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2  structures 1297  species 0  interactions 2176  sequences 54  architectures

Family: DWNN (PF08783)

Summary: DWNN domain

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The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

DWNN domain Provide feedback

DWNN is a ubiquitin like domain found at the N terminus of the RBBP6 family of splicing-associated proteins [1]. The DWNN domain is independently expressed in higher vertebrates so it may function as a novel ubiquitin-like modifier of other proteins [1].

Literature references

  1. Pugh DJ, Ab E, Faro A, Lutya PT, Hoffmann E, Rees DJ; , BMC Struct Biol. 2006;6:1.: DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways. PUBMED:16396680 EPMC:16396680


This tab holds annotation information from the InterPro database.

InterPro entry IPR014891

The ~75-residue DWNN (Domain With No Name) domain is highly conserved through eukaryotic species but is absent in prokaryotes. The DWNN domain is found only at the N terminus of the RBBP6 family of proteins which includes:

  • Mammalian RBBP6, a splicing-associated protein that plays a role in the induction of apoptosis and regulation of the cell cycle.
  • Drosophila melanogaster (Fruit fly) SNAMA (something that sticks like glue), a protein that appears to play a role in apoptosis.

All of the identified RBBP6 homologues include the DWNN domain, a CCHC-type zinc finger (see PROSITEDOC ) and a RING-type zinc finger (see PROSITEDOC ). The three domain form is found in plants, protozoa, fungi and microsporidia. The RBBP6 homologues in vertebrates, insects and worms are longer and include additional domains. In addition to forming part of the full-length RBBP6 protein, the DWNN domain is also expressed in vertebrates as a small protein containing a DWNN domain and a short C-terminal tail (RBBP6 variant 3). The DWNN domain adopts a fold similar to the ubiquitin one, characterised by two alpha-helices and four beta-sheets ordered as beta-beta-alpha-beta-alpha-beta along the sequence. The similarity of DWNN domain to ubiquitin and the presence of the RING finger suggest that the DWNN domain may act as an ubiquitin-like modifier, possibly playing a role in the regulation of the splicing machinery [ PUBMED:15733535 , PUBMED:16396680 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(109)
Full
(2176)
Representative proteomes UniProt
(3576)
RP15
(499)
RP35
(1149)
RP55
(1782)
RP75
(2335)
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HTML View  View           
PP/heatmap 1 View           

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(109)
Full
(2176)
Representative proteomes UniProt
(3576)
RP15
(499)
RP35
(1149)
RP55
(1782)
RP75
(2335)
Alignment:
Format:
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Sequence:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(109)
Full
(2176)
Representative proteomes UniProt
(3576)
RP15
(499)
RP35
(1149)
RP55
(1782)
RP75
(2335)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: pdb_2c7h
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Mistry J
Number in seed: 109
Number in full: 2176
Average length of the domain: 72.50 aa
Average identity of full alignment: 46 %
Average coverage of the sequence by the domain: 9.49 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.7 21.7
Trusted cut-off 21.7 22.0
Noise cut-off 21.6 21.6
Model length: 74
Family (HMM) version: 13
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the DWNN domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2KIT7 View 3D Structure Click here
A0A0G2KQ69 View 3D Structure Click here
A0A0G2L4E9 View 3D Structure Click here
A0A0N4STZ9 View 3D Structure Click here
A0A0N4SU28 View 3D Structure Click here
A0A0P0VX64 View 3D Structure Click here
A0A0P0VY02 View 3D Structure Click here
A0A0P0XV68 View 3D Structure Click here
A0A0R0FD25 View 3D Structure Click here
A0A0R4ILU0 View 3D Structure Click here
A0A0R4IQ56 View 3D Structure Click here
A0A1D6GL60 View 3D Structure Click here
A0A1D6KUS0 View 3D Structure Click here
A0A1D6KZ48 View 3D Structure Click here
A0A1D8PLB3 View 3D Structure Click here
A0A2R8PWH0 View 3D Structure Click here
A0A2R8PXS9 View 3D Structure Click here
A0A2R8PZW2 View 3D Structure Click here
A0A2R8Q0F2 View 3D Structure Click here
A0A2R8Q1D5 View 3D Structure Click here
A0A2R8Q3M0 View 3D Structure Click here
A0A2R8Q6K0 View 3D Structure Click here
A0A2R8Q7W1 View 3D Structure Click here
A0A2R8Q7X3 View 3D Structure Click here
A0A2R8Q827 View 3D Structure Click here
A0A2R8Q8Y6 View 3D Structure Click here
A0A2R8QCH9 View 3D Structure Click here
A0A2R8QDH0 View 3D Structure Click here
A0A2R8QF76 View 3D Structure Click here
A0A2R8QFC5 View 3D Structure Click here
A0A2R8QFD3 View 3D Structure Click here
A0A2R8QFW7 View 3D Structure Click here
A0A2R8QGU3 View 3D Structure Click here
A0A2R8QGU8 View 3D Structure Click here
A0A2R8QI35 View 3D Structure Click here
A0A2R8QJ76 View 3D Structure Click here
A0A2R8QJ83 View 3D Structure Click here
A0A2R8QP83 View 3D Structure Click here
A0A2R8QPF2 View 3D Structure Click here
A0A2R8QQ50 View 3D Structure Click here
A0A2R8QSF3 View 3D Structure Click here
A0A2R8QSR5 View 3D Structure Click here
A0A2R8RHQ4 View 3D Structure Click here
A0A2R8RJ99 View 3D Structure Click here
A0A2R8RXY4 View 3D Structure Click here
A8E553 View 3D Structure Click here
A8WHX4 View 3D Structure Click here
B9DFV2 View 3D Structure Click here
E7EXE9 View 3D Structure Click here
E7EZH1 View 3D Structure Click here
E7F162 View 3D Structure Click here
E7FBB1 View 3D Structure Click here
E7FCA1 View 3D Structure Click here
E7FD51 View 3D Structure Click here
E9QGQ8 View 3D Structure Click here
E9QJE8 View 3D Structure Click here
F1R5U9 View 3D Structure Click here
F4JP52 View 3D Structure Click here
G3V953 View 3D Structure Click here
I1K0S1 View 3D Structure Click here
O62235 View 3D Structure Click here
O94264 View 3D Structure Click here
P35728 View 3D Structure Click here
P97868 View 3D Structure Click here
Q54XF1 View 3D Structure Click here
Q6P2V0 View 3D Structure Click here
Q7Z6E9 View 3D Structure Click here
Q850T7 View 3D Structure Click here
Q9XZ21 View 3D Structure Click here