# STOCKHOLM 1.0
#=GF ID   Dsl1_N
#=GF AC   PF11988.9
#=GF DE   Retrograde transport protein Dsl1 N terminal
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Gavin OL;
#=GF SE   pdb_3etu
#=GF GA   25.00 25.00;
#=GF TC   35.60 28.90;
#=GF NC   22.80 19.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   19151722
#=GF RT   Structural characterization of Tip20p and Dsl1p, subunits of the
#=GF RT   Dsl1p vesicle tethering complex.
#=GF RA   Tripathi A, Ren Y, Jeffrey PD, Hughson FM;
#=GF RL   Nat Struct Mol Biol. 2009;16:114-123.
#=GF RN   [2]
#=GF RM   11493604
#=GF RT   The coatomer-interacting protein Dsl1p is required for
#=GF RT   Golgi-to-endoplasmic reticulum retrieval in yeast. 
#=GF RA   Andag U, Neumann T, Schmitt HD; 
#=GF RL   J Biol Chem 2001;276:39150-39160.
#=GF DR   INTERPRO; IPR021875;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Dsl1 is a peripheral membrane protein required for transport
#=GF CC   between the Golgi and the endoplasmic reticulum [1]. It is
#=GF CC   localised to the ER membrane, and in vitro it specifically binds
#=GF CC   to coatomer, the major component of the protein coat of COPI
#=GF CC   vesicles [2]. It is comprised primarily of alpha helical bundles
#=GF CC   [1]. It complexes with another subunit of the Dsl1p complex
#=GF CC   called Tip20 which forms heterodimers by pairing the N termini
#=GF CC   of each protein [1].  A central disorganised region between the
#=GF CC   N and C termini of Dsl1 contains binding sites for coatomer [1].
#=GF CC   The C terminus of Dsl1 contains a binding site to the Sec39
#=GF CC   subunit of the Dsl1p complex [1].
#=GF SQ   13
#=GS C5DYW5_ZYGRC/14-364  AC C5DYW5.1
#=GS G8ZQK5_TORDC/17-366  AC G8ZQK5.1
#=GS A7TF57_VANPO/11-362  AC A7TF57.1
#=GS G8BQ21_TETPH/12-363  AC G8BQ21.1
#=GS Q6FNZ0_CANGA/3-351   AC Q6FNZ0.1
#=GS G0WD68_NAUDC/10-396  AC G0WD68.1
#=GS G0V593_NAUCC/12-369  AC G0V593.1
#=GS H2AUI4_KAZAF/5-354   AC H2AUI4.1
#=GS J7S867_KAZNA/7-376   AC J7S867.1
#=GS I2GW53_TETBL/23-390  AC I2GW53.1
#=GS C5DK93_LACTC/23-365  AC C5DK93.1
#=GS Q6CUS2_KLULA/12-352  AC Q6CUS2.1
#=GS Q6CUS2_KLULA/12-352  DR PDB; 3K8P C; 333-352;
#=GS Q752C3_ASHGO/45-390  AC Q752C3.1
C5DYW5_ZYGRC/14-364             ..SKAEILESLGKD....PLLVNEKESKS...........DNKDDTPVDFEGILKRESSLNQELHDLASLRSISGLIMEFKANFELLELENCYYSLQNLRKKLR......DTSSLTKQSFSFQQSVFSHVDTMHLQLVGKLYEIISQWFWQV.......N.GDSITFKRLV...ELGEDSETMEYVPFITFVEQQYY..PDGFLDPDLWVIRHMKVGS.SQDTVVENLNSILRDYLNSNLMIETIKRFLFAKGGKITWEDLGNT.QKLHFK........QSGTDKVGERISNILNVVSFLNEGITPHDKHALAEKLGPLLANDLLQSVRSNAYSVLHSSDSPL.REEVSLVNEKLKFLSND............TRWNYQSNDVEDLLNDDQVHKNLLLDGVFENYALKIR
G8ZQK5_TORDC/17-366             LADRNGILHQLEDD....PVLINDELREP................SKIDTDAILKREMGLSRELREYTALKTVPSLVLEFKTNLHLLEFENSFYSLQTLRKKLR......DFSEILSQSYGLQRSVATYVDNMHLDLVNSLYSILNDGFWKI.......G.SDFVSFQEKV...AFGNDRVDIDYVDFMASMVSLYF..PQGHLDPKSWIISDMILGT.MQETVRAKLDFILKEYVKLSGVTNLIKSCIFAQSSEALLEDNNKTLKFRQSS........KKGDEKFKETLSSFKNVLQFLTETVVSQDKKILAERLGPSISTELMKSIKANASIIFRPENTHL.RDESLAINLILKDLSEN...........SDIWSYNGSELERLFSNSDIPTNLQVDKILQDQLTELR
A7TF57_VANPO/11-362             VADKERLLQLLRND....PLLSLNDDVEI...............TEKIDLEGLLKLDASLTEELHVLNSLKTIPSLILEFKANMEYLELENCYYSLQNLRKKLK......ENDTLVRQNIRLQQSVATYVDSLHVQLVDKLFDLISNHFWNF.......K.EHTISHKDEI...VYGKDKVKFDYETLLEFVNRDIF..PQNVLDFEHWLIKDMVMGD.LQEIVRERLSTIVKSYILFDSIIHDVKENIFNDKGIFTYDEDSKKLSLVDSR........SKDLDLLTEKLVGFGKLADYLLSCISKRDVVILSSRIGPSIAKESHKLIKENISSILQEQSTSI.KNLILELNDKLLSLSNA..........TNGVWNYSGNETEELLNDKQIYNNLLLDKIFEEQVNRIR
G8BQ21_TETPH/12-363             ..NEQSIKESLLQD....PLLFRNKSGDS..........VDSNSNELLSFESVMNKDTALVAELHDLNSLKQISDLILEFNANWEYIEVENCYYSLLNLRKKLK.....QNDTVLAKQNIRFQQSVITYVESLHLKLIEKVSDLLTEKFWNI.......T.SNSVVYNASV.....ELNNVKFEYKPFLEFLSNELIIENDNILDLNNWFIKDMSLGE.LHNMVRNKMKIILNDYLHFELLLNKLKEALFNSNMKFDYDVNNR..KLSWEE........NYHDVKSKDKLESLTNIVNYMNTELSELNSK.LIEKLSPLVANEFTKLVKGNISEIVQNENL...STTVLTLNESINNLKSF.........TQTASWYFDTAVINDLLKSKEVYNNLILDQILESHLEQLR
Q6FNZ0_CANGA/3-351              YADKDHVITELLKD....PVYLSRHNSLA...............THPKDENDLYALETKLEEELHDLKDLKIVSSLVKETQVNLDLMELENCYYSLYNLSKKLK......SSRSFLKQSLHFQRSVAVHVDELRIKLLSTIYDILATKFWSI.......S.ESSFEFHPDI...KWKEEEFMMKYEEFKSFVSKSFF..PDNAINNSHWLITDIIHSE.EQERMRNKLKDIYINYIDFASLTKAVKDALFSDEYEFEWSDNNY..TKLLIT........KRGALCIQKRIESFNNLLSFLEKGISNSDKFKLLTNLGKAIGIEFLRFVKSNATGIIDKNANSI.KQQTLLLNDRLKTISEQ...........SGAWNFDSDQISKLLNDEILYKSLLLDGVLGRAISDVR
G0WD68_NAUDC/10-396             LSNKDELISSIKDD....LLLLQNKNNITTTGNDAEDDLNVSKMDKTPDVNTILTKETQLATELHDLQQLKTISSLIMEFKTNFELFELENCFYSLQSLRKQIGTITINNNNPSFARQNYHFQRSVIVYIDSLHLDLISRIFEIITLKFWNI.......T.SESISFNPKLNVQTTDGLDVEIAYDSFISSIKNLYF..PNDIIDSEFWIISNVELND.LHESIRNKLQTIFKDYINLDGVSAMIKNAIFTNNKQFKYANNKLSIISSLTS........MNQTDFLTTTIESFQNIITFLNETLPLQDRNILLSKLGNTITTELLKFVKVNISKILNNENSNLMKDQTLKINTELITFAKHFTLSSSSHSGLNNFKNYDGQQIIELLNNNRIYYNLLLDNSLYDQIKQMR
G0V593_NAUCC/12-369             LGNRDALIQSIEQNLETPPLTATHDGNSS...............TQELNRGQLMMKEEQLSSQLHDLNNLKILSGLLIEFKTNFELLELENCFYSLQSIRKRIN....GNNNSSFLKQSFHFQRSVAVYVDTMHSTLIDKIFEIITTKFWQI.......NDTGSIAFHKKI...TYGPEDIDLEYESFIDFVKQQYF..PQNVLDSQLWIISDMDIND.LQENVRGKLQTILKSYIHLNVVIDRIKKSIFTKGKMFDYELGKLLFKDVSNI........TDNQSLLQETIASFTSLVRFFQDILIEDDCITVLTSLGNVISNELTKLVKQNASVILND.NSPL.KDRIIEVSKSLVKLADR..........TKNQWHFNDSEILNILNNEQIYFNLMLDKKFNEALEYMR
H2AUI4_KAZAF/5-354              LPDRETLISLVEQN.....LILKNKNTID...............DPSLEMNKILEEESKLSEELRDLTKLKTISSLLKEVNVNFELLEFENCYYSLKSLRSKLT.....ENNSVFIKQTYRFQRSTALYIDSLHSKLIDSIHEVITTKFWNI.......T.SNTIKFNPKI...KIGDDDVQFDYTEFMSFAKSSFF..TKDTSSSEFWFLATMELGD.YKENVRSKLNDINRNFIEFNNIIGSIKNLIYDDSVNVTYSTQDN..ILSFQK........GESNDYLEKIIEKSQAIVNFLTETFLPNNLYVIVSEVGSLLSTELFKTAKSNASQLLRDRKNPL.IDLVRSINSSLIKLSNE..........IKSNWKYNGSDIDHLLNDEKVYINLLIDKTFDAEIKMLR
J7S867_KAZNA/7-376              .PEREEVLLSVERD....PIFQGENGADV.........AASNYTQLTERIREVVAQEAQLGSMLHDLSVLKTFGDLLNEFNTNLAKSLFQDCYRALQTLRQKLN.....TSRDCFVKQPLHFQRSLMNYIDELHLTLIERIYEIISTDFWSV.......T.HDSITFHNKI..VCSEGSGGQFEYRQFMELVKKLFFWDDGEISTEDTWFLKDMDLNNPSSNIVRNKLSEISKNYLELNEIVVNLKRGIFDNSIKFEFQAESCTLSFTKVKNAIPNSSGSYNKAALASVVESINALADFLMQCIDGNDLVIILSKLGPLLSNELLNFLRKNATVILRDSDPSI.REGIVLINNRFGVLASK..........SNGFWNHNRNDIEHLLNDKQLYINLLVDDAFAKTFKEIR
I2GW53_TETBL/23-390             .NNRDILVASIKND....IESTIEDSPTQ.......PPTIETHIKAHIDPFVIQQEDTQLSNDLYELNKLKTITSLIMEFKTNYELMEYENCYYSLQNLRKKIH......ENEPILVKNYHLKQSLSSYADGLHVQLIEAIHSLVSKGFWKIPTVSASDNQNVSIEFQKII...HWGNGHIEFEYEFFIDFLRDALF..PDSKFDLQNWLITELVSTD.LQQIVKDNMDSLFNEYIQFSTLVHVLKTGIMNRNYSIVLTGEASNIINLQTK........LNSKSSIQDYLYSLENIIEYLKNTLLERDSITIFNQIGNYFFNEIIKLIKSNTYIILEDDGNDILKSQISKICNTLSFLSKR..........NTSIWKFDEDEITHLLNNRQLQSNLLVDKLFETKITTIR
C5DK93_LACTC/23-365             LNDQDAILAGIESD....PNLKMEGSARR...............EEPSDVQAILNQDVQLSKKLGALKELNLVANLIDEFKANFELWELENCYYSLQNLHKRLE....KVDMSLFPIQ...FQGLLKVHIDSLHVDLLSRIDKVMRQ.FWDI.......S.ARSVTFNQKI...AVDRDDVLLEYDSFSLFLKSCFF..SQDHFEPTSWFVATMNMGD.AKDKVTNLLATAFNEWVRLQTVQEKLKQFLFSANVCLSLK......GCTLGA........SENPGNLDDTLKSFEALVMFMKDVTTAEDTAVILAKLGNTLLTEIVKFVKQNSSHLFAPGTNY..KNSVVSLNTMLTELSHK..........GGKSWQYAGRELDNLINDDSVINNLMLDKLLQEQISAIR
Q6CUS2_KLULA/12-352             LSDTSALSQAIEAD....PQFKSSDSVHP..............KPNSKLLEEVLREDSDLTKDLAKYNQYKILSDLLKEFNTNYELNELENCYYSLQNIHKKFK.......DVNISGESFRFQQSVATYIDCLHLNVLERFKEV.SNMFYTI.......S.GNEMMFKKTI.....ELDSVEFNFDEMVELFENNFF..DHNMIDQTHWFIASTNLET.YKDKEIVLLQEILDDTVKLNPLIKFFKEFVFDEKCIMVRAE.....PGKLTL........ATSEYNSLDQIKSYQTLTTFIENDLSKHAKESVMIHFGNVLLTELLKIIRANPELLSNDKEQT..TEIISSIHDSLTKISEE............TEWAYDGFELNRILKDENIYTTLKFESMMQQRVIQIR
#=GR Q6CUS2_KLULA/12-352  SS    XXXXXXXXXXXXXX....XXXXXXXXXXX..............XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.......XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXX.......X.XXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXX........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXX............XXXXXXXXXXXXXXXXX--HHHHHHHHHHHHHHHHHH
Q752C3_ASHGO/45-390             LGNPMQVLAAIEDD....PSLWLDSSEKK...............PNHLALQELKQRDVEVTKTLQQHLRLKIVADLLIKYNSEIQCAEFTAAFETLRQCVQKAK.......SADVSAHGVRFEQAFNTYLSGLHAVFVRKLQGLLEE.VWHI.......H.DDGFSFQQQVSEKLDDAREHNFDYDTLVDMFNSCFL..KDGDIDERSWFFKNISMPD.VRDDVKQCVNSTYNNYIKLSQVKENLKGFLFSDSLRISCS......GTRLHV........DQGCETPAAKVESYVVLADYLLNVLSPVASNQILMTLGGAIVTEATKLLKQHSKELLSKEANQ..KKDLAHFNDTLVKLSSR..........KGSSWTYNGNALDKLLNDPETFATLMFEQHVHLHLLKLR
#=GC SS_cons                    XXXXXXXXXXXXXX....XXXXXXXXXXX..............XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.......XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXX.......X.XXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXX........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXX............XXXXXXXXXXXXXXXXX--HHHHHHHHHHHHHHHHHH
#=GC seq_cons                   lss+-pllpulcpD....Pllhpccsscs...............sppl-hpsllpc-spLop-L+-LspLKplouLlhEFpsNaELhElENCYYSLQsLRKKL+......sssshs+Qsh+FQpSVssYlDsLHlpLlc+la-lloptFWsI.......s.ssSlsFppcI...thst-clph-Y-sFlsFlcspaF..spshlD.ppWhIscMsls-.hp-pVRs+LssIhcsYlchssllcplKpslFscshphsassps...ttphsp........spsssplp-plcSapsllsFLppslstpDphhlls+LGsslusElhKhlKsNuotILpcpsssl.+cpllplNspLtpLSpc...........sstWsYsus-lpcLLNDcplYpNLllDphhppplpplR
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