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2916  structures 8574  species 0  interactions 172504  sequences 815  architectures

Family: adh_short_C2 (PF13561)

Summary: Enoyl-(Acyl carrier protein) reductase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds annotation information from the InterPro database.

No InterPro data for this Pfam family.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan NADP_Rossmann (CL0063), which has the following description:

A class of redox enzymes are two domain proteins. One domain, termed the catalytic domain, confers substrate specificity and the precise reaction of the enzyme. The other domain, which is common to this class of redox enzymes, is a Rossmann-fold domain. The Rossmann domain binds nicotinamide adenine dinucleotide (NAD+) and it is this cofactor that reversibly accepts a hydride ion, which is lost or gained by the substrate in the redox reaction. Rossmann domains have an alpha/beta fold, which has a central beta sheet, with approximately five alpha helices found surrounding the beta sheet.The strands forming the beta sheet are found in the following characteristic order 654123. The inter sheet crossover of the stands in the sheet form the NAD+ binding site [1]. In some more distantly relate Rossmann domains the NAD+ cofactor is replaced by the functionally similar cofactor FAD.

The clan contains the following 206 members:

2-Hacid_dh_C 3Beta_HSD 3HCDH_N 3HCDH_RFF adh_short adh_short_C2 ADH_zinc_N ADH_zinc_N_2 AdoHcyase_NAD AdoMet_MTase AlaDh_PNT_C Amino_oxidase ApbA AviRa B12-binding Bac_GDH Bin3 Bmt2 CbiJ CheR CMAS CmcI CoA_binding CoA_binding_2 CoA_binding_3 Cons_hypoth95 CoV_ExoN CoV_Methyltr_2 DAO DapB_N DFP DNA_methylase DOT1 DRE2_N DREV DUF1442 DUF1611_N DUF166 DUF1776 DUF2431 DUF268 DUF2855 DUF3410 DUF364 DUF43 DUF5129 DUF5130 DUF6094 DUF938 DXP_reductoisom DXPR_C Eco57I ELFV_dehydrog Eno-Rase_FAD_bd Eno-Rase_NADH_b Enoyl_reductase Epimerase F420_oxidored FAD_binding_2 FAD_binding_3 FAD_oxidored Fibrillarin FMO-like FmrO FtsJ fvmX7 G6PD_N GCD14 GDI GDP_Man_Dehyd GFO_IDH_MocA GIDA GidB GLF Glu_dehyd_C Glyco_hydro_4 Glyco_tran_WecG GMC_oxred_N Gp_dh_N GRAS GRDA HcgC HI0933_like HIM1 IlvN ISPD_C K_oxygenase KR LCM Ldh_1_N LpxI_N Lycopene_cycl Malic_M Mannitol_dh MCRA Met_10 Methyltr_RsmB-F Methyltr_RsmF_N Methyltrans_Mon Methyltrans_SAM Methyltransf_10 Methyltransf_11 Methyltransf_12 Methyltransf_14 Methyltransf_15 Methyltransf_16 Methyltransf_17 Methyltransf_18 Methyltransf_19 Methyltransf_2 Methyltransf_20 Methyltransf_21 Methyltransf_22 Methyltransf_23 Methyltransf_24 Methyltransf_25 Methyltransf_28 Methyltransf_29 Methyltransf_3 Methyltransf_30 Methyltransf_31 Methyltransf_32 Methyltransf_33 Methyltransf_34 Methyltransf_4 Methyltransf_5 Methyltransf_7 Methyltransf_8 Methyltransf_9 Methyltransf_PK MethyltransfD12 MetW Mg-por_mtran_C MOLO1 Mqo MT-A70 MTS Mur_ligase N2227 N6-adenineMlase N6_Mtase N6_N4_Mtase NAD_binding_10 NAD_binding_2 NAD_binding_3 NAD_binding_4 NAD_binding_5 NAD_binding_7 NAD_binding_8 NAD_binding_9 NAD_Gly3P_dh_N NAS NmrA NNMT_PNMT_TEMT NodS OCD_Mu_crystall Orbi_VP4 PALP PARP_regulatory PCMT PDH PglD_N Polysacc_syn_2C Polysacc_synt_2 Pox_MCEL Pox_mRNA-cap Prenylcys_lyase PrmA PRMT5 Pyr_redox Pyr_redox_2 Pyr_redox_3 Reovirus_L2 RmlD_sub_bind Rossmann-like rRNA_methylase RrnaAD Rsm22 RsmJ Sacchrp_dh_NADP SAM_MT SE Semialdhyde_dh Shikimate_DH Spermine_synth TehB THF_DHG_CYH_C Thi4 ThiF TPM_phosphatase TPMT TrkA_N TRM TRM13 TrmK tRNA_U5-meth_tr Trp_halogenase TylF Ubie_methyltran UDPG_MGDP_dh_N UPF0020 UPF0146 Urocanase V_cholerae_RfbT XdhC_C YjeF_N

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(315)
Full
(172504)
Representative proteomes UniProt
(677891)
RP15
(16853)
RP35
(70909)
RP55
(164802)
RP75
(293896)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(315)
Full
(172504)
Representative proteomes UniProt
(677891)
RP15
(16853)
RP35
(70909)
RP55
(164802)
RP75
(293896)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(315)
Full
(172504)
Representative proteomes UniProt
(677891)
RP15
(16853)
RP35
(70909)
RP55
(164802)
RP75
(293896)
Raw Stockholm Download     Download   Download        
Gzipped Download     Download   Download        

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:C2M4X7
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Coggill P
Number in seed: 315
Number in full: 172504
Average length of the domain: 229.10 aa
Average identity of full alignment: 26 %
Average coverage of the sequence by the domain: 85.10 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.0 27.0
Noise cut-off 26.9 26.9
Model length: 234
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the adh_short_C2 domain has been found. There are 2916 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0N7KN00 View 3D Structure Click here
A0A0P0VCB4 View 3D Structure Click here
A0A0P0W7F3 View 3D Structure Click here
A0A0P0WCP5 View 3D Structure Click here
A0A0P0X8K6 View 3D Structure Click here
A0A0P0X9S9 View 3D Structure Click here
A0A0P0X9T1 View 3D Structure Click here
A0A0P0X9T5 View 3D Structure Click here
A0A0P0XA14 View 3D Structure Click here
A0A0P0XA86 View 3D Structure Click here
A0A0P0XAP6 View 3D Structure Click here
A0A0P0Y590 View 3D Structure Click here
A0A0P0Y8Z9 View 3D Structure Click here
A0A0R0EY71 View 3D Structure Click here
A0A0R0EZU3 View 3D Structure Click here
A0A0R0F180 View 3D Structure Click here
A0A0R0F1L5 View 3D Structure Click here
A0A0R0F3X6 View 3D Structure Click here
A0A0R0F5Q2 View 3D Structure Click here
A0A0R0F6P0 View 3D Structure Click here
A0A0R0FB29 View 3D Structure Click here
A0A0R0FB78 View 3D Structure Click here
A0A0R0FC09 View 3D Structure Click here
A0A0R0H3D0 View 3D Structure Click here
A0A0R0HCQ2 View 3D Structure Click here
A0A0R0HKM9 View 3D Structure Click here
A0A0R0HXT4 View 3D Structure Click here
A0A0R0I4F6 View 3D Structure Click here
A0A0R0IY28 View 3D Structure Click here
A0A0R0J065 View 3D Structure Click here
A0A0R0J965 View 3D Structure Click here
A0A0R0JBZ9 View 3D Structure Click here
A0A0R0KN82 View 3D Structure Click here
A0A0R4J4G7 View 3D Structure Click here
A0A0R4J4K6 View 3D Structure Click here
A0A0R4J4R5 View 3D Structure Click here
A0A0R4J5C5 View 3D Structure Click here
A0A0R4J681 View 3D Structure Click here
A0A163UT65 View 3D Structure Click here
A0A1D6E789 View 3D Structure Click here
A0A1D6EBW2 View 3D Structure Click here
A0A1D6ED43 View 3D Structure Click here
A0A1D6F0W7 View 3D Structure Click here
A0A1D6F844 View 3D Structure Click here
A0A1D6GD81 View 3D Structure Click here
A0A1D6GEX5 View 3D Structure Click here
A0A1D6H8U6 View 3D Structure Click here
A0A1D6HXF7 View 3D Structure Click here
A0A1D6III9 View 3D Structure Click here
A0A1D6INN1 View 3D Structure Click here
A0A1D6J5I0 View 3D Structure Click here
A0A1D6JAW2 View 3D Structure Click here
A0A1D6JZQ9 View 3D Structure Click here
A0A1D6LAE4 View 3D Structure Click here
A0A1D6MBR4 View 3D Structure Click here
A0A1D6PMY8 View 3D Structure Click here
A0A1D6PPC1 View 3D Structure Click here
A0A1D6PZ66 View 3D Structure Click here
A0A1D8PCP4 View 3D Structure Click here
A0A1D8PPB1 View 3D Structure Click here
A0A1D8PTE1 View 3D Structure Click here
A0A1I9LQ55 View 3D Structure Click here
A0A1P8BDP1 View 3D Structure Click here
A0A1R3LXW2 View 3D Structure Click here
A0A1R3LXW2 View 3D Structure Click here
A0A2R8Q976 View 3D Structure Click here
A2BF91 View 3D Structure Click here
A4I067 View 3D Structure Click here
A4I111 View 3D Structure Click here
A4I345 View 3D Structure Click here
A4I3H1 View 3D Structure Click here
B0M195 View 3D Structure Click here
B2GV72 View 3D Structure Click here
B4FFM6 View 3D Structure Click here
B4FKY9 View 3D Structure Click here
B4FSX7 View 3D Structure Click here
B6T5Z2 View 3D Structure Click here
B6TAE7 View 3D Structure Click here
B6TYG2 View 3D Structure Click here
B7FAC8 View 3D Structure Click here
C0HDZ8 View 3D Structure Click here
C0P944 View 3D Structure Click here
C4JBV8 View 3D Structure Click here
C6KSZ2 View 3D Structure Click here
C6KSZ2 View 3D Structure Click here
C6SY07 View 3D Structure Click here
C6TBU9 View 3D Structure Click here
C6TC47 View 3D Structure Click here
C6TJ97 View 3D Structure Click here
C6TLW3 View 3D Structure Click here
C6TMK2 View 3D Structure Click here
D3ZEZ3 View 3D Structure Click here
D4A1J4 View 3D Structure Click here
D4A4Y2 View 3D Structure Click here
E9Q3D4 View 3D Structure Click here
F1QB21 View 3D Structure Click here
F4IKM1 View 3D Structure Click here
F4J2Z7 View 3D Structure Click here
F4J300 View 3D Structure Click here
F4JI53 View 3D Structure Click here
G5ECL7 View 3D Structure Click here
G5ECU4 View 3D Structure Click here
G5EGA6 View 3D Structure Click here
I1J812 View 3D Structure Click here
I1JL18 View 3D Structure Click here
I1JL18 View 3D Structure Click here
I1JQ60 View 3D Structure Click here
I1JQV4 View 3D Structure Click here
I1JQV5 View 3D Structure Click here
I1JRD7 View 3D Structure Click here
I1JSD6 View 3D Structure Click here
I1JWZ1 View 3D Structure Click here
I1KIE7 View 3D Structure Click here
I1KK25 View 3D Structure Click here
I1KK27 View 3D Structure Click here
I1KRZ2 View 3D Structure Click here
I1KZ09 View 3D Structure Click here
I1KZX6 View 3D Structure Click here
I1L6M9 View 3D Structure Click here
I1LIT1 View 3D Structure Click here
I1LJY0 View 3D Structure Click here
I1LLA0 View 3D Structure Click here
I1LMI8 View 3D Structure Click here
I1LNB1 View 3D Structure Click here
I1LPJ8 View 3D Structure Click here
I1LQL3 View 3D Structure Click here
I1LRJ6 View 3D Structure Click here
I1MI57 View 3D Structure Click here
I1MLA9 View 3D Structure Click here
I1MZ99 View 3D Structure Click here
I1N4V0 View 3D Structure Click here
I1NAR8 View 3D Structure Click here
I6XZC4 View 3D Structure Click here
I6Y1W3 View 3D Structure Click here
I6Y3S9 View 3D Structure Click here
I6Y778 View 3D Structure Click here
I6YCE1 View 3D Structure Click here
I6YCF0 View 3D Structure Click here
I6YEB6 View 3D Structure Click here
K7KC65 View 3D Structure Click here
K7KG80 View 3D Structure Click here
K7KGR3 View 3D Structure Click here
K7KVW4 View 3D Structure Click here
K7LGJ5 View 3D Structure Click here
K7LRL4 View 3D Structure Click here
K7LRL6 View 3D Structure Click here
K7LT97 View 3D Structure Click here
K7MT82 View 3D Structure Click here
K7MTQ6 View 3D Structure Click here
K7MXM3 View 3D Structure Click here
K7MZA6 View 3D Structure Click here
K7TY10 View 3D Structure Click here
K7U066 View 3D Structure Click here
K7V9S5 View 3D Structure Click here
K7W0B3 View 3D Structure Click here
M0R983 View 3D Structure Click here
M0RCW1 View 3D Structure Click here
O06348 View 3D Structure Click here
O13908 View 3D Structure Click here
O16619 View 3D Structure Click here
O16969 View 3D Structure Click here
O16971 View 3D Structure Click here
O16995 View 3D Structure Click here
O17574 View 3D Structure Click here
O42866 View 3D Structure Click here
O45236 View 3D Structure Click here
O45709 View 3D Structure Click here
O49332 View 3D Structure Click here
O61709 View 3D Structure Click here
O74470 View 3D Structure Click here
O80711 View 3D Structure Click here
O80711 View 3D Structure Click here
O80713 View 3D Structure Click here
O80714 View 3D Structure Click here
P0AEK2 View 3D Structure Click here
P0AEK4 View 3D Structure Click here
P0AFS3 View 3D Structure Click here
P0AG84 View 3D Structure Click here
P0CG22 View 3D Structure Click here
P0DKI3 View 3D Structure Click here
P15047 View 3D Structure Click here
P32573 View 3D Structure Click here
P33368 View 3D Structure Click here
P37440 View 3D Structure Click here
P37769 View 3D Structure Click here
P50160 View 3D Structure Click here
P50171 View 3D Structure Click here
P52037 View 3D Structure Click here
P76633 View 3D Structure Click here
P87218 View 3D Structure Click here
P87219 View 3D Structure Click here
P95286 View 3D Structure Click here
P9WGQ1 View 3D Structure Click here
P9WGQ3 View 3D Structure Click here
P9WGQ5 View 3D Structure Click here
P9WGQ9 View 3D Structure Click here
P9WGR1 View 3D Structure Click here
P9WGR9 View 3D Structure Click here
P9WGS5 View 3D Structure Click here
P9WGS7 View 3D Structure Click here
P9WGT1 View 3D Structure Click here
P9WGT3 View 3D Structure Click here
Q0D3U7 View 3D Structure Click here
Q0D3U9 View 3D Structure Click here
Q0D3V0 View 3D Structure Click here
Q0D3V2 View 3D Structure Click here
Q0D3V8 View 3D Structure Click here
Q0DM18 View 3D Structure Click here
Q0JDU3 View 3D Structure Click here
Q10216 View 3D Structure Click here
Q10CW5 View 3D Structure Click here
Q10MQ8 View 3D Structure Click here
Q10NH7 View 3D Structure Click here
Q13268 View 3D Structure Click here
Q149L0 View 3D Structure Click here
Q16698 View 3D Structure Click here
Q17724 View 3D Structure Click here
Q17726 View 3D Structure Click here
Q18946 View 3D Structure Click here
Q19108 View 3D Structure Click here
Q19246 View 3D Structure Click here
Q19774 View 3D Structure Click here
Q19890 View 3D Structure Click here
Q1EPL7 View 3D Structure Click here
Q1LWX6 View 3D Structure Click here
Q21929 View 3D Structure Click here
Q22230 View 3D Structure Click here
Q23116 View 3D Structure Click here
Q2FVE2 View 3D Structure Click here
Q2FVT8 View 3D Structure Click here
Q2FZ53 View 3D Structure Click here
Q2FZQ3 View 3D Structure Click here
Q2G1M1 View 3D Structure Click here
Q2QV59 View 3D Structure Click here
Q2R3G3 View 3D Structure Click here
Q2R5F6 View 3D Structure Click here
Q42182 View 3D Structure Click here
Q4D828 View 3D Structure Click here
Q4DPL5 View 3D Structure Click here
Q53KZ3 View 3D Structure Click here
Q54D03 View 3D Structure Click here
Q54PL1 View 3D Structure Click here
Q54QN6 View 3D Structure Click here
Q561X9 View 3D Structure Click here
Q567C7 View 3D Structure Click here
Q567K5 View 3D Structure Click here
Q59RC4 View 3D Structure Click here
Q59SL5 View 3D Structure Click here
Q5A1C0 View 3D Structure Click here
Q5A8I5 View 3D Structure Click here
Q5AEJ7 View 3D Structure Click here
Q5BLE6 View 3D Structure Click here
Q5GAU6 View 3D Structure Click here
Q5SMM7 View 3D Structure Click here
Q64591 View 3D Structure Click here
Q6DEH9 View 3D Structure Click here
Q6H5J0 View 3D Structure Click here
Q6K447 View 3D Structure Click here
Q6MGB5 View 3D Structure Click here
Q6NV34 View 3D Structure Click here
Q6P0H7 View 3D Structure Click here
Q6Z0I4 View 3D Structure Click here
Q6ZF50 View 3D Structure Click here
Q75JT8 View 3D Structure Click here
Q75KH3 View 3D Structure Click here
Q7FAE1 View 3D Structure Click here
Q7SYD0 View 3D Structure Click here
Q7TS56 View 3D Structure Click here
Q7X779 View 3D Structure Click here
Q7XDQ8 View 3D Structure Click here
Q7XL00 View 3D Structure Click here
Q7XLC5 View 3D Structure Click here
Q7XNL8 View 3D Structure Click here
Q7XZH5 View 3D Structure Click here
Q7Z4W1 View 3D Structure Click here
Q84JJ3 View 3D Structure Click here
Q84NR4 View 3D Structure Click here
Q852E3 View 3D Structure Click here
Q8I2S7 View 3D Structure Click here
Q8IPP8 View 3D Structure Click here
Q8JZV9 View 3D Structure Click here
Q8K354 View 3D Structure Click here
Q8MXS8 View 3D Structure Click here
Q8N4T8 View 3D Structure Click here
Q8RX32 View 3D Structure Click here
Q8SX57 View 3D Structure Click here
Q8VID1 View 3D Structure Click here
Q91VT4 View 3D Structure Click here
Q91X52 View 3D Structure Click here
Q920P0 View 3D Structure Click here
Q92506 View 3D Structure Click here
Q93761 View 3D Structure Click here
Q942W0 View 3D Structure Click here
Q94K41 View 3D Structure Click here
Q99LB2 View 3D Structure Click here
Q99MZ7 View 3D Structure Click here
Q9BL81 View 3D Structure Click here
Q9BPX1 View 3D Structure Click here
Q9BTZ2 View 3D Structure Click here
Q9BUT1 View 3D Structure Click here
Q9BY49 View 3D Structure Click here
Q9C826 View 3D Structure Click here
Q9CQ62 View 3D Structure Click here
Q9FZ42 View 3D Structure Click here
Q9LHT0 View 3D Structure Click here
Q9LTV6 View 3D Structure Click here
Q9LW34 View 3D Structure Click here
Q9LW35 View 3D Structure Click here
Q9M1K9 View 3D Structure Click here
Q9M2E2 View 3D Structure Click here
Q9MA93 View 3D Structure Click here
Q9N5G1 View 3D Structure Click here
Q9N5G2 View 3D Structure Click here
Q9N5G3 View 3D Structure Click here
Q9N5G4 View 3D Structure Click here
Q9NUI1 View 3D Structure Click here
Q9S9W2 View 3D Structure Click here
Q9SCU0 View 3D Structure Click here
Q9SGI2 View 3D Structure Click here
Q9SLA8 View 3D Structure Click here
Q9SQR2 View 3D Structure Click here
Q9SQR4 View 3D Structure Click here
Q9SVQ9 View 3D Structure Click here
Q9U1L2 View 3D Structure Click here
Q9URX0 View 3D Structure Click here
Q9VNF3 View 3D Structure Click here
Q9VNF4 View 3D Structure Click here
Q9VRJ4 View 3D Structure Click here
Q9VWP2 View 3D Structure Click here
Q9W4U2 View 3D Structure Click here
Q9WV68 View 3D Structure Click here
Q9WVK3 View 3D Structure Click here
Q9XE46 View 3D Structure Click here
Q9Y6Z9 View 3D Structure Click here
Q9Z2M4 View 3D Structure Click here
Q9ZUH5 View 3D Structure Click here
Q9ZW03 View 3D Structure Click here
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Q9ZW12 View 3D Structure Click here
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Q9ZW20 View 3D Structure Click here