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144  structures 8136  species 0  interactions 43818  sequences 429  architectures

Family: Hydrolase_4 (PF12146)

Summary: Serine aminopeptidase, S33

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Serine aminopeptidase, S33 Provide feedback

This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with PF00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR022742

This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. The majority of the members in this entry carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in SWISSPROT .

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(75)
Full
(43818)
Representative proteomes UniProt
(170086)
RP15
(5895)
RP35
(20336)
RP55
(41348)
RP75
(69428)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(75)
Full
(43818)
Representative proteomes UniProt
(170086)
RP15
(5895)
RP35
(20336)
RP55
(41348)
RP75
(69428)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(75)
Full
(43818)
Representative proteomes UniProt
(170086)
RP15
(5895)
RP35
(20336)
RP55
(41348)
RP75
(69428)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: PFAM-B_2243 (release 23.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Assefa S
Number in seed: 75
Number in full: 43818
Average length of the domain: 190.60 aa
Average identity of full alignment: 16 %
Average coverage of the sequence by the domain: 57.54 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.0 27.0
Noise cut-off 26.9 26.9
Model length: 239
Family (HMM) version: 10
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Hydrolase_4 domain has been found. There are 144 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0N7KCU7 View 3D Structure Click here
A0A0N7KCU9 View 3D Structure Click here
A0A0P0V6T5 View 3D Structure Click here
A0A0P0VA40 View 3D Structure Click here
A0A0P0VG76 View 3D Structure Click here
A0A0P0WLL3 View 3D Structure Click here
A0A0P0XQC2 View 3D Structure Click here
A0A0R0EP12 View 3D Structure Click here
A0A0R0F6S0 View 3D Structure Click here
A0A0R0G7N3 View 3D Structure Click here
A0A0R0GYE0 View 3D Structure Click here
A0A0R0H139 View 3D Structure Click here
A0A0R0J7Z0 View 3D Structure Click here
A0A0R0K1E0 View 3D Structure Click here
A0A0R0KR96 View 3D Structure Click here
A0A0R4IR37 View 3D Structure Click here
A0A0R4J3Q5 View 3D Structure Click here
A0A0R4J4M5 View 3D Structure Click here
A0A143ZYA4 View 3D Structure Click here
A0A1D6EEF7 View 3D Structure Click here
A0A1D6EFU2 View 3D Structure Click here
A0A1D6G2H2 View 3D Structure Click here
A0A1D6G8Q9 View 3D Structure Click here
A0A1D6GJ05 View 3D Structure Click here
A0A1D6H339 View 3D Structure Click here
A0A1D6I3V4 View 3D Structure Click here
A0A1D6I888 View 3D Structure Click here
A0A1D6J713 View 3D Structure Click here
A0A1D6K3R1 View 3D Structure Click here
A0A1D6K8I4 View 3D Structure Click here
A0A1D6KBA0 View 3D Structure Click here
A0A1D6LEV6 View 3D Structure Click here
A0A1D6LIQ4 View 3D Structure Click here
A0A1D6LIT5 View 3D Structure Click here
A0A1D6LS00 View 3D Structure Click here
A0A1D6MGD2 View 3D Structure Click here
A0A1D6MS65 View 3D Structure Click here
A0A1D6MT51 View 3D Structure Click here
A0A1D6MTI2 View 3D Structure Click here
A0A1D6N7M7 View 3D Structure Click here
A0A1D6NF31 View 3D Structure Click here
A0A1D6NKD9 View 3D Structure Click here
A0A1D6P4C5 View 3D Structure Click here
A0A1D6PID0 View 3D Structure Click here
A0A1D8PEQ8 View 3D Structure Click here
A0A1D8PR14 View 3D Structure Click here
A0A1D8PU91 View 3D Structure Click here
A0A1I9LSS3 View 3D Structure Click here
A0A1P8B9I4 View 3D Structure Click here
A0A1P8BG34 View 3D Structure Click here
A0A2R8QG70 View 3D Structure Click here
A0A2R8QQD0 View 3D Structure Click here
A0A368UGV3 View 3D Structure Click here
A0A368UH84 View 3D Structure Click here
A0A5K1K859 View 3D Structure Click here
A1ZBH3 View 3D Structure Click here
A3BYJ4 View 3D Structure Click here
A4I567 View 3D Structure Click here
A4I6N9 View 3D Structure Click here
A4IBE6 View 3D Structure Click here
A4IBU0 View 3D Structure Click here
A8E7G9 View 3D Structure Click here
B4F7W5 View 3D Structure Click here
B4FK75 View 3D Structure Click here
B4FMQ7 View 3D Structure Click here
B4FRE0 View 3D Structure Click here
B4FUQ1 View 3D Structure Click here
B5DFK7 View 3D Structure Click here
B6SVG4 View 3D Structure Click here
C0H4Q4 View 3D Structure Click here
C0H4R4 View 3D Structure Click here
C0PHP5 View 3D Structure Click here
C0PJN3 View 3D Structure Click here
C4JBK5 View 3D Structure Click here
C6TML4 View 3D Structure Click here
D3ZUQ1 View 3D Structure Click here
D4A1B6 View 3D Structure Click here
E7FGL4 View 3D Structure Click here
F1R0S2 View 3D Structure Click here
F4I353 View 3D Structure Click here
F4IZK0 View 3D Structure Click here
F4J341 View 3D Structure Click here
F4JBL2 View 3D Structure Click here
F4JDQ6 View 3D Structure Click here
F4JUP6 View 3D Structure Click here
F6RR30 View 3D Structure Click here
G3UZN6 View 3D Structure Click here
I1J6J7 View 3D Structure Click here
I1JQM5 View 3D Structure Click here
I1JRC3 View 3D Structure Click here
I1JUW8 View 3D Structure Click here
I1JXE1 View 3D Structure Click here
I1K067 View 3D Structure Click here
I1K2L6 View 3D Structure Click here
I1KC89 View 3D Structure Click here
I1KN70 View 3D Structure Click here
I1L419 View 3D Structure Click here
I1L419 View 3D Structure Click here
I1L4C4 View 3D Structure Click here
I1LD14 View 3D Structure Click here
I1LD56 View 3D Structure Click here
I1LEK1 View 3D Structure Click here
I1LFD8 View 3D Structure Click here
I1LX24 View 3D Structure Click here
I1LY02 View 3D Structure Click here
I1LZL9 View 3D Structure Click here
I1M929 View 3D Structure Click here
I1MI16 View 3D Structure Click here
I1MLC9 View 3D Structure Click here
I1MLR6 View 3D Structure Click here
I1MSG4 View 3D Structure Click here
I1MSK5 View 3D Structure Click here
I1MSK5 View 3D Structure Click here
I1MUK7 View 3D Structure Click here
I1N4S9 View 3D Structure Click here
I1N6H0 View 3D Structure Click here
I1N6U0 View 3D Structure Click here
I1NFJ7 View 3D Structure Click here
I1NHC0 View 3D Structure Click here
K7KTZ0 View 3D Structure Click here
K7L0K3 View 3D Structure Click here
K7L417 View 3D Structure Click here
K7L8U0 View 3D Structure Click here
K7LBB5 View 3D Structure Click here
K7LC59 View 3D Structure Click here
K7LLR9 View 3D Structure Click here
K7LVQ8 View 3D Structure Click here
K7LXQ1 View 3D Structure Click here
K7LXV6 View 3D Structure Click here
K7LYV1 View 3D Structure Click here
K7MAZ0 View 3D Structure Click here
K7MJ87 View 3D Structure Click here
K7MNG1 View 3D Structure Click here
K7MWQ6 View 3D Structure Click here
K7MXK9 View 3D Structure Click here
K7N020 View 3D Structure Click here
K7N361 View 3D Structure Click here
K7N5C9 View 3D Structure Click here
K7VEI4 View 3D Structure Click here
K7VKQ2 View 3D Structure Click here
O04083 View 3D Structure Click here
O05805 View 3D Structure Click here
O07427 View 3D Structure Click here
O22248 View 3D Structure Click here
O35678 View 3D Structure Click here
O53321 View 3D Structure Click here
O76462 View 3D Structure Click here
O80627 View 3D Structure Click here
O80628 View 3D Structure Click here
O94305 View 3D Structure Click here
P28321 View 3D Structure Click here
P42840 View 3D Structure Click here
P54069 View 3D Structure Click here
P76092 View 3D Structure Click here
P77538 View 3D Structure Click here
P87056 View 3D Structure Click here
P9WLC7 View 3D Structure Click here
Q07379 View 3D Structure Click here
Q0DGD6 View 3D Structure Click here
Q0JK71 View 3D Structure Click here
Q0JN90 View 3D Structure Click here
Q21221 View 3D Structure Click here
Q2FXG5 View 3D Structure Click here
Q2FYZ3 View 3D Structure Click here
Q2G025 View 3D Structure Click here
Q2G0V7 View 3D Structure Click here
Q2QTQ5 View 3D Structure Click here
Q2QUI2 View 3D Structure Click here
Q2QXL8 View 3D Structure Click here
Q2QYZ9 View 3D Structure Click here
Q32LS6 View 3D Structure Click here
Q33B71 View 3D Structure Click here
Q4CQ95 View 3D Structure Click here
Q4CSM0 View 3D Structure Click here
Q4D8H9 View 3D Structure Click here
Q4DBN1 View 3D Structure Click here
Q4DHN8 View 3D Structure Click here
Q4DHV2 View 3D Structure Click here
Q4DVR5 View 3D Structure Click here
Q4DZP6 View 3D Structure Click here
Q4E4T5 View 3D Structure Click here
Q4VWY7 View 3D Structure Click here
Q54CT5 View 3D Structure Click here
Q556N4 View 3D Structure Click here
Q55EQ3 View 3D Structure Click here
Q59K70 View 3D Structure Click here
Q59U61 View 3D Structure Click here
Q5ALW7 View 3D Structure Click here
Q5AMS7 View 3D Structure Click here
Q5FC17 View 3D Structure Click here
Q5N7J6 View 3D Structure Click here
Q5XIJ5 View 3D Structure Click here
Q5ZC21 View 3D Structure Click here
Q5ZC24 View 3D Structure Click here
Q656F2 View 3D Structure Click here
Q69XI0 View 3D Structure Click here
Q6ASW1 View 3D Structure Click here
Q6AY17 View 3D Structure Click here
Q6AYT7 View 3D Structure Click here
Q6NKN2 View 3D Structure Click here
Q6PCB6 View 3D Structure Click here
Q6YUU0 View 3D Structure Click here
Q6ZCV6 View 3D Structure Click here
Q75JJ5 View 3D Structure Click here
Q7F959 View 3D Structure Click here
Q7JKU8 View 3D Structure Click here
Q7L211 View 3D Structure Click here
Q7M759 View 3D Structure Click here
Q7Z5M8 View 3D Structure Click here
Q7ZVZ7 View 3D Structure Click here
Q7ZWC2 View 3D Structure Click here
Q80UX8 View 3D Structure Click here
Q84JV3 View 3D Structure Click here
Q84SE0 View 3D Structure Click here
Q86I88 View 3D Structure Click here
Q8GWG9 View 3D Structure Click here
Q8H4S9 View 3D Structure Click here
Q8I1Z1 View 3D Structure Click here
Q8I2E8 View 3D Structure Click here
Q8I2F3 View 3D Structure Click here
Q8I2F3 View 3D Structure Click here
Q8I4R0 View 3D Structure Click here
Q8I4R0 View 3D Structure Click here
Q8IB95 View 3D Structure Click here
Q8IBZ2 View 3D Structure Click here
Q8IC45 View 3D Structure Click here
Q8IC45 View 3D Structure Click here
Q8IIG3 View 3D Structure Click here
Q8IJ22 View 3D Structure Click here
Q8IK20 View 3D Structure Click here
Q8IK22 View 3D Structure Click here
Q8IK68 View 3D Structure Click here
Q8IK69 View 3D Structure Click here
Q8ILZ4 View 3D Structure Click here
Q8IM74 View 3D Structure Click here
Q8IM74 View 3D Structure Click here
Q8IM75 View 3D Structure Click here
Q8N2K0 View 3D Structure Click here
Q8R431 View 3D Structure Click here
Q8RX69 View 3D Structure Click here
Q8RXN7 View 3D Structure Click here
Q8VCV1 View 3D Structure Click here
Q8VYJ0 View 3D Structure Click here
Q8VYT1 View 3D Structure Click here
Q8VZV6 View 3D Structure Click here
Q94AM5 View 3D Structure Click here
Q94D81 View 3D Structure Click here
Q94DD0 View 3D Structure Click here
Q965S2 View 3D Structure Click here
Q96GS6 View 3D Structure Click here
Q99685 View 3D Structure Click here
Q99JW1 View 3D Structure Click here
Q99LR1 View 3D Structure Click here
Q9AWW1 View 3D Structure Click here
Q9C942 View 3D Structure Click here
Q9FF34 View 3D Structure Click here
Q9FMQ5 View 3D Structure Click here
Q9FVW6 View 3D Structure Click here
Q9FZ68 View 3D Structure Click here
Q9LFQ7 View 3D Structure Click here
Q9LTX5 View 3D Structure Click here
Q9LY90 View 3D Structure Click here
Q9LYG5 View 3D Structure Click here
Q9M3D0 View 3D Structure Click here
Q9M3D1 View 3D Structure Click here
Q9S7U7 View 3D Structure Click here
Q9SB70 View 3D Structure Click here
Q9SN79 View 3D Structure Click here
Q9U1Z6 View 3D Structure Click here
Q9XVA7 View 3D Structure Click here
Q9ZUN7 View 3D Structure Click here