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Q4DAS0 View 3D Structure Click here
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Q4DF57 View 3D Structure Click here
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Q54II4 View 3D Structure Click here
Q54IX3 View 3D Structure Click here
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Q54QD3 View 3D Structure Click here
Q54TC2 View 3D Structure Click here
Q54UL7 View 3D Structure Click here
Q54YT4 View 3D Structure Click here
Q556G1 View 3D Structure Click here
Q556P4 View 3D Structure Click here
Q55AJ2 View 3D Structure Click here
Q55GE3 View 3D Structure Click here
Q59Z38 View 3D Structure Click here
Q5A1B1 View 3D Structure Click here
Q5AC33 View 3D Structure Click here
Q5ANC5 View 3D Structure Click here
Q5JMM6 View 3D Structure Click here
Q5XI39 View 3D Structure Click here
Q5XI95 View 3D Structure Click here
Q62465 View 3D Structure Click here
Q64437 View 3D Structure Click here
Q64442 View 3D Structure Click here
Q64563 View 3D Structure Click here
Q67J16 View 3D Structure Click here
Q6AYT0 View 3D Structure Click here
Q6DHM3 View 3D Structure Click here
Q6ERW5 View 3D Structure Click here
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Q6ERW9 View 3D Structure Click here
Q6ERX1 View 3D Structure Click here
Q6GQN8 View 3D Structure Click here
Q6H5W1 View 3D Structure Click here
Q6K840 View 3D Structure Click here
Q6NXA6 View 3D Structure Click here
Q6NZZ1 View 3D Structure Click here
Q6P0S5 View 3D Structure Click here
Q6ZBH2 View 3D Structure Click here
Q6ZHS4 View 3D Structure Click here
Q75JD7 View 3D Structure Click here
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Q7EYM8 View 3D Structure Click here
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Q7XMU7 View 3D Structure Click here
Q7XWU3 View 3D Structure Click here
Q80TB8 View 3D Structure Click here
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Q86AG4 View 3D Structure Click here
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Q8BGC4 View 3D Structure Click here
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