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155  structures 425  species 0  interactions 7564  sequences 123  architectures

Family: EphA2_TM (PF14575)

Summary: Ephrin type-A receptor 2 transmembrane domain

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Ephrin type-A receptor 2 transmembrane domain Provide feedback

Epha2_TM represents the left-handed dimer transmembrane domain of of EphA2 receptor. This domain oligomerises and is important for the active signalling process.

Literature references

  1. Bocharov EV, Mayzel ML, Volynsky PE, Mineev KS, Tkach EN, Ermolyuk YS, Schulga AA, Efremov RG, Arseniev AS;, Biophys J. 2010;98:881-889.: Left-handed dimer of EphA2 transmembrane domain: Helix packing diversity among receptor tyrosine kinases. PUBMED:20197042 EPMC:20197042


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR027936

This entry represents the left-handed dimer transmembrane domain of Ephrin receptors. This domain oligomerises and is important for the active signalling process [ PUBMED:20197042 ].

Proteins containing this domain include the ephrin type-A and type-B receptors. Ephrin receptors (Ephs) are a group of receptor tyrosine kinases that are activated in response to binding ephrin ligands residing on adjacent cells [ PUBMED:12094214 ]. This binding leads to contact-dependent bidirectional signaling into neighbouring cells [ PUBMED:12094214 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(124)
Full
(7564)
Representative proteomes UniProt
(12012)
RP15
(437)
RP35
(1747)
RP55
(5502)
RP75
(7641)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(124)
Full
(7564)
Representative proteomes UniProt
(12012)
RP15
(437)
RP35
(1747)
RP55
(5502)
RP75
(7641)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(124)
Full
(7564)
Representative proteomes UniProt
(12012)
RP15
(437)
RP35
(1747)
RP55
(5502)
RP75
(7641)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: CATH:2k9yA00
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Coggill P
Number in seed: 124
Number in full: 7564
Average length of the domain: 73.60 aa
Average identity of full alignment: 41 %
Average coverage of the sequence by the domain: 8.12 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 28.9 28.9
Trusted cut-off 28.9 28.9
Noise cut-off 28.8 28.7
Model length: 76
Family (HMM) version: 9
Download: download the raw HMM for this family

Species distribution

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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the EphA2_TM domain has been found. There are 155 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JY48 View 3D Structure Click here
A0A0G2L6L8 View 3D Structure Click here
A0A2R8QFV0 View 3D Structure Click here
A0A2R8QG72 View 3D Structure Click here
A0A2R8QJW7 View 3D Structure Click here
A2CEJ3 View 3D Structure Click here
D3ZBN3 View 3D Structure Click here
D3ZDH4 View 3D Structure Click here
D3ZH39 View 3D Structure Click here
D3ZZK3 View 3D Structure Click here
E7F2W4 View 3D Structure Click here
E7F533 View 3D Structure Click here
F1LX55 View 3D Structure Click here
F1Q9D9 View 3D Structure Click here
F1QEJ3 View 3D Structure Click here
F1QJD4 View 3D Structure Click here
F1QSD6 View 3D Structure Click here
F1RCL1 View 3D Structure Click here
F6P3V1 View 3D Structure Click here
M0RDA4 View 3D Structure Click here
O08644 View 3D Structure Click here
O08680 View 3D Structure Click here
O09127 View 3D Structure Click here
O13146 View 3D Structure Click here
O13147 View 3D Structure Click here
O15197 View 3D Structure Click here
O42422 View 3D Structure Click here
O61460 View 3D Structure Click here
O73875 View 3D Structure Click here
O73878 View 3D Structure Click here
P09759 View 3D Structure Click here
P0C0K6 View 3D Structure Click here
P0C0K7 View 3D Structure Click here
P21709 View 3D Structure Click here
P28693 View 3D Structure Click here
P29317 View 3D Structure Click here
P29318 View 3D Structure Click here
P29319 View 3D Structure Click here
P29320 View 3D Structure Click here
P29322 View 3D Structure Click here