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217  structures 502  species 0  interactions 24443  sequences 1929  architectures

Family: Ig_2 (PF13895)

Summary: Immunoglobulin domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Immunoglobulin domain". More...

Immunoglobulin domain Edit Wikipedia article

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This is the Wikipedia entry entitled "Immunoglobulin superfamily". More...

Immunoglobulin superfamily Edit Wikipedia article

Immunoglobulin superfamily
PDB 1a2y EBI.jpg
Antibody in complex with hen egg white lysozyme.[1]
Identifiers
SymbolIgSF
PfamPF00047
Pfam clanCL0011
InterProIPR013151
PROSITEPS50835
SCOPe1tlk / SUPFAM
OPM superfamily193
OPM protein3bib
CDDcd00096
Membranome2
Immunoglobulin-like (ligands)
Identifiers
SymbolIg protein ligands
Membranome64
Immunoglobulin-like adhesion molecules
Identifiers
SymbolIgSF CAM
Membranome110

The immunoglobulin superfamily (IgSF) is a large protein superfamily of cell surface and soluble proteins that are involved in the recognition, binding, or adhesion processes of cells. Molecules are categorized as members of this superfamily based on shared structural features with immunoglobulins (also known as antibodies); they all possess a domain known as an immunoglobulin domain or fold. Members of the IgSF include cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins. They are commonly associated with roles in the immune system. Otherwise, the sperm-specific protein IZUMO1, a member of the immunoglobulin superfamily, has also been identified as the only sperm membrane protein essential for sperm-egg fusion.

Immunoglobulin domains

Proteins of the IgSF possess a structural domain known as an immunoglobulin (Ig) domain. Ig domains are named after the immunoglobulin molecules. They contain about 70-110 amino acids and are categorized according to their size and function.[2] Ig-domains possess a characteristic Ig-fold, which has a sandwich-like structure formed by two sheets of antiparallel beta strands. Interactions between hydrophobic amino acids on the inner side of the sandwich and highly conserved disulfide bonds formed between cysteine residues in the B and F strands, stabilize the Ig-fold. One end of the Ig domain has a section called the complementarity determining region that is important for the specificity of antibodies for their ligands. It is believed that the structure of variable subgenes of Ig and the surface immunoglobulin determine the propensity of chronic or tonic BCR signalling.

Classification

The Ig like domains can be classified as IgV, IgC1, IgC2, or IgI.[3]

Most Ig domains are either variable (IgV) or constant (IgC).

  • IgV: IgV domains with 9 beta strands are generally longer than IgC domains with 7 beta strands.
  • IgC1 and IgC2: Ig domains of some members of the IgSF resemble IgV domains in the amino acid sequence, yet are similar in size to IgC domains. These are called IgC2 domains, while standard IgC domains are called IgC1 domains.
  • IgI: Other Ig domains exist that are called intermediate (I) domains.[4]

Members

The Ig domain was reported to be the most populous family of proteins in the human genome with 765 members identified.[5] Members of the family can be found even in the bodies of animals with a simple physiological structure such as poriferan sponges. They have also been found in bacteria, where their presence is thought to be due to horizontal gene transfer.[6]

Members of the immunoglobulin superfamily
Molecule function/category Examples Description
Antigen receptors Antigen receptors found on the surface of T and B lymphocytes in all jawed vertebrates belong to the IgSF. Immunoglobulin molecules (the antigen receptors of B cells) are the founding members of the IgSF. In humans, there are five distinct types of immunoglobulin molecule all containing a heavy chain with four Ig domains and a light chain with two Ig domains. The antigen receptor of T cells is the T cell receptor (TCR), which is composed of two chains, either the TCR-alpha and -beta chains, or the TCR-delta and gamma chains. All TCR chains contain two Ig domains in the extracellular portion; one IgV domain at the N-terminus and one IgC1 domain adjacent to the cell membrane.
Antigen presenting molecules The ligands for TCRs are major histocompatibility complex (MHC) proteins. These come in two forms; MHC class I forms a dimer with a molecule called beta-2 microglobulin (β2M) and interacts with the TCR on cytotoxic T cells and MHC class II has two chains (alpha and beta) that interact with the TCR on helper T cells. MHC class I, MHC class II and β2M molecules all possess Ig domains and are therefore also members of the IgSF.
Co-receptors Co-receptors and accessory molecules: Other molecules on the surfaces of T cells also interact with MHC molecules during TCR engagement. These are known as co-receptors. In lymphocyte populations, the co-receptor CD4 is found on helper T cells and the co-receptor CD8 is found on cytotoxic T cells. CD4 has four Ig domains in its extracellular portion and functions as a monomer. CD8, in contrast, functions as a dimer with either two identical alpha chains or, more typically, with an alpha and beta chain. CD8-alpha and CD8-beta each has one extracellular IgV domain in its extracellular portion. A co-receptor complex is also used by the BCR, including CD19, an IgSF molecule with two IgC2-domains.
Antigen receptor accessory molecules A further molecule is found on the surface of T cells that is also involved in signaling from the TCR. CD3 is a molecule that helps to transmit a signal from the TCR following its interaction with MHC molecules. Three different chains make up CD3 in humans, the gamma chain, delta chain and epsilon chain, all of which are IgSF molecules with a single Ig domain.

Similar to the situation with T cells, B cells also have cell surface co-receptors and accessory molecules that assist with cell activation by the B Cell Receptor (BCR)/immunoglobulin. Two chains are used or signaling, CD79a and CD79b that both possess a single Ig domain.

Co-stimulatory or inhibitory molecules Co-stimulatory or inhibitory molecules: Co-stimulatory and inhibitory signaling receptors and ligands control the activation, expansion and effector functions of cells. One major group of IgSF co-stimulatory receptors are molecules of the CD28 family; CD28, CTLA-4, program death-1 (PD-1), the B- and T-lymphocyte attenuator (BTLA, CD272), and the inducible T-cell co-stimulator (ICOS, CD278);[7] and their IgSF ligands belong to the B7 family; CD80 (B7-1), CD86 (B7-2), ICOS ligand, PD-L1 (B7-H1), PD-L2 (B7-DC), B7-H3, and B7-H4 (B7x/B7-S1).[8]
Receptors on Natural killer cells
Receptors on Leukocytes
IgSF CAMs
  • NCAMs
  • ICAM-1
  • CD2 subset
  • Type IIa and Type IIb RPTPs, described in Receptor tyrosine kinases/phosphatases subsection below
Cytokine receptors
Growth factor receptors
Receptor tyrosine kinases/phosphatases
Ig binding receptors
Cytoskeleton
Others

References

  1. ^ Dall'Acqua W, Goldman ER, Lin W, Teng C, Tsuchiya D, Li H, Ysern X, Braden BC, Li Y, Smith-Gill SJ, Mariuzza RA (June 1998). "A mutational analysis of binding interactions in an antigen-antibody protein-protein complex". Biochemistry. 37 (22): 7981–91. doi:10.1021/bi980148j. PMID 9609690.
  2. ^ Barclay AN (August 2003). "Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules". Seminars in Immunology. 15 (4): 215–23. doi:10.1016/S1044-5323(03)00047-2. PMID 14690046.
  3. ^ B. D. Gomperts; Ijsbrand M. Kramer; Peter E. R. Tatham (1 July 2009). Signal transduction. Academic Press. pp. 378–. ISBN 978-0-12-369441-6. Retrieved 28 November 2010.
  4. ^ Harpaz Y, Chothia C (May 1994). "Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains". Journal of Molecular Biology. 238 (4): 528–39. doi:10.1006/jmbi.1994.1312. PMID 8176743.
  5. ^ Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, et al. (February 2001). "Initial sequencing and analysis of the human genome" (PDF). Nature. 409 (6822): 860–921. doi:10.1038/35057062. PMID 11237011.
  6. ^ Bateman A, Eddy SR, Chothia C (September 1996). "Members of the immunoglobulin superfamily in bacteria". Protein Science. 5 (9): 1939–41. doi:10.1002/pro.5560050923. PMC 2143528. PMID 8880921.
  7. ^ Peggs KS, Allison JP (September 2005). "Co-stimulatory pathways in lymphocyte regulation: the immunoglobulin superfamily". British Journal of Haematology. 130 (6): 809–24. doi:10.1111/j.1365-2141.2005.05627.x. PMID 16156851.
  8. ^ Greenwald RJ, Freeman GJ, Sharpe AH (2005). "The B7 family revisited". Annual Review of Immunology. 23: 515–48. doi:10.1146/annurev.immunol.23.021704.115611. PMID 15771580.
  9. ^ Boles KS, Stepp SE, Bennett M, Kumar V, Mathew PA (June 2001). "2B4 (CD244) and CS1: novel members of the CD2 subset of the immunoglobulin superfamily molecules expressed on natural killer cells and other leukocytes". Immunological Reviews. 181: 234–49. doi:10.1034/j.1600-065X.2001.1810120.x. PMID 11513145.
  10. ^ Fraser CC, Howie D, Morra M, Qiu Y, Murphy C, Shen Q, Gutierrez-Ramos JC, Coyle A, Kingsbury GA, Terhorst C (February 2002). "Identification and characterization of SF2000 and SF2001, two new members of the immune receptor SLAM/CD2 family". Immunogenetics. 53 (10–11): 843–50. doi:10.1007/s00251-001-0415-7. PMID 11862385.
  11. ^ Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (September 2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". Journal of Immunology. 171 (5): 2485–95. doi:10.4049/jimmunol.171.5.2485. PMID 12928397.

External links

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Immunoglobulin domain Provide feedback

This domain contains immunoglobulin-like domains.

Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR007110

The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three (in alpha, delta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are highly modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. The domains in Ig and Ig-like molecules are grouped into four types: V-set (variable; INTERPRO ), C1-set (constant-1; INTERPRO ), C2-set (constant-2; INTERPRO ) and I-set (intermediate; INTERPRO ) [ PUBMED:9417933 ]. Structural studies have shown that these domains share a common core Greek-key beta-sandwich structure, with the types differing in the number of strands in the beta-sheets as well as in their sequence patterns [ PUBMED:15327963 , PUBMED:11377196 ].

Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions, including cell-cell recognition, cell-surface receptors, muscle structure and the immune system [ PUBMED:10698639 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Ig (CL0011), which has the following description:

Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The superfamily can be divided into discrete structural sets, by the presence or absence of beta-strands in the structure and the length of the domains [1]. Proteins containing domains of the C1 and V-sets are mostly molecules of the vertebrate immune system. Proteins of the C2-set are mainly lymphocyte antigens, this differs from the composition of the C2-set as originally proposed [1]. The I-set is intermediate in structure between the C1 and V-sets and is found widely in cell surface proteins as well as intracellular muscle proteins.

The clan contains the following 34 members:

Adeno_E3_CR1 Adhes-Ig_like bCoV_NS7A bCoV_NS8 C1-set C2-set C2-set_2 CD4-extracel DUF1968 Herpes_gE Herpes_gI Herpes_glycop_D I-set ICAM_N ig Ig_2 Ig_3 Ig_4 Ig_5 Ig_6 Ig_7 Ig_C17orf99 Ig_C19orf38 Ig_Tie2_1 Izumo-Ig K1 Marek_A ObR_Ig PTCRA Receptor_2B4 UL141 V-set V-set_2 V-set_CD47

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(40)
Full
(24443)
Representative proteomes UniProt
(41808)
RP15
(2185)
RP35
(6117)
RP55
(19864)
RP75
(28396)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(40)
Full
(24443)
Representative proteomes UniProt
(41808)
RP15
(2185)
RP35
(6117)
RP55
(19864)
RP75
(28396)
Alignment:
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Sequence:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(40)
Full
(24443)
Representative proteomes UniProt
(41808)
RP15
(2185)
RP35
(6117)
RP55
(19864)
RP75
(28396)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 40
Number in full: 24443
Average length of the domain: 85.60 aa
Average identity of full alignment: 18 %
Average coverage of the sequence by the domain: 17.88 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.0 27.0
Noise cut-off 26.9 26.9
Model length: 79
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Ig_2 domain has been found. There are 217 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A023GPK8 View 3D Structure Click here
A0A096MIU6 View 3D Structure Click here
A0A096MIU6 View 3D Structure Click here
A0A0B4J1F3 View 3D Structure Click here
A0A0B4J1G0 View 3D Structure Click here
A0A0B4J1G0 View 3D Structure Click here
A0A0B4J2J1 View 3D Structure Click here
A0A0B4J2J1 View 3D Structure Click here
A0A0B4K7N1 View 3D Structure Click here
A0A0G2JTC1 View 3D Structure Click here
A0A0G2JVH3 View 3D Structure Click here
A0A0G2K320 View 3D Structure Click here
A0A0G2K320 View 3D Structure Click here
A0A0G2K320 View 3D Structure Click here
A0A0G2K320 View 3D Structure Click here
A0A0G2K320 View 3D Structure Click here
A0A0G2K3P6 View 3D Structure Click here
A0A0G2K3P6 View 3D Structure Click here
A0A0G2KAU3 View 3D Structure Click here
A0A0G2KAU3 View 3D Structure Click here
A0A0G2KBC9 View 3D Structure Click here
A0A0G2KQC0 View 3D Structure Click here
A0A0G2L6Q4 View 3D Structure Click here
A0A0G2L6Q4 View 3D Structure Click here
A0A0G2L6Q4 View 3D Structure Click here
A0A0G2L985 View 3D Structure Click here
A0A0N4SU26 View 3D Structure Click here
A0A0R4IDT4 View 3D Structure Click here
A0A0R4IP15 View 3D Structure Click here
A0A0R4IPM4 View 3D Structure Click here
A0A0R4IUJ1 View 3D Structure Click here
A0A0R4IUJ1 View 3D Structure Click here
A0A0R4IVQ8 View 3D Structure Click here
A0A140LFQ2 View 3D Structure Click here
A0A140LFQ2 View 3D Structure Click here
A0A140LFQ2 View 3D Structure Click here
A0A140LGN5 View 3D Structure Click here
A0A140LGN5 View 3D Structure Click here
A0A140LGT7 View 3D Structure Click here
A0A140LGT8 View 3D Structure Click here
A0A140LH70 View 3D Structure Click here
A0A1W2Q6G2 View 3D Structure Click here
A0A2R8PZ27 View 3D Structure Click here
A0A2R8PZ27 View 3D Structure Click here
A0A2R8PZ27 View 3D Structure Click here
A0A2R8Q572 View 3D Structure Click here
A0A2R8QRQ4 View 3D Structure Click here
A0A2R8RMY1 View 3D Structure Click here
A1YIY0 View 3D Structure Click here
A1Z9X4 View 3D Structure Click here
A4JYK0 View 3D Structure Click here
A4JYK0 View 3D Structure Click here
A4JYR5 View 3D Structure Click here
A5PMX0 View 3D Structure Click here
A6NI73 View 3D Structure Click here
A8KB21 View 3D Structure Click here
A8KB21 View 3D Structure Click here
A8KB21 View 3D Structure Click here
B0CM22 View 3D Structure Click here
B0S595 View 3D Structure Click here
B0S595 View 3D Structure Click here
B0S595 View 3D Structure Click here
B1Q236 View 3D Structure Click here
B6A8C7 View 3D Structure Click here
B6A8R8 View 3D Structure Click here
C0HJX2 View 3D Structure Click here
C0HJX2 View 3D Structure Click here
C0HJX3 View 3D Structure Click here
C0HJX3 View 3D Structure Click here
D3YZF7 View 3D Structure Click here
D3Z7A9 View 3D Structure Click here
D3ZB51 View 3D Structure Click here
D3ZCA1 View 3D Structure Click here
D3ZD88 View 3D Structure Click here
D3ZD88 View 3D Structure Click here
D3ZQE1 View 3D Structure Click here
D3ZQP6 View 3D Structure Click here
D3ZQX2 View 3D Structure Click here
D3ZRM2 View 3D Structure Click here
D3ZW99 View 3D Structure Click here
D3ZXU3 View 3D Structure Click here
D4A8M3 View 3D Structure Click here
D4A8M3 View 3D Structure Click here
D4A980 View 3D Structure Click here
D4AAQ4 View 3D Structure Click here
E7EZZ7 View 3D Structure Click here
E7F2B3 View 3D Structure Click here
E7F4T9 View 3D Structure Click here
E7F5V6 View 3D Structure Click here
E7F933 View 3D Structure Click here
E7F933 View 3D Structure Click here
E7FBB6 View 3D Structure Click here
E7FBE1 View 3D Structure Click here
E7FBY6 View 3D Structure Click here
E7FFL5 View 3D Structure Click here
E7FGV3 View 3D Structure Click here
E7FGV3 View 3D Structure Click here
E9PTD7 View 3D Structure Click here
E9PZ19 View 3D Structure Click here
E9Q1Z6 View 3D Structure Click here
E9Q1Z6 View 3D Structure Click here
E9QA28 View 3D Structure Click here
E9QII6 View 3D Structure Click here
F1LNP8 View 3D Structure Click here
F1LX58 View 3D Structure Click here
F1LX58 View 3D Structure Click here
F1LX58 View 3D Structure Click here
F1LYQ4 View 3D Structure Click here
F1LYQ4 View 3D Structure Click here
F1M0B5 View 3D Structure Click here
F1M5N2 View 3D Structure Click here
F1M652 View 3D Structure Click here
F1M652 View 3D Structure Click here
F1M652 View 3D Structure Click here
F1QGR0 View 3D Structure Click here
F1QHY0 View 3D Structure Click here
F1QIU5 View 3D Structure Click here
F1QLP4 View 3D Structure Click here
F1QN52 View 3D Structure Click here
F1QQM9 View 3D Structure Click here
F1QQM9 View 3D Structure Click here
F1QSB6 View 3D Structure Click here
F1QXJ2 View 3D Structure Click here
F1R0R0 View 3D Structure Click here
F1R1B9 View 3D Structure Click here
F1R1B9 View 3D Structure Click here
F1R827 View 3D Structure Click here
F1R827 View 3D Structure Click here
F1RAZ3 View 3D Structure Click here
F1RAZ3 View 3D Structure Click here
F1RAZ3 View 3D Structure Click here
F1RC10 View 3D Structure Click here
F6PDU0 View 3D Structure Click here
F6PZL4 View 3D Structure Click here
F6PZL4 View 3D Structure Click here
F7FIX1 View 3D Structure Click here
F8VQ94 View 3D Structure Click here
F8VQ94 View 3D Structure Click here
G5ED65 View 3D Structure Click here
H2KZ60 View 3D Structure Click here
M0R8A3 View 3D Structure Click here
M0R9S3 View 3D Structure Click here
M0RCP1 View 3D Structure Click here
M0RCP1 View 3D Structure Click here
O75015 View 3D Structure Click here
O75015 View 3D Structure Click here
O75019 View 3D Structure Click here
O75019 View 3D Structure Click here
O75022 View 3D Structure Click here
O75023 View 3D Structure Click here
O75326 View 3D Structure Click here
O94779 View 3D Structure Click here
O95256 View 3D Structure Click here
P04217 View 3D Structure Click here
P06731 View 3D Structure Click here
P06731 View 3D Structure Click here
P06731 View 3D Structure Click here
P08101 View 3D Structure Click here
P08101 View 3D Structure Click here
P08508 View 3D Structure Click here
P08508 View 3D Structure Click here
P08637 View 3D Structure Click here
P08637 View 3D Structure Click here
P09326 View 3D Structure Click here
P0C191 View 3D Structure Click here
P0C191 View 3D Structure Click here
P10252 View 3D Structure Click here
P11464 View 3D Structure Click here
P11464 View 3D Structure Click here
P11465 View 3D Structure Click here
P12314 View 3D Structure Click here
P12318 View 3D Structure Click here
P12318 View 3D Structure Click here
P12319 View 3D Structure Click here
P12371 View 3D Structure Click here
P13504 View 3D Structure Click here
P13597 View 3D Structure Click here
P13688 View 3D Structure Click here
P14719 View 3D Structure Click here
P14778 View 3D Structure Click here
P16284 View 3D Structure Click here
P16573 View 3D Structure Click here
P20273 View 3D Structure Click here
P20489 View 3D Structure Click here
P23505 View 3D Structure Click here
P23505 View 3D Structure Click here
P26151 View 3D Structure Click here
P26151 View 3D Structure Click here
P27645 View 3D Structure Click here
P27645 View 3D Structure Click here
P29533 View 3D Structure Click here
P31809 View 3D Structure Click here
P31994 View 3D Structure Click here
P31994 View 3D Structure Click here
P31995 View 3D Structure Click here
P31995 View 3D Structure Click here
P31997 View 3D Structure Click here
P35329 View 3D Structure Click here
P40199 View 3D Structure Click here
P42081 View 3D Structure Click here
P50895 View 3D Structure Click here
P50895 View 3D Structure Click here
P57097 View 3D Structure Click here
P59901 View 3D Structure Click here
P59901 View 3D Structure Click here
P70211 View 3D Structure Click here
P70232 View 3D Structure Click here
P97484 View 3D Structure Click here
P97484 View 3D Structure Click here
P97603 View 3D Structure Click here
P97798 View 3D Structure Click here
Q00887 View 3D Structure Click here
Q00888 View 3D Structure Click here
Q00888 View 3D Structure Click here
Q00889 View 3D Structure Click here
Q00889 View 3D Structure Click here
Q00993 View 3D Structure Click here
Q01965 View 3D Structure Click here
Q02955 View 3D Structure Click here
Q07407 View 3D Structure Click here
Q08180 View 3D Structure Click here
Q08481 View 3D Structure Click here
Q08BX5 View 3D Structure Click here
Q08ET2 View 3D Structure Click here
Q12866 View 3D Structure Click here
Q13046 View 3D Structure Click here
Q13046 View 3D Structure Click here
Q15109 View 3D Structure Click here
Q15223 View 3D Structure Click here
Q15238 View 3D Structure Click here
Q15238 View 3D Structure Click here
Q16557 View 3D Structure Click here
Q19LI2 View 3D Structure Click here
Q26261 View 3D Structure Click here
Q2TBA3 View 3D Structure Click here
Q2WEN9 View 3D Structure Click here
Q2WEN9 View 3D Structure Click here
Q3B8P2 View 3D Structure Click here
Q3B8P2 View 3D Structure Click here
Q3SWT0 View 3D Structure Click here
Q3TB92 View 3D Structure Click here
Q4V892 View 3D Structure Click here
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