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0  structures 176  species 0  interactions 274  sequences 3  architectures

Family: NPAT_C (PF15712)

Summary: NPAT C terminus

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This is the Wikipedia entry entitled "NPAT (gene)". More...

NPAT (gene) Edit Wikipedia article

Aliases NPAT, E14, E14/p220, nuclear protein, co-activator of histone transcription, nuclear protein, coactivator of histone transcription
External IDs MGI: 107605 HomoloGene: 1888 GeneCards: NPAT
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for NPAT
Genomic location for NPAT
Band n/a Start 108,157,215 bp[1]
End 108,222,642 bp[1]
RNA expression pattern
PBB GE NPAT 209798 at fs.png

PBB GE NPAT 211584 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 108.16 – 108.22 Mb Chr 11: 53.54 – 53.57 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Protein NPAT also known as nuclear protein of the ATM locus is a protein that in humans is encoded by the NPAT gene.[5][6]


NPAT (gene) has been shown to interact with Glyceraldehyde 3-phosphate dehydrogenase[7] and POU2F1.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149308 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033054 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Imai T, Sugawara T, Nishiyama A, Shimada R, Ohki R, Seki N, Sagara M, Ito H, Yamauchi M, Hori T (Jun 1997). "The structure and organization of the human NPAT gene". Genomics. 42 (3): 388–92. PMID 9205109. doi:10.1006/geno.1997.4769. 
  6. ^ "Entrez Gene: NPAT nuclear protein, ataxia-telangiectasia locus". 
  7. ^ a b Zheng L, Roeder RG, Luo Y (Jul 2003). "S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component". Cell. 114 (2): 255–66. PMID 12887926. doi:10.1016/S0092-8674(03)00552-X. 

Further reading

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

NPAT C terminus Provide feedback

No Pfam abstract.

Literature references

  1. Imai T, Sugawara T, Nishiyama A, Shimada R, Ohki R, Seki N, Sagara M, Ito H, Yamauchi M, Hori T;, Genomics. 1997;42:388-392.: The structure and organization of the human NPAT gene. PUBMED:9205109 EPMC:9205109

This tab holds annotation information from the InterPro database.

InterPro entry IPR031442

Protein NPAT is required for progression through the G1 and S phases of the cell cycle, and for S phase entry [ PUBMED:12665581 , PUBMED:15555599 ]. It regulates histone gene expression as well as nonhistone targets that influence competency for cell cycle progression [ PUBMED:17974976 ].

This entry represents the C-terminal domain of NPAT.

Domain organisation

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We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

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HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...


This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

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Seed source: Jackhmmer:Q14207
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Eberhardt R
Number in seed: 8
Number in full: 274
Average length of the domain: 551.50 aa
Average identity of full alignment: 48 %
Average coverage of the sequence by the domain: 45.37 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 81.8 27.0
Noise cut-off 17.9 25.8
Model length: 680
Family (HMM) version: 7
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0R4IH22 View 3D Structure Click here
A0A0R4IH22 View 3D Structure Click here
D4A6Y1 View 3D Structure Click here
Q14207 View 3D Structure Click here
Q8BMA5 View 3D Structure Click here

Family Structural Model

The structural model below was generated by the Baker group with the trRosetta software using the Pfam UniProt multiple sequence alignment.

The InterPro website shows the contact map for the Pfam SEED alignment. Hovering or clicking on a contact position will highlight its connection to other residues in the alignment, as well as on the 3D structure.

Improved protein structure prediction using predicted inter-residue orientations. Jianyi Yang, Ivan Anishchenko, Hahnbeom Park, Zhenling Peng, Sergey Ovchinnikov, David Baker Proceedings of the National Academy of Sciences Jan 2020, 117 (3) 1496-1503; DOI: 10.1073/pnas.1914677117;