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193  structures 1361  species 0  interactions 39471  sequences 1458  architectures

Family: SH3_9 (PF14604)

Summary: Variant SH3 domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "SH3 domain". More...

SH3 domain Edit Wikipedia article

SH3 domain
1shg SH3 domain.png
Ribbon diagram of the SH3 domain, alpha spectrin, from chicken (PDB accession code 1SHG), colored from blue (N-terminus) to red (C-terminus).
Identifiers
Symbol SH3_1
Pfam PF00018
Pfam clan CL0010
InterPro IPR001452
SMART SM00326
PROSITE PS50002
SCOP 1shf
SUPERFAMILY 1shf
CDD cd00174

The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues. Initially, SH3 was described as a conserved sequence in the viral adaptor protein v-Crk. This domain is also present in the molecules of phospholipase and several cytoplasmic tyrosine kinases such as Abl and Src.[1][2] It has also been identified in several other protein families such as: PI3 Kinase, Ras GTPase-activating protein, CDC24 and cdc25.[3][4][5] SH3 domains are found in proteins of signaling pathways regulating the cytoskeleton, the Ras protein, and the Src kinase and many others. The SH3 proteins interact with adaptor proteins and tyrosine kinases. Interacting with tyrosine kinases SH3 proteins usually bind far away from the active site. Approximately 300 SH3 domains are found in proteins encoded in the human genome. In addition to that, the SH3 domain was responsible for controlling protein-protein interactions in the signal transduction pathways[6] and regulating the interactions of proteins involved in the cytoplasmic signaling.[7]

Structure

The SH3 domain has a characteristic beta-barrel fold that consists of five or six β-strands arranged as two tightly packed anti-parallel β sheets. The linker regions may contain short helices. The SH3-type fold is an ancient fold found in eukaryotes as well as prokaryotes.[8]

Peptide binding

The classical SH3 domain is usually found in proteins that interact with other proteins and mediate assembly of specific protein complexes, typically via binding to proline-rich peptides in their respective binding partner. Classical SH3 domains are restricted in humans to intracellular proteins, although the small human MIA family of extracellular proteins also contain a domain with an SH3-like fold.

Many SH3-binding epitopes of proteins have a consensus sequence that can be represented as a regular expression or Short linear motif:

-X-P-p-X-P-
 1 2 3 4 5

with 1 and 4 being aliphatic amino acids, 2 and 5 always and 3 sometimes being proline. The sequence binds to the hydrophobic pocket of the SH3 domain. More recently, SH3 domains that bind to a core consensus motif R-x-x-K have been described. Examples are the C-terminal SH3 domains of adaptor proteins like Grb2 and Mona (a.k.a. Gads, Grap2, Grf40, GrpL etc.). Other SH3 binding motifs have emerged and are still emerging in the course of various molecular studies, highlighting the versatility of this domain.

SH3 interactomes

SH3 domain mediated protein-protein interaction networks, i.e., SH3 interactomes, revealed that worm SH3 interactome resembles the analogous yeast network because it is significantly enriched for proteins with roles in endocytosis.[9][10] Nevertheless, orthologous SH3 domain-mediated interactions are highly rewired between worm and yeast.[9]

Proteins with SH3 domain

See also

References

  1. ^ Pawson T, Schlessingert J (July 1993). "SH2 and SH3 domains". Current Biology. 3 (7): 434–42. PMID 15335710. doi:10.1016/0960-9822(93)90350-W. 
  2. ^ Mayer BJ (April 2001). "SH3 domains: complexity in moderation". Journal of Cell Science. 114 (Pt 7): 1253–63. PMID 11256992. 
  3. ^ Musacchio A, Gibson T, Lehto VP, Saraste M (July 1992). "SH3--an abundant protein domain in search of a function". FEBS Letters. 307 (1): 55–61. PMID 1639195. doi:10.1016/0014-5793(92)80901-R. 
  4. ^ Mayer BJ, Baltimore D (January 1993). "Signalling through SH2 and SH3 domains". Trends in Cell Biology. 3 (1): 8–13. PMID 14731533. doi:10.1016/0962-8924(93)90194-6. 
  5. ^ Pawson T (February 1995). "Protein modules and signalling networks". Nature. 373 (6515): 573–80. PMID 7531822. doi:10.1038/373573a0. 
  6. ^ Schlessinger J (February 1994). "SH2/SH3 signaling proteins". Current Opinion in Genetics & Development. 4 (1): 25–30. PMID 8193536. doi:10.1016/0959-437X(94)90087-6. 
  7. ^ Koch CA, Anderson D, Moran MF, Ellis C, Pawson T (May 1991). "SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins". Science. 252 (5006): 668–74. PMID 1708916. 
  8. ^ Whisstock JC, Lesk AM (April 1999). "SH3 domains in prokaryotes". Trends in Biochemical Sciences. 24 (4): 132–3. PMID 10322416. doi:10.1016/s0968-0004(99)01366-3. 
  9. ^ a b Xin, Xiaofeng; Gfeller, David; Cheng, Jackie; Tonikian, Raffi; Sun, Lin; Guo, Ailan; Lopez, Lianet; Pavlenco, Alevtina; Akintobi, Adenrele (2013-01-01). "SH3 interactome conserves general function over specific form". Molecular Systems Biology. 9: 652. ISSN 1744-4292. PMC 3658277Freely accessible. PMID 23549480. doi:10.1038/msb.2013.9. 
  10. ^ Tonikian, Raffi; Xin, Xiaofeng; Toret, Christopher P.; Gfeller, David; Landgraf, Christiane; Panni, Simona; Paoluzi, Serena; Castagnoli, Luisa; Currell, Bridget (2009-10-01). "Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins". PLOS Biology. 7 (10): e1000218. ISSN 1545-7885. PMC 2756588Freely accessible. PMID 19841731. doi:10.1371/journal.pbio.1000218. 

External links

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Variant SH3 domain Provide feedback

No Pfam abstract.

Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001452

SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues [ PUBMED:15335710 , PUBMED:11256992 ]. They are found in a great variety of intracellular or membrane-associated proteins [ PUBMED:1639195 , PUBMED:14731533 , PUBMED:7531822 ] for example, in a variety of proteins with enzymatic activity, in adaptor proteins, such as fodrin and yeast actin binding protein ABP-1.

The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices. The surface of the SH3-domain bears a flat, hydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions. The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins, altering their subcellular location and mediating the assembly of large multiprotein complexes [ PUBMED:7953536 ].

The crystal structure of the SH3 domain of the cytoskeletal protein spectrin, and the solution structures of SH3 domains of phospholipase C (PLC-y) and phosphatidylinositol 3-kinase p85 alpha-subunit, have been determined [ PUBMED:1279434 , PUBMED:7684655 , PUBMED:7681365 ]. In spite of relatively limited sequence similarity, their overall structures are similar. The domains belong to the alpha+beta structural class, with 5 to 8 beta-strands forming 2 tightly-packed, anti-parallel beta-sheets arranged in a barrel-like structure, and intervening loops sometimes forming helices. Conserved aliphatic and aromatic residues form a hydrophobic core (A11, L23, A29, V34, W42, L52 and V59 in PLC-y [ PUBMED:7681365 ]) and a hydrophobic pocket on the molecular surface (L12, F13, W53 and P55 in PLC-y). The conserved core is believed to stabilise the fold, while the pocket is thought to serve as a binding site for target proteins. Conserved carboxylic amino acids located in the loops, on the periphery of the pocket (D14 and E22), may be involved in protein-protein interactions via proline-rich regions. The N- and C-terminal are packed in close proximity, indicating that they are independent structural modules.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan SH3 (CL0010), which has the following description:

Src homology-3 (SH3) domains are comprised of about 60 amino acids, performing either an assembly or regulatory role. For example, SH3 domains in the Grb2 adaptor protein are essential for protein-protein interactions and signal transduction in the p21 Ras-dependent growth factor signaling pathway. Alternatively, SH3 performs a regulatory role in the Src family of tyrosine kinases. SH3 domains bind a variety of peptide ligands, many of which contain a PxxP motif. This PxxP motif is flanked by different specificity elements [1]. Structures of SH3 domains, both free and ligand complexed, have provided insights into the mechanism of ligand recognition. The SH3 fold consists of two anti-parallel beta sheets that lie at right angles to each other. Within the fold, there are two variable loops, referred to as RT and n-Src loops. When SH3 binds to its ligand, the proline rich ligand adopts a PPII helix conformation, with the PPII helix structure recognised by a pair of grooves on the surface of the SH3 domain that bind turns of the helix. The SH3 grooves are formed by a series of nearly parallel, well-conserved aromatic residues [1].

The clan contains the following 37 members:

CAP_GLY DUF150_C DUF1541 DUF1653 DUF3104 DUF3247 DUF3601 DUF4453 DUF4648 Gemin6 Gemin7 GW hSH3 IN_DBD_C KapB MLVIN_C Myosin_N NdhS SH3_1 SH3_10 SH3_11 SH3_12 SH3_13 SH3_14 SH3_15 SH3_16 SH3_17 SH3_18 SH3_19 SH3_2 SH3_3 SH3_4 SH3_5 SH3_6 SH3_9 SlpA YjdM

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(23)
Full
(39471)
Representative proteomes UniProt
(68727)
RP15
(4957)
RP35
(13698)
RP55
(33687)
RP75
(46961)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(23)
Full
(39471)
Representative proteomes UniProt
(68727)
RP15
(4957)
RP35
(13698)
RP55
(33687)
RP75
(46961)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(23)
Full
(39471)
Representative proteomes UniProt
(68727)
RP15
(4957)
RP35
(13698)
RP55
(33687)
RP75
(46961)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer, JCSG:target_422527
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Coggill P
Number in seed: 23
Number in full: 39471
Average length of the domain: 51.40 aa
Average identity of full alignment: 32 %
Average coverage of the sequence by the domain: 7.05 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 30.0 30.0
Trusted cut-off 30.0 30.0
Noise cut-off 29.9 29.9
Model length: 49
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SH3_9 domain has been found. There are 193 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0B4J1A8 View 3D Structure Click here
A0A0B4JDC9 View 3D Structure Click here
A0A0B4K774 View 3D Structure Click here
A0A0B4KI34 View 3D Structure Click here
A0A0B4KI34 View 3D Structure Click here
A0A0B4KI34 View 3D Structure Click here
A0A0G2JUA7 View 3D Structure Click here
A0A0G2JZL7 View 3D Structure Click here
A0A0G2K1Z2 View 3D Structure Click here
A0A0G2K5Z4 View 3D Structure Click here
A0A0K3AS36 View 3D Structure Click here
A0A0K3AV08 View 3D Structure Click here
A0A0R4IAC5 View 3D Structure Click here
A0A0R4IAC5 View 3D Structure Click here
A0A0R4IAX0 View 3D Structure Click here
A0A0R4IB08 View 3D Structure Click here
A0A0R4IB32 View 3D Structure Click here
A0A0R4IFS3 View 3D Structure Click here
A0A0R4IH27 View 3D Structure Click here
A0A0R4IHF0 View 3D Structure Click here
A0A0R4IK14 View 3D Structure Click here
A0A0R4IK14 View 3D Structure Click here
A0A0R4IK14 View 3D Structure Click here
A0A0R4IM47 View 3D Structure Click here
A0A0R4IP30 View 3D Structure Click here
A0A0R4IRY0 View 3D Structure Click here
A0A0R4IS36 View 3D Structure Click here
A0A0R4IWX6 View 3D Structure Click here
A0A1D6GMZ7 View 3D Structure Click here
A0A1D6JXC6 View 3D Structure Click here
A0A1D6JXF7 View 3D Structure Click here
A0A1D6KR14 View 3D Structure Click here
A0A1D8PJ75 View 3D Structure Click here
A0A2R8PW69 View 3D Structure Click here
A0A2R8Q0C3 View 3D Structure Click here
A0A2R8Q1X3 View 3D Structure Click here
A0A2R8Q1X3 View 3D Structure Click here
A0A2R8Q4K6 View 3D Structure Click here
A0A2R8QEN6 View 3D Structure Click here
A0A2R8QEY4 View 3D Structure Click here
A0A2R8QFY5 View 3D Structure Click here
A0A2R8QMI5 View 3D Structure Click here
A0A2R8QN78 View 3D Structure Click here
A0A2R8QQ83 View 3D Structure Click here
A0A2R8QU03 View 3D Structure Click here
A0A2R8RRY5 View 3D Structure Click here
A0A2R8RXI8 View 3D Structure Click here
A0A2R9YJM4 View 3D Structure Click here
A0A2R9YJN1 View 3D Structure Click here
A1A4S6 View 3D Structure Click here
A1IGU3 View 3D Structure Click here
A1IGU4 View 3D Structure Click here
A1Z7A6 View 3D Structure Click here
A1ZAY1 View 3D Structure Click here
A2BFG9 View 3D Structure Click here
A2VCY2 View 3D Structure Click here
A4HV44 View 3D Structure Click here
A4I2Z1 View 3D Structure Click here
A4IBA4 View 3D Structure Click here
A5D8S5 View 3D Structure Click here
A5D8S5 View 3D Structure Click here
A5D8S5 View 3D Structure Click here
A5PMM5 View 3D Structure Click here
A6NI28 View 3D Structure Click here
A6NJZ7 View 3D Structure Click here
A6NNM3 View 3D Structure Click here
A7KAX9 View 3D Structure Click here
A8DZ19 View 3D Structure Click here
A8E7E7 View 3D Structure Click here
A8E7E7 View 3D Structure Click here
B0BNK4 View 3D Structure Click here
B0R118 View 3D Structure Click here
B0UXW1 View 3D Structure Click here
B0UYA0 View 3D Structure Click here
B1WBZ1 View 3D Structure Click here
B2GUW2 View 3D Structure Click here
B2RQE8 View 3D Structure Click here
B5RHZ3 View 3D Structure Click here
B6T6P3 View 3D Structure Click here
D0IN10 View 3D Structure Click here
D3Z8S0 View 3D Structure Click here
D3Z8S0 View 3D Structure Click here
D3ZG83 View 3D Structure Click here
D3ZY64 View 3D Structure Click here
D3ZZ38 View 3D Structure Click here
D4A164 View 3D Structure Click here
D4A2Y9 View 3D Structure Click here
D4A3M8 View 3D Structure Click here
D4A3X7 View 3D Structure Click here
D4A454 View 3D Structure Click here
D4A7X9 View 3D Structure Click here
D4A7Z1 View 3D Structure Click here
D4A901 View 3D Structure Click here
D4A9G6 View 3D Structure Click here
D4AB50 View 3D Structure Click here
D4AD36 View 3D Structure Click here
E7EY47 View 3D Structure Click here
E7F0G8 View 3D Structure Click here
E7F1U2 View 3D Structure Click here
E7F1U2 View 3D Structure Click here
E7F1U2 View 3D Structure Click here
E7F3M3 View 3D Structure Click here
E7F667 View 3D Structure Click here
E7F6M0 View 3D Structure Click here
E7F8C7 View 3D Structure Click here
E7FD40 View 3D Structure Click here
E7FDF1 View 3D Structure Click here
E7FDV0 View 3D Structure Click here
E7FF53 View 3D Structure Click here
E9PT59 View 3D Structure Click here
E9Q7D5 View 3D Structure Click here
E9QHH4 View 3D Structure Click here
E9QJP6 View 3D Structure Click here
E9QJP6 View 3D Structure Click here
E9QJP6 View 3D Structure Click here
F1LRA7 View 3D Structure Click here
F1LRS8 View 3D Structure Click here
F1LRS8 View 3D Structure Click here
F1LUU6 View 3D Structure Click here
F1LV21 View 3D Structure Click here
F1LW07 View 3D Structure Click here
F1LYA6 View 3D Structure Click here
F1M0F6 View 3D Structure Click here
F1M107 View 3D Structure Click here
F1M2Q1 View 3D Structure Click here
F1M5H6 View 3D Structure Click here
F1MAK3 View 3D Structure Click here
F1Q5J2 View 3D Structure Click here
F1Q932 View 3D Structure Click here
F1QAX6 View 3D Structure Click here
F1QCM5 View 3D Structure Click here
F1QCM5 View 3D Structure Click here
F1QGH8 View 3D Structure Click here
F1QI09 View 3D Structure Click here
F1QIB3 View 3D Structure Click here
F1QJ54 View 3D Structure Click here
F1QK94 View 3D Structure Click here
F1QKS7 View 3D Structure Click here
F1QW63 View 3D Structure Click here
F1R0C1 View 3D Structure Click here
F1R0Z9 View 3D Structure Click here
F1R0Z9 View 3D Structure Click here
F1R1C3 View 3D Structure Click here
F1R1N9 View 3D Structure Click here
F1R1N9 View 3D Structure Click here
F1RDJ4 View 3D Structure Click here
F1RDK4 View 3D Structure Click here
F1RE41 View 3D Structure Click here
F6NRK2 View 3D Structure Click here
F6P057 View 3D Structure Click here
F6PEI4 View 3D Structure Click here
F7FH17 View 3D Structure Click here
G3V9M2 View 3D Structure Click here
G3V9N7 View 3D Structure Click here
G4RZC8 View 3D Structure Click here
G5EC32 View 3D Structure Click here
G5EC32 View 3D Structure Click here
G5EC32 View 3D Structure Click here
H2KZV6 View 3D Structure Click here
I1J846 View 3D Structure Click here
I1JSK2 View 3D Structure Click here
I1K661 View 3D Structure Click here
I1K731 View 3D Structure Click here
I1LJ75 View 3D Structure Click here
I1LPY2 View 3D Structure Click here
I3ITI8 View 3D Structure Click here
K7LF98 View 3D Structure Click here
M0R4F8 View 3D Structure Click here
M0R6D9 View 3D Structure Click here
M0R6D9 View 3D Structure Click here
M0R7A6 View 3D Structure Click here
M0R7A6 View 3D Structure Click here
M9ND00 View 3D Structure Click here
M9ND00 View 3D Structure Click here
M9ND00 View 3D Structure Click here
M9ND00 View 3D Structure Click here
O00499 View 3D Structure Click here
O08539 View 3D Structure Click here
O08838 View 3D Structure Click here
O08839 View 3D Structure Click here
O14559 View 3D Structure Click here
O15034 View 3D Structure Click here
O15034 View 3D Structure Click here
O35177 View 3D Structure Click here
O35413 View 3D Structure Click here
O43150 View 3D Structure Click here
O43281 View 3D Structure Click here
O43586 View 3D Structure Click here
O43639 View 3D Structure Click here
O54967 View 3D Structure Click here
O55033 View 3D Structure Click here
O60504 View 3D Structure Click here
O60504 View 3D Structure Click here
O60861 View 3D Structure Click here
O76041 View 3D Structure Click here
O94868 View 3D Structure Click here
O94875 View 3D Structure Click here
O95153 View 3D Structure Click here
P16333 View 3D Structure Click here
P32790 View 3D Structure Click here
P38822 View 3D Structure Click here
P49418 View 3D Structure Click here
P57075 View 3D Structure Click here
P62484 View 3D Structure Click here
P70248 View 3D Structure Click here
P80192 View 3D Structure Click here
P97306 View 3D Structure Click here
P97814 View 3D Structure Click here
Q02779 View 3D Structure Click here
Q07912 View 3D Structure Click here
Q08EC4 View 3D Structure Click here
Q10929 View 3D Structure Click here
Q10NK5 View 3D Structure Click here
Q12774 View 3D Structure Click here
Q13387 View 3D Structure Click here
Q14247 View 3D Structure Click here
Q14511 View 3D Structure Click here
Q14847 View 3D Structure Click here
Q15811 View 3D Structure Click here
Q16584 View 3D Structure Click here
Q18501 View 3D Structure Click here
Q19951 View 3D Structure Click here
Q1AAU6 View 3D Structure Click here
Q1JPR9 View 3D Structure Click here
Q1LWE6 View 3D Structure Click here
Q1LX61 View 3D Structure Click here
Q1MT71 View 3D Structure Click here
Q21004 View 3D Structure Click here
Q21430 View 3D Structure Click here
Q337C1 View 3D Structure Click here
Q3KR97 View 3D Structure Click here
Q3U1V8 View 3D Structure Click here
Q3U5C8 View 3D Structure Click here
Q3USJ8 View 3D Structure Click here
Q3UTJ2 View 3D Structure Click here
Q3V3E1 View 3D Structure Click here
Q4DNY3 View 3D Structure Click here
Q4DST6 View 3D Structure Click here
Q4DST6 View 3D Structure Click here
Q4DU36 View 3D Structure Click here
Q4KM68 View 3D Structure Click here
Q4V9A1 View 3D Structure Click here
Q4VAA7 View 3D Structure Click here
Q54F41 View 3D Structure Click here
Q54FG5 View 3D Structure Click here
Q54YF3 View 3D Structure Click here
Q555L8 View 3D Structure Click here
Q556K1 View 3D Structure Click here
Q55AN3 View 3D Structure Click here
Q5ALV2 View 3D Structure Click here
Q5AQ36 View 3D Structure Click here
Q5FVG7 View 3D Structure Click here
Q5I0D6 View 3D Structure Click here
Q5I1X5 View 3D Structure Click here
Q5PPJ9 View 3D Structure Click here
Q5RG20 View 3D Structure Click here
Q5TCX8 View 3D Structure Click here
Q5TZC7 View 3D Structure Click here
Q5U2X5 View 3D Structure Click here
Q5VV41 View 3D Structure Click here
Q5XIL4 View 3D Structure Click here
Q5XIL4 View 3D Structure Click here
Q60598 View 3D Structure Click here
Q61644 View 3D Structure Click here
Q61792 View 3D Structure Click here
Q62270 View 3D Structure Click here
Q62417 View 3D Structure Click here
Q62418 View 3D Structure Click here
Q64355 View 3D Structure Click here
Q66HA1 View 3D Structure Click here
Q66HL2 View 3D Structure Click here
Q66L42 View 3D Structure Click here
Q69ZI1 View 3D Structure Click here
Q69ZI1 View 3D Structure Click here
Q69ZI1 View 3D Structure Click here
Q6A573 View 3D Structure Click here
Q6AYC6 View 3D Structure Click here
Q6AYE2 View 3D Structure Click here
Q6EV76 View 3D Structure Click here
Q6GMH1 View 3D Structure Click here
Q6PFQ3 View 3D Structure Click here
Q6PFY1 View 3D Structure Click here
Q6TXD4 View 3D Structure Click here
Q6TXD4 View 3D Structure Click here
Q6UXY1 View 3D Structure Click here
Q6WKZ7 View 3D Structure Click here
Q6XZF7 View 3D Structure Click here
Q6Y5D8 View 3D Structure Click here
Q6ZMT1 View 3D Structure Click here
Q6ZQ82 View 3D Structure Click here
Q71F54 View 3D Structure Click here
Q71F54 View 3D Structure Click here
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