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174  structures 7105  species 0  interactions 95565  sequences 12602  architectures

Family: TPR_16 (PF13432)

Summary: Tetratricopeptide repeat

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Tetratricopeptide repeat Provide feedback

This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.

Internal database links

This tab holds annotation information from the InterPro database.

No InterPro data for this Pfam family.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan TPR (CL0020), which has the following description:

Tetratricopeptide-like repeats are found in a numerous and diverse proteins involved in such functions as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.

The clan contains the following 176 members:

Adaptin_N Alkyl_sulf_dimr ANAPC3 ANAPC5 ANAPC8 APC_rep API5 Arm Arm_2 Arm_3 Arm_vescicular Atx10homo_assoc B56 BAF250_C BTAD CAS_CSE1 ChAPs CHIP_TPR_N CID CLASP_N Clathrin Clathrin-link Clathrin_H_link Clathrin_propel Cnd1 Cnd3 Coatomer_E Cohesin_HEAT Cohesin_load ComR_TPR COPI_C CPL CRM1_C CRM1_repeat CRM1_repeat_3 Cse1 CTK3 DHR-2 DIL DNA_alkylation Dopey_N Drf_FH3 Drf_GBD DUF1822 DUF2019 DUF2225 DUF3385 DUF3458_C DUF3808 DUF3856 DUF4042 DUF5588 DUF5691 DUF6340 DUF6377 DUF924 EAD11 EST1 EST1_DNA_bind FAT Fis1_TPR_C Fis1_TPR_N Foie-gras_1 GUN4_N HAT HEAT HEAT_2 HEAT_EZ HEAT_PBS HEAT_UF HemY_N HrpB1_HrpK HSM3_C HSM3_N IBB IBN_N IFRD Importin_rep Importin_rep_2 Importin_rep_3 Importin_rep_4 Importin_rep_5 Importin_rep_6 Insc_C KAP Leuk-A4-hydro_C LRV LRV_FeS MA3 MIF4G MIF4G_like MIF4G_like_2 MMS19_C Mo25 MRP-S27 Mtf2 NARP1 Neurochondrin Nipped-B_C Nro1 NSF Paf67 ParcG PC_rep PHAT PI3Ka PknG_TPR PPP5 PPR PPR_1 PPR_2 PPR_3 PPR_long PPTA Proteasom_PSMB PUF Rapsyn_N RIX1 RNPP_C RPM2 RPN7 Sel1 SHNi-TPR SNAP SPO22 SRP_TPR_like ST7 Suf SusD-like SusD-like_2 SusD-like_3 SusD_RagB SYCP2_ARLD TAF6_C TAL_effector TAtT Tcf25 TIP120 TOM20_plant TPR_1 TPR_10 TPR_11 TPR_12 TPR_14 TPR_15 TPR_16 TPR_17 TPR_18 TPR_19 TPR_2 TPR_20 TPR_21 TPR_22 TPR_3 TPR_4 TPR_5 TPR_6 TPR_7 TPR_8 TPR_9 TPR_MalT TTC7_N UNC45-central Upf2 V-ATPase_H_C V-ATPase_H_N Vac14_Fab1_bd Vitellogenin_N Vps39_1 W2 WSLR Wzy_C_2 Xpo1 YcaO_C YfiO Zmiz1_N

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(64)
Full
(95565)
Representative proteomes UniProt
(412021)
RP15
(17081)
RP35
(47521)
RP55
(90277)
RP75
(140944)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(64)
Full
(95565)
Representative proteomes UniProt
(412021)
RP15
(17081)
RP35
(47521)
RP55
(90277)
RP75
(140944)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(64)
Full
(95565)
Representative proteomes UniProt
(412021)
RP15
(17081)
RP35
(47521)
RP55
(90277)
RP75
(140944)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:Q2Y5H2
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Coggill P
Number in seed: 64
Number in full: 95565
Average length of the domain: 61.90 aa
Average identity of full alignment: 18 %
Average coverage of the sequence by the domain: 16.82 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 32.7 15.5
Trusted cut-off 32.7 15.5
Noise cut-off 32.6 15.4
Model length: 68
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the TPR_16 domain has been found. There are 174 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JZ94 View 3D Structure Click here
A0A0G2K2B5 View 3D Structure Click here
A0A0G2K435 View 3D Structure Click here
A0A0G2K6D0 View 3D Structure Click here
A0A0G2K6D0 View 3D Structure Click here
A0A0G2K726 View 3D Structure Click here
A0A0G2K726 View 3D Structure Click here
A0A0M3HEL6 View 3D Structure Click here
A0A0M3HEL6 View 3D Structure Click here
A0A0M3HEL6 View 3D Structure Click here
A0A0M3HEL6 View 3D Structure Click here
A0A0P0VG31 View 3D Structure Click here
A0A0P0VKB5 View 3D Structure Click here
A0A0P0VV58 View 3D Structure Click here
A0A0R0HQK4 View 3D Structure Click here
A0A0R4IFJ1 View 3D Structure Click here
A0A131MBT2 View 3D Structure Click here
A0A1D6E2B4 View 3D Structure Click here
A0A1D6EMD0 View 3D Structure Click here
A0A1D6EMD0 View 3D Structure Click here
A0A1D6FA34 View 3D Structure Click here
A0A1D6HEP0 View 3D Structure Click here
A0A1D6HKP2 View 3D Structure Click here
A0A1D6HT76 View 3D Structure Click here
A0A1D6JVE9 View 3D Structure Click here
A0A1D6KDC8 View 3D Structure Click here
A0A1D6KI98 View 3D Structure Click here
A0A1D6KMF8 View 3D Structure Click here
A0A1D6KTN8 View 3D Structure Click here
A0A1D6NJK2 View 3D Structure Click here
A0A1D6NUA9 View 3D Structure Click here
A0A1D6Q322 View 3D Structure Click here
A0A1D6QED3 View 3D Structure Click here
A0A1D6QKF6 View 3D Structure Click here
A0A1D8PN90 View 3D Structure Click here
A0A1D8PNA3 View 3D Structure Click here
A0A1D8PNA3 View 3D Structure Click here
A0A1D8PQM5 View 3D Structure Click here
A0A1D8PRX3 View 3D Structure Click here
A0A1L1SSC7 View 3D Structure Click here
A1A5S1 View 3D Structure Click here
A1L1S9 View 3D Structure Click here
A1L1S9 View 3D Structure Click here
A1Z8E9 View 3D Structure Click here
A2A3L6 View 3D Structure Click here
A4HS50 View 3D Structure Click here
A4HSG3 View 3D Structure Click here
A4HZ52 View 3D Structure Click here
A4I1X3 View 3D Structure Click here
A4I1X3 View 3D Structure Click here
A4I2R4 View 3D Structure Click here
A4I2R4 View 3D Structure Click here
A4I5Y0 View 3D Structure Click here
A4I5Y0 View 3D Structure Click here
A4I5Y0 View 3D Structure Click here
A4I636 View 3D Structure Click here
A4I8A6 View 3D Structure Click here
A4IB35 View 3D Structure Click here
A4IB35 View 3D Structure Click here
A4IB35 View 3D Structure Click here
A4ICT7 View 3D Structure Click here
A4ICT7 View 3D Structure Click here
A4IDK2 View 3D Structure Click here
A8MYJ7 View 3D Structure Click here
A8MYJ7 View 3D Structure Click here
A8MYJ7 View 3D Structure Click here
A8WHT8 View 3D Structure Click here
A8WHT8 View 3D Structure Click here
A9C3Q3 View 3D Structure Click here
B0R0W1 View 3D Structure Click here
B0S6W0 View 3D Structure Click here
B0S6W0 View 3D Structure Click here
B0S6W0 View 3D Structure Click here
B0S6W0 View 3D Structure Click here
B1WBT5 View 3D Structure Click here
B4FW32 View 3D Structure Click here
B4FYX3 View 3D Structure Click here
B5X0I6 View 3D Structure Click here
B5X0I6 View 3D Structure Click here
B5X0I6 View 3D Structure Click here
B6SSY1 View 3D Structure Click here
B6SSY1 View 3D Structure Click here
B9DHG0 View 3D Structure Click here
B9F5R6 View 3D Structure Click here
C0PEY7 View 3D Structure Click here
C0PEY7 View 3D Structure Click here
C4J723 View 3D Structure Click here
D3ZIT4 View 3D Structure Click here
D3ZIT4 View 3D Structure Click here
D3ZIT4 View 3D Structure Click here
D3ZL50 View 3D Structure Click here
D3ZZJ4 View 3D Structure Click here
D4A2M3 View 3D Structure Click here
D4A2M3 View 3D Structure Click here
D4A333 View 3D Structure Click here
E7F2R1 View 3D Structure Click here
E7F2R1 View 3D Structure Click here
E7F8D3 View 3D Structure Click here
E7FG92 View 3D Structure Click here
E7FGF7 View 3D Structure Click here
E7FGF7 View 3D Structure Click here
E7FGF7 View 3D Structure Click here
F1Q597 View 3D Structure Click here
F1QD06 View 3D Structure Click here
F1QF84 View 3D Structure Click here
F1QF84 View 3D Structure Click here
F1QPL6 View 3D Structure Click here
F1R498 View 3D Structure Click here
F1RD24 View 3D Structure Click here
F1RE04 View 3D Structure Click here
F4IBX5 View 3D Structure Click here
F4IBX5 View 3D Structure Click here
F4IBX5 View 3D Structure Click here
F4IXE4 View 3D Structure Click here
F4JS25 View 3D Structure Click here
F4JS25 View 3D Structure Click here
F4KEY9 View 3D Structure Click here
F8VPK0 View 3D Structure Click here
G3UYY4 View 3D Structure Click here
G3V897 View 3D Structure Click here
G5ED37 View 3D Structure Click here
G5ED37 View 3D Structure Click here
G5EE04 View 3D Structure Click here
I1J9X8 View 3D Structure Click here
I1JGL8 View 3D Structure Click here
I1JPL2 View 3D Structure Click here
I1JTR1 View 3D Structure Click here
I1K0K7 View 3D Structure Click here
I1K0K7 View 3D Structure Click here
I1K2A6 View 3D Structure Click here
I1K3Q2 View 3D Structure Click here
I1K580 View 3D Structure Click here
I1K868 View 3D Structure Click here
I1KDK4 View 3D Structure Click here
I1KDL9 View 3D Structure Click here
I1KG23 View 3D Structure Click here
I1KMR2 View 3D Structure Click here
I1KMR2 View 3D Structure Click here
I1KQM0 View 3D Structure Click here
I1KT37 View 3D Structure Click here
I1KVV0 View 3D Structure Click here
I1L1N9 View 3D Structure Click here
I1LD61 View 3D Structure Click here
I1LD61 View 3D Structure Click here
I1LGM2 View 3D Structure Click here
I1LT60 View 3D Structure Click here
I1LT60 View 3D Structure Click here
I1LV56 View 3D Structure Click here
I1LWZ1 View 3D Structure Click here
I1LXC7 View 3D Structure Click here
I1LYW5 View 3D Structure Click here
I1LYW5 View 3D Structure Click here
I1M1D5 View 3D Structure Click here
I1M319 View 3D Structure Click here
I1MAS5 View 3D Structure Click here
I1MAS5 View 3D Structure Click here
I1MF50 View 3D Structure Click here
I1MHE8 View 3D Structure Click here
I1MHE8 View 3D Structure Click here
I1MRQ7 View 3D Structure Click here
I1MRQ7 View 3D Structure Click here
I1MVQ3 View 3D Structure Click here
I1MVQ3 View 3D Structure Click here
I1N4V8 View 3D Structure Click here
I1N6L5 View 3D Structure Click here
I1NA82 View 3D Structure Click here
I1NE04 View 3D Structure Click here
I1NEN3 View 3D Structure Click here
I1NEN3 View 3D Structure Click here
I1NEN3 View 3D Structure Click here
K7K3Y9 View 3D Structure Click here
K7K4N6 View 3D Structure Click here
K7K4N6 View 3D Structure Click here
K7KJI6 View 3D Structure Click here
K7KLL1 View 3D Structure Click here
K7KQY8 View 3D Structure Click here
K7KUC7 View 3D Structure Click here
K7KUC7 View 3D Structure Click here
K7KUC7 View 3D Structure Click here
K7KYM0 View 3D Structure Click here
K7LA10 View 3D Structure Click here
K7LJ63 View 3D Structure Click here
K7LJ63 View 3D Structure Click here
K7LJ63 View 3D Structure Click here
K7LNY4 View 3D Structure Click here
K7LSR3 View 3D Structure Click here
K7MR42 View 3D Structure Click here
K7N441 View 3D Structure Click here
K7N441 View 3D Structure Click here
K7TYW1 View 3D Structure Click here
K7U1N1 View 3D Structure Click here
K7VJP9 View 3D Structure Click here
K7VJP9 View 3D Structure Click here
K7VJS8 View 3D Structure Click here
K7VJS8 View 3D Structure Click here
K7VK95 View 3D Structure Click here
M0RBH7 View 3D Structure Click here
O06917 View 3D Structure Click here
O09012 View 3D Structure Click here
O14607 View 3D Structure Click here
O15550 View 3D Structure Click here
O15550 View 3D Structure Click here
O35450 View 3D Structure Click here
O42668 View 3D Structure Click here
O46085 View 3D Structure Click here
O60184 View 3D Structure Click here
O70546 View 3D Structure Click here
O94325 View 3D Structure Click here
P14922 View 3D Structure Click here
P33339 View 3D Structure Click here
P35056 View 3D Structure Click here
P37650 View 3D Structure Click here
P37650 View 3D Structure Click here
P37650 View 3D Structure Click here
P38042 View 3D Structure Click here
P45955 View 3D Structure Click here
P50542 View 3D Structure Click here
P76585 View 3D Structure Click here
P76585 View 3D Structure Click here
P91175 View 3D Structure Click here
Q0HA38 View 3D Structure Click here
Q10MH4 View 3D Structure Click here
Q10MH4 View 3D Structure Click here
Q10NP2 View 3D Structure Click here
Q10NP2 View 3D Structure Click here
Q12797 View 3D Structure Click here
Q13217 View 3D Structure Click here
Q2M2R8 View 3D Structure Click here
Q2M2R8 View 3D Structure Click here
Q2M2R8 View 3D Structure Click here
Q2QNH6 View 3D Structure Click here
Q2QNH6 View 3D Structure Click here
Q32PZ3 View 3D Structure Click here
Q336U8 View 3D Structure Click here
Q3B7U9 View 3D Structure Click here
Q3U687 View 3D Structure Click here
Q3UV71 View 3D Structure Click here
Q3UV71 View 3D Structure Click here
Q43468 View 3D Structure Click here
Q49AM3 View 3D Structure Click here
Q49AM3 View 3D Structure Click here
Q4CZM3 View 3D Structure Click here
Q4CZM3 View 3D Structure Click here
Q4CZM3 View 3D Structure Click here
Q4D661 View 3D Structure Click here
Q4D9G7 View 3D Structure Click here
Q4DCN5 View 3D Structure Click here
Q4DCN5 View 3D Structure Click here
Q4DCS1 View 3D Structure Click here
Q4DHE6 View 3D Structure Click here
Q4DPQ9 View 3D Structure Click here
Q4DR66 View 3D Structure Click here
Q4DWX5 View 3D Structure Click here
Q4DX47 View 3D Structure Click here
Q4DX47 View 3D Structure Click here
Q4DYD9 View 3D Structure Click here
Q4DYI7 View 3D Structure Click here
Q4E265 View 3D Structure Click here
Q4E4D8 View 3D Structure Click here
Q4E4D8 View 3D Structure Click here
Q4E4H1 View 3D Structure Click here
Q54H74 View 3D Structure Click here
Q54IP0 View 3D Structure Click here
Q54Y92 View 3D Structure Click here
Q54YA9 View 3D Structure Click here
Q56A06 View 3D Structure Click here
Q57711 View 3D Structure Click here
Q58823 View 3D Structure Click here
Q5ADP3 View 3D Structure Click here
Q5APB7 View 3D Structure Click here
Q5BK48 View 3D Structure Click here
Q5I0X7 View 3D Structure Click here
Q5JNB5 View 3D Structure Click here
Q5PR66 View 3D Structure Click here
Q5QNE5 View 3D Structure Click here
Q5T4D3 View 3D Structure Click here
Q5T4D3 View 3D Structure Click here
Q5T4D3 View 3D Structure Click here
Q5TYX3 View 3D Structure Click here
Q67YJ9 View 3D Structure Click here
Q6MG81 View 3D Structure Click here
Q6NNB2 View 3D Structure Click here
Q6NNB2 View 3D Structure Click here
Q6PGP7 View 3D Structure Click here
Q6PGP7 View 3D Structure Click here
Q6PGP7 View 3D Structure Click here
Q6YZI0 View 3D Structure Click here
Q6ZKM0 View 3D Structure Click here
Q6ZKM0 View 3D Structure Click here
Q75JW7 View 3D Structure Click here
Q7K4B6 View 3D Structure Click here
Q7K4B6 View 3D Structure Click here
Q7KRS6 View 3D Structure Click here
Q7XHN9 View 3D Structure Click here
Q7XHN9 View 3D Structure Click here
Q7XHN9 View 3D Structure Click here
Q7ZU45 View 3D Structure Click here
Q84JR9 View 3D Structure Click here
Q86TZ1 View 3D Structure Click here
Q8BG19 View 3D Structure Click here
Q8BG19 View 3D Structure Click here
Q8BSY0 View 3D Structure Click here
Q8C0S4 View 3D Structure Click here
Q8C437 View 3D Structure Click here
Q8CD92 View 3D Structure Click here
Q8H9E4 View 3D Structure Click here
Q8IUR5 View 3D Structure Click here
Q8IUR5 View 3D Structure Click here
Q8IUR5 View 3D Structure Click here
Q8IYB4 View 3D Structure Click here
Q8LGU6 View 3D Structure Click here
Q8N394 View 3D Structure Click here
Q8NA56 View 3D Structure Click here
Q8NBP0 View 3D Structure Click here
Q8NDW8 View 3D Structure Click here
Q8NEE8 View 3D Structure Click here
Q8NEE8 View 3D Structure Click here
Q8RWG2 View 3D Structure Click here
Q8RWG2 View 3D Structure Click here
Q8S8L9 View 3D Structure Click here
Q8S8L9 View 3D Structure Click here
Q8TAM2 View 3D Structure Click here
Q8VD72 View 3D Structure Click here
Q91YR7 View 3D Structure Click here
Q91YW3 View 3D Structure Click here
Q925N3 View 3D Structure Click here
Q99615 View 3D Structure Click here
Q99KD5 View 3D Structure Click here
Q99LG4 View 3D Structure Click here
Q9CB03 View 3D Structure Click here
Q9CB03 View 3D Structure Click here
Q9CX34 View 3D Structure Click here
Q9CX34 View 3D Structure Click here
Q9FFI4 View 3D Structure Click here
Q9FFI4 View 3D Structure Click here
Q9FMA3 View 3D Structure Click here
Q9H3U1 View 3D Structure Click here
Q9LX19 View 3D Structure Click here
Q9LYW9 View 3D Structure Click here
Q9N593 View 3D Structure Click here
Q9QYI3 View 3D Structure Click here
Q9SIN1 View 3D Structure Click here
Q9UJX3 View 3D Structure Click here
Q9UJX3 View 3D Structure Click here
Q9V3W1 View 3D Structure Click here
Q9V3X5 View 3D Structure Click here
Q9VCN6 View 3D Structure Click here
Q9VF81 View 3D Structure Click here
Q9VHW4 View 3D Structure Click here
Q9VK41 View 3D Structure Click here
Q9VKC8 View 3D Structure Click here
Q9VPN5 View 3D Structure Click here
Q9VQE9 View 3D Structure Click here
Q9VVU6 View 3D Structure Click here
Q9W1T9 View 3D Structure Click here
Q9W3Y6 View 3D Structure Click here
Q9WVM3 View 3D Structure Click here
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