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0  structures 489  species 0  interactions 3045  sequences 82  architectures

Family: EDR1 (PF14381)

Summary: Ethylene-responsive protein kinase Le-CTR1

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Ethylene-responsive protein kinase Le-CTR1 Provide feedback

EDR1 regulates disease resistance and ethylene-induced senescence, and is also involved in stress response signalling and cell death regulation [1].

Literature references

  1. Tang D, Christiansen KM, Innes RW;, Plant Physiol. 2005;138:1018-1026.: Regulation of plant disease resistance, stress responses, cell death, and ethylene signaling in Arabidopsis by the EDR1 protein kinase. PUBMED:15894742 EPMC:15894742


Internal database links

This tab holds annotation information from the InterPro database.

No InterPro data for this Pfam family.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(49)
Full
(3045)
Representative proteomes UniProt
(4699)
RP15
(330)
RP35
(1500)
RP55
(2433)
RP75
(3421)
Jalview View  View  View  View  View  View  View 
HTML View  View           
PP/heatmap 1 View           

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(49)
Full
(3045)
Representative proteomes UniProt
(4699)
RP15
(330)
RP35
(1500)
RP55
(2433)
RP75
(3421)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(49)
Full
(3045)
Representative proteomes UniProt
(4699)
RP15
(330)
RP35
(1500)
RP55
(2433)
RP75
(3421)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Coggill P
Number in seed: 49
Number in full: 3045
Average length of the domain: 178.10 aa
Average identity of full alignment: 33 %
Average coverage of the sequence by the domain: 21.85 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.5 27.0
Noise cut-off 26.6 26.7
Model length: 203
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0VJX9 View 3D Structure Click here
A0A0P0XQM6 View 3D Structure Click here
A0A0R0EQY1 View 3D Structure Click here
A0A0R0KNY9 View 3D Structure Click here
A0A0R0L6V6 View 3D Structure Click here
A0A1D6DZ75 View 3D Structure Click here
A0A1D6DZX3 View 3D Structure Click here
A0A1D6ELX5 View 3D Structure Click here
A0A1D6F8W2 View 3D Structure Click here
A0A1D6G1G3 View 3D Structure Click here
A0A1D6HK91 View 3D Structure Click here
A0A1D6JP61 View 3D Structure Click here
A0A1D6L3Q8 View 3D Structure Click here
A0A1D6NG10 View 3D Structure Click here
A0A1D6NRI5 View 3D Structure Click here
A0A1D6QPV0 View 3D Structure Click here
A0A1D6QQC6 View 3D Structure Click here
A2AU72 View 3D Structure Click here
B7FA58 View 3D Structure Click here
C0H563 View 3D Structure Click here
C0PDB4 View 3D Structure Click here
C0PDS7 View 3D Structure Click here
E7F083 View 3D Structure Click here
F4IAN2 View 3D Structure Click here
F4IP61 View 3D Structure Click here
F4IPV6 View 3D Structure Click here
F4JQX7 View 3D Structure Click here
I1JPX3 View 3D Structure Click here
I1JV83 View 3D Structure Click here
I1K5D0 View 3D Structure Click here
I1KEM9 View 3D Structure Click here
I1KJ44 View 3D Structure Click here
I1KQJ4 View 3D Structure Click here
I1L468 View 3D Structure Click here
I1LBH2 View 3D Structure Click here
I1LDZ0 View 3D Structure Click here
I1LZF4 View 3D Structure Click here
I1M3L5 View 3D Structure Click here
I1M918 View 3D Structure Click here
I1NGL1 View 3D Structure Click here
I1NIU9 View 3D Structure Click here
K7K8Z6 View 3D Structure Click here
K7KE95 View 3D Structure Click here
K7L1Q4 View 3D Structure Click here
K7LD86 View 3D Structure Click here
K7LHS5 View 3D Structure Click here
K7LUH0 View 3D Structure Click here
K7LW65 View 3D Structure Click here
K7M7T5 View 3D Structure Click here
K7MNG9 View 3D Structure Click here
K7VYR3 View 3D Structure Click here
M0R914 View 3D Structure Click here
O64486 View 3D Structure Click here
Q05609 View 3D Structure Click here
Q0DNN7 View 3D Structure Click here
Q0JKH6 View 3D Structure Click here
Q10RG4 View 3D Structure Click here
Q337Y0 View 3D Structure Click here
Q4E4B3 View 3D Structure Click here
Q5W041 View 3D Structure Click here
Q6ER39 View 3D Structure Click here
Q6Z2V3 View 3D Structure Click here
Q7JYM7 View 3D Structure Click here
Q7XPL1 View 3D Structure Click here
Q8S9K4 View 3D Structure Click here
Q94AB2 View 3D Structure Click here
Q9C9U5 View 3D Structure Click here
Q9FPR3 View 3D Structure Click here

trRosetta Structure

The structural model below was generated by the Baker group with the trRosetta software using the Pfam UniProt multiple sequence alignment.

The InterPro website shows the contact map for the Pfam SEED alignment. Hovering or clicking on a contact position will highlight its connection to other residues in the alignment, as well as on the 3D structure.

Improved protein structure prediction using predicted inter-residue orientations. Jianyi Yang, Ivan Anishchenko, Hahnbeom Park, Zhenling Peng, Sergey Ovchinnikov, David Baker Proceedings of the National Academy of Sciences Jan 2020, 117 (3) 1496-1503; DOI: 10.1073/pnas.1914677117;