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1746  structures 2498  species 0  interactions 91636  sequences 2451  architectures

Family: EF-hand_7 (PF13499)

Summary: EF-hand domain pair

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "EF hand". More...

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

EF-hand domain pair Provide feedback

No Pfam abstract.

Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002048

Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both sides by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1, 3, 5, 7, 9 and 12; these residues are denoted by X, Y, Z, -Y, -X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand). Ca2 binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers [ PUBMED:9228939 , PUBMED:8848832 , PUBMED:7553064 , PUBMED:7656053 , PUBMED:10591109 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(87)
Full
(91636)
Representative proteomes UniProt
(205570)
RP15
(19225)
RP35
(44263)
RP55
(78308)
RP75
(102722)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(87)
Full
(91636)
Representative proteomes UniProt
(205570)
RP15
(19225)
RP35
(44263)
RP55
(78308)
RP75
(102722)
Alignment:
Format:
Order:
Sequence:
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Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(87)
Full
(91636)
Representative proteomes UniProt
(205570)
RP15
(19225)
RP35
(44263)
RP55
(78308)
RP75
(102722)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:A0LDI7
Previous IDs: EF_hand_5;
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 87
Number in full: 91636
Average length of the domain: 68.60 aa
Average identity of full alignment: 26 %
Average coverage of the sequence by the domain: 18.32 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 30.0 30.0
Trusted cut-off 30.0 30.0
Noise cut-off 29.9 29.9
Model length: 71
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the EF-hand_7 domain has been found. There are 1746 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A096QYB9 View 3D Structure Click here
A0A0B4J305 View 3D Structure Click here
A0A0B4J305 View 3D Structure Click here
A0A0G2JTC2 View 3D Structure Click here
A0A0G2JTC2 View 3D Structure Click here
A0A0G2K014 View 3D Structure Click here
A0A0G2K9F5 View 3D Structure Click here
A0A0G2KPF8 View 3D Structure Click here
A0A0G2KPF8 View 3D Structure Click here
A0A0G2QC04 View 3D Structure Click here
A0A0N7KI98 View 3D Structure Click here
A0A0N7KSE8 View 3D Structure Click here
A0A0P0VGM2 View 3D Structure Click here
A0A0P0VJ08 View 3D Structure Click here
A0A0P0W4M1 View 3D Structure Click here
A0A0P0WI02 View 3D Structure Click here
A0A0P0Y6P1 View 3D Structure Click here
A0A0P0Y6T7 View 3D Structure Click here
A0A0R0EI74 View 3D Structure Click here
A0A0R0EIV3 View 3D Structure Click here
A0A0R0EWC3 View 3D Structure Click here
A0A0R0EWC3 View 3D Structure Click here
A0A0R0EXE0 View 3D Structure Click here
A0A0R0F9G1 View 3D Structure Click here
A0A0R0F9G1 View 3D Structure Click here
A0A0R0FHA0 View 3D Structure Click here
A0A0R0FIW3 View 3D Structure Click here
A0A0R0FIW3 View 3D Structure Click here
A0A0R0FUC5 View 3D Structure Click here
A0A0R0FXE6 View 3D Structure Click here
A0A0R0FXE6 View 3D Structure Click here
A0A0R0FYA3 View 3D Structure Click here
A0A0R0FYA3 View 3D Structure Click here
A0A0R0G0J8 View 3D Structure Click here
A0A0R0G0J8 View 3D Structure Click here
A0A0R0G3H9 View 3D Structure Click here
A0A0R0GE95 View 3D Structure Click here
A0A0R0H1G4 View 3D Structure Click here
A0A0R0H1G4 View 3D Structure Click here
A0A0R0H759 View 3D Structure Click here
A0A0R0H759 View 3D Structure Click here
A0A0R0HP89 View 3D Structure Click here
A0A0R0HUD3 View 3D Structure Click here
A0A0R0HX14 View 3D Structure Click here
A0A0R0HX14 View 3D Structure Click here
A0A0R0HX26 View 3D Structure Click here
A0A0R0HX26 View 3D Structure Click here
A0A0R0IE10 View 3D Structure Click here
A0A0R0JFP2 View 3D Structure Click here
A0A0R0JFP2 View 3D Structure Click here
A0A0R0JW45 View 3D Structure Click here
A0A0R0K362 View 3D Structure Click here
A0A0R0K362 View 3D Structure Click here
A0A0R0K362 View 3D Structure Click here
A0A0R0K5I7 View 3D Structure Click here
A0A0R0K5I7 View 3D Structure Click here
A0A0R0KC76 View 3D Structure Click here
A0A0R0KXZ6 View 3D Structure Click here
A0A0R0LDG2 View 3D Structure Click here
A0A0R0LDG2 View 3D Structure Click here
A0A0R0LGJ0 View 3D Structure Click here
A0A0R0LNW3 View 3D Structure Click here
A0A0R0LNW3 View 3D Structure Click here
A0A0R4IPL6 View 3D Structure Click here
A0A0R4IPL6 View 3D Structure Click here
A0A0R4IPX8 View 3D Structure Click here
A0A0R4ITL7 View 3D Structure Click here
A0A0R4IU57 View 3D Structure Click here
A0A0R4IV76 View 3D Structure Click here
A0A0R4IVN1 View 3D Structure Click here
A0A0R4IVN1 View 3D Structure Click here
A0A0R4J3Q2 View 3D Structure Click here
A0A0R4J3Q2 View 3D Structure Click here
A0A143ZWW4 View 3D Structure Click here
A0A143ZWW4 View 3D Structure Click here
A0A143ZXT2 View 3D Structure Click here
A0A143ZXT2 View 3D Structure Click here
A0A144A1Y0 View 3D Structure Click here
A0A144A1Y0 View 3D Structure Click here
A0A168GZC0 View 3D Structure Click here
A0A1B0GWK0 View 3D Structure Click here
A0A1D6EFQ0 View 3D Structure Click here
A0A1D6EIK3 View 3D Structure Click here
A0A1D6EIK3 View 3D Structure Click here
A0A1D6EIL6 View 3D Structure Click here
A0A1D6EIL6 View 3D Structure Click here
A0A1D6EL56 View 3D Structure Click here
A0A1D6ET06 View 3D Structure Click here
A0A1D6ET06 View 3D Structure Click here
A0A1D6F4L6 View 3D Structure Click here
A0A1D6F9Y1 View 3D Structure Click here
A0A1D6F9Y1 View 3D Structure Click here
A0A1D6FBD8 View 3D Structure Click here
A0A1D6FSM1 View 3D Structure Click here
A0A1D6FSM1 View 3D Structure Click here
A0A1D6G9R1 View 3D Structure Click here
A0A1D6G9R1 View 3D Structure Click here
A0A1D6GER7 View 3D Structure Click here
A0A1D6GFX7 View 3D Structure Click here
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A0A1D6GKA4 View 3D Structure Click here
A0A1D6GKA4 View 3D Structure Click here
A0A1D6GPK2 View 3D Structure Click here
A0A1D6GRJ1 View 3D Structure Click here
A0A1D6GRJ1 View 3D Structure Click here
A0A1D6GU50 View 3D Structure Click here
A0A1D6H355 View 3D Structure Click here
A0A1D6HZA8 View 3D Structure Click here
A0A1D6HZA8 View 3D Structure Click here
A0A1D6I8J3 View 3D Structure Click here
A0A1D6ICZ3 View 3D Structure Click here
A0A1D6ICZ3 View 3D Structure Click here
A0A1D6IMS2 View 3D Structure Click here
A0A1D6INZ6 View 3D Structure Click here
A0A1D6IU46 View 3D Structure Click here
A0A1D6IU46 View 3D Structure Click here
A0A1D6IX89 View 3D Structure Click here
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A0A1D6JAZ1 View 3D Structure Click here
A0A1D6JD07 View 3D Structure Click here
A0A1D6JI85 View 3D Structure Click here
A0A1D6JRA0 View 3D Structure Click here
A0A1D6JRA0 View 3D Structure Click here
A0A1D6K120 View 3D Structure Click here
A0A1D6K1S1 View 3D Structure Click here
A0A1D6K1S1 View 3D Structure Click here
A0A1D6K352 View 3D Structure Click here
A0A1D6K8R2 View 3D Structure Click here
A0A1D6KGU1 View 3D Structure Click here
A0A1D6KGU1 View 3D Structure Click here
A0A1D6KIH2 View 3D Structure Click here
A0A1D6KIH5 View 3D Structure Click here
A0A1D6KII9 View 3D Structure Click here
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A0A1D6KM77 View 3D Structure Click here
A0A1D6KNR5 View 3D Structure Click here
A0A1D6KTF9 View 3D Structure Click here
A0A1D6KXI8 View 3D Structure Click here
A0A1D6L3Q6 View 3D Structure Click here
A0A1D6L655 View 3D Structure Click here
A0A1D6L6Z5 View 3D Structure Click here
A0A1D6L6Z9 View 3D Structure Click here
A0A1D6L6Z9 View 3D Structure Click here
A0A1D6L8S9 View 3D Structure Click here
A0A1D6M674 View 3D Structure Click here
A0A1D6M674 View 3D Structure Click here
A0A1D6M749 View 3D Structure Click here
A0A1D6MLW6 View 3D Structure Click here
A0A1D6MLW6 View 3D Structure Click here
A0A1D6MQ76 View 3D Structure Click here
A0A1D6MTQ3 View 3D Structure Click here
A0A1D6MTQ3 View 3D Structure Click here
A0A1D6MUP6 View 3D Structure Click here
A0A1D6MUP6 View 3D Structure Click here
A0A1D6MXK9 View 3D Structure Click here
A0A1D6MYW4 View 3D Structure Click here
A0A1D6MYW4 View 3D Structure Click here
A0A1D6N1F7 View 3D Structure Click here
A0A1D6N1F7 View 3D Structure Click here
A0A1D6N998 View 3D Structure Click here
A0A1D6N998 View 3D Structure Click here
A0A1D6NLC2 View 3D Structure Click here
A0A1D6P195 View 3D Structure Click here
A0A1D6PB15 View 3D Structure Click here
A0A1D6PBR7 View 3D Structure Click here
A0A1D6PRV3 View 3D Structure Click here
A0A1D6PZJ5 View 3D Structure Click here
A0A1D6QA01 View 3D Structure Click here
A0A1D6QH05 View 3D Structure Click here
A0A1D6QJ18 View 3D Structure Click here
A0A1D6QJ18 View 3D Structure Click here
A0A1D6QMM1 View 3D Structure Click here
A0A1D6QRR0 View 3D Structure Click here
A0A1D8PEF8 View 3D Structure Click here
A0A1D8PMF8 View 3D Structure Click here
A0A1D8PMF8 View 3D Structure Click here
A0A1D8PP58 View 3D Structure Click here
A0A1D8PP58 View 3D Structure Click here
A0A1D8PSE1 View 3D Structure Click here
A0A1D8PSM8 View 3D Structure Click here
A0A1D8PSM8 View 3D Structure Click here
A0A1N7SYW5 View 3D Structure Click here
A0A1P8AP52 View 3D Structure Click here
A0A1X7YE88 View 3D Structure Click here
A0A1X7YH95 View 3D Structure Click here
A0A286Y9G4 View 3D Structure Click here
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A0A286YB91 View 3D Structure Click here
A0A2C9C3L3 View 3D Structure Click here
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A0A2R8QCR4 View 3D Structure Click here
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A0A2R8QKE6 View 3D Structure Click here
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A0A2R8QMM6 View 3D Structure Click here
A0A2R8QMW7 View 3D Structure Click here
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A0A2R8QP29 View 3D Structure Click here
A0A2R8QP29 View 3D Structure Click here
A0A2R8QQY2 View 3D Structure Click here
A0A2R8RIQ9 View 3D Structure Click here
A0A2R8RK83 View 3D Structure Click here
A0A2R8RUA0 View 3D Structure Click here
A0A2R8RZP8 View 3D Structure Click here
A0A368UGB1 View 3D Structure Click here
A0A368UGI4 View 3D Structure Click here
A0A368UGL6 View 3D Structure Click here
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A0A5K1K8H0 View 3D Structure Click here
A0A5K1K8H0 View 3D Structure Click here
A0PJX0 View 3D Structure Click here
A1A600 View 3D Structure Click here
A1Z777 View 3D Structure Click here
A1Z777 View 3D Structure Click here
A2ASZ8 View 3D Structure Click here
A2CEQ0 View 3D Structure Click here
A2ZVI7 View 3D Structure Click here
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A3AM33 View 3D Structure Click here
A3C020 View 3D Structure Click here
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A4HT58 View 3D Structure Click here
A4HT95 View 3D Structure Click here
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A4HU13 View 3D Structure Click here
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A4HY14 View 3D Structure Click here
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A4I000 View 3D Structure Click here
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A4I0X7 View 3D Structure Click here
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A4I620 View 3D Structure Click here
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A4I967 View 3D Structure Click here
A4IA04 View 3D Structure Click here
A4IBL2 View 3D Structure Click here
A4ID29 View 3D Structure Click here
A4ID29 View 3D Structure Click here
A4ID37 View 3D Structure Click here
A5WW21 View 3D Structure Click here
A8Y589 View 3D Structure Click here
A9JTH1 View 3D Structure Click here
B0BNB8 View 3D Structure Click here
B0G159 View 3D Structure Click here
B0G159 View 3D Structure Click here
B0S5T6 View 3D Structure Click here
B1AUS6 View 3D Structure Click here
B1WBU2 View 3D Structure Click here
B1WC67 View 3D Structure Click here
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B2RXC8 View 3D Structure Click here
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B4FF99 View 3D Structure Click here
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B4FY36 View 3D Structure Click here
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B6SRA7 View 3D Structure Click here
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C0HHV7 View 3D Structure Click here
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C0P445 View 3D Structure Click here
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