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53  structures 216  species 0  interactions 18699  sequences 552  architectures

Family: PRY (PF13765)

Summary: SPRY-associated domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

SPRY-associated domain Provide feedback

PRY is a 50-60 amino acids domain associated with SPRY domains, adjacent to its N-terminal. PRY and SPRY domains are structurally very similar and consist of a beta sandwich fold [1,2,3]. Distant homologues are domains in butyrophilin/marenostrin/pyrin, evolutionarily more ancient than SPRY/B30.2 counterpart.

Literature references

  1. Stehlik C, Reed JC;, J Exp Med. 2004;200:551-558.: The PYRIN connection: novel players in innate immunity and inflammation. PUBMED:15353551 EPMC:15353551

  2. D'Cruz AA, Babon JJ, Norton RS, Nicola NA, Nicholson SE;, Protein Sci. 2013;22:1-10.: Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity. PUBMED:23139046 EPMC:23139046

  3. Woo JS, Suh HY, Park SY, Oh BH;, Mol Cell. 2006;24:967-976.: Structural basis for protein recognition by B30.2/SPRY domains. PUBMED:17189197 EPMC:17189197


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR006574

PRY is a 50-60 amino acids domain associated with SPRY domains, adjacent to its N-terminal. The SPRY domain ( INTERPRO ) is a protein-protein interaction module involved in many important signaling pathways [ PUBMED:23139046 , PUBMED:17189197 ]. Distant homologues are domains in butyrophilin/marenostrin/pyrin, evolutionarily more ancient than SPRY/B30.2 counterpart. PRY and SPRY domains are structurally very similar and consist of a beta sandwich fold [ PUBMED:23139046 , PUBMED:17189197 ]. Ca2+-release from the sarcoplasmic or endoplasmic reticulum, the intracellular Ca2+ store, is mediated by the ryanodine receptor (RyR) and/or the inositol trisphosphate receptor (IP3R).

The proteins identified by the PRY domain, clearly fall into 3 sets which can be defined by their combination of signatures:

  • This group contains an immunoglobulin domain N-terminal to the PRY and butyrophilin domains. Butyrophilins are glycoproteins that are expressed on the apical surfaces of secretory cells in lactating mammary tissue and which may function in the secretion of milk-fat droplets.
  • This group contain a RING-finger domain N-terminal to the PRY domain. The RING-finger is a specialised type of Zn-finger of 40 to 60 residues that binds two atoms of zinc, and is probably involved in mediating protein-protein interactions. There are two different variants, the C3HC4-type and a C3H2C3-type, which is clearly related despite the different cysteine/histidine pattern. The latter type is sometimes referred to as 'RING-H2 finger' is not found associated with this group of proteins. This set of proteins are described as TRIM (TRIpartite Motif) family members and are involved in cellular compartmentalisation [ PUBMED:11331580 ]. The TRIM family sequences are defined by a Ring finger domain, a B-box type1 (B1) and a B-box type 2 (B2) followed by a coiled-coil (CC) region [ PUBMED:1412709 ]. Genes belonging to this family are implicated in a variety of processes such as development and cell growth and are involved in human disease.

Many of these proteins, with the PRY domain have a number of C-terminal signatures, SPRY, RFP-like (also known as B30.2 domain or PRYSPRY) and butyrophilin domain [ PUBMED:9866204 ].

The third set of proteins have the C-terminal signatures but have no N-terminal RING-finger or immunoglobulin domain signatures. These proteins have not been functionally described.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(120)
Full
(18699)
Representative proteomes UniProt
(31468)
RP15
(1231)
RP35
(5415)
RP55
(17082)
RP75
(22471)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(120)
Full
(18699)
Representative proteomes UniProt
(31468)
RP15
(1231)
RP35
(5415)
RP55
(17082)
RP75
(22471)
Alignment:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(120)
Full
(18699)
Representative proteomes UniProt
(31468)
RP15
(1231)
RP35
(5415)
RP55
(17082)
RP75
(22471)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:B0V264
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Coggill P
Number in seed: 120
Number in full: 18699
Average length of the domain: 48.60 aa
Average identity of full alignment: 38 %
Average coverage of the sequence by the domain: 8.89 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.5 27.5
Trusted cut-off 27.5 27.5
Noise cut-off 27.4 27.4
Model length: 49
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PRY domain has been found. There are 53 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0A0MPM8 View 3D Structure Click here
A0A0A0MPR3 View 3D Structure Click here
A0A0A0MPR4 View 3D Structure Click here
A0A0A0MPS0 View 3D Structure Click here
A0A0A0MPT9 View 3D Structure Click here
A0A0A0MPU9 View 3D Structure Click here
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A0A0G2KRG9 View 3D Structure Click here
A0A0G2KUT8 View 3D Structure Click here
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A0A0H2UKH6 View 3D Structure Click here
A0A0N4SU11 View 3D Structure Click here
A0A0R4I9L8 View 3D Structure Click here
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A0A0R4IA89 View 3D Structure Click here
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A0A0R4IAM8 View 3D Structure Click here
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A0A0R4IBN3 View 3D Structure Click here
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A0A0R4IBP6 View 3D Structure Click here
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A0A0R4IDG6 View 3D Structure Click here
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A0A0R4IDW8 View 3D Structure Click here
A0A0R4IDY8 View 3D Structure Click here
A0A0R4IE13 View 3D Structure Click here
A0A0R4IE23 View 3D Structure Click here
A0A0R4IEH8 View 3D Structure Click here
A0A0R4IEU6 View 3D Structure Click here
A0A0R4IF79 View 3D Structure Click here
A0A0R4IFH2 View 3D Structure Click here
A0A0R4IFT7 View 3D Structure Click here
A0A0R4IG29 View 3D Structure Click here
A0A0R4IG69 View 3D Structure Click here
A0A0R4IG87 View 3D Structure Click here
A0A0R4IG92 View 3D Structure Click here
A0A0R4IG99 View 3D Structure Click here
A0A0R4IH12 View 3D Structure Click here
A0A0R4IHD9 View 3D Structure Click here
A0A0R4IHE6 View 3D Structure Click here
A0A0R4IHG5 View 3D Structure Click here
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A0A0R4II04 View 3D Structure Click here
A0A0R4II18 View 3D Structure Click here
A0A0R4II21 View 3D Structure Click here
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A0A0R4III4 View 3D Structure Click here
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A0A0R4IIL0 View 3D Structure Click here
A0A0R4IIW8 View 3D Structure Click here
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A0A0R4IJZ5 View 3D Structure Click here
A0A0R4IK34 View 3D Structure Click here
A0A0R4IK57 View 3D Structure Click here
A0A0R4IK73 View 3D Structure Click here
A0A0R4IKI3 View 3D Structure Click here
A0A0R4IKS9 View 3D Structure Click here
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A0A0R4IL07 View 3D Structure Click here
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A0A0R4ILF5 View 3D Structure Click here
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A0A0R4IM02 View 3D Structure Click here
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A0A0R4IMC8 View 3D Structure Click here
A0A0R4IN16 View 3D Structure Click here
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A0A0R4IP08 View 3D Structure Click here
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A0A0R4IP74 View 3D Structure Click here
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A0A0R4IT41 View 3D Structure Click here
A0A0R4ITY0 View 3D Structure Click here
A0A0R4IU43 View 3D Structure Click here
A0A0R4IU77 View 3D Structure Click here
A0A0R4IUB8 View 3D Structure Click here
A0A0R4IUB9 View 3D Structure Click here
A0A0R4IUE8 View 3D Structure Click here
A0A0R4IUF9 View 3D Structure Click here
A0A0R4IUI9 View 3D Structure Click here
A0A0R4IUM1 View 3D Structure Click here
A0A0R4IUR5 View 3D Structure Click here
A0A0R4IUS0 View 3D Structure Click here
A0A0R4IUS8 View 3D Structure Click here
A0A0R4IUT0 View 3D Structure Click here
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A0A0R4IV10 View 3D Structure Click here
A0A0R4IV55 View 3D Structure Click here
A0A0R4IVV9 View 3D Structure Click here
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A0A1B0GWP0 View 3D Structure Click here
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A0A286Y887 View 3D Structure Click here
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A0A2R8Q496 View 3D Structure Click here
A0A2R8Q4I3 View 3D Structure Click here
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A0A2R8QQU4 View 3D Structure Click here
A0A2R8QRH9 View 3D Structure Click here
A0A2R8RLF6 View 3D Structure Click here
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A0A2R8RR89 View 3D Structure Click here
A0A2R8RZP6 View 3D Structure Click here
A0A2R8S055 View 3D Structure Click here
A0JPQ4 View 3D Structure Click here
A2BFT4 View 3D Structure Click here
A2RT81 View 3D Structure Click here
A3KQE0 View 3D Structure Click here
A3KQG8 View 3D Structure Click here
A4IG09 View 3D Structure Click here
A4QPC6 View 3D Structure Click here
A6NK02 View 3D Structure Click here
A6NLU0 View 3D Structure Click here
A8E7M3 View 3D Structure Click here
A8WG17 View 3D Structure Click here
A8WG25 View 3D Structure Click here
A9JSZ8 View 3D Structure Click here
B0S6J1 View 3D Structure Click here
B0S6R8 View 3D Structure Click here
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B1H278 View 3D Structure Click here
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B3DJG6 View 3D Structure Click here
B3DK63 View 3D Structure Click here
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E9PW10 View 3D Structure Click here
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E9QDK0 View 3D Structure Click here
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E9QH21 View 3D Structure Click here
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E9QI03 View 3D Structure Click here
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F1LMK2 View 3D Structure Click here
F1LRV5 View 3D Structure Click here
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F1Q547 View 3D Structure Click here
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F1QS63 View 3D Structure Click here
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F1QZB6 View 3D Structure Click here
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F1R020 View 3D Structure Click here
F1R0A0 View 3D Structure Click here
F1R358 View 3D Structure Click here
F1R3B6 View 3D Structure Click here
F1R437 View 3D Structure Click here
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F1R991 View 3D Structure Click here
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F1RD34 View 3D Structure Click here
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F6NI41 View 3D Structure Click here
F6NI48 View 3D Structure Click here
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F6NK02 View 3D Structure Click here
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F6P427 View 3D Structure Click here
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F6P534 View 3D Structure Click here
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F6PA60 View 3D Structure Click here
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H0WEE9 View 3D Structure Click here
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I3IRV5 View 3D Structure Click here
K7DY09 View 3D Structure Click here
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K7DY86 View 3D Structure Click here
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M0R7E0 View 3D Structure Click here
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O00478 View 3D Structure Click here
O00481 View 3D Structure Click here
O00635 View 3D Structure Click here
O15344 View 3D Structure Click here
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O75677 View 3D Structure Click here
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O95361 View 3D Structure Click here
P14373 View 3D Structure Click here
P19474 View 3D Structure Click here
P62603 View 3D Structure Click here
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Q08C26 View 3D Structure Click here
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Q309B1 View 3D Structure Click here
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Q6UX41 View 3D Structure Click here
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Q80V85 View 3D Structure Click here
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