# STOCKHOLM 1.0 #=GF ID DNA_pol3_a_NI #=GF AC PF14480.7 #=GF DE DNA polymerase III polC-type N-terminus I #=GF AU Eberhardt R;0000-0001-6152-1369 #=GF SE Pfam-B_853 (release 23.0) #=GF GA 22.00 22.00; #=GF TC 22.10 22.00; #=GF NC 21.90 21.90; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 10048037 #=GF RT A 'gram-negative-type' DNA polymerase III is essential for #=GF RT replication of the linear chromosome of Streptomyces coelicolor #=GF RT A3(2). #=GF RA Flett F, de Mello Jungmann-Campello D, Mersinias V, Koh SL, #=GF RA Godden R, Smith CP; #=GF RL Mol Microbiol. 1999;31:949-958. #=GF RN [2] #=GF RM 17532183 #=GF RT Replication-associated purine asymmetry may contribute to #=GF RT strand-biased gene distribution. #=GF RA Hu J, Zhao X, Yu J; #=GF RL Genomics. 2007;90:186-194. #=GF RN [3] #=GF RM 21740522 #=GF RT The N-terminal region of the bacterial DNA polymerase PolC #=GF RT features a pair of domains, both distantly related to domain V #=GF RT of the DNA polymerase III tau subunit. #=GF RA Timinskas K, Venclovas C; #=GF RL FEBS J. 2011;278:3109-3118. #=GF DR INTERPRO; IPR028112; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC This is the first N-terminal domain, NI domain, of the DNA #=GF CC polymerase III polC subunit A that is found only in Firmicutes. #=GF CC DNA polymerase polC-type III enzyme functions as the 'replicase' #=GF CC in low G + C Gram-positive bacteria [1]. Purine asymmetry is a #=GF CC characteristic of organisms with a heterodimeric DNA polymerase #=GF CC III alpha-subunit constituted by polC which probably plays a #=GF CC direct role in the maintenance of strand-biased gene #=GF CC distribution; since, among prokaryotic genomes, the distribution #=GF CC of genes on the leading and lagging strands of the replication #=GF CC fork is known to be biased [2]. It has been predicted that the #=GF CC N-terminus of polC folds into two globular domains, NI and NII. #=GF CC A predicted patch of elecrostatic potential at the surface of #=GF CC this domain suggests a possible involvement in nucleic acid #=GF CC binding [3]. This domain is associated with DNA_pol3_alpha #=GF CC Pfam:PF07733 and DNA_pol3_a_NI Pfam:PF11490. #=GF SQ 122 #=GS I0JMQ0_HALH3/8-80 AC I0JMQ0.1 #=GS DPO3_LISMO/11-84 AC Q8Y7G1.1 #=GS C4L659_EXISA/6-77 AC C4L659.1 #=GS B1YI67_EXIS2/8-79 AC B1YI67.1 #=GS C0ZF56_BREBN/10-82 AC C0ZF56.1 #=GS D3FU09_BACPE/11-83 AC D3FU09.1 #=GS Q5WFT7_BACSK/11-82 AC Q5WFT7.1 #=GS D6XU04_BACIE/11-83 AC D6XU04.1 #=GS DPO3_BACHD/11-83 AC Q9KA72.1 #=GS E6TSS6_BACCJ/11-83 AC E6TSS6.1 #=GS DPO3_STRT2/4-78 AC Q5M6H0.1 #=GS DPO3_LACRD/8-79 AC A5VJD5.1 #=GS G2SNX4_LACRR/8-78 AC G2SNX4.1 #=GS Q74IS3_LACJO/7-80 AC Q74IS3.1 #=GS Q5FJN1_LACAC/7-80 AC Q5FJN1.1 #=GS F9VG59_LACGL/4-77 AC F9VG59.1 #=GS DPO3_LACLA/4-77 AC Q9CDT7.1 #=GS DPO3_LACS1/8-81 AC Q1WUF9.1 #=GS DPO3_LACSS/8-81 AC Q38W73.1 #=GS T0U435_9ENTE/7-80 AC T0U435.1 #=GS G4L2F8_TETHN/7-80 AC G4L2F8.1 #=GS V5XNY1_ENTMU/7-80 AC V5XNY1.1 #=GS Q3XZ68_ENTFC/7-80 AC Q3XZ68.1 #=GS F3YAY6_MELPT/8-81 AC F3YAY6.1 #=GS Q831W8_ENTFA/8-81 AC Q831W8.1 #=GS B9DTD3_STRU0/4-78 AC B9DTD3.1 #=GS DPO3_STRP1/4-78 AC P0C0B8.1 #=GS DPO3_STRMU/4-78 AC Q8DWE0.1 #=GS DPO3_STRA5/4-78 AC P63984.1 #=GS DPO3_STRSY/4-78 AC A4VXT1.1 #=GS DPO3_STRR6/4-78 AC Q8DRA5.1 #=GS DPO3_LACPL/8-77 AC Q88VK2.1 #=GS DPO3_LACBA/8-80 AC Q03QS9.1 #=GS J9W7F6_LACBU/8-80 AC J9W7F6.1 #=GS K8EHS7_CARML/8-81 AC K8EHS7.2 #=GS F8HZD1_WEIKK/8-78 AC F8HZD1.1 #=GS B3PN84_MYCA5/8-74 AC B3PN84.1 #=GS Q6MTP4_MYCMS/4-74 AC Q6MTP4.1 #=GS W6AHC2_9MOLU/4-73 AC W6AHC2.1 #=GS Q6F1H8_MESFL/5-74 AC Q6F1H8.1 #=GS B8I6E2_CLOCE/6-82 AC B8I6E2.1 #=GS DPO3_CLOPE/5-72 AC Q8XJR3.1 #=GS A5N837_CLOK5/6-75 AC A5N837.1 #=GS Q18BG8_PEPD6/3-75 AC Q18BG8.1 #=GS W8U6V8_PEPAC/5-75 AC W8U6V8.1 #=GS A6TRL2_ALKMQ/8-77 AC A6TRL2.1 #=GS A8MHH9_ALKOO/8-77 AC A8MHH9.1 #=GS A3DE49_CLOTH/12-81 AC A3DE49.1 #=GS R7IVU6_9CLOT/12-80 AC R7IVU6.1 #=GS G8LUX8_CLOCD/7-75 AC G8LUX8.1 #=GS W0E8A2_9FIRM/3-71 AC W0E8A2.1 #=GS Q24PE2_DESHY/3-71 AC Q24PE2.1 #=GS L0F587_DESDL/3-71 AC L0F587.1 #=GS R4KA36_CLOPA/3-70 AC R4KA36.1 #=GS U5RVB3_9CLOT/3-70 AC U5RVB3.1 #=GS R5TDH8_9CLOT/4-74 AC R5TDH8.1 #=GS A9KMW9_LACP7/6-77 AC A9KMW9.1 #=GS R5VKK3_9CLOT/4-74 AC R5VKK3.1 #=GS R7C799_9CLOT/4-74 AC R7C799.1 #=GS R7JS25_9FIRM/4-75 AC R7JS25.1 #=GS R6RVW6_9FIRM/4-74 AC R6RVW6.1 #=GS I5ASV5_EUBCE/10-79 AC I5ASV5.1 #=GS R6VLL9_9FIRM/4-75 AC R6VLL9.1 #=GS G2T3I4_ROSHA/4-75 AC G2T3I4.1 #=GS C4ZA67_AGARV/4-75 AC C4ZA67.1 #=GS R5UJX4_9FIRM/4-75 AC R5UJX4.1 #=GS R7QWE4_9FIRM/4-75 AC R7QWE4.1 #=GS R5TZH5_9FIRM/4-75 AC R5TZH5.1 #=GS R6C713_9CLOT/4-75 AC R6C713.1 #=GS R6K544_9FIRM/3-74 AC R6K544.1 #=GS R5DX15_9FIRM/3-74 AC R5DX15.1 #=GS R7R8X6_9FIRM/4-75 AC R7R8X6.1 #=GS E0S506_BUTPB/4-75 AC E0S506.1 #=GS E0S1M7_BUTPB/4-75 AC E0S1M7.1 #=GS R6EL95_9FIRM/4-75 AC R6EL95.1 #=GS R5GZR6_9FIRM/5-75 AC R5GZR6.1 #=GS R7ISQ5_9FIRM/6-77 AC R7ISQ5.1 #=GS R5UBP6_9FIRM/9-80 AC R5UBP6.1 #=GS R5QJB9_9FIRM/9-80 AC R5QJB9.1 #=GS R7G242_9FIRM/4-75 AC R7G242.1 #=GS R6PV65_9CLOT/4-75 AC R6PV65.1 #=GS R5D348_9FIRM/4-75 AC R5D348.1 #=GS R6JN83_9CLOT/4-75 AC R6JN83.1 #=GS R7AFL5_9CLOT/3-74 AC R7AFL5.1 #=GS D9QZZ3_CLOSW/4-75 AC D9QZZ3.1 #=GS R5NQF1_9FIRM/5-74 AC R5NQF1.1 #=GS R5L625_9FIRM/5-76 AC R5L625.1 #=GS R6NZT4_9FIRM/4-75 AC R6NZT4.1 #=GS F7V6D4_CLOSS/4-75 AC F7V6D4.1 #=GS R6R2B1_9FIRM/10-81 AC R6R2B1.1 #=GS D4MXN1_ANAHA/7-78 AC D4MXN1.1 #=GS F2JHJ0_CELLD/10-80 AC F2JHJ0.1 #=GS R5K4Z0_9CLOT/7-78 AC R5K4Z0.1 #=GS R5JW45_9FIRM/8-79 AC R5JW45.1 #=GS D5XF07_THEPJ/17-87 AC D5XF07.1 #=GS R5APA7_9FIRM/5-76 AC R5APA7.1 #=GS R6P456_9FIRM/5-76 AC R6P456.1 #=GS G2KUC0_LACSM/8-79 AC G2KUC0.1 #=GS DPO3_PEDPA/8-77 AC Q03FS8.1 #=GS G8PDB8_PEDCP/8-79 AC G8PDB8.1 #=GS F2I510_AERUA/7-77 AC F2I510.1 #=GS N0ASU4_9BACI/10-83 AC N0ASU4.1 #=GS U5L7T9_9BACI/10-82 AC U5L7T9.1 #=GS G2TJH3_BACCO/11-83 AC G2TJH3.1 #=GS B7GG80_ANOFW/8-80 AC B7GG80.1 #=GS Q5L0J3_GEOKA/19-91 AC Q5L0J3.1 #=GS C5D9C4_GEOSW/9-81 AC C5D9C4.1 #=GS Q65JJ0_BACLD/11-83 AC Q65JJ0.1 #=GS A8FDC2_BACP2/11-83 AC A8FDC2.1 #=GS DPO3_BACSU/10-82 AC P13267.2 #=GS F2F2T2_SOLSS/12-84 AC F2F2T2.1 #=GS L0EEX3_THECK/10-82 AC L0EEX3.1 #=GS C6D2T0_PAESJ/10-82 AC C6D2T0.1 #=GS E3EHF4_PAEPS/10-82 AC E3EHF4.1 #=GS D3E6Q2_GEOS4/10-82 AC D3E6Q2.1 #=GS X5A204_9BACL/10-82 AC X5A204.1 #=GS Q03YC3_LEUMM/8-79 AC Q03YC3.1 #=GS DPO3_OCEIH/8-80 AC Q8EQU6.1 #=GS K0IYJ9_AMPXN/8-80 AC K0IYJ9.1 #=GS B9EBE5_MACCJ/8-80 AC B9EBE5.1 #=GS DPO3_STAEQ/8-80 AC Q5HPS7.2 #=GS DPO3_STAA8/6-78 AC Q2G1Z8.1 I0JMQ0_HALH3/8-80 KMHYLLEQIQFP..HE.LIEPHFRDS.TMEKLTVYRETKEWHFHFKMPQPLPPAVYELFTTKLQSTFRAIA.EVK.WTI DPO3_LISMO/11-84 RFQLLMTQIGLQ..DVTTYEEFTKDA.KIEKLVADKKNKTWQFHLHVPQIFPAALFHMMDVGMKRAFSQIA.ETE.MQI C4L659_EXISA/6-77 KMQLLLSDLGIT.....TETDLFDQA.ELSRLVVNKKRRTWTFYFSFPKVLPYDVHQLFMSRLESRYATFADEVY.ARF B1YI67_EXIS2/8-79 RMALLMSDLELP...TGIVEEFFTDA.SLEKLRVQKATATWTFHIRLTQILPQNVYQMFNSRLKSRYQQFA.EVKLL.. C0ZF56_BREBN/10-82 RFSLLVKQMEVP..DE.WVERFFLDA.QIEKLELYKQNKEWVFHFALPRMIPADVYAVFTKRLTHTFSHLA.KVD.TRF D3FU09_BACPE/11-83 RFQLLLSQLQFP..EE.VIHGVFKDG.KIRKLTILKEKRTWHFHIDLPLLIPAHLYELFGQKLKETFTHIA.TVG.FTF Q5WFT7_BACSK/11-82 RLQLLLDQLQIP..DD..GRPHFQDG.YIEKLAISKEQKIWHFFIRLERLLPAEWCELFKGRLAQTFRDIA.NAR.CSF D6XU04_BACIE/11-83 RFDLLMDQVQMP..ED.IRERFLRDG.WIESLTVHKKERKWLFRFRLSVPMTKEAYERFSAKLIHGLSHIA.DVQ.FML DPO3_BACHD/11-83 RFKLLMEQLLIP..ED.VTANHLKDG.KIEKLTIKKDERRWHFQLSIPTVLPASIYELLADRLVQTFSHIA.KVS.FQI E6TSS6_BACCJ/11-83 RLQLLLEQIAIP..QE.MIDSHFREG.TIEKLEVYKNEKKWHFYISLPSILPFPVFQLFYSHIQKRLEHIA.KVD.ITL DPO3_STRT2/4-78 KFKLLLKQIHFP..QHEEAYNEIKSG.SIESVKLFKSKRQWFFVFSFRNLLSYETFTLFDNLLHSSFDSLGAKVS.YMI DPO3_LACRD/8-79 LFGKLLEQIHFP..E..KDNSAFRNA.AVQSVVVHKKSRQWEFHLIFNKALPYDLFTQFNQSLQLGFKDIA.KVS.LKI G2SNX4_LACRR/8-78 MFEKLLEQIKWQ..DD...REVFSDA.LIEKVEVHTKSKRWDFYLETNDILPFQTFAKLNQLVETSFRPIC.KTR.LHF Q74IS3_LACJO/7-80 LFKKLLDQIKFP..DKFEDNDIVQNG.EIENVDVYANERKWKIHVFFDTPLDFETYRSLNELIHETFEPFV.NVE.LLV Q5FJN1_LACAC/7-80 LFLKLLKQVRFP..DTFEDNDLLQKG.KIENVDVYAKEHRWDIHVFFDTPLRYDTYVALRKAIEETFASFV.NVN.FFV F9VG59_LACGL/4-77 LFEKLMDQIKMP..NQIRESALFSSA.DIENVEVHTERKLWKFQLKFEKILPVEQWKVLSGLIESAFSTIA.ETE.LSI DPO3_LACLA/4-77 LFEKLMEQIKMP..PNLRRSSQFEHA.DIENVEVHTASKLWHFQLIFDEILPIDTYKLLTELTETAFSTIA.RTE.ISV DPO3_LACS1/8-81 LFKKLLRQINWE..NKHGFEEVFTNA.EIQKVEVHVESKVWNFHLQIEDILPYEVFYQFYQQLQLAFKDIA.KVD.ITL DPO3_LACSS/8-81 LFQKLLEQIALP..ADVAHYPGFKTG.QVEQVIVHETSKRWTFKLHFDNVLPFAVYTAFEEHLEAAFQAIA.AVS.IEI T0U435_9ENTE/7-80 TFEILLEQINAG..PDLRQHPLIQTA.QIKQVVVHRQSKAWTFYLQFDTLLPVMVYQSFKQHLELAFKEIA.AVR.MII G4L2F8_TETHN/7-80 TFEILLDQIQLD..ETMRENPLIKQG.KIKQVIVHKQSQNWTFVLSFAKILPAMIYQSFRQNLEMAFQDIA.SVD.MVI V5XNY1_ENTMU/7-80 LFEKLLEQIQLE..ETEKAHPLISAG.EMEQVVVHRKSRLWEFTLRFPAILPVMLYRSLVQHVILAFKEIA.EVK.ITV Q3XZ68_ENTFC/7-80 LFEKLLEQIQLE..EAEKNHPLLTAG.EMDSVVVHRKSRLWEFTLHFSKILPIMLYRSLTQHLTIAFKDIA.QVK.LNI F3YAY6_MELPT/8-81 LFAKLLTQIQLK..ETEQGHQLMQQG.KIEKVVVHQHSRLWEFNFEFEEILPVHLYQSFIQHLMLAFQSIA.TVS.VKI Q831W8_ENTFA/8-81 LFDKLMTQIQLD..DTAKEHPLIQNG.RIDKVIVHQQSRLWEFHLSFDELMPVMLYQTFMQQLELAFQQIA.QVS.VQI B9DTD3_STRU0/4-78 LFVKLMEQIEMP..LEMRTSSAFSTA.DIIEVKVHSVSRLWEFHFQMAEILPIAIYKELDYRLKTTFEQADIKAV.FDI DPO3_STRP1/4-78 LFAKLMDQIEMP..LDMRRSSAFSSA.DIIEVKVHSVSRLWEFHFAFAAVLPIATYRELHDRLIRTFEAADIKVT.FDI DPO3_STRMU/4-78 LFKKLMDQIEMP..LEMKNSRVFSSA.DIVEVKVYPESRIWDFRFSFETILPIDFYQELRSRLVTSFETADIKAV.FDI DPO3_STRA5/4-78 LFKKLMDQIEMP..LEIKNSSVFSSA.DIIEVKVHSLSRLWEFHFSFPELLPIEVYRELQTRLVNSFEKADIKAT.FDI DPO3_STRSY/4-78 KFQLLLQQIGMP..LDARQSGAFSTA.TIEKVVLHKVSKLWEFTFRFETPLPLMDYQLFKARLATEFEKVGNKIQ.FSI DPO3_STRR6/4-78 SFEILMNQLGMP..AEMRQAPALAQA.NIERVVVHKISKVWEFHFVFSNILPIEIFLELKKGLSEEFSKTGNKAV.FEI DPO3_LACPL/8-77 MFEKLLEQIEMP......TGPEFTEA.AIDKLTVHQASKVWEFHLHFQHVLPYTQFMTFQNKLQIAFKEIA.RVT.FTI DPO3_LACBA/8-80 LFEKLLQQLDLT..SE.ADQPYFQTA.TVDRLTVHEQSRRWQFLLKLPSMLPFTAFVDFHNHLQVAFREIA.TVE.ATI J9W7F6_LACBU/8-80 LFEKLLEQLQWT..QA.NELPYFEDA.KIDRLEVHKQSQRWQFDISLPRILPFEVFNDFNARLQSAFKEIA.DVS.LNI K8EHS7_CARML/8-81 LFQKLLEQINLH..QELDYQPYFEKA.SIRKVTVHKQSKLWHFDFYFQDILPFEIYQNFSEKLQIAFRSIA.AIS.FSI F8HZD1_WEIKK/8-78 QFQVLAKQLQFE.....KIPQGFKNA.ELQKLTVHENSKVWQFKLDLPALPAVQETADFVHRLTMSFQHLA.EPD.FKF B3PN84_MYCA5/8-74 TFLKLCKEIKFE......LNDEFRGT.SFKEAKLNKSTHKWTFDIIFPHHISIDNFKDFKTHLDKRFPNNN.....FSF Q6MTP4_MYCMS/4-74 KILGIFKKIGIE..LDQTDYIYFKDAILVETPRISQIKNKGYLHVEIKDFLPIDVLKKIEDKLKNNQ.....YFN.FKL W6AHC2_9MOLU/4-73 NLREFLEKLNIF..FNQEEEKYFEDG.QIMDAYFSESINMLRVFIRIKDFLPINVLHKLETSLVTNT.....YVP.TKL Q6F1H8_MESFL/5-74 KVLELFQKLKIN..LNEGELSYFEHS.EIEKATISSLKSKLRLSLKIKNFLPIRVLSEIHEKCVGSE.....EIK.IKL B8I6E2_CLOCE/6-82 NINRFLYDLFPDAMDFDGEFSALKQL.KVERMSVFIKANRLEIHTISSDIVSIALIMKAEECLKQKLGAPNLTLK.VKC DPO3_CLOPE/5-72 FVKQINRSIKSD.......DNLNDLEFEITKFQLLKKSNTLRTIIKSKDQLSEEQKKIIKQYIKKAIGF...EIN.IEI A5N837_CLOK5/6-75 .VKMLQEDLDLD.......SNTMTESIKLLKIQYLKKSNKLKVVLKSQESLDSRIQSKIRDIINKKLGGFC.SIELIWY Q18BG8_PEPD6/3-75 SIKEYLDKLEIN...NSGLGKQLKEV.YINRVVYFKEDKIVYFYLTSKDIVSHELLDKFKEELMYKLDYFK.DMR.MKI W8U6V8_PEPAC/5-75 ..RDYIKKIGID...TQELHPLIGDA.FLSKAVYFKENKALDIHIEPGGVVSAAELVKLQAQIKSKLCWLD.NVR.LKV A6TRL2_ALKMQ/8-77 SLHDFLTRLNIN.......CDKLNGDFQVQDLKFYKKSRKLILGLKSHEIINSEELDHILREVEEALKIPN.PIK.IEY A8MHH9_ALKOO/8-77 NFNYFLDCFGIE.......GNHLYESCFVEKLQYMKNSNRIFISFISKKILSHKEIERSLEQLTNVVQAKL.KSK.VDT A3DE49_CLOTH/12-81 ..SELFPEVINN....ENERELFDTA.RIQNINVYKKSRKLEIFIVSDTLIPAKTLDSVEQSFKKLFELEQVHLR.VS. R7IVU6_9CLOT/12-80 KIGDLFSDYKTN........SNIEDA.EIARMNLLKKINTLEIEMQAKEYIEIKEIWYFEKFLRQRFQFEQVHIK.IKY G8LUX8_CLOCD/7-75 RVNEVFSDYEVD........GNISSA.VIQSAILKRKSRTLEIKLSSDKYINVREIEGLNTYIRKKFALNDSEIT.VEY W0E8A2_9FIRM/3-71 RINEIFSDYDAG........DNINTA.IVKAVIVSEKSKTLEMKISSDKYIQIKEIKALNTFIRERLALNDSKII.VEY Q24PE2_DESHY/3-71 RVQEIFRNFEAG........VSLNTA.IVKAVVLKEKSKTLEMKISSDNYIEVSDLESLNQFIREQLTLEDSEII.VEY L0F587_DESDL/3-71 SVNEIFSDYEAG........LNLSTA.LVKAVVLKEKSKALEMRICSDQYISIEEIAALNQFIRQRLSLDDSEII.VEY R4KA36_CLOPA/3-70 RINEIFSDYAAN........GNINTA.IVESVVLSKKSKRLDMEISSDKYIEIREFEDLNRFIRKRFALEDSIIS.VK. U5RVB3_9CLOT/3-70 RINEIFSDYETE........GNINAA.IVESVVLSKKTKTLEMKINSDKYIEIKEIQRLNKFIRERFSLKNSKID.VR. R5TDH8_9CLOT/4-74 LLQETFADLRLT....ARQQSVFEEV.YVERLCLLREQKRVEVHIVSEHIIPYREIALLEYAL.NQLFDKA.GFT.VQV A9KMW9_LACP7/6-77 LFFEVFDTLNVE....KEIYELFSDI.SVLKALVSKNNGNVHIYIQSTHLISRKQIKMMEFQLQKQLFSST.KSR.VKL R5VKK3_9CLOT/4-74 .FFEAFPELSVD....DKMYDMFAGV.QVEKVNASKTKMLALIHCTSDQLLHYRTLKNMEYKLYRQIFRSI.GVN.PHL R7C799_9CLOT/4-74 .FFEAFPELSIE....DSLYNYFSGT.MVEKVSASRTKMLAFIYCQSDQLLHRRTIHTMEHALYSQVFRKM.GVQ.PKL R7JS25_9FIRM/4-75 QFQEVFPDLRIE....GGMAELLDTV.EVSRVSINKKKDLLRIYVVSHQWIHKKYIYQLERQIEEQLFSNV.PLR.VKI R6RVW6_9FIRM/4-74 EFLDVFRNLELN....GELKALLKEV.VVTKVSVNQKKDHIRVYIRSRQWIHKKYIYALEEAIASQCFRGV.PMT.VK. I5ASV5_EUBCE/10-79 .LSEVFPNLDLE....GDLDEYLKFA.RVKRIAMDRRRNVLHVYLDSTQWIQKKYIYELEKQIREKLFPRT.EIS.VK. R6VLL9_9FIRM/4-75 DFLEVFLGLEVE....KELKALLEDV.KVTKIAVNPKKDRMRVYIQSIQWIQKKYIYALEKQIKKQFFASA.QIQ.IKI G2T3I4_ROSHA/4-75 RFFDVFPSLQVE....GDMKNLLTET.EVTKVGMNHERDHLRVYLSSTRLIHKKDIRQLESAIAQQIFKGR.MMQ.VKV C4ZA67_AGARV/4-75 TFKEVFPTLKLD....KDMENLLENA.DVTRISVNHARDFYKIYVKAKRLIFKKNIWKLEESIKKQIFKSK.DIT.VKI R5UJX4_9FIRM/4-75 AFREAFPTLKLE....EELEGLLDTT.EVTKISANHEHTHIRIYLRAKRLIFKKNIWKLEKAITEQIFQNR.AIQ.VKI R7QWE4_9FIRM/4-75 PFFEVFPTLKVG....EETKNLLSEV.EVTRVSTNTRKDILRVYIAGRRLIPKKKIYQLETGIKKQLFPTR.DMT.IKF R5TZH5_9FIRM/4-75 SFFEVFPQLKLD....TDLHGMLDDA.TVSKVSTTRQRNSLRIYLGCGRLLPKEKIYFLESELKRQLFPHH.TMN.IKI R6C713_9CLOT/4-75 AFLEVFAGLKLP....TQVGRQFEDV.EVLKITSTSKKDFLRIYISSEHLISKEIVYKAENEIKNQLFKNN.DLT.VKI R6K544_9FIRM/3-74 KFLDVFRTLKLP....DDIRVYMENV.EVTKVSKTSTNSLARVYIKNDKVISKKIIYKVEDALKKQIFRIQ.NMD.VRI R5DX15_9FIRM/3-74 KFFEVFNTLKVP....EEIGVYLTDT.EVTRVSKTSTNSLARVYLSSERLISKQVIYKAEDALKKQIFRMK.NMD.VRI R7R8X6_9FIRM/4-75 NFFEAFPNLKLT....GARKDLFEQV.VVERITATRRKDILRIYIRSERLIEKEDVYGVEQEIKKQFFPKD.NII.IKI E0S506_BUTPB/4-75 MFFEAFPMLKVD....DDIFNDMKSV.EIEKISSTKKHDFIRIYIKSSILIEKSTIYKIEKSIQDQLFSGV.NVT.VKV E0S1M7_BUTPB/4-75 SFFDVFPALKLD....AGTKEIMEQT.MVEKVSTTRKQDFIRIYISSNKLIDKSDILKTESGIKKQLFGNQ.DLT.VKI R6EL95_9FIRM/4-75 PFFEVFPNLQLH....TDIHDLMGQT.EVERVSATKRRDFLRVYLKSTRLIQKADIWTAEQEIKKQLFPDA.NLT.VKI R5GZR6_9FIRM/5-75 .FMEVFPELVLE....QEVRALFEKV.KVERVTTTRQKDLIRVYISCGRLIPKTVIFRVEEEIARQLFPNC.NIT.IKI R7ISQ5_9FIRM/6-77 RFFQVFPELKLE....NDLTELLSLV.QIDRIAANHKKDAIRVYMTGTRIIPKKSIYMVQDEIEKQMFGTG.NIR.VQI R5UBP6_9FIRM/9-80 TFFEVFPTLRAD....GELKMLFQDV.EVKKITTNSTREFLHIHMVSHHLIPKKVIWKMEQSIKEQLFGTA.SVA.IQI R5QJB9_9FIRM/9-80 KFFHVFPTLRAD....DDVRLLFSDV.EVKKITTNSRRDFLNIYIFSRHLIQKKQIFQMEQCIKDQLFAKT.AVA.VHI R7G242_9FIRM/4-75 PFFEVFPTLKVK....DDIQMMFQGV.EVTKVSTNSTRDFIRVSLYSRHLIQKKHIYEVERLLKQQLFARS.HIQ.VSV R6PV65_9CLOT/4-75 QFFDVFPTLKVN....SDCKVLFENV.EVTKVTTNSDRDYLHVHLFSTHLLAKSWIYKMETMIKEQLFGRN.RIR.IRI R5D348_9FIRM/4-75 KFFEVFPTLKVK....DDMRLLLQDV.EVSKVTTNSNRDFVRIHIESAHLLQKKMIYRVESMVKEQLFGKN.RLQ.IEV R6JN83_9CLOT/4-75 NFLEVFPTLNIA....ESLKELLGLV.QVEKVTTTRDRSSIRIYLKSARLIHKQNIYDLERGIRDQLFPDK.QVA.IKI R7AFL5_9CLOT/3-74 PFLDVFPDLHIT....DNLRELLELV.EVERVTASRDRSSIRVYIVCPRLIHKQNIYGLEKGIKDQLFPGK.RVT.IKI D9QZZ3_CLOSW/4-75 KFLEVFPSLHIT....DELRELLNLV.EVEKVTLGRDRSSIRIYLMSPRLIHKQNIYGLEKGIKDQLFPSK.RLT.IKI R5NQF1_9FIRM/5-74 RFFEVFDGIKVD....AELLELFSDI.MVKRIVNNRAKSSIRIYIESNRLIHKSDIYKIEKAVASMF..ND.RLS.VKI R5L625_9FIRM/5-76 KFFDVFQTIKLN....DELTAMFEYV.DITKIATNVDHTKMRIYIESSRLIEKSAIFTVRDEIARNLRTGK.RVE.IEI R6NZT4_9FIRM/4-75 LFFEVFPTLKIT....GEMSALLKET.EITKVASNSAQNALRIYLESTRLIPKPEIYHIEQEIRQQLFPHK.EVA.VKI F7V6D4_CLOSS/4-75 LFSDVFCELQLT....EDMQTFLKDV.SVSRVTTNREHTRLRVYMESPHLIDKMRIFQLQDLISRQLFHKK.MEV.III R6R2B1_9FIRM/10-81 EFFQVFPDLKVS....GDVKELFRTV.CIRQVLFKKSKNTLFISFTSDHLIPRIDTWRMEQQIREQLFSKR.YVK.IRF D4MXN1_ANAHA/7-78 PFFSVFPDLKVS....DDVRSLFEDA.NIREITLKKKENTLKISFQCDHLISRVDTWRMERTIREQLFSKR.FVK.IRF F2JHJ0_CELLD/10-80 AFFEVLTELKVD....DKLQQLFEPV.GIKKVVFEQATEHLEIYLSSKELLNRPMLLKMQRAIKDQLFKTA.PLS.IT. R5K4Z0_9CLOT/7-78 LFFEVFPELNMD....KELSSLFEDT.MIEKVVMKQAERQLIISLLSKHLISRPKIVQVEDIICGHLFRGR.GYK.VII R5JW45_9FIRM/8-79 AFFVVFPEFSMS....EELNELFRDT.YILKITNITADKKLVIDLNSSHLISRQKIDLAAENLKKYIFGTR.KYE.VII D5XF07_THEPJ/17-87 .LFDFIAEADLP....DEVKKVLLQA.SVAKVEISNAKKMWRIHLTLPEIVETKHLKVLEQLIAREIPQLS.KVE.FAI R5APA7_9FIRM/5-76 KFELVFQKISLS....LPLLEAFQGT.EVRKLTIHKKERTVSIEIAANKMIPLQKQEELKGALLESLPGIQ.AVS.LAV R6P456_9FIRM/5-76 LFEKVFDGLKLS....ANVKTVLKNT.LVDNLSISTKGRKMIVDLSSDIFIDENCIVDFREDLADAFPDLN.TID.INL G2KUC0_LACSM/8-79 KFNKLLDQIKIN..DE..YRSEFENA.EIEQVRVHQKSKQWDFHFFIPHVLSYQAFIDFVTGLQTAFSNIA.KVD.FYI DPO3_PEDPA/8-77 QFRVLLEQIDLL......DNAELKDG.SIKDLTVHSNSKRWTFSFEFNDILPLQIFVEFHHQLVNTFGSIA.QID.FSI G8PDB8_PEDCP/8-79 QFQTLLEHIGLL....NYDDNNLKTG.KIKNLIIHKESKEWEFYFEFEDVLDFETFLNFQNHLKNEFKAIA.QIK.YQI F2I510_AERUA/7-77 MFQTLLRQMHWQ.....SDDENIKQG.SIEEVIVHQVSRCYQFNIRFPERLPFSAYQLFYAQLTNTFQAIA.KVK.LKV N0ASU4_9BACI/10-83 QFLVLLQQLQMT..ED.AIVQHFEHA.QLQKVVVDKELTKYHFHFLIEKILPANIFSLLAARLQRTFSYIA.KTSTFSL U5L7T9_9BACI/10-82 RFHLLLQQLQLT..ED.AFVKHFENA.QIDKVVIEKQAKKWHFYFMFDSILPCSVFSRFSVQLEKTFSHIA.NTS.FTI G2TJH3_BACCO/11-83 RFQILLRQLELL..DD.RFYEHFKYG.EIEKLVVERQSKRWHFYFLLEKILPFEVYLTFTTRLRQAFQHIA.DVR.FSI B7GG80_ANOFW/8-80 RFFILLQQLQLT..SS.SIANDLAHG.RINKVVVNKQTKCWHFYFQFPTILRANVYAEFRKRLIEQFRHIA.HVQ.CTI Q5L0J3_GEOKA/19-91 RFLILLEQLKMT..SD.EWMPHFREA.AIRKVVIDKEEKSWHFYFQFDNVLPVHVYKTFADRLQTAFRHIA.AVR.HTM C5D9C4_GEOSW/9-81 RFQVLLQQLELT..SD.EFVPYFSEA.GIQKLVIEKEKKCWHFYFLLPKILPYQVYQLFTQKLVHAFHHIA.NVK.YTI Q65JJ0_BACLD/11-83 QFQILLQQLNVT..ED.TMIRHLEGG.QIIKLTVHKNKKTWHFHFKLRNVLPYQIFERFHSQLTRTFSHIA.QVT.CSI A8FDC2_BACP2/11-83 QFHILLNQIQMT..DD.DLSRYFEEG.EIVKLTVHKLAKTWHFLFKFKALLPYKVYAMFLSRLTNAFSHIA.QVT.CTI DPO3_BACSU/10-82 QFQILLQQINMT..DD.TFMTYFEHG.EIKKLTIHKASKSWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIA.KVT.SSI F2F2T2_SOLSS/12-84 KFLLLLQQLELT..DD.VYMSFFENG.TLERVTVHKKKRVWDFKIKIENILPYQVYQLLRMRMVEKFSPIA.NVL.LTI L0EEX3_THECK/10-82 KLGLLLEKIGLT..GE.EAASDFADG.LLDRVEVSAASRRWTFFIRKKSVLPARQYSLLVSRARETFGPIA.DVE.FVL C6D2T0_PAESJ/10-82 RFELLMQQAGLP...LEIINSYYKDG.YIEQVIVGKSNRKWTFCIRKTSLVPYKAFMALTQAVNMKFAHIA.EIS.FKL E3EHF4_PAEPS/10-82 RLELLMKQVVMP...AGVVDPYFLDG.WIDQVEISRTNKDWNITIAKETLVPAQVYRTFCIQVQEKMSHIA.KIT.FRF D3E6Q2_GEOS4/10-82 RFELLIKQGEVP...ANLVEPYFLDG.VIEQVETSRNSKDWRITVQKETLVPAEVYRTFCLRIQEKMGHIA.KIK.FVF X5A204_9BACL/10-82 RFELLMKQGEIP...PALIDPYFLDG.YIDRVEISRGNRDWRIVVAKQSLVPAQAYRTFCLRMRERLQHIA.KVS.FLF Q03YC3_LEUMM/8-79 QLQHLLTHIQLP....EEIHHYFDDG.CLSQVDVSVSQKMWLFHVEIEQILPVNVYMQFQQYLRTAFTNIA.VVQ.LQI DPO3_OCEIH/8-80 KLKLLLEQIRMP..DN.EIEAHFSNS.YLDKVEVHKADKKWHFYINIDHVLPFQTYQLFHHSLKESFASIA.EVS.LTL K0IYJ9_AMPXN/8-80 KMNVLLDQINLN..VN.EQRQYFDQS.MLLKLEVFKQEKRWNFQFQLESILPIELFKQFRSKLQEAFKMVA.TVT.FTL B9EBE5_MACCJ/8-80 KFKVLLKQLQIE...DLFTIPDLDEA.ELTKIDVYKHDRRWHMYFKFQTHLPYELFALLKSKIKEHFERIA.TVT.FEI DPO3_STAEQ/8-80 KFKVLADQIKIS...NQLEQDILEQG.ELTRIDVSNKNRTWTFQISLPHFLSHEDYLLFTHAIEEEFKEIA.TVA.IDF DPO3_STAA8/6-78 KFKVLADQIKIS...NQLDAEILNSG.ELTRIDVSNKNRTWEFHITLPQFLAHEDYLLFINAIEQEFKDIA.NVT.CRF #=GC seq_cons pFtclhpplpls.....phpshhpsu.plc+lslp+pp+phchalphscllshphhhphppplppphtths.plp.hpl //