# STOCKHOLM 1.0 #=GF ID 2C_adapt #=GF AC PF08793.13 #=GF DE 2-cysteine adaptor domain #=GF AU Iyer LM;0000-0002-4844-2022 #=GF GA 22.0 22.0 #=GF NC 21.9 21.0 #=GF TC 22.0 22.3 #=GF SE Iyer L #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF RN [1] #=GF RM 16494962 #=GF RT Evolutionary genomics of nucleo-cytoplasmic large DNA viruses. #=GF RA Iyer LM, Balaji S, Koonin EV, Aravind L; #=GF RL Virus Res. 2006;117:156-184. #=GF DR INTERPRO; IPR014901; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC The virus-specific 2-cysteine adaptor domain is found fused to #=GF CC OTU/A20-like peptidases and S/T protein kinases. The domain #=GF CC associations of these proteins indicate that they might function #=GF CC as viral adaptors connecting the kinases and OTU/A20 peptidases #=GF CC to specific targets [1]. #=GF SQ 114 Q5YFM6.1/8-40 VCEDFHL.....DP.SRNPRTGKLIKEGGPVYRKLMEEC-- Q5YFM6.1/63-96 KCDEFRR.....DP.SRNPTTGRPIKIDGPIYKKLIRECG- Q5YFM6.1/114-147 KCDEFRR.....DP.SRNPITGKTIKVGGPVYRKLEKECS- Q5YFM6.1/181-214 -CAAFDR.....DP.TRNPITGRPIKRDGPVYRRLVEDCEG Q5YFM6.1/236-269 KCDEFHR.....DP.SVNPATGRPIKYGGPAFRKLLRECG- Q5YFM6.1/284-316 -CDEFRR.....DP.TKNPITGRTIKTGGPVHTRLLGECA- Q5YFM6.1/341-374 KCSAFLR.....DP.ATNPSTGKNIKEGGPTYNKLMRECS- Q5YFM6.1/403-436 KCEEFLE.....NP.GINPETGKTIKHGGPVYTRLIKECA- Q5YFM6.1/461-494 KCQKFRQ.....NR.RHNPENGKRIKKGGPVYMRLVKECA- Q5YFM6.1/520-552 -CFAFQR.....NP.GINPVTGKAIKIGGPKYKSLVKACG- Q6GZV6.1/5-38 YCDEFER.....NP.TRNPRTGRTIKRGGPVFRALERECS- Q6GZV6.1/69-101 -CPEFAR.....DP.TRNPRTGRPIKRGGPVFRALERECA- Q6GZV6.1/139-171 -CPEFAR.....DP.TRNPRTGRTIKRGGPTYRALEAECA- Q6GZV6.1/249-283 VCERFAA.....DP.TRNPVTGSPLSRNDPLYTDLMEICKG Q6GZV6.1/302-336 TCEAFCR.....DP.TRNPVTGQKMRRNGIEYQMFAEECDC A0A0A0VEA1.1/93-126 YCDEFER.....NP.TRNPRTGRTIKRGGPVFRALERECS- A0A0A0VEA1.1/157-189 -CPEFAR.....DP.TRNPRTGRPIKRGGPVFRALERECA- A0A0A0VEA1.1/227-259 -CPEFAR.....DP.TRNPRTGRTIKRGGPTYRALEAECA- A0A0A0VEA1.1/332-366 VCERFAA.....DP.TRNPVTGSPLSRNDPLYTDLMEICKG A0A0A0VEA1.1/385-419 TCEAFCR.....DP.TKNPVTGQKMRRNGIEYQMFAEECDC A0A1B2ITV9.1/5-38 YCDEFER.....NP.TRNPRTGRTIKRGGPVFRALERECS- A0A1B2ITV9.1/69-101 -CPEFAR.....DP.TRNPRTGRPIKSGGPVFRALERECA- A0A1B2ITV9.1/139-171 -CPEFAR.....DP.TRNPRTGRTIKRGGPTYRALEAECA- A0A1B2ITV9.1/249-283 VCERFAA.....DP.TRNPVTGSPLSRNDPLYTDLMEICKG A0A1B2ITV9.1/302-336 TCEAFCR.....DP.TRNPVTGQKMRRNGIEYQMFAEECDC C3RWM0.1/5-38 YCDEFER.....NP.TRNPRTGRTIKRGGPVFRALERECS- C3RWM0.1/69-101 -CPEFAR.....DP.TRNPRTGRPIKRGGPVFRALEMECA- C3RWM0.1/139-171 -CPEFAR.....DP.TRNPRTGRTIKRGGPTYRALEAECA- C3RWM0.1/244-278 VCERFAA.....DP.TRNPVTGSPLSRNDPLYTDLMEICKG C3RWM0.1/297-331 TCDAFCR.....DP.TRNPVTGHKMRRNGIAYQMFAEECDC A0A1B2IU69.1/5-38 YCDEFER.....DP.TRNPRTGRTIKRGGPVFRALERECS- A0A1B2IU69.1/69-101 -CPEFAR.....DP.TRNPRTGRTIKRGGPVFRALERECA- A0A1B2IU69.1/136-168 -CPEFAR.....DP.TRNPRTGRTIKRGGPTYRALEAECA- A0A1B2IU69.1/224-258 VCERFAA.....DP.TRNPVTGSPLSRNDPLYTDLMEICGG A0A1B2IU69.1/277-311 TCEAFCR.....DP.TRNPVTGQKMCRNGIEYQMFAEECDC I2BFU9.1/93-126 YCDEFER.....NP.TRNPRTGRTIKREGPVFRALERECS- I2BFU9.1/157-189 -CPEFAR.....DP.TRNPRTGRTIKRGGPVFRALERECA- I2BFU9.1/227-259 -CPEFAR.....DP.TRNPRTGRTIKRGGPTYRALEAECA- I2BFU9.1/364-398 VCERFAA.....DP.TRNPVTGSPLSRNDPLYVDLMEICGG I2BFU9.1/417-451 TCEAFCR.....DP.TRNPVTGQKMRRNSIEYQMVAEECDC A0A3T0PNK7.1/5-38 YCDEFER.....NP.TRNPRTGRTIKRGGPMFRALERECS- A0A3T0PNK7.1/69-101 -CPEFAR.....DP.TRNPRTGRTIKGGGPVFRALERECA- A0A3T0PNK7.1/139-171 -CPEFAR.....DP.TRNPRTSRTIKRGGPTYRALEAECA- A0A3T0PNK7.1/246-280 VCERFAA.....DP.TRNPVTGSPLSRNDPLYTDLMEICGG A0A3T0PNK7.1/299-333 TCEAFCR.....DP.TRNPVTGQKMRRNGIEYQMFAEECDC Q0E553.1/14-48 QCETFKR.....NKqAVSPLTNCPIDKFGRTAARFRKECD- Q0E553.1/60-94 VCKKFLA.....NK.TVSPYSGRPIKPGKKLYNDLEKHCSG Q0E553.1/142-176 YCTNFHR.....DE.SRNPLTGKKLVPTSPIRKAWHKMCSG Q0E553.1/184-218 KCIAFDK.....ND.KINPFTGRPINENNDTYRMIYSMCHG Q8QUQ5.1/7-42 KCNQLRN.....NRyTVNPVSNRAIAPRGDTANTLRRICEQ Q8QUQ5.1/46-79 -CAEYKR.....SP.RYNPWTDRTLAPGSPKHNLISGMCGG Q8QUQ5.1/124-156 -CALYYD.....DP.TVNPFTDEPLRRYSPIDDLLYRNCE- Q8QUQ5.1/164-197 QCRAFEE.....NP.DVNPNTGRRISPTGPIASSMRRRCM- A0A3Q9EG92.1/7-42 KCKQLRR.....NRyTVNPVSNRSIAPRGDTANTLRRICEQ A0A3Q9EG92.1/46-79 -CAEYKR.....SP.RYNPWTDRTLGPGSPKHNLISGMCGG A0A3Q9EG92.1/124-156 -CALYYD.....DP.TVNPFTDGPLRRYSPIDDLLYRNCE- A0A3Q9EG92.1/164-197 QCRAFEE.....NP.DVNPNTGRRISPTGPIASSMRRRCM- A4KXB6.1/14-48 QCETFIR....nNK.AVSPLTNKPIDVYGRAAARFRRDCN- A4KXB6.1/60-94 VCKKFLA.....NK.SVSPYSGRPIKRGAKLYNDLTKHCSG A4KXB6.1/170-203 -CATFSR.....NE.SINPITGKKLIGTSPIRKAWHRMCAG A4KXB6.1/211-245 KCMAFDK.....ND.KKNPFTGRSIRPEQPAYRMVYSMCHG A0A2K8ES92.1/14-48 QCETFIR....nNK.AVSPLTNKPIDVHGRAAARFRRDCN- A0A2K8ES92.1/60-94 VCKKFLA.....NK.SVSPYSGRPIKRGAKLYNDLTKHCSG A0A2K8ES92.1/170-203 -CATFSR.....NE.SINPITGKKLIGTSPIRKAWHRMCAG A0A2K8ES92.1/211-245 KCMAFDK.....ND.KKNPFTGRSIRPEQAAYRMVYSMCHG A0A4P8NQR7.1/8-41 -CNTFKR.....SGySVNPVTKRTISPSGSVSKTMQNVCS- A0A4P8NQR7.1/45-78 YCRSYNA.....NP.SVNPWTGKPLTNNSSLHTTIRNLCN- A0A4P8NQR7.1/127-159 -CARYVM.....ER.DINPFTDKPLTKYSPLADALYRECE- A0A4P8NQR7.1/168-201 -CNEFER.....NP.HRNPETGRAIKANGPTSRSFKRRCDG A0A2K9QQV2.1/27-61 QCEDFIS.....SLqKKNPITNRKIDVFGSTAASLRRNCS- A0A2K9QQV2.1/79-112 KCTEFLS.....NP.RENPITGRKLAANKPTYKKFVKVCG- A0A2K9QQV2.1/188-221 -CTKFIN.....ND.KINPKTNKNIKYKGPTYKKIVTKCKQ A0A2K9QQV2.1/234-267 -CNEFHQ.....NAkKKNPITGRKIAVGSVVQRRIVSQCG- Q06VE0.1/27-61 QCEDFIS.....SLqKKNPITNRKIDVFGSTAASLRRNCS- Q06VE0.1/79-112 KCTEFLS.....NP.RENPITGRKLAANKPTYKKFVKVCG- Q06VE0.1/176-209 -CTKFIN.....ND.KINPKTNKNIKYKGPTYKKIVTKCKQ Q06VE0.1/222-255 -CNEFHQ.....NAkKKNPITGRKIAVGSVVQRRIVSQCG- A0A4P8NQW5.1/54-86 -CNDYSR.....DP.MRNPWTKRPMTRDSRMHNIMKYICE- A0A4P8NQW5.1/178-211 -CKRFDR.....NP.NINPISERRISPHGAIAKGLRSKCAG F2NYT7.1/130-162 -CAEFDR.....NP.GVNPLTSRKIKIDGPVYKKLQKDCA- A0A3Q9EFW5.1/37-75 VCNDLALcs.qhTD.TYNPWTDRALLPDSPVHDMIDYVCNT Q91FE6.1/4-37 KCSKWHE.....QP.LINPLTNRKIKKNGPTYKELERECG- A0A1J0FA53.1/61-94 -CSKWKA.....NP.LVNPATGRKIKKDGPVYEKIQKKCMG O41158.2/64-96 -CSKWKA.....NP.LVNPATGRKIKKDGPVYEKIQKKCS- Q8QUQ6.1/37-75 VCNDLALcs.qhTD.TYNPWTDRALLPDSPVHDMIDYVCNT A7IY44.1/60-92 -CAKWKT.....NP.LVNPATGRKIKKDGPVYKKIQQKCS- A7RCQ1.1/60-92 -CAKWKT.....NP.LVNPATGRKIKKDGPVYKKIQQKCS- Q91FU0.1/65-97 -CEQWLA.....NK.GINPRTGKAIKIGGPTYKKLEMECK- A0A369RNE0.1/42-61 -------.....--.-INPTTGRQIKINGPTYRKIH----- A0A068QLN5.1/59-91 -CEEWIK.....NP.GVNPKTGRAIKIGGPVYKKLEKECG- Q91FE4.1/7-45 KCDEWEKir.lnSS.PKNPFTKRNVKKDGPTYKKIDLICKH Q197F0.1/8-47 KCYEWDIak.kkSPlPKSPLTGRKLKQHGPTWKKITAECAT B3SDT9.1/42-61 -------.....--.-INPTTGRQIKINGPTYRKIH----- A0A068QL52.1/5-37 -CKDWHE.....QP.LVNPVTNRIIKKNGPTYRELEKKCG- S6DF84.1/5-37 -CAKWHS.....QP.LVNPVTNRKIKVGGPKYKELERECG- W8QE80.1/4-36 -CTEWRN.....NP.SINPLTNRYIKKGGKVYKQLEDKCG- W8W1F2.1/5-37 -CAKWHS.....QP.LVNPVTNRKIKVGGPKYKELERKCG- A0A068QKK2.1/33-71 KCDEWKQrgrlvTS.PVNPFTNRKIKKDGPTYKKVELICN- W8W2G5.1/4-37 KCAMWHL.....QP.LVNPVTNRKIKRGGLVYQKLEQECG- W8W275.1/5-37 -CAKWHS.....QP.LVNPVTNRKIKVGGPKYKELEQKCG- A0A291B0T2.1/32-64 VCIQWFN.....NP.NVNPRTNRKIKTFGPTYRALTDEC-- A0A1B2RW91.1/15-48 VCDEFEA.....NP.DYNPKTGKKIKKTGLVYKRLVKKCK- W8W2X2.1/5-42 KCKEWAKd..rlSPtPKNPLTNRKIKVGGPKYKELDKDCE- S6DF51.1/5-42 KCKEWAKd..rlSPtPKNPLTNRKIKVGGPKYKELDKDCE- W8W228.1/5-42 KCKEWAKd..rlSPsPKNPLTNRKIKVGGPKYKELDKDCE- A0A1B2RW80.1/16-50 VCESFKQ.....NP.GVNPTTSRKILPTGRIYKHLVKFCKT A0A1B2RVW2.1/5-38 -CQQFFE.....NP.YVNPKTKRKILKNKRTYNNLVKECGG E3T4L7.1/16-42 ---KWHY.....NK.TVNPRTNRPIKVNGKIYQYLN----- A0A3R8YPI2.1/9-27 -------.....-K.TVNPATGRAVEPTSPAHR-------- D2XB15.1/6-23 -------.....--.LVNPKTGRKILRGGPTHL-------- T2AY63.1/6-23 -------.....--.LVNPKTGRKILRGGPTHL-------- A0A4T0UTF1.1/61-82 ---LFPR.....SP.QANPTTGRKMRRDGPL---------- A0A397ICS7.1/28-52 ----WRK.....PK.IYNPKTNRMIAIDGPTYNKL------ V9SEA1.1/4-22 -------.....--.LVNPETGRNILRNGPTHLS------- //