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69  structures 260  species 0  interactions 11532  sequences 345  architectures

Family: Cadherin_2 (PF08266)

Summary: Cadherin-like

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Cadherin". More...

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Cadherin-like Provide feedback

This cadherin domain is usually the most N-terminal copy of the domain.

Literature references

  1. Elledge HM, Kazmierczak P, Clark P, Joseph JS, Kolatkar A, Kuhn P, Muller U;, Proc Natl Acad Sci U S A. 2010;107:10708-10712.: Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members. PUBMED:20498078 EPMC:20498078

  2. Trivedi M, Laurence JS, Williams TD, Middaugh CR, Siahaan TJ;, Int J Pharm. 2012;431:16-25.: Improving the stability of the EC1 domain of E-cadherin by thiol alkylation of the cysteine residue. PUBMED:22531851 EPMC:22531851


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR013164

Cadherins are a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in all solid tissues of the organism which modulate a wide variety of processes including cell polarisation and migration [ PUBMED:2197976 , PUBMED:14570569 ]. Cadherin-mediated cell-cell junctions are formed as a result of interaction between extracellular domains of identical cadherins, which are located on the membranes of the neighbouring cells. The stability of these adhesive junctions is ensured by binding of the intracellular cadherin domain with the actin cytoskeleton. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro, while those that contain the same cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin expression causes morphological changes involving the positional segregation of cells into layers, suggesting they may play an important role in the sorting of different cell types during morphogenesis, histogenesis and regeneration. They may also be involved in the regulation of tight and gap junctions, and in the control of intercellular spacing. Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins.

Structurally, cadherins comprise a number of domains: classically, these include a signal sequence; a propeptide of around 130 residues; a single transmembrane domain and five tandemly repeated extracellular cadherin domains, 4 of which are cadherin repeats, and the fifth contains 4 conserved cysteines and a N-terminal cytoplasmic domain [ PUBMED:11736639 ]. However, proteins are designated as members of the broadly defined cadherin family if they have one or more cadherin repeats. A cadherin repeat is an independently folding sequence of approximately 110 amino acids that contains motifs with the conserved sequences DRE, DXNDNAPXF, and DXD. Crystal structures have revealed that multiple cadherin domains form Ca2+-dependent rod-like structures with a conserved Ca2+-binding pocket at the domain-domain interface. Cadherins depend on calcium for their function: calcium ions bind to specific residues in each cadherin repeat to ensure its proper folding, to confer rigidity upon the extracellular domain and is essential for cadherin adhesive function and for protection against protease digestion.

This entry represents a cadherin domain that is usually found at the N terminus of cadherin proteins.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan E-set (CL0159), which has the following description:

This clan includes a diverse range of domains that have an Ig-like fold and appear to be distantly related to each other. The clan includes: PKD domains, cadherins and several families of bacterial Ig-like domains as well as viral tail fibre proteins. it also includes several Fibronectin type III domain-containing families.

The clan contains the following 238 members:

A2M A2M_BRD A2M_recep AA9 Adeno_GP19K AlcCBM31 Alpha-amylase_N Alpha_adaptinC2 Alpha_E2_glycop Anth_Ig Arch_flagellin aRib Arylsulfotran_N ASF1_hist_chap ATG19 BACON BACON_2 BatD BIg21 Big_1 Big_10 Big_11 Big_12 Big_13 Big_2 Big_3 Big_3_2 Big_3_3 Big_3_4 Big_3_5 Big_4 Big_5 Big_6 Big_7 Big_8 Big_9 Bile_Hydr_Trans BiPBP_C bMG1 bMG10 bMG3 bMG5 bMG6 BslA BsuPI Cadherin Cadherin-like Cadherin_2 Cadherin_3 Cadherin_4 Cadherin_5 Cadherin_pro CagX Calx-beta Candida_ALS_N CARDB CBM39 CBM_X2 CD45 CelD_N Ceramidse_alk_C CHB_HEX_C CHB_HEX_C_1 ChitinaseA_N ChiW_Ig_like Chlam_OMP6 CHU_C Coatamer_beta_C COP-gamma_platf CopC CshA_repeat Cyc-maltodext_N Cytomega_US3 DsbC DUF11 DUF1410 DUF1425 DUF1929 DUF2271 DUF3244 DUF3327 DUF3416 DUF3458 DUF3501 DUF3823_C DUF3859 DUF4165 DUF4179 DUF4426 DUF4469 DUF4625 DUF4879 DUF4959 DUF4981 DUF4982 DUF4998 DUF5001 DUF5008 DUF5011 DUF5065 DUF5115 DUF525 DUF5643 DUF6383 DUF916 EB_dh ECD EpoR_lig-bind ERAP1_C EstA_Ig_like Expansin_C Filamin FixG_C Flavi_glycop_C FlgD_ig fn3 Fn3-like fn3_2 fn3_4 fn3_5 fn3_6 FN3_7 Fn3_assoc fn3_PAP GBS_Bsp-like Glucodextran_B Glyco_hydro2_C5 Glyco_hydro_2 Gmad2 GMP_PDE_delta GPI-anchored Hanta_G1 He_PIG HECW_N HemeBinding_Shp Hemocyanin_C Herpes_BLLF1 HYR IFNGR1 Ig_GlcNase Ig_mannosidase IL12p40_C Il13Ra_Ig IL17R_fnIII_D1 IL17R_fnIII_D2 IL2RB_N1 IL3Ra_N IL4Ra_N IL6Ra-bind Inhibitor_I42 Inhibitor_I71 InlK_D3 Integrin_alpha2 Interfer-bind Invasin_D3 IRK_C IrmA Iron_transport LEA_2 Lep_receptor_Ig LIFR_N Lipase_bact_N LPMO_10 LRR_adjacent LTD Mannosidase_ig MetallophosC MG1 MG2 MG3 MG4 Mo-co_dimer N_BRCA1_IG Na_K-ATPase NEAT Neocarzinostat Neurexophilin NPCBM_assoc PapD_C PBP-Tp47_c Peptidase_C25_C Phlebo_G2_C PhoD_N PKD PKD_2 PKD_3 PKD_4 PKD_5 PKD_6 Por_Secre_tail Pox_vIL-18BP Psg1 PTP_tm Pur_ac_phosph_N Qn_am_d_aII Qn_am_d_aIII RabGGT_insert Reeler REJ RET_CLD1 RET_CLD3 RET_CLD4 RGI_lyase RHD_dimer Rho_GDI Rib RibLong SCAB-Ig SKICH SLAM SoxZ SprB SusE SVA SWM_repeat T2SS-T3SS_pil_N Tafi-CsgC TarS_C1 TcA_RBD TcfC TIG TIG_2 TIG_plexin TIG_SUH Tissue_fac Top6b_C Transglut_C Transglut_N TRAP_beta TraQ_transposon UL16 Velvet WIF Wzt_C Y_Y_Y YBD ZirS_C Zona_pellucida

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(45)
Full
(11532)
Representative proteomes UniProt
(19806)
RP15
(1176)
RP35
(3968)
RP55
(10498)
RP75
(14185)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(45)
Full
(11532)
Representative proteomes UniProt
(19806)
RP15
(1176)
RP35
(3968)
RP55
(10498)
RP75
(14185)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(45)
Full
(11532)
Representative proteomes UniProt
(19806)
RP15
(1176)
RP35
(3968)
RP55
(10498)
RP75
(14185)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_179 (release 17.0)
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD
Number in seed: 45
Number in full: 11532
Average length of the domain: 82.20 aa
Average identity of full alignment: 35 %
Average coverage of the sequence by the domain: 9.47 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.5 21.5
Trusted cut-off 21.5 21.5
Noise cut-off 21.4 21.4
Model length: 83
Family (HMM) version: 14
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Cadherin_2 domain has been found. There are 69 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0A6YY83 View 3D Structure Click here
A0A0G2K6T9 View 3D Structure Click here
A0A0G2K8I5 View 3D Structure Click here
A0A0G2K9D7 View 3D Structure Click here
A0A0G2L924 View 3D Structure Click here
A0A0H2UKU4 View 3D Structure Click here
A0A0J9YJK6 View 3D Structure Click here
A0A0N4SU21 View 3D Structure Click here
A0A0N4SUB1 View 3D Structure Click here
A0A0N4SUG2 View 3D Structure Click here
A0A0R4I9J8 View 3D Structure Click here
A0A0R4I9U6 View 3D Structure Click here
A0A0R4IAV5 View 3D Structure Click here
A0A0R4IAX7 View 3D Structure Click here
A0A0R4IBQ5 View 3D Structure Click here
A0A0R4IEA8 View 3D Structure Click here
A0A0R4IEF6 View 3D Structure Click here
A0A0R4IF36 View 3D Structure Click here
A0A0R4IFD4 View 3D Structure Click here
A0A0R4IHN2 View 3D Structure Click here
A0A0R4ILP7 View 3D Structure Click here
A0A0R4IM90 View 3D Structure Click here
A0A0R4IML6 View 3D Structure Click here
A0A0R4IMS0 View 3D Structure Click here
A0A0R4IP57 View 3D Structure Click here
A0A0R4IQQ5 View 3D Structure Click here
A0A0R4IRQ9 View 3D Structure Click here
A0A0R4IS47 View 3D Structure Click here
A0A0R4ITD9 View 3D Structure Click here
A0A0R4IYS4 View 3D Structure Click here
A0A0R4IZ29 View 3D Structure Click here
A0A0R4IZD7 View 3D Structure Click here
A0A286Y8Q2 View 3D Structure Click here
A0A286YBK8 View 3D Structure Click here
A0A2R8PZP3 View 3D Structure Click here
A0A2R8Q015 View 3D Structure Click here
A0A2R8Q3A5 View 3D Structure Click here
A0A2R8Q416 View 3D Structure Click here
A0A2R8Q658 View 3D Structure Click here
A0A2R8QGH0 View 3D Structure Click here
A0A2R8QHA1 View 3D Structure Click here
A0A2R8QHK7 View 3D Structure Click here
A0A2R8QKI6 View 3D Structure Click here
A0A2R8QME5 View 3D Structure Click here
A0A2R8QMH2 View 3D Structure Click here
A0A2R8QMY8 View 3D Structure Click here
A0A2R8RHT3 View 3D Structure Click here
A0A2R8RI00 View 3D Structure Click here
A0A2R8RIS9 View 3D Structure Click here
A0A2R8RLA9 View 3D Structure Click here
A0A2R8RMH2 View 3D Structure Click here
A0A2R8RQG5 View 3D Structure Click here
A0A2R8RQZ3 View 3D Structure Click here
A0A2R8RZH1 View 3D Structure Click here
A0A2R8S0H4 View 3D Structure Click here
C4P342 View 3D Structure Click here
D3Z8Y3 View 3D Structure Click here
D3ZE55 View 3D Structure Click here
D3ZM08 View 3D Structure Click here
D3ZPN0 View 3D Structure Click here
D3ZQX5 View 3D Structure Click here
D3ZQX9 View 3D Structure Click here
D3ZQY0 View 3D Structure Click here
D3ZQY5 View 3D Structure Click here
D3ZUH3 View 3D Structure Click here
D4A455 View 3D Structure Click here
D4A477 View 3D Structure Click here
D4A497 View 3D Structure Click here
D4A7P5 View 3D Structure Click here
D4ACT6 View 3D Structure Click here
D4ACT8 View 3D Structure Click here
D4ACU0 View 3D Structure Click here
D4ACU2 View 3D Structure Click here
D4ACU3 View 3D Structure Click here
E7EYF4 View 3D Structure Click here
E7F1K6 View 3D Structure Click here
E7F376 View 3D Structure Click here
E7F4G4 View 3D Structure Click here
E7F4M6 View 3D Structure Click here
E7F5T8 View 3D Structure Click here
E7F647 View 3D Structure Click here
E7F9B5 View 3D Structure Click here
E7FAU6 View 3D Structure Click here
E7FBE3 View 3D Structure Click here
E9PSN7 View 3D Structure Click here
E9PT16 View 3D Structure Click here
E9PT60 View 3D Structure Click here
E9PXF0 View 3D Structure Click here
E9PXQ7 View 3D Structure Click here
E9Q5G2 View 3D Structure Click here
F1LN21 View 3D Structure Click here
F1LRA0 View 3D Structure Click here
F1LS01 View 3D Structure Click here
F1M6B6 View 3D Structure Click here
F1M7D0 View 3D Structure Click here
F1M9W4 View 3D Structure Click here
F1MA46 View 3D Structure Click here
F1QAA1 View 3D Structure Click here
F1QIY1 View 3D Structure Click here
F1QRP2 View 3D Structure Click here
F1QUV5 View 3D Structure Click here
F1QWK1 View 3D Structure Click here
F1QWR6 View 3D Structure Click here
F1QWR8 View 3D Structure Click here
F1QXY7 View 3D Structure Click here
F1RBC7 View 3D Structure Click here
F1RC97 View 3D Structure Click here
F1REQ8 View 3D Structure Click here
F2Z3R5 View 3D Structure Click here
F2Z3R8 View 3D Structure Click here
F6NJQ3 View 3D Structure Click here
F6ZNL5 View 3D Structure Click here
F7EKI5 View 3D Structure Click here
F8VPK8 View 3D Structure Click here
G3V8N1 View 3D Structure Click here
G3V8N4 View 3D Structure Click here
G3V8N7 View 3D Structure Click here
G3V8P0 View 3D Structure Click here
G3V8P1 View 3D Structure Click here
G3V987 View 3D Structure Click here
G3V9G0 View 3D Structure Click here
G3V9R7 View 3D Structure Click here
M0R4V1 View 3D Structure Click here
M0R5H4 View 3D Structure Click here
M0R8Z9 View 3D Structure Click here
M0RC78 View 3D Structure Click here
M3ZCP6 View 3D Structure Click here
O14917 View 3D Structure Click here
O55134 View 3D Structure Click here
O60245 View 3D Structure Click here
O60330 View 3D Structure Click here
O88689 View 3D Structure Click here
O95206 View 3D Structure Click here
Q08174 View 3D Structure Click here
Q63418 View 3D Structure Click here
Q68HB8 View 3D Structure Click here
Q6DD96 View 3D Structure Click here
Q6NYV7 View 3D Structure Click here
Q6PB90 View 3D Structure Click here
Q767I8 View 3D Structure Click here
Q7TSK3 View 3D Structure Click here
Q805F0 View 3D Structure Click here
Q80TF3 View 3D Structure Click here
Q8CDY9 View 3D Structure Click here
Q8CFX3 View 3D Structure Click here
Q8TAB3 View 3D Structure Click here
Q8VHR0 View 3D Structure Click here
Q91UZ8 View 3D Structure Click here
Q91V48 View 3D Structure Click here
Q91VD8 View 3D Structure Click here
Q91VE5 View 3D Structure Click here
Q91XW9 View 3D Structure Click here
Q91XX0 View 3D Structure Click here
Q91XX1 View 3D Structure Click here
Q91XX3 View 3D Structure Click here
Q91XX4 View 3D Structure Click here
Q91XX5 View 3D Structure Click here
Q91XX6 View 3D Structure Click here
Q91XX7 View 3D Structure Click here
Q91XX8 View 3D Structure Click here
Q91XX9 View 3D Structure Click here
Q91XY0 View 3D Structure Click here
Q91XY2 View 3D Structure Click here
Q91XY3 View 3D Structure Click here
Q91XY4 View 3D Structure Click here
Q91XY5 View 3D Structure Click here
Q91XY6 View 3D Structure Click here
Q91XY7 View 3D Structure Click here
Q91XY8 View 3D Structure Click here
Q91XY9 View 3D Structure Click here
Q91XZ0 View 3D Structure Click here
Q91XZ2 View 3D Structure Click here
Q91XZ4 View 3D Structure Click here
Q91XZ5 View 3D Structure Click here
Q91XZ6 View 3D Structure Click here
Q91XZ7 View 3D Structure Click here
Q91XZ8 View 3D Structure Click here
Q91XZ9 View 3D Structure Click here
Q91Y00 View 3D Structure Click here
Q91Y01 View 3D Structure Click here
Q91Y02 View 3D Structure Click here
Q91Y03 View 3D Structure Click here
Q91Y04 View 3D Structure Click here
Q91Y06 View 3D Structure Click here
Q91Y07 View 3D Structure Click here
Q91Y08 View 3D Structure Click here
Q91Y09 View 3D Structure Click here
Q91Y10 View 3D Structure Click here
Q91Y11 View 3D Structure Click here
Q91Y12 View 3D Structure Click here
Q91Y13 View 3D Structure Click here
Q91Y14 View 3D Structure Click here
Q91Y15 View 3D Structure Click here
Q91Y16 View 3D Structure Click here
Q91Y17 View 3D Structure Click here
Q91Y18 View 3D Structure Click here
Q91Y19 View 3D Structure Click here
Q91Y20 View 3D Structure Click here
Q91Y21 View 3D Structure Click here
Q96TA0 View 3D Structure Click here
Q9BZA7 View 3D Structure Click here
Q9BZA8 View 3D Structure Click here
Q9H158 View 3D Structure Click here
Q9HC56 View 3D Structure Click here
Q9HCL0 View 3D Structure Click here
Q9NPG4 View 3D Structure Click here
Q9NRJ7 View 3D Structure Click here
Q9P2E7 View 3D Structure Click here
Q9UN66 View 3D Structure Click here
Q9UN67 View 3D Structure Click here
Q9UN70 View 3D Structure Click here
Q9UN71 View 3D Structure Click here
Q9UN72 View 3D Structure Click here
Q9UN73 View 3D Structure Click here
Q9UN74 View 3D Structure Click here
Q9UN75 View 3D Structure Click here
Q9Y5E1 View 3D Structure Click here
Q9Y5E2 View 3D Structure Click here
Q9Y5E3 View 3D Structure Click here
Q9Y5E4 View 3D Structure Click here
Q9Y5E5 View 3D Structure Click here
Q9Y5E6 View 3D Structure Click here
Q9Y5E7 View 3D Structure Click here
Q9Y5E8 View 3D Structure Click here
Q9Y5E9 View 3D Structure Click here
Q9Y5F0 View 3D Structure Click here
Q9Y5F1 View 3D Structure Click here
Q9Y5F2 View 3D Structure Click here
Q9Y5F3 View 3D Structure Click here
Q9Y5F6 View 3D Structure Click here
Q9Y5F7 View 3D Structure Click here
Q9Y5F8 View 3D Structure Click here
Q9Y5F9 View 3D Structure Click here
Q9Y5G0 View 3D Structure Click here
Q9Y5G1 View 3D Structure Click here
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Q9Y5G3 View 3D Structure Click here
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Q9Y5G6 View 3D Structure Click here
Q9Y5G7 View 3D Structure Click here
Q9Y5G8 View 3D Structure Click here
Q9Y5G9 View 3D Structure Click here
Q9Y5H0 View 3D Structure Click here
Q9Y5H1 View 3D Structure Click here
Q9Y5H2 View 3D Structure Click here
Q9Y5H3 View 3D Structure Click here
Q9Y5H4 View 3D Structure Click here
Q9Y5H5 View 3D Structure Click here
Q9Y5H6 View 3D Structure Click here
Q9Y5H7 View 3D Structure Click here
Q9Y5H8 View 3D Structure Click here
Q9Y5H9 View 3D Structure Click here
Q9Y5I0 View 3D Structure Click here
Q9Y5I1 View 3D Structure Click here
Q9Y5I2 View 3D Structure Click here
Q9Y5I3 View 3D Structure Click here
Q9Y5I4 View 3D Structure Click here