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297  structures 7983  species 0  interactions 114355  sequences 3325  architectures

Family: AMP-binding_C (PF13193)

Summary: AMP-binding enzyme C-terminal domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

AMP-binding enzyme C-terminal domain Provide feedback

This is a small domain that is found C terminal to PF00501. It has a central beta sheet core that is flanked by alpha helices.

Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR025110

This is a small domain that is found C-terminal to INTERPRO . It has a central beta sheet core that is flanked by alpha helices.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan AMP-binding_C (CL0531), which has the following description:

This superfamily contains domains found at the C-terminus of AMP-binding enzyme.

The clan contains the following 2 members:

AMP-binding_C AMP-binding_C_2

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(246)
Full
(114355)
Representative proteomes UniProt
(471055)
RP15
(11786)
RP35
(47397)
RP55
(109956)
RP75
(196945)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(246)
Full
(114355)
Representative proteomes UniProt
(471055)
RP15
(11786)
RP35
(47397)
RP55
(109956)
RP75
(196945)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(246)
Full
(114355)
Representative proteomes UniProt
(471055)
RP15
(11786)
RP35
(47397)
RP55
(109956)
RP75
(196945)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:O26318
Previous IDs: DUF4009;
Type: Domain
Sequence Ontology: SO:0000417
Author: Mistry J , Eberhardt R
Number in seed: 246
Number in full: 114355
Average length of the domain: 77.10 aa
Average identity of full alignment: 29 %
Average coverage of the sequence by the domain: 10.34 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 24.5 24.5
Trusted cut-off 24.5 24.5
Noise cut-off 24.4 24.4
Model length: 76
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the AMP-binding_C domain has been found. There are 297 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A096PZ50 View 3D Structure Click here
A0A096S078 View 3D Structure Click here
A0A096TWZ2 View 3D Structure Click here
A0A0B4KFE4 View 3D Structure Click here
A0A0G2K047 View 3D Structure Click here
A0A0N7KGJ1 View 3D Structure Click here
A0A0P0WAB9 View 3D Structure Click here
A0A0P0WS15 View 3D Structure Click here
A0A0R0ECE8 View 3D Structure Click here
A0A0R0FB43 View 3D Structure Click here
A0A0R0G952 View 3D Structure Click here
A0A0R0HAN2 View 3D Structure Click here
A0A0R0HJB4 View 3D Structure Click here
A0A0R0J7V1 View 3D Structure Click here
A0A0R0J8J4 View 3D Structure Click here
A0A0R0JEV3 View 3D Structure Click here
A0A0R4IRL6 View 3D Structure Click here
A0A1D6DQH1 View 3D Structure Click here
A0A1D6DTL5 View 3D Structure Click here
A0A1D6H286 View 3D Structure Click here
A0A1D6H9J3 View 3D Structure Click here
A0A1D6HRG6 View 3D Structure Click here
A0A1D6I1A4 View 3D Structure Click here
A0A1D6JIH7 View 3D Structure Click here
A0A1D6JMW4 View 3D Structure Click here
A0A1D6KA74 View 3D Structure Click here
A0A1D6KNK6 View 3D Structure Click here
A0A1D6KW34 View 3D Structure Click here
A0A1D6LWI0 View 3D Structure Click here
A0A1D6MEX0 View 3D Structure Click here
A0A1D6NY94 View 3D Structure Click here
A0A1D6Q0V8 View 3D Structure Click here
A0A1D6Q7M3 View 3D Structure Click here
A0A1D6QGV9 View 3D Structure Click here
A0A286Y8C0 View 3D Structure Click here
A0A2R8QA86 View 3D Structure Click here
A0A2R8QFY7 View 3D Structure Click here
A0A368UIA6 View 3D Structure Click here
A0A368UID0 View 3D Structure Click here
A0A4V0ING4 View 3D Structure Click here
A1Z8Z9 View 3D Structure Click here
A2VCY4 View 3D Structure Click here
A4HYA8 View 3D Structure Click here
A4HYB7 View 3D Structure Click here
A4I093 View 3D Structure Click here
A4I0C2 View 3D Structure Click here
A4I3J3 View 3D Structure Click here
A9JRA7 View 3D Structure Click here
B0S5C4 View 3D Structure Click here
B4G058 View 3D Structure Click here
B6SS27 View 3D Structure Click here
B6ST13 View 3D Structure Click here
B6SV29 View 3D Structure Click here
B6SWA5 View 3D Structure Click here
B6SYY5 View 3D Structure Click here
B7FA23 View 3D Structure Click here
B9DGD6 View 3D Structure Click here
C0PGQ6 View 3D Structure Click here
C6KTB4 View 3D Structure Click here
C6KTB4 View 3D Structure Click here
D3ZJA9 View 3D Structure Click here
D3ZUX7 View 3D Structure Click here
D3ZZN3 View 3D Structure Click here
D4A2B8 View 3D Structure Click here
E7F2S8 View 3D Structure Click here
E9AGS6 View 3D Structure Click here
E9Q9W4 View 3D Structure Click here
F1QAA7 View 3D Structure Click here
F1QBA8 View 3D Structure Click here
F1QQH3 View 3D Structure Click here
F1QYS7 View 3D Structure Click here
F1RAK0 View 3D Structure Click here
F4HUK6 View 3D Structure Click here
F4K1G2 View 3D Structure Click here
F6NGD6 View 3D Structure Click here
G3V7V3 View 3D Structure Click here
G3V9U0 View 3D Structure Click here
H2BER4 View 3D Structure Click here
H2KZ58 View 3D Structure Click here
I1J4L4 View 3D Structure Click here
I1JAL3 View 3D Structure Click here
I1JAL4 View 3D Structure Click here
I1JAM0 View 3D Structure Click here
I1JCB2 View 3D Structure Click here
I1JHQ5 View 3D Structure Click here
I1JHQ6 View 3D Structure Click here
I1JHQ7 View 3D Structure Click here
I1K3Y1 View 3D Structure Click here
I1KC54 View 3D Structure Click here
I1KGM8 View 3D Structure Click here
I1KV61 View 3D Structure Click here
I1L0F0 View 3D Structure Click here
I1L0K8 View 3D Structure Click here
I1L367 View 3D Structure Click here
I1LCM8 View 3D Structure Click here
I1LE62 View 3D Structure Click here
I1LG54 View 3D Structure Click here
I1LI90 View 3D Structure Click here
I1LJJ1 View 3D Structure Click here
I1LM68 View 3D Structure Click here
I1LQ81 View 3D Structure Click here
I1LVS4 View 3D Structure Click here
I1MBP4 View 3D Structure Click here
I1MBP5 View 3D Structure Click here
I1MBZ0 View 3D Structure Click here
I1MC91 View 3D Structure Click here
I1MG38 View 3D Structure Click here
I1ML63 View 3D Structure Click here
I1MRP0 View 3D Structure Click here
I1MSS0 View 3D Structure Click here
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I1MZI9 View 3D Structure Click here
I1N0A3 View 3D Structure Click here
I1N7E7 View 3D Structure Click here
I1N846 View 3D Structure Click here
I1ND18 View 3D Structure Click here
I1NGC4 View 3D Structure Click here
I1NHS0 View 3D Structure Click here
I6Y0L1 View 3D Structure Click here
I6Y0X0 View 3D Structure Click here
I6YGC8 View 3D Structure Click here
K7KAF7 View 3D Structure Click here
K7KCC2 View 3D Structure Click here
K7KDZ7 View 3D Structure Click here
K7KK80 View 3D Structure Click here
K7KP23 View 3D Structure Click here
K7LAC1 View 3D Structure Click here
K7LCL6 View 3D Structure Click here
K7LF62 View 3D Structure Click here
K7LKF3 View 3D Structure Click here
K7LNS5 View 3D Structure Click here
K7LTN2 View 3D Structure Click here
K7M8C1 View 3D Structure Click here
K7UE06 View 3D Structure Click here
K7VBT8 View 3D Structure Click here
K7VHQ0 View 3D Structure Click here
O02171 View 3D Structure Click here
O02200 View 3D Structure Click here
O05295 View 3D Structure Click here
O05307 View 3D Structure Click here
O05819 View 3D Structure Click here
O06417 View 3D Structure Click here
O06831 View 3D Structure Click here
O07169 View 3D Structure Click here
O07411 View 3D Structure Click here
O14975 View 3D Structure Click here
O16481 View 3D Structure Click here
O16775 View 3D Structure Click here
O18693 View 3D Structure Click here
O35488 View 3D Structure Click here
O44560 View 3D Structure Click here
O45873 View 3D Structure Click here
O53406 View 3D Structure Click here
O53551 View 3D Structure Click here
O70490 View 3D Structure Click here
O74976 View 3D Structure Click here
O80658 View 3D Structure Click here
O88561 View 3D Structure Click here
P0C5B6 View 3D Structure Click here
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P10378 View 3D Structure Click here
P17814 View 3D Structure Click here
P27550 View 3D Structure Click here
P31552 View 3D Structure Click here
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P33121 View 3D Structure Click here
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P38135 View 3D Structure Click here
P38137 View 3D Structure Click here
P40976 View 3D Structure Click here
P41216 View 3D Structure Click here
P52910 View 3D Structure Click here
P69451 View 3D Structure Click here
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P78773 View 3D Structure Click here
P95227 View 3D Structure Click here
P96396 View 3D Structure Click here
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P97524 View 3D Structure Click here
P9WQ37 View 3D Structure Click here
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P9WQ51 View 3D Structure Click here
P9WQ55 View 3D Structure Click here
P9WQ61 View 3D Structure Click here
P9WQ63 View 3D Structure Click here
P9WQD1 View 3D Structure Click here
Q01574 View 3D Structure Click here
Q08AH1 View 3D Structure Click here
Q08AH3 View 3D Structure Click here
Q0DV32 View 3D Structure Click here
Q0IZQ6 View 3D Structure Click here
Q0P4F7 View 3D Structure Click here
Q10896 View 3D Structure Click here
Q10MK9 View 3D Structure Click here
Q10S60 View 3D Structure Click here
Q10S72 View 3D Structure Click here
Q14DH7 View 3D Structure Click here
Q17577 View 3D Structure Click here
Q18496 View 3D Structure Click here
Q18916 View 3D Structure Click here
Q19339 View 3D Structure Click here
Q19878 View 3D Structure Click here
Q1LVA8 View 3D Structure Click here
Q20121 View 3D Structure Click here
Q20264 View 3D Structure Click here
Q21166 View 3D Structure Click here
Q23404 View 3D Structure Click here
Q2FV14 View 3D Structure Click here
Q2FZW6 View 3D Structure Click here
Q2G0K3 View 3D Structure Click here
Q2G1C7 View 3D Structure Click here
Q2G1H9 View 3D Structure Click here
Q2G1H9 View 3D Structure Click here
Q2G294 View 3D Structure Click here
Q2G2V3 View 3D Structure Click here
Q2R2L5 View 3D Structure Click here
Q336M7 View 3D Structure Click here
Q3E6Y4 View 3D Structure Click here
Q3UNX5 View 3D Structure Click here
Q3URE1 View 3D Structure Click here
Q42524 View 3D Structure Click here
Q42982 View 3D Structure Click here
Q499N5 View 3D Structure Click here
Q4DCB9 View 3D Structure Click here
Q4DG51 View 3D Structure Click here
Q4DQY7 View 3D Structure Click here
Q4DYN2 View 3D Structure Click here
Q4G176 View 3D Structure Click here
Q4LDG0 View 3D Structure Click here
Q53FZ2 View 3D Structure Click here
Q54HD3 View 3D Structure Click here
Q54P77 View 3D Structure Click here
Q54P78 View 3D Structure Click here
Q54P79 View 3D Structure Click here
Q54WL7 View 3D Structure Click here
Q54YU1 View 3D Structure Click here
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Q559P5 View 3D Structure Click here
Q55GS0 View 3D Structure Click here
Q55GU6 View 3D Structure Click here
Q59NN4 View 3D Structure Click here
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Q5K4L6 View 3D Structure Click here
Q60714 View 3D Structure Click here
Q67W82 View 3D Structure Click here
Q68CK6 View 3D Structure Click here
Q69RG7 View 3D Structure Click here
Q6AYT9 View 3D Structure Click here
Q6ETN3 View 3D Structure Click here
Q6H798 View 3D Structure Click here
Q6NUN0 View 3D Structure Click here
Q6P1M0 View 3D Structure Click here
Q6PCB7 View 3D Structure Click here
Q6SKG1 View 3D Structure Click here
Q6YUT4 View 3D Structure Click here
Q6YYZ2 View 3D Structure Click here
Q6ZAC1 View 3D Structure Click here
Q75JX7 View 3D Structure Click here
Q7F1X5 View 3D Structure Click here
Q7KVJ6 View 3D Structure Click here
Q7KVU5 View 3D Structure Click here
Q7TN78 View 3D Structure Click here
Q7XPV4 View 3D Structure Click here
Q7XQ93 View 3D Structure Click here
Q7XXL2 View 3D Structure Click here
Q80W40 View 3D Structure Click here
Q84P21 View 3D Structure Click here
Q84P23 View 3D Structure Click here
Q84P24 View 3D Structure Click here
Q84P25 View 3D Structure Click here
Q84P26 View 3D Structure Click here
Q8BGA8 View 3D Structure Click here
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Q8H151 View 3D Structure Click here
Q8K0L3 View 3D Structure Click here
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Q8RU95 View 3D Structure Click here
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Q91VA0 View 3D Structure Click here
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Q9ES38 View 3D Structure Click here
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Q9LPK6 View 3D Structure Click here
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Q9LQ12 View 3D Structure Click here
Q9LQS1 View 3D Structure Click here
Q9LU36 View 3D Structure Click here
Q9M0X9 View 3D Structure Click here
Q9NR19 View 3D Structure Click here
Q9NUB1 View 3D Structure Click here
Q9QXG4 View 3D Structure Click here
Q9S725 View 3D Structure Click here
Q9S777 View 3D Structure Click here
Q9SEY5 View 3D Structure Click here
Q9SFW5 View 3D Structure Click here
Q9SMT7 View 3D Structure Click here
Q9SNJ6 View 3D Structure Click here
Q9SS00 View 3D Structure Click here
Q9SS01 View 3D Structure Click here
Q9UAV8 View 3D Structure Click here
Q9UKU0 View 3D Structure Click here
Q9VC92 View 3D Structure Click here
Q9VCC6 View 3D Structure Click here
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Q9VP61 View 3D Structure Click here
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Q9W171 View 3D Structure Click here
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Q9XIA9 View 3D Structure Click here
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