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89  structures 4631  species 0  interactions 32371  sequences 1131  architectures

Family: HEAT_2 (PF13646)

Summary: HEAT repeats

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "HEAT repeat domain". More...

HEAT repeat domain Edit Wikipedia article

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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

HEAT repeats Provide feedback

This family includes multiple HEAT repeats.

Internal database links

This tab holds annotation information from the InterPro database.

No InterPro data for this Pfam family.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan TPR (CL0020), which has the following description:

Tetratricopeptide-like repeats are found in a numerous and diverse proteins involved in such functions as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.

The clan contains the following 176 members:

Adaptin_N Alkyl_sulf_dimr ANAPC3 ANAPC5 ANAPC8 APC_rep API5 Arm Arm_2 Arm_3 Arm_vescicular Atx10homo_assoc B56 BAF250_C BTAD CAS_CSE1 ChAPs CHIP_TPR_N CID CLASP_N Clathrin Clathrin-link Clathrin_H_link Clathrin_propel Cnd1 Cnd3 Coatomer_E Cohesin_HEAT Cohesin_load ComR_TPR COPI_C CPL CRM1_C CRM1_repeat CRM1_repeat_3 Cse1 CTK3 DHR-2 DIL DNA_alkylation Dopey_N Drf_FH3 Drf_GBD DUF1822 DUF2019 DUF2225 DUF3385 DUF3458_C DUF3808 DUF3856 DUF4042 DUF5588 DUF5691 DUF6340 DUF6377 DUF924 EAD11 EST1 EST1_DNA_bind FAT Fis1_TPR_C Fis1_TPR_N Foie-gras_1 GUN4_N HAT HEAT HEAT_2 HEAT_EZ HEAT_PBS HEAT_UF HemY_N HrpB1_HrpK HSM3_C HSM3_N IBB IBN_N IFRD Importin_rep Importin_rep_2 Importin_rep_3 Importin_rep_4 Importin_rep_5 Importin_rep_6 Insc_C KAP Leuk-A4-hydro_C LRV LRV_FeS MA3 MIF4G MIF4G_like MIF4G_like_2 MMS19_C Mo25 MRP-S27 Mtf2 NARP1 Neurochondrin Nipped-B_C Nro1 NSF Paf67 ParcG PC_rep PHAT PI3Ka PknG_TPR PPP5 PPR PPR_1 PPR_2 PPR_3 PPR_long PPTA Proteasom_PSMB PUF Rapsyn_N RIX1 RNPP_C RPM2 RPN7 Sel1 SHNi-TPR SNAP SPO22 SRP_TPR_like ST7 Suf SusD-like SusD-like_2 SusD-like_3 SusD_RagB SYCP2_ARLD TAF6_C TAL_effector TAtT Tcf25 TIP120 TOM20_plant TPR_1 TPR_10 TPR_11 TPR_12 TPR_14 TPR_15 TPR_16 TPR_17 TPR_18 TPR_19 TPR_2 TPR_20 TPR_21 TPR_22 TPR_3 TPR_4 TPR_5 TPR_6 TPR_7 TPR_8 TPR_9 TPR_MalT TTC7_N UNC45-central Upf2 V-ATPase_H_C V-ATPase_H_N Vac14_Fab1_bd Vitellogenin_N Vps39_1 W2 WSLR Wzy_C_2 Xpo1 YcaO_C YfiO Zmiz1_N

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(119)
Full
(32371)
Representative proteomes UniProt
(142964)
RP15
(5987)
RP35
(16777)
RP55
(30423)
RP75
(47398)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(119)
Full
(32371)
Representative proteomes UniProt
(142964)
RP15
(5987)
RP35
(16777)
RP55
(30423)
RP75
(47398)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(119)
Full
(32371)
Representative proteomes UniProt
(142964)
RP15
(5987)
RP35
(16777)
RP55
(30423)
RP75
(47398)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:C2M4W3
Previous IDs: none
Type: Repeat
Sequence Ontology: SO:0001068
Author: Bateman A
Number in seed: 119
Number in full: 32371
Average length of the domain: 87.80 aa
Average identity of full alignment: 21 %
Average coverage of the sequence by the domain: 22.70 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.7 27.7
Trusted cut-off 27.7 27.7
Noise cut-off 27.6 27.6
Model length: 88
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Tree controls

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the HEAT_2 domain has been found. There are 89 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0R0EYR1 View 3D Structure Click here
A0A1D6DVZ1 View 3D Structure Click here
A0A1D6E013 View 3D Structure Click here
A0A1D6HPT4 View 3D Structure Click here
A0A1D6HPT4 View 3D Structure Click here
A0A1D6HPT7 View 3D Structure Click here
A0A1D6IHP1 View 3D Structure Click here
A0A1D6IYV8 View 3D Structure Click here
A0A1D6JDW4 View 3D Structure Click here
A0A1D6L0X5 View 3D Structure Click here
A0A1D6LKF6 View 3D Structure Click here
A0A1D6P323 View 3D Structure Click here
A0A1D6PTZ0 View 3D Structure Click here
A0A1D8PJE8 View 3D Structure Click here
A0A1X7YHS4 View 3D Structure Click here
A0A2R8Q718 View 3D Structure Click here
A4I2C0 View 3D Structure Click here
A4I2C0 View 3D Structure Click here
A4I3Q0 View 3D Structure Click here
A5PMV7 View 3D Structure Click here
B2RY50 View 3D Structure Click here
B8JHR9 View 3D Structure Click here
B8JHR9 View 3D Structure Click here
B9EJR8 View 3D Structure Click here
D3ZA65 View 3D Structure Click here
D3ZSB9 View 3D Structure Click here
D3ZXG2 View 3D Structure Click here
D3ZZQ6 View 3D Structure Click here
D4A781 View 3D Structure Click here
E7F2X3 View 3D Structure Click here
E9Q357 View 3D Structure Click here
F1R8B4 View 3D Structure Click here
I1JDU7 View 3D Structure Click here
I1JP19 View 3D Structure Click here
I1K5H2 View 3D Structure Click here
I1KIV5 View 3D Structure Click here
I1KQE8 View 3D Structure Click here
I1KSC8 View 3D Structure Click here
I1L4D3 View 3D Structure Click here
I1LEY1 View 3D Structure Click here
I1ML09 View 3D Structure Click here
I1NFG9 View 3D Structure Click here
K7V7I6 View 3D Structure Click here
O18167 View 3D Structure Click here
O48844 View 3D Structure Click here
O60518 View 3D Structure Click here
O88761 View 3D Structure Click here
P0ADK6 View 3D Structure Click here
P0ADK6 View 3D Structure Click here
P30154 View 3D Structure Click here
P32565 View 3D Structure Click here
Q2FX88 View 3D Structure Click here
Q2FYK3 View 3D Structure Click here
Q2QLW3 View 3D Structure Click here
Q2QLW3 View 3D Structure Click here
Q2QLW3 View 3D Structure Click here
Q2QSC9 View 3D Structure Click here
Q2QXB3 View 3D Structure Click here
Q2QXB3 View 3D Structure Click here
Q38845 View 3D Structure Click here
Q38950 View 3D Structure Click here
Q38951 View 3D Structure Click here
Q3TXS7 View 3D Structure Click here
Q4DN31 View 3D Structure Click here
Q4DSX1 View 3D Structure Click here
Q4DXC0 View 3D Structure Click here
Q4QQT4 View 3D Structure Click here
Q54JM5 View 3D Structure Click here
Q556G4 View 3D Structure Click here
Q556G4 View 3D Structure Click here
Q59Z14 View 3D Structure Click here
Q59Z14 View 3D Structure Click here
Q5A3L0 View 3D Structure Click here
Q5ADN1 View 3D Structure Click here
Q5EB20 View 3D Structure Click here
Q5PPJ4 View 3D Structure Click here
Q5PPJ4 View 3D Structure Click here
Q5W041 View 3D Structure Click here
Q5XI34 View 3D Structure Click here
Q5XI34 View 3D Structure Click here
Q642H5 View 3D Structure Click here
Q6K4K9 View 3D Structure Click here
Q6Z921 View 3D Structure Click here
Q6ZL37 View 3D Structure Click here
Q76MZ3 View 3D Structure Click here
Q76MZ3 View 3D Structure Click here
Q7TNP2 View 3D Structure Click here
Q7ZUX6 View 3D Structure Click here
Q7ZUX6 View 3D Structure Click here
Q7ZUX6 View 3D Structure Click here
Q8BKC5 View 3D Structure Click here
Q8I701 View 3D Structure Click here
Q8IKH3 View 3D Structure Click here
Q93VS8 View 3D Structure Click here
Q94JW0 View 3D Structure Click here
Q94JW0 View 3D Structure Click here
Q94K48 View 3D Structure Click here
Q94K48 View 3D Structure Click here
Q96HW7 View 3D Structure Click here
Q99460 View 3D Structure Click here
Q99LN9 View 3D Structure Click here
Q99LN9 View 3D Structure Click here
Q99LN9 View 3D Structure Click here
Q9BU89 View 3D Structure Click here
Q9BU89 View 3D Structure Click here
Q9D3W1 View 3D Structure Click here
Q9P6K9 View 3D Structure Click here
Q9P6K9 View 3D Structure Click here
Q9V3P6 View 3D Structure Click here
Q9VN44 View 3D Structure Click here
X1WHF5 View 3D Structure Click here