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48  structures 722  species 0  interactions 879  sequences 5  architectures

Family: TetR_C_2 (PF08361)

Summary: MAATS-type transcriptional repressor, C-terminal region

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MAATS-type transcriptional repressor, C-terminal region Provide feedback

This family is named after the various transcriptional regulatory proteins that it contains, including MtrR (Q6RV06), AcrR (P34000), ArpR (Q9KJC4), TtgR (Q9AIU0) and SmeT (Q8KLP4). These are members of the TetR family of transcriptional repressors, that are involved in the control of expression of multidrug resistance proteins [1,2,3].

Literature references

  1. Klein JR, Henrich B, Plapp R; , Mol Gen Genet 1991;230:230-240.: Molecular analysis and nucleotide sequence of the envCD operon of Escherichia coli. PUBMED:1720861 EPMC:1720861

  2. Kieboom J, de Bont J; , Microbiology 2001;147:43-51.: Identification and molecular characterization of an efflux system involved in Pseudomonas putida S12 multidrug resistance. PUBMED:11160799 EPMC:11160799

  3. Sanchez P, Alonso A, Martinez JL; , Antimicrob Agents Chemother 2002;46:3386-3393.: Cloning and characterization of SmeT, a repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF. PUBMED:12384340 EPMC:12384340

Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR013572

This entry is named after the various transcriptional regulatory proteins that it contains, including MtrR ( SWISSPROT ), AcrR ( SWISSPROT ), ArpR ( SWISSPROT ), TtgR ( SWISSPROT ) and SmeT ( SWISSPROT ). These are members of the TetR (tetracycline resistance) family of transcriptional repressors, that are involved in the control of expression of multidrug resistance proteins [ PUBMED:1720861 , PUBMED:11160799 , PUBMED:12384340 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan TetR_C (CL0174), which has the following description:

This clan features families of transcriptional regulators for multidrug efflux pumps, which belong to the TetR superfamily. They are induced by the presence of a variety of factors, such as antibiotics or organic solvents. The C-terminal region featured in these families is thought to contain the inducer-binding site; the divergent sequences in this region allow for the binding of a variety of different inducers [1-4].

The clan contains the following 38 members:

CecR_C TetR_C_1 TetR_C_10 TetR_C_11 TetR_C_13 TetR_C_14 TetR_C_15 TetR_C_16 TetR_C_17 TetR_C_18 TetR_C_19 TetR_C_2 TetR_C_20 TetR_C_21 TetR_C_22 TetR_C_23 TetR_C_24 TetR_C_25 TetR_C_26 TetR_C_27 TetR_C_28 TetR_C_29 TetR_C_3 TetR_C_30 TetR_C_31 TetR_C_32 TetR_C_33 TetR_C_34 TetR_C_35 TetR_C_36 TetR_C_37 TetR_C_38 TetR_C_4 TetR_C_5 TetR_C_6 TetR_C_7 TetR_C_8 TetR_C_9


We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

Representative proteomes UniProt
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Representative proteomes UniProt

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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

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HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...


This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_3020 (release 18.0)
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Fenech M
Number in seed: 8
Number in full: 879
Average length of the domain: 117.60 aa
Average identity of full alignment: 23 %
Average coverage of the sequence by the domain: 55.58 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.0 22.0
Trusted cut-off 22.0 22.0
Noise cut-off 21.9 21.9
Model length: 121
Family (HMM) version: 13
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the TetR_C_2 domain has been found. There are 48 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
P0ACS9 View 3D Structure Click here
P0ACT2 View 3D Structure Click here