Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
481  structures 7230  species 0  interactions 74762  sequences 630  architectures

Family: Abhydrolase_6 (PF12697)

Summary: Alpha/beta hydrolase family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Alpha/beta hydrolase fold". More...

Alpha/beta hydrolase fold Edit Wikipedia article

  • From a page move: This is a redirect from a page that has been moved (renamed). This page was kept as a redirect to avoid breaking links, both internal and external, that may have been made to the old page name.

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Alpha/beta hydrolase family Provide feedback

This family contains alpha/beta hydrolase enzymes of diverse specificity.

Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000073

The alpha/beta hydrolase fold [ PUBMED:1409539 ] is common to a number of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of each enzyme is an alpha/beta-sheet (rather than a barrel), containing 8 strands connected by helices [ PUBMED:1409539 ]. The enzymes are believed to have diverged from a common ancestor, preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best conserved structural features of the fold. Esterase (EST) from Pseudomonas putida is a member of the alpha/beta hydrolase fold superfamily of enzymes [ PUBMED:16321951 ].

In most of the family members the beta-strands are parallels, but some have an inversion of the first strands, which gives it an antiparallel orientation. The catalytic triad residues are presented on loops. One of these is the nucleophile elbow and is the most conserved feature of the fold. Some other members lack one or all of the catalytic residues. Some members are therefore inactive but others are involved in surface recognition. The ESTHER database [ PUBMED:14681380 ] gathers and annotates all the published information related to gene and protein sequences of this superfamily [ PUBMED:14681380 ].

This entry represents fold-1 of alpha/beta hydrolase.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(392)
Full
(74762)
Representative proteomes UniProt
(256144)
RP15
(7388)
RP35
(30867)
RP55
(69467)
RP75
(120515)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(392)
Full
(74762)
Representative proteomes UniProt
(256144)
RP15
(7388)
RP35
(30867)
RP55
(69467)
RP75
(120515)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(392)
Full
(74762)
Representative proteomes UniProt
(256144)
RP15
(7388)
RP35
(30867)
RP55
(69467)
RP75
(120515)
Raw Stockholm Download   Download   Download   Download   Download      
Gzipped Download   Download   Download   Download   Download      

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:Q186D8_CLOD6
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 392
Number in full: 74762
Average length of the domain: 240.40 aa
Average identity of full alignment: 14 %
Average coverage of the sequence by the domain: 75.35 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.3 26.3
Trusted cut-off 26.3 26.3
Noise cut-off 26.2 26.2
Model length: 220
Family (HMM) version: 9
Download: download the raw HMM for this family

Species distribution

Sunburst controls

Hide

Weight segments by...


Change the size of the sunburst

Small
Large

Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

Align selected sequences to HMM

Generate a FASTA-format file

Clear selection

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls

Hide

The tree shows the occurrence of this domain across different species. More...

Loading...

Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Abhydrolase_6 domain has been found. There are 481 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2KLD8 View 3D Structure Click here
A0A0N7KNQ7 View 3D Structure Click here
A0A0N7KUF3 View 3D Structure Click here
A0A0P0VKU6 View 3D Structure Click here
A0A0P0VL05 View 3D Structure Click here
A0A0P0WA76 View 3D Structure Click here
A0A0P0WLG3 View 3D Structure Click here
A0A0P0Y2E9 View 3D Structure Click here
A0A0R0F173 View 3D Structure Click here
A0A0R0FX16 View 3D Structure Click here
A0A0R0FZI3 View 3D Structure Click here
A0A0R0H3N4 View 3D Structure Click here
A0A0R0HJA9 View 3D Structure Click here
A0A0R0J288 View 3D Structure Click here
A0A0R0JZ89 View 3D Structure Click here
A0A0R0KSE4 View 3D Structure Click here
A0A0R0KSW6 View 3D Structure Click here
A0A1D6E9W6 View 3D Structure Click here
A0A1D6EBM3 View 3D Structure Click here
A0A1D6EIZ2 View 3D Structure Click here
A0A1D6EPY8 View 3D Structure Click here
A0A1D6F0J0 View 3D Structure Click here
A0A1D6GZY7 View 3D Structure Click here
A0A1D6HBN0 View 3D Structure Click here
A0A1D6I9S4 View 3D Structure Click here
A0A1D6IHR0 View 3D Structure Click here
A0A1D6JQE3 View 3D Structure Click here
A0A1D6JQE5 View 3D Structure Click here
A0A1D6K4T4 View 3D Structure Click here
A0A1D6K6X4 View 3D Structure Click here
A0A1D6KGV8 View 3D Structure Click here
A0A1D6KRT1 View 3D Structure Click here
A0A1D6LZZ6 View 3D Structure Click here
A0A1D6MEA6 View 3D Structure Click here
A0A1D6N247 View 3D Structure Click here
A0A1D6N249 View 3D Structure Click here
A0A1D6N250 View 3D Structure Click here
A0A1D6N251 View 3D Structure Click here
A0A1D6N5C2 View 3D Structure Click here
A0A1D6N6L0 View 3D Structure Click here
A0A1D6N9M8 View 3D Structure Click here
A0A1D6NQW1 View 3D Structure Click here
A0A1D6Q835 View 3D Structure Click here
A0A1D6QGM6 View 3D Structure Click here
A0A1D6QGN0 View 3D Structure Click here
A0A1I9LMU3 View 3D Structure Click here
A0A368UI94 View 3D Structure Click here
A4HVP2 View 3D Structure Click here
A4HWS5 View 3D Structure Click here
A4I052 View 3D Structure Click here
A4I286 View 3D Structure Click here
A4I4Z6 View 3D Structure Click here
A4I7Q7 View 3D Structure Click here
A4IJ41 View 3D Structure Click here
A8MQE3 View 3D Structure Click here
A8MRK8 View 3D Structure Click here
B4F8S1 View 3D Structure Click here
B4FB63 View 3D Structure Click here
B4FG65 View 3D Structure Click here
B4FGW5 View 3D Structure Click here
B4FHV3 View 3D Structure Click here
B4FI57 View 3D Structure Click here
B4FMK4 View 3D Structure Click here
B4FNJ4 View 3D Structure Click here
B4G163 View 3D Structure Click here
B6TRW7 View 3D Structure Click here
B9G928 View 3D Structure Click here
C0P7Z1 View 3D Structure Click here
C0P9M6 View 3D Structure Click here
C0PEF2 View 3D Structure Click here
C0PNM1 View 3D Structure Click here
C6TDC4 View 3D Structure Click here
C6TLG3 View 3D Structure Click here
D3ZXK4 View 3D Structure Click here
D4A4W4 View 3D Structure Click here
E7F054 View 3D Structure Click here
E7F881 View 3D Structure Click here
E7F9Y7 View 3D Structure Click here
E9QD39 View 3D Structure Click here
F4I0K9 View 3D Structure Click here
F4IDE6 View 3D Structure Click here
F4IE65 View 3D Structure Click here
F4IEK5 View 3D Structure Click here
F4IMK2 View 3D Structure Click here
F4IMK4 View 3D Structure Click here
F4JKY3 View 3D Structure Click here
F4JRA6 View 3D Structure Click here
F4K2M9 View 3D Structure Click here
F4KA67 View 3D Structure Click here
F4KBJ3 View 3D Structure Click here
I1J464 View 3D Structure Click here
I1J5Z8 View 3D Structure Click here
I1J9C0 View 3D Structure Click here
I1JAK1 View 3D Structure Click here
I1JAK7 View 3D Structure Click here
I1JCW4 View 3D Structure Click here
I1JCW9 View 3D Structure Click here
I1JH58 View 3D Structure Click here
I1JQ43 View 3D Structure Click here
I1JQE4 View 3D Structure Click here
I1JUT3 View 3D Structure Click here
I1JYD1 View 3D Structure Click here
I1JZE9 View 3D Structure Click here
I1K217 View 3D Structure Click here
I1K2B0 View 3D Structure Click here
I1K9B3 View 3D Structure Click here
I1KB51 View 3D Structure Click here
I1KB59 View 3D Structure Click here
I1KFZ3 View 3D Structure Click here
I1KGZ1 View 3D Structure Click here
I1KH49 View 3D Structure Click here
I1KIU3 View 3D Structure Click here
I1KT03 View 3D Structure Click here
I1KVA9 View 3D Structure Click here
I1KVG4 View 3D Structure Click here
I1KWG6 View 3D Structure Click here
I1L4F3 View 3D Structure Click here
I1L5J6 View 3D Structure Click here
I1L9C6 View 3D Structure Click here
I1LA04 View 3D Structure Click here
I1LG41 View 3D Structure Click here
I1LG50 View 3D Structure Click here
I1LH91 View 3D Structure Click here
I1LHI0 View 3D Structure Click here
I1LNZ2 View 3D Structure Click here
I1LTV2 View 3D Structure Click here
I1LVY4 View 3D Structure Click here
I1LZ13 View 3D Structure Click here
I1LZJ5 View 3D Structure Click here
I1M5Q5 View 3D Structure Click here
I1MCJ1 View 3D Structure Click here
I1MNE2 View 3D Structure Click here
I1MNL5 View 3D Structure Click here
I1MTT3 View 3D Structure Click here
I1MVQ0 View 3D Structure Click here
I1MY81 View 3D Structure Click here
I1N4M1 View 3D Structure Click here
I1N5B6 View 3D Structure Click here
I1NAQ3 View 3D Structure Click here
I1NDY7 View 3D Structure Click here
I1NID8 View 3D Structure Click here
I6XU97 View 3D Structure Click here
I6Y1I1 View 3D Structure Click here
I6YCQ4 View 3D Structure Click here
I6YGL1 View 3D Structure Click here
K7K6S4 View 3D Structure Click here
K7K6S5 View 3D Structure Click here
K7KTB0 View 3D Structure Click here
K7KTV2 View 3D Structure Click here
K7L147 View 3D Structure Click here
K7LFK6 View 3D Structure Click here
K7LW21 View 3D Structure Click here
K7MNL1 View 3D Structure Click here
K7N0Z1 View 3D Structure Click here
K7N5A5 View 3D Structure Click here
K7USI8 View 3D Structure Click here
K7VBZ2 View 3D Structure Click here
K7VKR9 View 3D Structure Click here
K7VM64 View 3D Structure Click here
K7VQD8 View 3D Structure Click here
K7VSH0 View 3D Structure Click here
K7VVA6 View 3D Structure Click here
K7WEE6 View 3D Structure Click here
L0TC47 View 3D Structure Click here
O06338 View 3D Structure Click here
O06575 View 3D Structure Click here
O06576 View 3D Structure Click here
O13912 View 3D Structure Click here
O23171 View 3D Structure Click here
O23227 View 3D Structure Click here
O23512 View 3D Structure Click here
O33185 View 3D Structure Click here
O53363 View 3D Structure Click here
O53388 View 3D Structure Click here
O80472 View 3D Structure Click here
O80474 View 3D Structure Click here
O80475 View 3D Structure Click here
O80476 View 3D Structure Click here
O80477 View 3D Structure Click here
O86348 View 3D Structure Click here
P37355 View 3D Structure Click here
P75736 View 3D Structure Click here
P75895 View 3D Structure Click here
P77044 View 3D Structure Click here
P9WLR1 View 3D Structure Click here
P9WNH1 View 3D Structure Click here
P9WNH3 View 3D Structure Click here
Q0D4Q8 View 3D Structure Click here
Q0D4U5 View 3D Structure Click here
Q0DJY2 View 3D Structure Click here
Q0IQJ8 View 3D Structure Click here
Q0IWN4 View 3D Structure Click here
Q0JCY4 View 3D Structure Click here
Q0JG98 View 3D Structure Click here
Q0JG99 View 3D Structure Click here
Q10J20 View 3D Structure Click here
Q10N00 View 3D Structure Click here
Q10QA5 View 3D Structure Click here
Q10QZ0 View 3D Structure Click here
Q10SN6 View 3D Structure Click here
Q12405 View 3D Structure Click here
Q1L8N7 View 3D Structure Click here
Q1LV46 View 3D Structure Click here
Q2FZL6 View 3D Structure Click here
Q2QYI3 View 3D Structure Click here
Q2QYJ1 View 3D Structure Click here
Q2RBB3 View 3D Structure Click here
Q3V1F8 View 3D Structure Click here
Q4CWX5 View 3D Structure Click here
Q4DLU0 View 3D Structure Click here
Q4DPT2 View 3D Structure Click here
Q4DPY4 View 3D Structure Click here
Q4DQM2 View 3D Structure Click here
Q4DTI8 View 3D Structure Click here
Q4DY49 View 3D Structure Click here
Q4FZT2 View 3D Structure Click here
Q4PSL3 View 3D Structure Click here
Q501F6 View 3D Structure Click here
Q54EK1 View 3D Structure Click here
Q54QE7 View 3D Structure Click here
Q54TN3 View 3D Structure Click here
Q59LU6 View 3D Structure Click here
Q5I0C4 View 3D Structure Click here
Q5JMQ8 View 3D Structure Click here
Q5N8H1 View 3D Structure Click here
Q5NBT2 View 3D Structure Click here
Q5VQE5 View 3D Structure Click here
Q5XI64 View 3D Structure Click here
Q60DW4 View 3D Structure Click here
Q60EW8 View 3D Structure Click here
Q652J5 View 3D Structure Click here
Q69XR3 View 3D Structure Click here
Q6DGG1 View 3D Structure Click here
Q6ES31 View 3D Structure Click here
Q6ESF3 View 3D Structure Click here
Q6L556 View 3D Structure Click here
Q6MX03 View 3D Structure Click here
Q6NL07 View 3D Structure Click here
Q6YVH6 View 3D Structure Click here
Q6ZC62 View 3D Structure Click here
Q7T387 View 3D Structure Click here
Q7XTM8 View 3D Structure Click here
Q7XVG5 View 3D Structure Click here
Q7ZV37 View 3D Structure Click here
Q84JL7 View 3D Structure Click here
Q8BVQ5 View 3D Structure Click here
Q8H025 View 3D Structure Click here
Q8K4F5 View 3D Structure Click here
Q8NFV4 View 3D Structure Click here
Q8R2Y0 View 3D Structure Click here
Q8RXC1 View 3D Structure Click here
Q8S0U8 View 3D Structure Click here
Q8S0V0 View 3D Structure Click here
Q8S125 View 3D Structure Click here
Q8S8S9 View 3D Structure Click here
Q8S9K8 View 3D Structure Click here
Q8VCR7 View 3D Structure Click here
Q8VXV0 View 3D Structure Click here
Q8VZ57 View 3D Structure Click here
Q8W3F1 View 3D Structure Click here
Q8W3F4 View 3D Structure Click here
Q91ZH7 View 3D Structure Click here
Q922Q6 View 3D Structure Click here
Q940H7 View 3D Structure Click here
Q94F26 View 3D Structure Click here
Q95R98 View 3D Structure Click here
Q96IU4 View 3D Structure Click here
Q9AS70 View 3D Structure Click here
Q9BIB3 View 3D Structure Click here
Q9BUJ0 View 3D Structure Click here
Q9C913 View 3D Structure Click here
Q9C914 View 3D Structure Click here
Q9C915 View 3D Structure Click here
Q9C976 View 3D Structure Click here
Q9FFZ1 View 3D Structure Click here
Q9FJ29 View 3D Structure Click here
Q9FLL7 View 3D Structure Click here
Q9FVW3 View 3D Structure Click here
Q9FWB5 View 3D Structure Click here
Q9FWB6 View 3D Structure Click here
Q9H6B9 View 3D Structure Click here
Q9LFT6 View 3D Structure Click here
Q9LNR2 View 3D Structure Click here
Q9LVL9 View 3D Structure Click here
Q9M9P1 View 3D Structure Click here
Q9M9W5 View 3D Structure Click here
Q9N366 View 3D Structure Click here
Q9P7D2 View 3D Structure Click here
Q9S7P1 View 3D Structure Click here
Q9SG92 View 3D Structure Click here
Q9SJM9 View 3D Structure Click here
Q9SQR3 View 3D Structure Click here
Q9SZU7 View 3D Structure Click here
Q9T0G1 View 3D Structure Click here
Q9VD00 View 3D Structure Click here
Q9VGJ4 View 3D Structure Click here
Q9VP50 View 3D Structure Click here
Q9W048 View 3D Structure Click here
Q9XI20 View 3D Structure Click here
Q9Y570 View 3D Structure Click here
Q9ZVN2 View 3D Structure Click here