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0  structures 209  species 0  interactions 1178  sequences 18  architectures

Family: CEP170_C (PF15308)

Summary: CEP170 C-terminus

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This is the Wikipedia entry entitled "CEP170". More...

CEP170 Edit Wikipedia article

Available structures
PDBOrtholog search: PDBe RCSB
AliasesCEP170, FAM68A, KAB, KIAA0470, centrosomal protein 170
External IDsOMIM: 613023 MGI: 1918348 HomoloGene: 22844 GeneCards: CEP170
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CEP170
Genomic location for CEP170
Band1q43Start243,124,428 bp[1]
End243,255,348 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 243.12 – 243.26 MbChr 1: 176.73 – 176.81 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.[5][6]


The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with the intraflagellar transport protein 81 (IFT81), the SH3-domain containing protein PRAX-1, and is phosphorylated by cyclin dependent kinase 1 ( Cdk1) and polo-like kinase 1 ( PLK1), and functions in maintaining Microtubule organization, cell morphology and cilium stability.[5]

The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.[5]


  1. ^ a b c ENSG00000276725 GRCh38: Ensembl release 89: ENSG00000143702, ENSG00000276725 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057335 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c "Entrez Gene: CEP170 centrosomal protein 170kDa".
  6. ^ Guarguaglini G, Duncan PI, Stierhof YD, Holmström T, Duensing S, Nigg EA (March 2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles". Molecular Biology of the Cell. 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC 551476. PMID 15616186.

External links

  • Human CEP170 genome location and CEP170 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 170 kDa (CEP170)

Further reading

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

CEP170 C-terminus Provide feedback

This family includes the C-terminus of centrosomal protein of 170 kDa (CEP170) [1].

Literature references

  1. Guarguaglini G, Duncan PI, Stierhof YD, Holmstrom T, Duensing S, Nigg EA;, Mol Biol Cell. 2005;16:1095-1107.: The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles. PUBMED:15616186 EPMC:15616186

This tab holds annotation information from the InterPro database.

InterPro entry IPR029300

This entry represents the C terminus of centrosomal protein of 170kDa (CEP170) [ PUBMED:15616186 ].

Centrosomal protein of 170kDa (Cep170) plays a role in microtubule organisation [ PUBMED:15616186 ]. Human Cep170 is constantly expressed throughout the cell cycle, but phosphorylated during mitosis. Cep170 is a substrate of Polo-like kinase 1 (Plk1) [ PUBMED:15616186 ]. It is associated with the mature mother centriole. Cep170 is also required for Kif2b-induced microtubule depolymerisation [ PUBMED:23087211 ].

Domain organisation

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Curation and family details

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Seed source: Jackhmmer:Q96L14
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Eberhardt R , Coggill P , Hetherington K
Number in seed: 19
Number in full: 1178
Average length of the domain: 528.80 aa
Average identity of full alignment: 46 %
Average coverage of the sequence by the domain: 44.49 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 29.8 27.3
Noise cut-off 25.5 26.8
Model length: 682
Family (HMM) version: 8
Download: download the raw HMM for this family

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