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4  structures 4190  species 0  interactions 12956  sequences 105  architectures

Family: MFS_2 (PF13347)

Summary: MFS/sugar transport protein

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

MFS/sugar transport protein Provide feedback

This family is part of the major facilitator superfamily of membrane transport proteins.

Internal database links

This tab holds annotation information from the InterPro database.

No InterPro data for this Pfam family.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan MFS (CL0015), which has the following description:

The major facilitator superfamily (MFS) is one of the two largest families of membrane transporters found on Earth [1]. It is present ubiquitously in bacteria, archaea, and eukarya and includes members that can function by solute uniport, solute/cation symport, solute/cation antiport and/or solute/solute antiport with inwardly and/or outwardly directed polarity [1]. All permeases of the MFS possess either 12 or 14 transmembrane helices [1].

The clan contains the following 23 members:

Acatn ATG22 BT1 Folate_carrier FPN1 LacY_symp MFS_1 MFS_1_like MFS_2 MFS_3 MFS_4 MFS_5 MFS_Mycoplasma Nodulin-like Nuc_H_symport Nucleoside_tran OATP PTR2 PUCC Sugar_tr TLC TRI12 UNC-93

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(19)
Full
(12956)
Representative proteomes UniProt
(55587)
RP15
(1657)
RP35
(5922)
RP55
(12173)
RP75
(19849)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(19)
Full
(12956)
Representative proteomes UniProt
(55587)
RP15
(1657)
RP35
(5922)
RP55
(12173)
RP75
(19849)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(19)
Full
(12956)
Representative proteomes UniProt
(55587)
RP15
(1657)
RP35
(5922)
RP55
(12173)
RP75
(19849)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:Q7P3E5
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A
Number in seed: 19
Number in full: 12956
Average length of the domain: 348.40 aa
Average identity of full alignment: 15 %
Average coverage of the sequence by the domain: 75.51 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.0 27.0
Noise cut-off 26.9 26.9
Model length: 427
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Tree controls

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the MFS_2 domain has been found. There are 4 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JUB6 View 3D Structure Click here
A0A0G2JUB6 View 3D Structure Click here
A0A0R4J720 View 3D Structure Click here
A0A1D6EZJ3 View 3D Structure Click here
A0A1D6HBC2 View 3D Structure Click here
A0A1D6HQ35 View 3D Structure Click here
A0A1D6IHU8 View 3D Structure Click here
A0A1D6PJB8 View 3D Structure Click here
A0A1L1SUA2 View 3D Structure Click here
A0A2R8Q1P7 View 3D Structure Click here
A0A2R8Q8K6 View 3D Structure Click here
A0A2R8QBJ5 View 3D Structure Click here
A0A2R8QLL9 View 3D Structure Click here
A0A2R8RHV2 View 3D Structure Click here
A0A2R8RNG9 View 3D Structure Click here
A6NFX1 View 3D Structure Click here
A8WG95 View 3D Structure Click here
B1WBW6 View 3D Structure Click here
B4FX10 View 3D Structure Click here
C4J5U5 View 3D Structure Click here
D3ZR99 View 3D Structure Click here
D4A482 View 3D Structure Click here
D4ADC6 View 3D Structure Click here
E7FCM0 View 3D Structure Click here
E9QH03 View 3D Structure Click here
F1M4E3 View 3D Structure Click here
F1M4T5 View 3D Structure Click here
F1QZ62 View 3D Structure Click here
F1R3C0 View 3D Structure Click here
H2KZ27 View 3D Structure Click here
H2KZU5 View 3D Structure Click here
I1JD84 View 3D Structure Click here
I1JD85 View 3D Structure Click here
I1JH46 View 3D Structure Click here
I1JV08 View 3D Structure Click here
I1KTR2 View 3D Structure Click here
I1KXR9 View 3D Structure Click here
I1LD90 View 3D Structure Click here
I1MNY7 View 3D Structure Click here
I1MNY8 View 3D Structure Click here
I1MNY9 View 3D Structure Click here
I1MNZ0 View 3D Structure Click here
I1N171 View 3D Structure Click here
K7KF87 View 3D Structure Click here
K7KU34 View 3D Structure Click here
K7ME40 View 3D Structure Click here
K7WGT4 View 3D Structure Click here
O14091 View 3D Structure Click here
P02921 View 3D Structure Click here
P0CE44 View 3D Structure Click here
P31435 View 3D Structure Click here
P32136 View 3D Structure Click here
P32137 View 3D Structure Click here
P75683 View 3D Structure Click here
Q0D566 View 3D Structure Click here
Q10R54 View 3D Structure Click here
Q14CX5 View 3D Structure Click here
Q14CX5 View 3D Structure Click here
Q19498 View 3D Structure Click here
Q39231 View 3D Structure Click here
Q39232 View 3D Structure Click here
Q3T9M1 View 3D Structure Click here
Q3U481 View 3D Structure Click here
Q54SX3 View 3D Structure Click here
Q55GN9 View 3D Structure Click here
Q5BKX6 View 3D Structure Click here
Q5PRC2 View 3D Structure Click here
Q5U3U7 View 3D Structure Click here
Q67YF8 View 3D Structure Click here
Q69JW3 View 3D Structure Click here
Q6A329 View 3D Structure Click here
Q6DEJ6 View 3D Structure Click here
Q6NUT3 View 3D Structure Click here
Q6PDE8 View 3D Structure Click here
Q6PDE8 View 3D Structure Click here
Q6YK44 View 3D Structure Click here
Q7KWK4 View 3D Structure Click here
Q8I3H5 View 3D Structure Click here
Q8L7S2 View 3D Structure Click here
Q8L7Z7 View 3D Structure Click here
Q8NA29 View 3D Structure Click here
Q8S7U2 View 3D Structure Click here
Q948L0 View 3D Structure Click here
Q9C8X2 View 3D Structure Click here
Q9DA75 View 3D Structure Click here
Q9FE59 View 3D Structure Click here
Q9UMX9 View 3D Structure Click here
Q9ZVK6 View 3D Structure Click here