# STOCKHOLM 1.0
#=GF ID   Mur_ligase_M
#=GF AC   PF08245.13
#=GF DE   Mur ligase middle domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_26 (release 17.0)
#=GF GA   21.20 21.20;
#=GF TC   21.20 21.20;
#=GF NC   21.10 21.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   9218784
#=GF RT   Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate
#=GF RT   ligase from Escherichia coli. 
#=GF RA   Bertrand JA, Auger G, Fanchon E, Martin L, Blanot D, van
#=GF RA   Heijenoort J, Dideberg O; 
#=GF RL   EMBO J 1997;16:3416-3425.
#=GF DR   INTERPRO; IPR013221;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF SQ   55
#=GS MURE_DEIRA/111-311    AC Q9RXL3.1
#=GS MURE_BORBU/116-322    AC O51219.1
#=GS MURE2_OCEIH/109-314   AC Q8CZE4.1
#=GS MURE_STAA8/108-312    AC Q2FZP6.1
#=GS MURE_STAA8/108-312    DR PDB; 4C12 A; 108-312;
#=GS MURE_STAA8/108-312    DR PDB; 4C13 A; 108-312;
#=GS MURE_ORYSJ/334-542    AC Q94LU9.1
#=GS MURE_TROWT/122-324    AC Q83GN3.2
#=GS MURE_LACLA/114-311    AC Q9CEN1.1
#=GS MURE_HELPY/72-270     AC O26027.1
#=GS MURD_NITEU/118-301    AC Q82VS5.1
#=GS MURD_BACTN/107-285    AC Q8A256.2
#=GS MURD_CHLTE/113-307    AC Q8KGD2.1
#=GS MURD_CLOAB/123-298    AC Q97EB9.1
#=GS Q899A3_CLOTE/480-691  AC Q899A3.1
#=GS Q8KCE3_CHLTE/110-299  AC Q8KCE3.1
#=GS MURC_AQUAE/111-290    AC O67373.1
#=GS MURC_CLOAB/116-295    AC Q97E89.1
#=GS MURF_SYNY3/114-291    AC P45450.1
#=GS Q8F648_LEPIN/118-301  AC Q8F648.1
#=GS Q894B8_CLOTE/113-298  AC Q894B8.1
#=GS Q8RDP8_FUSNN/280-455  AC Q8RDP8.1
#=GS Q9WY78_THEMA/87-272   AC Q9WY78.1
#=GS Q9WY78_THEMA/87-272   DR PDB; 3ZL8 A; 87-272;
#=GS Q8E0G5_STRA5/105-285  AC Q8E0G5.1
#=GS MURF_BACSU/111-292    AC P96613.1
#=GS MURF_BORBU/123-307    AC Q44777.2
#=GS MURF_TREPA/119-299    AC O83401.1
#=GS MURF_RICPR/104-294    AC O05953.2
#=GS Q2YM67_BRUA2/118-308  AC Q2YM67.1
#=GS Q9A596_CAUVC/104-294  AC Q9A596.1
#=GS H2VFN8_ZYMMO/103-295  AC H2VFN8.1
#=GS Q82VS7_NITEU/108-297  AC Q82VS7.1
#=GS Q87WY1_PSESM/108-297  AC Q87WY1.1
#=GS MURF_ECOLI/105-293    AC P11880.2
#=GS MURF_ECOLI/105-293    DR PDB; 1GG4 A; 105-293;
#=GS MURF_ECOLI/105-293    DR PDB; 1GG4 B; 605-793;
#=GS Q8KGD0_CHLTE/121-311  AC Q8KGD0.1
#=GS Q8R777_CALS4/162-354  AC Q8R777.1
#=GS Q82AE0_STRAW/107-297  AC Q82AE0.1
#=GS MURE_THEMA/108-304    AC Q9WY79.1
#=GS MURE_THEMA/108-304    DR PDB; 4BUB B; 108-304;
#=GS MURE_THEMA/108-304    DR PDB; 4BUB A; 108-304;
#=GS MURE_RICPR/96-302     AC O05954.1
#=GS MURE_ZYMMO/108-311    AC Q9RNM2.4
#=GS MURE_RHIME/110-313    AC Q92NL6.1
#=GS MURE_ECOLI/114-318    AC P22188.2
#=GS MURE_ECOLI/114-318    DR PDB; 1E8C B; 113-318;
#=GS MURE_ECOLI/114-318    DR PDB; 1E8C A; 113-318;
#=GS MURE_BUCBP/119-327    AC P59419.1
#=GS MURE_WIGBR/116-321    AC Q8D2Z1.1
#=GS MURE_RALSO/123-332    AC Q8XVI2.1
#=GS D4ZDU8_SHEVD/112-315  AC D4ZDU8.1
#=GS MURE_NEIMB/112-315    AC Q9K0Y9.1
#=GS MURE_BACTN/109-305    AC Q8A254.1
#=GS MURE1_OCEIH/109-315   AC Q8CZE6.1
#=GS MURE_BACHD/107-310    AC Q9K9S4.1
#=GS MURE_NOSS1/114-316    AC Q8YWF0.1
#=GS MURE_STRCO/123-324    AC Q9S2W7.1
#=GS MURE1_CLOAB/108-305   AC Q97H84.1
#=GS MURE_FUSNN/106-302    AC Q8R635.1
#=GS MURE_CALS4/107-305    AC Q8R9G2.2
#=GS MURE2_CLOAB/109-309   AC Q97FC1.1
#=GS MURE_CHLTR/107-307    AC O84271.1
MURE_DEIRA/111-311               VTGTDGKTTTSWLTRHLL..RSAG.LATG.LLSTVGYELPDGE.LRHFPAHFTTPEAPQVQDTLREMVA....AGAQATVLEASSHALSL..DRVRG...VDWDVAVWTHLSSEHLD..FH.GTLDN.YFADKRKLV.ERAR.........FAVLN..VDDPW..TAQLRGIAPG......ETTYSAENQH.......ADWRAQ.DIEERHSGLHF.........RVV.S..PAGDFQ....AEL...PMIGR...FNVANALAGMAAA
MURE_BORBU/116-322               VTGTDGKSSVCYYIYLLF..KKKG.VKVG.FISTVFFDDGSGS.LIKNPYRQSTPESTEIHSFLSTMVK....NEAQYAILESTSHGLDLETARLID...VNYFAVVFTNIGHEHLE..FH.GTIQN.YLNVKLGLF.RSVSDDA.....GFGVIN..LDDLY..SSDFKNAVKKSFTY..SLKSSKAD...........FFVS.FIDEKTDSTRF.........EFY.H..KGVKYL....ANV...SLLGS...FNVENVMAALILV
MURE2_OCEIH/109-314              VTGTNGKTTVTTIINHLL..TDNE.LSTA.LIGTNGFQINKD...IYSSSNNTTSDVLTNQHMLYEAKN....QGVTHVAMEVSSHGLEQ..GRLWG...IDFTVATFTNLSHEHLD..YH.GSMEE.YAATKVQLF.SSLAIQPNK..QKIAVLN..RDDNW..YEYFQKRTPVQ.....IVSYGIYEQA.......D.FRAT.AIKYYKDRTSF.........ELL.T..PEGSFQ....VQT...KLMGE...FNVYNVLAAIASV
MURE_STAA8/108-312               VTGTNGKTSIATMIHLIQ..RKLQ.KNSA.YLGTNGFQINET....KTKGANTTPETVSLTKKIKEAVD....AGAESMTLEVSSHGLVL..GRLRG...VEFDVAIFSNLTQDHLD..FH.GTMEA.YGHAKSLLF.SQLGEDLSK..EKYVVLN..NDDS.....FSEYLRTVTPYE..VFSYGIDEEA........QFMAK.NIQESLQGVSF.........DFV.T..PFGTYP....VKS...PYVGK...FNISNIMAAMIAV
#=GR MURE_STAA8/108-312    SS    EESSS-HHHHHHHHHHHH..HHTT.--EE.EEETTEEEETTE....EE--S-SS--HHHHHHHHHHHHH....TT-SEEEEE--HHHHHT..TTTTT...---SEEEE----S--HH..HH.SSHHH.HHHHHHHHH.HTT-S-TTS..--EEEEE..TTST.....THHHHHTT--SE..EEEEESSS--........SEEEE.EEEEETTEEEE.........EEE.E..TTEEEE....EEE...SS-SH...HHHHHHHHHHHHH
MURE_ORYSJ/334-542               VAGTDGVTTTAHLVRAMY..EAMG.VRTG.MVGVLGAYAFGNN..KLDAQPDASGDPIAVQRLMATMLY....NGAEAALLEATTDGMPS..SGVDSE..IDYDIAVLTNVRHAGDE..AG.MTYEE.YMNSMASLF.SRMVDPER....HRKVVN..IDDPS..APFFAAQ.GGQDVP..VVTYSFENKK.......ADVHTL.KYQLSLFETEV.........LVQ.T..PHGILE....ISS...GLLGR...DNIYNILASVAVG
MURE_TROWT/122-324               ITGTNGKTSTMHIAAKLL..EMMG.ISCG.ISTTIGSSASE......SDSCLTTPELCQLYARIFTAKQ....ARADFFALEASSHAINR..GRLGD...IVLEVAAFTNLTPEHME..EH.KNMEA.YYQAKKALF.LNKRS.N......SAVIN..IDTP.....YGIRLFKETGCS..ASVISENTKYGL...DHKLFWQA.SVRR..VGLSFG.......FTLISP..SGYRVE....SSI...SLLGK...AFALNTCMAIVI.
MURE_LACLA/114-311               LTGTKGKTTSAYFAKAIL..DKMNGGKTA.LLSTAQTTLDGK...NYFKSELTTPESLDLLEMMAKALT....NGMTHLVMEVSSQAYKT..ERVYG...LTFDVGVFLNISPDHIGPVEH.PTLED.YFYCKRQLL.KNSR.........YFVAN..SEMNH..FAIIKEELKERKIP..HAFYGADSEN.......KIIESK.GLHFVTDGS...............V..SGA.......FDI...RLLGR...FNQENALATALAT
MURE_HELPY/72-270                ITGTNGKTTTASLMYSLL..LDL....NK.KTALLGTRGFFINNERIKEKGLTTPTLLELYSDLEEAVR....LKCEYFIMEVSSHAIVQ..KRIAG...LDFALKILTNITSDHLD..FH.QSIEN.YRDAKNSFF.K...DEG......LKVIN..RDET.........NALFNPVN..AHTYALDKKAH......LNVQAF.SLNPS.....ISASL.CYQQDLRDP..NFKEIA...LMHS...PLLGR...YNLYNILAGV...
MURD_NITEU/118-301               ITGSNGKTTVTSMVGEMV..KNA....GW.DVEVAG................N....IGPAALDALMQRMDANKWPHLWALELSSF.......QLETTSSLRPDAATVLNLSEDHLD..RYD.SIEE.YAAAKARIF.SRPHNNG......CVQIL..NRDD.....ARVYAMADKNSK..QVTFGLSAPV........SDEEF.GLLP..GGSDVWLA..QGSTHLLKT............SEL...AVAGL...HNAANALAALALC
MURD_BACTN/107-285               ITGSNGKTTTTSLIYHIF..KSA....DL.NVGLAG................N....IGKSLALQVAEE.....HHDYYIIELSSF.......QLDNMYNFRANIAVLMNITPDHLD..RYDHCMQN.YIDAKFRIT.QNQTTDD......AFIFW..NDDP.....IIKQELAKHGLK..AHLYPFAAVK.......ED..GA.IAYVEDHEVKI...........TEP..IAFNME...QEEL...ALTGQ...HNLYNSLAAGISA
MURD_CHLTE/113-307               ITGTDGKTTTATLLHRIC..AAEGERKGF.RAFSVG................N....IGIPFSSEVPGM....TAADIAVLELSSY.......QLEACFDFRPNIAVLTNVTPDHMD..RYGGSIEA.YATAKYRIH.ARQGAGD......TLIYN..HDDPI..LRAHFDRSEPWPFR..LVRLGLRAET.......LDVAPGDFVSV..EDGEIVVRASGSTERLMRV............DEIMKPGFRGE...HNLYNALSSVAAA
MURD_CLOAB/123-298               VTGSDGKTTTTTLIYNML..KEE....GY.KTWVGG................N....IGTPLFSKIKEV....STKDKVVLELSSF.......QLMTI.DVSPEVAVVTNLSPNHLD..IH.KNMEE.YINAKKNIF.THQSKGN......VLIIN..RDNE.....ITNNMESEALGD..LLKFSRNEKV........KNG....AYYNKQDGNIYL....FENKICNK............DDI...KIKGM...DNVKNFMAAFCAV
Q899A3_CLOTE/480-691             VTGTNGKTTTTRLIAHIF..DLAG.YKTG.FTSTGGIYID........GNIIDEGDTTGYNSALTLLTN....KEVEAIVLETARGGIIKKGLAYDLA.....DVGVITNITTDHLGLDGI.DTLED.LAYVKSLIG.EAVKDEG......YVVLN..ADDV.....MSMKIINRIKSN..VILFSKDKNNKF...IREYLNKGCFAIYVHEGYMY...........IEKDNKIIPLININNIKI...GLQGKL.DYNIENAMAACAVG
Q8KCE3_CHLTE/110-299             VAGTHGKTTTTSLVAWLL..EAG....GLLPGFLIG......................GIPENFGDGCRPSGLSEPGFFVTEGDEYDSAFFDKRSKFL.HYRPDIAIINNVEFDHAD..IF.DSLDD.IKKSFRLLV.NLVPSNG......LLIVN..ADDP.....NSMEVSAKAFCR..VETFGLNGNA.........EWTAADIATDTDGTS............FTVVRDSEAIG...RVKV...PLFGN...YNVMNALAATAAA
MURC_AQUAE/111-290               VSGSHGKTTTTSMIAEIL..INA....GLEPTVIIG................GRLKRLGTNAKL.........GRGELLVSEADES.......DGSFL.KLQPAVAVITNVDKEHLD..FY.ENFER.VKEAFEQFM.NSVPFYG......FAVVN..LDDP.....TLAQLVKKSHER..VITYGINSPA.........LVRAKNLYLKEGRYE............FGVEFKGKELG...RIHL...GIAGI...HNVYNALAATGVA
MURC_CLOAB/116-295               ISGTHGKTTTTSMVSHIA..LTE....DVDPTILVG................GNLDIINGNVLA.........GKSDYFITEACEY.......KASFL.EFYPYIGVILNIDADHLD..YY.KNIDD.IENTFAKFV.NLIPKEG......YLIAN..ADDK.....RVARVASNATCN..VVSFGIDNGD..........IRAKNISFNESGFSS...........FDVYKSSELLF...NIEL...NVPGK...HNILNALSAIASA
MURF_SYNY3/114-291               VTGSVGKTTTKELIAAVL..SQF....GN.VHKTRA................NYNNEIGVPKTLLELSP.....DHDFAIVEMAMRGRGQ.IALLADI..AKPTIGLITNVGTAHIG..LL.GSELA.IAEAKCELL.AHQPPES......TAILN..RDNA.....LLMETAQRFWQG.KTITYGLEGG...............DVHGTVDGENL................ILDGVS....LPL...PLAGV...HNASNYLAAIALA
Q8F648_LEPIN/118-301             VTGSSGKTTTKELLGNCLKNLEE....SA.LVVTEK................NYNNEIGLPFTLFKISD.....QTRVVVCELGMNHKGE.ISRLSQI..AKPDYAIITTIGTAHIE..FL.ESQKN.IAKAKGEIV.EGLKKGG......KLFYP..NTGEY..SKILKNKTRKHGNK.LVLTKSDKIFS..............ILQKKSSGFLL................EYKNKK....IQW...NLPGE...KLLENLSVAITCL
Q894B8_CLOTE/113-298             ITGSTGKTSTKDLTASVL..GAK....YK.VFKTEG................NFNNEIGLPLMIFKLDK.....TYDIAVLEMGMSNFGE.IHKMAKT..ALPDIAIITNIGISHIE..NL.KSRDN.ILKAKLEII.DFFGEDN......ILIVN..GEDD......LLGNLKEEKYK..LIKTGLGKNH.......NIYAYDINLNEKSVS..............FKIFEDGDELQ....IDI...PVPGK...HNVLNSLLAIACG
Q8RDP8_FUSNN/280-455             ITGSNGKTTTKDIVYSLL..SVK....AK.TLKTEG................NYNNHIGLPYTLLNVTD.....EEKFVVLEMGMSSLGE.IRRLGEI..SSPNYAIITNIGDSHIE..FL.KTRDN.VFKAKTELL.EFVNKEN......TFVCG...DDK.........YLAKLDVN..KIGFNNSNTY..............KIESYKFSDKG...........SKFVLDGKE......YEM...SLLGK...HNISNTAIAIELA
Q9WY78_THEMA/87-272              VTGSSGKTTTKEILYNLLKNKRS.......VFKTPG................NMNTEYGLPLSILNDYK.....GEEILVLEMAASRPGD.IAHLCKI..APPDVAVLLNVGSAHLE..FF.GTRER.IMETKMEII.KHSKENA......IAVTL..FDDP.......DLRKEVPRYR.NTLFFGKEGGDSVL..KDWWYYEGSTIAEFEAFDSL..........................FTV...KLSGYWNGGQLLNIAASLCVM
#=GR Q9WY78_THEMA/87-272   SS    EE-SS-HHHHHHHHHHHHTTTS-.......EEE--T................T--TTTHHHHHHHHH--.....--SEEEEE---SSTTH.HHHHHHH..S--SEEEE---TTTTHH..HH.-SHHH.HHHHHTHHH.HTS-TT-......EEEEE..TTSH.......HHHHHGGGTS.EEEEEESSSSSEEE..EEEEEETTEEEEEEEETTEE..........................EEE...EEES---HHHHHHHHHHHHHH
Q8E0G5_STRA5/105-285             VTGSNGKTTTKDMIAAIL..STT....YK.TYKTQG................NYNNEIGLPYTVLHMPE.....DTEKIILEMGQDHLGD.IHVLSEI..AKPRIAVVTLIGEAHLE..FF.GSREK.IAEGKMQIT.DGMSSDG......ILIAP...GDP.......IIDPYLPANQ.MTIRFGHDQEL..............QVTELKEEKHS...........LTFKTNALEHQ....LRI...PVPGK...YNATNAMVAAYVG
MURF_BACSU/111-292               VTGSNGKTTTKDMIHAVL..GTQ....YR.VHKTGG................NFNNHIGLPLTVLAMPE.....NTEIAVLEMGMSAKGE.IDLLSRL..ANPDAAVITNIGESHMQ..DL.GSREG.IAEAKLEII.NGLKEDG......VLIYI..GDEP.........LLQNAYSC.QTKTYGTGTHN.......DY.....QLQDVSQSEEG...........THFTIKGIENT....FFI...PILGK...HNVMNAMAAIAAG
MURF_BORBU/123-307               ITGSNGKTTTKEMLYSIL..SKK....YK.TYKTWG................NLNSDIGLPLSILRVEG.....NEEYAVFEVGVSYVGE.MDLLSQI..LKPEIVIITNISYAHMQ..AF.KELQA.IAFEKSKIIGKNIE.........IFVVN..EMNDYCVYLEKRAKIANPNVK..IVYFDFENLS...............IKSFSFLDGK...........FSFDFVYKGFE....YSI...LLLGR...HNIFNAIGCINLA
MURF_TREPA/119-299               ITGSSGKTTVKEMARAVF..SER....YR.VVATPG................NLNSEIGLPQSLFFVRA.....EHEVGIFELGMNRRGE.MRTLAQI..LVPHYAIITNVGCAHVG..IL.GTQQA.IAEEKKEIF.SQFTEHS......VGFVP...DDA......YRVFLSNIPYG.RVVVYDQGGRGLATEVIDEGLRGSRVLYQGRW..............................IRV...PLPGV...HNAKNALAVIALA
MURF_RICPR/104-294               ITGSVGKTSTKEALKILLQHDFI.......VFASRG................NFNNYLGLLINLASMAD.....DTEYAIFELGMNHQGE.ISELVQI..LKPNIAMINNISEAHLE..FF.HSLEE.IAEAKCEIF.KNFSKND......IAIIN..ASNNC..YNKILSILKNLSIT.NIYSFGHSSKA.......SA...KLILYKTLGEQVH...........LQYYINNKFID....ITI...PFIPR...HFANNYTGVLLII
Q2YM67_BRUA2/118-308             VTGSVGKTTTKEALRHVL..SDV....GK.VHASAA................SFNNHWGVPLTLARMPA.....DVDYGVFEIGMNHHGE.IRPLVKM..VRPHVALITLIAPAHLG..HF.ANLEE.IAVAKAEIF.EGIVPGG......YALLN..RDDKR..FRQLQELAEKAGVE.HIATFGENARA........DYRLR.DVKLHPTCS............CMTVKIGTHEAA....VKV...GIPGR...HVVQNMLAVLGAA
Q9A596_CAUVC/104-294             VTGSVGKTSVTRAIEAGL..RLA....GK.AHASVK................SYNNHIGVPLTLARMPR.....DTERAVFEVGMNHAGE.IVPLSGF..VRPHAVAITTVGPVHIE..NF.SDGEAGVARAKAEIL.AGLQPGG......IAVLN..ADNHW..FDFLKGEAEKVGAT..VWSFGEAAGA.......TA.....RLTGFQVEGAG.........ATVSVDLRGEALT....FPI...HQTGV...HWGPNSLCVLLML
H2VFN8_ZYMMO/103-295             ITGSVGKTSTKESLRLAL..ERMA..PEK.VHYSLK................SYNNHVGVPLSLARMPE.....ESLFGIFEMGMNHAGE.LSDLTKL..VQPDVALITAIAPAHAA..FF.ADETA.IAEAKSEIF.EGLSSGG......IAIIP..HDSPY..RDLLTAKAQEKKAE..IRSFGFGEGA........TIRAQ.NIVREADGRVL.........VTASI..RDRQLV....FSM...AMAAE...HWISNAMAVLAVV
Q82VS7_NITEU/108-297             VTGSNGKTTVKEMIAAIFRCEFG....LENVLATTG................NLNNDIGVPQMLLQLDS.....RHVGAVIEMGMNHAGE.IAWLSRL..AAPTIAVITNAGTAHIE..YL.GTTEA.IARAKGEIF.EGLEEQG......VAIIN..ADDP.....HARLWRQLAGNR.PVVDFSMNGTA.......AV...SARQPAHPSGDR............WLLQLPDDTIE....ITL...QVPGR...HNVYNALAAAAAA
Q87WY1_PSESM/108-297             VTGSSGKTTVKEMLASIL..RTR....GP.VLATRG................NLNNELGVPLTLLELAP.....EYTSAVIELGASRVGE.IAYTVSL..TKPHVVIITNAGTAHVG..EF.GGPER.IVEAKGEIL.EGVEASG......TAVLN..LEDK.....AFPIWRKRAGHR.NILTFALADAA.......AD.FHAGELSRDARGCPS...........FTMASPLGSAQ....VQL...NLLGT...HNVTNALAAAAAA
MURF_ECOLI/105-293               LTGSSGKTSVKEMTAAIL..SQC....GN.TLYTAG................NLNNDIGVPMTLLRLTP.....EYDYAVIELGANHQGE.IAWTVSL..TRPEAALVNNLAAAHLE..GF.GSLAG.VAKAKGEIF.SGLPENG......IAIMN..ADNN.....DWLNWQSVIGSR.KVWRFSPNAAN.......SD.FTATNIHVTSHGTE............FTLQTPTGSVD....VLL...PLPGR...HNIANALAAAALS
#=GR MURF_ECOLI/105-293    SS    EE-SS-HHHHHHHHHHHH..CCC....S-.EEE--T................T--STTHHHHHHTT--T.....T-SEEEEE---SSTTH.HHHHHHH..H--SEEEE---------..--.--HHH.HHHHHHGGG.GG--TT-......EEEEE..TTB-.....-HHHHHHHHTTS.EEEEE-SS-TT.......-S.BEEEEEEE-SSSEE............EEEEETTEEEE....EEE...-SSST...HHHHHHHHHHHHH
Q8KGD0_CHLTE/121-311             IGGSNGKTTTKEMLAAVL..STS....FN.VLVTQG................NYNNHLGVPLTLLQMRR.....DTEVAVIEMGINHPGE.MEFLSSL..AKPTHGLLTNIGHEHLE..FF.GSLDG.VADAEAALF.RYLEAHG.....GTAFVN..LDDH.......RLAAAGASLS.RKTGYGAQPGA.......GRAWWAEQIGADRVGRVS...........FTLCSESGVHQ...PVAM...QFVGR...HNVINAVAASAVG
Q8R777_CALS4/162-354             ITGSYGKTSTKHFITAVL..SEK....FS.VLMTPE................SYNTPMGVTKVIRNELK....DTHQIFVCEMGARQRGD.IKVLVKL..ANPKIGVITSIGPQHLE..TF.GTIEN.VAKTKFELV.EGLPEDG......IAVLN..GDNY.....YCRTFGEKFAVR..KLFYGTESPIE.....RKYFLWAENIINTRQGLKF...........DAVTEDGMRIK....CEV...PLLGR...HNVSNLLAAISVA
Q82AE0_STRAW/107-297             LTGSAGKTSTKDLIAQVLRSKAP.......TVFTPG................SLNNEIGLPLTALSATE.....ETKFLVLEMGARGIGH.IRYLADL..TPPKVGLVLNVGTAHIG..EF.GGREQ.IAQAKGELV.EGLPPAED...GGAAILN..ADDP.....LVRAMASRTKAR..VILFGESDEA.......DV..RAENVRLTAGGQPS...........FSLHTPSGCSD....VTM...RLYGE...HHVSNALAAAAVA
MURE_THEMA/108-304               VTGTNGKTTTTMMIYHML..TSLG.ERGS.VLTTAVKRILGN....SYYDDITTPDAITILSAMKENRE....GGGKFFALEVSSHALVQ..QRVEG...VRFDVGIFTNISRDHLD..FH.GTFEN.YLKAKLHLF.DLLKDDG......VAVLNESLADA...........FNRKSR..KITFGTSKNA.......D.YRLG.NIEVSWEGTQF.........VLE.T..PDGLLK....VFT...RAIGD...FNAYNAAAAIAAL
#=GR MURE_THEMA/108-304    SS    EESSS-HHHHHHHHHHHH..HCTS.---E.EE-SS-EE-SS-....B--SS-SS--HHHHHHHHHHHHH....CT-SEEEEE--CCHHHC..TTTSS...--EEEEEE----SSSTT..-S.SSHHH.HHHHHHGGG.CCEEEEE......EEEEEGGGTTT...........--S-SE..EEEEESSTTS.......S.EEEE.EEEEETTEEEE.........EEE.-..SSS-EE....EEE...SS--T...THHHHHHHHHHHH
MURE_RICPR/96-302                VTGTNGKSSVVSYIAQAY..SLLK.KKAA.FIGTIGLEIFGSNNIINDVPSLTTFDYLSFRKVAHNLAE....DSIEYLAFEASSHGLEQ..GRLGK...TKVNIVSFTSFSQDHLD..YH.HTKEN.YLLAKLKLF.TDHLLPS.....GIAILN..SDIEE..IEFVKDYLHNNNVK..FITVGKKGD..........LQIT.KITCSLTGQNI.........DFI.F..NNIIYN....LHT...LIIGS...FQASNLLIAALTL
MURE_ZYMMO/108-311               VTGTNGKTSVAELCRQLW..TIT....GH.KAASIGTLGVITA.KNSYSLGMTTPDVVTFLSCCSDLAR....ADISHVIFEASSHGLDQ..YRSDG...AKVIAGAFTSFSRDHLD..YH.GTMER.YLAAKLRLFDERIAPDG......TAVIW..ADDPA..ATTVIAHVQKRGLK..LIDIGEKAEA.........IRLV.NREADSQGQMI.........TLS.I..KGESYK....IRL...PLIGG...YQLSNALVAAGLV
MURE_RHIME/110-313               VTGTAGKTSVASFTRQIW..AHSG.FSAA.MIGTTGVVAPGR....TEYGSLTTPDPVSLHKLLAELAD....EGVTHAAMEASSHGLDQ..RRLDG...VELAAAAFTNLGRDHMD..YH.PTVEH.YMASKMRLF.GALLPK.G....SPAVIF..ADDQW..SAEAIAAARKAGHD..VRTVGRNGDF.........IALK.RVEHFRHKQSA.........EVH.V..GDDIYE....IHV...PLAGD...FQIANALVAAGLA
MURE_ECOLI/114-318               VTGTNGKTTTTQLLAQWS..QLLG.EISA.VMGTVGNGLLGK....VIPTENTTGSAVDVQHELAGLVD....QGATFCAMEVSSHGLVQ..HRVAA...LKFAASVFTNLSRDHLD..YH.GDMEH.YEAAKWLLY.SEHH.CG......QAIIN..ADDE.....VGRRWLAKL.PD..AVAVSMEDHINPN.CHGRWLKAT.EVNYHDSGATI.........RFS.S..SWGDGE....IES...HLMGA...FNVSNLLLALAT.
#=GR MURE_ECOLI/114-318    SS    EESSS-HHHHHHHHHHHH..HHTT.--EE.EECTTEEEETT-....-B--SSSS--HHHHHHHHHHHHH....TT--EEEEE--HHHHHT..TTTTT...-B-SEEEE----S--HH..HH.SSHHH.HHHHHHHHH.HTSB.--......EEEEE..TTSH.....HHHHHHTT-.TT..-EEEESSS---TT.T-SEEEEEE.EEEE-SS-EEE.........EEE.E..TT--EE....EEE...-S-SH...HHHHHHHHHHHH.
MURE_BUCBP/119-327               ITGTNGKSTTTHIVSQWA..NLLN.VKIG.IMGTLGHGINNN....LKKTDNTTESSANIHQFLYHMLK....QNIKTFAIEISSHGIVQ..HRIEQ...LPFKIAILTNITPEHLD..YH.RTMDN.YINAKKAFF.FKYNIN.......TLIIN..ADDLI..AKTWIKKLNHKN....VITITTKDQNFNSISPKKWIHAN.KIIQKQNCTNI.........HFN.S..SWGHGI....LNS...TLIGH...FNVINILLALATL
MURE_WIGBR/116-321               ITGTNGKTTISHFIAKWL..FLLG.EKIG.IIGTLGYGCLNK....MKKSKNTTNSAIKCQKLLNFFLK....KNINTVVMEVSSHGLHQ..NRVNN...INFFSAIFSNLSQDHID..YH.KNMMQ.YEQSKWKLF.SKLNVY.......KYIIN..YDDVI..GKNWIKKIPNSIIV.STKKNSIKKFKN......LKMYVK.DIFFHYFGTKL.........SIS.S..SWGSCV....INT...KIFGE...FNINNLLLSFVAL
MURE_RALSO/123-332               VTGTNGKTSCSQWIAQAL..SRQG.ERCA.VVGTLGTGFVDA....LVATGFTTPDAIQLQHSLADLHR....AGARAVAMEVSSHGLEQ..GRADG...TRFDIALFTNLTQDHLD..YH.GTMAE.YELAKARLF.GWPGLR.......AAVIN..RDDAA..GGRLLAGLRAGIE...AVEYGIDGEAAAQRGAGHWLRAT.NVRAHRTGTTF.........DVD.G..SFGRAT....VHS...PMVGL...FNVSNQLGVLGVL
D4ZDU8_SHEVD/112-315             VTGTNGKTSITQLMAQLV..ALQ....GK.QASLMGTLGNGLW.GDLVESGNTTADPITIAAQLQDFDL....AGADLCAMEVSSHGLIQ..NRVAA...VPFDVAVFTNLSRDHLD..YH.GTMQA.YGDAKKRLF.KFSSL.Q......SSLIN..LDDEV..GRQWLSE..EQEAK..HLGFSICSAHAD....AASIYTQ.DNHLHHQGVMA.........MLV.W..PEGRAK....LAS...PLLGS...FNLSNLVAALGA.
MURE_NEIMB/112-315               VAGTNGKTSITQWLAQAA..DLL....GE.KTAIVGTVGNGFW.GALEETTHTTPAPVDVQTLLYRFRQ....QGATVAAMEVSSHGLDQ..SRVNG...VSFRSAIFTNLTRDHLD..YH.GTMEA.YGAIKSRLF.YWHGLK.......HAVIN..VDDEY..GAELVGRLKKDCPDLAVYSYGFSEHA........DIRIT.DFTASSDGIA..........AVFQT..PWGEGK....CRT...RLLGR...FNAQNLAACIAL.
MURE_BACTN/109-305               VTGTNGKTTIATLLYNTF..RYFG.YKVG.LISTVCNYIDDQ....PIPTEHTTPDPITLNRLLGQMAD....EGCKYVFMEVSSHSIAQ..KRISG...LKFAGGIFTNLTRDHLD..YH.KTVEN.YLKAKKKFF.DDMPKNA......FSLTN..LDDKN..GLVMTQNTRSK.....VYTYSLRSLS.......D.FKGR.VIESHFEGMLL................DFNNHE....LAV...QFIGK...FNASNLLAVFGAA
MURE1_OCEIH/109-315              VTGTNGKTTVTYLLDKIF..EYHQ.KKAG.VIGTIQVKIGEE....TFPIVNTTPNALELQKTFHVMRE....KDVKQGIMEVSSHALDM..GRVYG...CDYDIAVFTNLSQDHLD..YH.QDIQD.YLRAKSLLF.AQLGNGYDSEKEKYAIIN...DDDS..SSHLLKRSTAQH....VITYSCKKEA.......T.IMAK.DIELTASGIRF.........KLH.S..PLGNIT....IQS...RLMGM...FNVYNMLAASAAA
MURE_BACHD/107-310               VTGTNGKTTITHLIEKIM..QDQG.KMTG.LIGTMYTKIGHE....LKETKNTTPESLVLQRTFADMKK....SGVTTAMMEVSSHALQS..GRVRG...CDFDVAVFSNLTPDHLD..YH.GTMER.YKFAKGLLF.AQLGNTYQ...GKVAVLN..ADDPA..SADFAEMTIAQ.....VVTYGIENEA.......D.FQAE.NVRITSTGTTF.........ELA.A..FEERME....LSI...HLIGK...FSVYNVLAAAAAA
MURE_NOSS1/114-316               VTGTNGKTTTTHLIEFFL..TKAK.LSTA.LMGTLYTRWPGF....EQTATHTTPFAVELQQQLAQAVN....AGCEFGVMEVSSHALAQ..GRVLG...CPFEVGVFSNLTQDHLD..YH.SDMED.YFAAKALLF.SPEYLKG......RAIIN..ADDTY..GQRLIKALSPEK....VWSYSVNDSS.......ADLWMS.DLSYEPNGVTG.........TIH.T..PEGNVS....FRS...PLVGQ...YNLENLLAAVGAV
MURE_STRCO/123-324               ITGTSGKTTTAYLVEGGL..RTAK..STG.LIGTVEMRIGDE....RIKSERTTPEATDLQALFAVMRE....RGTEAVAMEVSSHALVL..GRVDA...CVFDIAVFTNLSPEHME..FH.SGMED.YFQAKAQLF.TPKRSR.......LGVVN..VDDEY..GRRLAKE...ATVP..VVTYSAEGHPD......ADWRAD.EVEVGPLDSTF.........TVLGP..KGERIA....AKS...PLAGP...FNVANTLAAIVAL
MURE1_CLOAB/108-305              ITGTNGKTTSTYMMKSML..ESSG.YKVG.LIGTIANYIGDK....KIESHRTTPESLELQKLFSDMVH....DKIDYCVMEVSSHSLYL..DRVYG...IVFEEGIFTNLTQDHLD..FH.KTFEN.YYKAKMILF.KNSK.........RSIIN..IDDKY..GERVFKDAGND.....KITYGLTEKA.......D.LKAE.NLKMTSRGTEF.........DLC.Y..RGLREH....VKI...NIPGK...YNVYNALGSVAAC
MURE_FUSNN/106-302               VTGTNGKTSSTYMIEKLM..GD.I..PIT.RIGTIEYKIGDK....VFEAVNTTPESLDLIKIFDKTLK....KKIEYVIMEVSSHSLEI..GRVEV...LDFDYALFTNLTQDHLD..YH.LTMEN.YFQAKRKLF.LKLKDI......NNSVIN..VDDEY..GKRLYDEFIVDNPE..IISYGIEN.........GDLEGD.....YSDDGYI.........DVK.Y..KNQIEK....VKF...SLLGD...FNLYNTLGAIGIA
MURE_CALS4/107-305               ITGTNGKTSVTYMLKAIL..EQQN.NKVG.LVGTIQNMIGDR....VIPTTHTTPESLDLQELFSLMVN....EGVKYVVMEVSSHSLAL..HRVDS...CDFDIAVFTNLSQDHLD..FH.ESMEE.YAKTKSKLF.KMAKK........ASVIN..IDDKY..SSMMIESSKGK.....VLTYGIKDFA.......Y.VMAK.EIKNSLSGVKF.........KVQ.I..QDKKEE....ISL...KIPGL...FSVYNALAAITVA
MURE2_CLOAB/109-309              VTGTNGKTTVIHYIRDML..EAFG.NSTG.TIGTLGYELKDKE.INVEKINPTTPEALELNQILRDFID....KGAKNAVMEVTSSALMK..HRVDY...CSFKVGVFTNLSQDHLD..EH.GTIEN.YKNEKIKLF.KMCP.........VGVIN..LDDNI..AGEIIEKGTCE.....FFTYGVLTNA.......D.LTAS.DMVYKPNSVSF.........NVH.Y..KGISSK....VKV...NVPGE...FTVYNVLAAIGSL
MURE_CHLTR/107-307               ITGTNGKTTVSCLVRELM..ERSG.RRTG.LIGTIEHILGEN....RIIDSFTTPDAILLQKYFAEMVK....QNLSAAVMEVSSIGMAL..GRVRE...TEFLAGVLTNITSDHLD..FH.GSLEE.YIAAKKQFF.ASLPEKG......IAVVN..LDCEY..APSFLNGSQAR.....AVSYAIHQEA.......D.YRAD.RLKLYSSGSSY.........DIW.Y..QGQVFP....CET...SLIGE...HNVYNVLASLAVV
#=GC SS_cons                     EESSS-HHHHHHHHHHHHTTHCTT.--EE.EEETTCEEETTE....EE-SSSSS-THHHHHHHHHHHHH....TT-SEEEEE--HCHHHC.HTTTCCH..CBESEEEE---TSTTHH..HH.SSHHH.HHHHHHHHH.HTSETTCTS....EEEEEGGTTSC.....CHHHHHCTCCTC.EEEEEESSSTSECC.TECECEEEEEEEEEETTEEEE.........EEEEEEETTEEEE....EEE...SSCSC..HHHHHHHHHHHHHH
#=GC seq_cons                    lTGosGKTTosphltplL..ppt....st.hhuThG................shsstlsl.ttltphhc....tsschslhEluupuhsp..t+lss...sp.clAlhTNlup-HL-..aa.sohEs.hhpAKtclF.pthttps......hullN..hDDs.....hhhtthpptt.p..slsauhpsps.........hhht.plphppputph...........h.h..tttphp....lpl...slhGc...aNlhNsLAAluss
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