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121  structures 3230  species 0  interactions 11798  sequences 181  architectures

Family: ERAP1_C (PF11838)

Summary: ERAP1-like C-terminal domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

ERAP1-like C-terminal domain Provide feedback

This large domain is composed of 16 alpha helices organized as 8 HEAT-like repeats. This domain forms a concave face that faces towards the active site of the peptidase.

Literature references

  1. Nguyen TT, Chang SC, Evnouchidou I, York IA, Zikos C, Rock KL, Goldberg AL, Stratikos E, Stern LJ;, Nat Struct Mol Biol. 2011;18:604-613.: Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. PUBMED:21478864 EPMC:21478864


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR024571

This large domain is composed of 16 alpha helices organised as 8 HEAT-like repeats. This domain forms a concave face that faces towards the active site of the peptidase.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan E-set (CL0159), which has the following description:

This clan includes a diverse range of domains that have an Ig-like fold and appear to be distantly related to each other. The clan includes: PKD domains, cadherins and several families of bacterial Ig-like domains as well as viral tail fibre proteins. it also includes several Fibronectin type III domain-containing families.

The clan contains the following 238 members:

A2M A2M_BRD A2M_recep AA9 Adeno_GP19K AlcCBM31 Alpha-amylase_N Alpha_adaptinC2 Alpha_E2_glycop Anth_Ig Arch_flagellin aRib Arylsulfotran_N ASF1_hist_chap ATG19 BACON BACON_2 BatD BIg21 Big_1 Big_10 Big_11 Big_12 Big_13 Big_2 Big_3 Big_3_2 Big_3_3 Big_3_4 Big_3_5 Big_4 Big_5 Big_6 Big_7 Big_8 Big_9 Bile_Hydr_Trans BiPBP_C bMG1 bMG10 bMG3 bMG5 bMG6 BslA BsuPI Cadherin Cadherin-like Cadherin_2 Cadherin_3 Cadherin_4 Cadherin_5 Cadherin_pro CagX Calx-beta Candida_ALS_N CARDB CBM39 CBM_X2 CD45 CelD_N Ceramidse_alk_C CHB_HEX_C CHB_HEX_C_1 ChitinaseA_N ChiW_Ig_like Chlam_OMP6 CHU_C Coatamer_beta_C COP-gamma_platf CopC CshA_repeat Cyc-maltodext_N Cytomega_US3 DsbC DUF11 DUF1410 DUF1425 DUF1929 DUF2271 DUF3244 DUF3327 DUF3416 DUF3458 DUF3501 DUF3823_C DUF3859 DUF4165 DUF4179 DUF4426 DUF4469 DUF4625 DUF4879 DUF4959 DUF4981 DUF4982 DUF4998 DUF5001 DUF5008 DUF5011 DUF5065 DUF5115 DUF525 DUF5643 DUF6383 DUF916 EB_dh ECD EpoR_lig-bind ERAP1_C EstA_Ig_like Expansin_C Filamin FixG_C Flavi_glycop_C FlgD_ig fn3 Fn3-like fn3_2 fn3_4 fn3_5 fn3_6 FN3_7 Fn3_assoc fn3_PAP GBS_Bsp-like Glucodextran_B Glyco_hydro2_C5 Glyco_hydro_2 Gmad2 GMP_PDE_delta GPI-anchored Hanta_G1 He_PIG HECW_N HemeBinding_Shp Hemocyanin_C Herpes_BLLF1 HYR IFNGR1 Ig_GlcNase Ig_mannosidase IL12p40_C Il13Ra_Ig IL17R_fnIII_D1 IL17R_fnIII_D2 IL2RB_N1 IL3Ra_N IL4Ra_N IL6Ra-bind Inhibitor_I42 Inhibitor_I71 InlK_D3 Integrin_alpha2 Interfer-bind Invasin_D3 IRK_C IrmA Iron_transport LEA_2 Lep_receptor_Ig LIFR_N Lipase_bact_N LPMO_10 LRR_adjacent LTD Mannosidase_ig MetallophosC MG1 MG2 MG3 MG4 Mo-co_dimer N_BRCA1_IG Na_K-ATPase NEAT Neocarzinostat Neurexophilin NPCBM_assoc PapD_C PBP-Tp47_c Peptidase_C25_C Phlebo_G2_C PhoD_N PKD PKD_2 PKD_3 PKD_4 PKD_5 PKD_6 Por_Secre_tail Pox_vIL-18BP Psg1 PTP_tm Pur_ac_phosph_N Qn_am_d_aII Qn_am_d_aIII RabGGT_insert Reeler REJ RET_CLD1 RET_CLD3 RET_CLD4 RGI_lyase RHD_dimer Rho_GDI Rib RibLong SCAB-Ig SKICH SLAM SoxZ SprB SusE SVA SWM_repeat T2SS-T3SS_pil_N Tafi-CsgC TarS_C1 TcA_RBD TcfC TIG TIG_2 TIG_plexin TIG_SUH Tissue_fac Top6b_C Transglut_C Transglut_N TRAP_beta TraQ_transposon UL16 Velvet WIF Wzt_C Y_Y_Y YBD ZirS_C Zona_pellucida

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(692)
Full
(11798)
Representative proteomes UniProt
(29252)
RP15
(2131)
RP35
(5272)
RP55
(10717)
RP75
(15322)
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HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(692)
Full
(11798)
Representative proteomes UniProt
(29252)
RP15
(2131)
RP35
(5272)
RP55
(10717)
RP75
(15322)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(692)
Full
(11798)
Representative proteomes UniProt
(29252)
RP15
(2131)
RP35
(5272)
RP55
(10717)
RP75
(15322)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: PFAM-B_2558 (release 23.0)
Previous IDs: DUF3358;
Type: Domain
Sequence Ontology: SO:0000417
Author: Assefa S , Coggill P , Bateman A
Number in seed: 692
Number in full: 11798
Average length of the domain: 292.70 aa
Average identity of full alignment: 20 %
Average coverage of the sequence by the domain: 35.13 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 38.2 38.2
Trusted cut-off 38.2 38.3
Noise cut-off 38.1 38.1
Model length: 315
Family (HMM) version: 10
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the ERAP1_C domain has been found. There are 121 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0B4KH77 View 3D Structure Click here
A0A0R0J526 View 3D Structure Click here
A0A0R0K477 View 3D Structure Click here
A0A0R4ICL9 View 3D Structure Click here
A0A0R4INQ5 View 3D Structure Click here
A0A0R4IZV6 View 3D Structure Click here
A0A1D6H703 View 3D Structure Click here
A0A1D6I2Y6 View 3D Structure Click here
A0A1D6KPN1 View 3D Structure Click here
A0A1D8PQC4 View 3D Structure Click here
A0A286YAT8 View 3D Structure Click here
A0A2R8Q716 View 3D Structure Click here
A0A2R8QBK0 View 3D Structure Click here
A0A2R8RIM7 View 3D Structure Click here
A0A2R8RTV8 View 3D Structure Click here
A2BGR0 View 3D Structure Click here
A4I4T3 View 3D Structure Click here
B8JIB4 View 3D Structure Click here
D3ZZW8 View 3D Structure Click here
E7F123 View 3D Structure Click here
E7F2N2 View 3D Structure Click here
E9AHB1 View 3D Structure Click here
E9QIR0 View 3D Structure Click here
F1M9V7 View 3D Structure Click here
F1Q5Y3 View 3D Structure Click here
F1QRM9 View 3D Structure Click here
G5EGH4 View 3D Structure Click here
H2L0M5 View 3D Structure Click here
I1JTZ0 View 3D Structure Click here
I1K8E3 View 3D Structure Click here
L7N655 View 3D Structure Click here
P15144 View 3D Structure Click here
P15684 View 3D Structure Click here
P16406 View 3D Structure Click here
P32454 View 3D Structure Click here
P37898 View 3D Structure Click here
P40462 View 3D Structure Click here
P50123 View 3D Structure Click here
P55786 View 3D Structure Click here
P97449 View 3D Structure Click here
P97629 View 3D Structure Click here
Q07075 View 3D Structure Click here
Q0J2B5 View 3D Structure Click here
Q0J5V5 View 3D Structure Click here
Q0KI00 View 3D Structure Click here
Q0KI25 View 3D Structure Click here
Q10836 View 3D Structure Click here
Q11011 View 3D Structure Click here
Q17405 View 3D Structure Click here
Q22317 View 3D Structure Click here
Q22531 View 3D Structure Click here
Q22531 View 3D Structure Click here
Q4CPW3 View 3D Structure Click here
Q4D5P1 View 3D Structure Click here
Q4DLT0 View 3D Structure Click here
Q4E686 View 3D Structure Click here
Q4TT88 View 3D Structure Click here
Q557I4 View 3D Structure Click here
Q55CT4 View 3D Structure Click here
Q55CY7 View 3D Structure Click here
Q55CY8 View 3D Structure Click here
Q59KZ1 View 3D Structure Click here
Q6K4E7 View 3D Structure Click here
Q6P179 View 3D Structure Click here
Q6Q4G3 View 3D Structure Click here
Q6Z6L4 View 3D Structure Click here
Q7KRW4 View 3D Structure Click here
Q7PLV6 View 3D Structure Click here
Q8C129 View 3D Structure Click here
Q8IN25 View 3D Structure Click here
Q8INH6 View 3D Structure Click here
Q8IRH1 View 3D Structure Click here
Q8K093 View 3D Structure Click here
Q8MRN5 View 3D Structure Click here
Q8SWX4 View 3D Structure Click here
Q8VZH2 View 3D Structure Click here
Q95SR0 View 3D Structure Click here
Q9EQH2 View 3D Structure Click here
Q9JJ22 View 3D Structure Click here
Q9NZ08 View 3D Structure Click here
Q9U2H2 View 3D Structure Click here
Q9UIQ6 View 3D Structure Click here
Q9UKU6 View 3D Structure Click here
Q9USX1 View 3D Structure Click here
Q9VAM2 View 3D Structure Click here
Q9VD85 View 3D Structure Click here
Q9VD87 View 3D Structure Click here
Q9VFW9 View 3D Structure Click here
Q9VFX0 View 3D Structure Click here
Q9VJN2 View 3D Structure Click here
Q9VTL4 View 3D Structure Click here
Q9VTL4 View 3D Structure Click here
Q9W1S1 View 3D Structure Click here
Q9W2S7 View 3D Structure Click here
Q9W2S8 View 3D Structure Click here