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64  structures 2168  species 0  interactions 7620  sequences 379  architectures

Family: Pur_ac_phosph_N (PF16656)

Summary: Purple acid Phosphatase, N-terminal domain

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Purple acid Phosphatase, N-terminal domain Provide feedback

This domain is found at the N-terminus of Purple acid phosphatase proteins.

Literature references

  1. Klabunde T, Strater N, Frohlich R, Witzel H, Krebs B;, J Mol Biol. 1996;259:737-748.: Mechanism of Fe(III)-Zn(II) purple acid phosphatase based on crystal structures. PUBMED:8683579 EPMC:8683579


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR015914

Purple acid phosphatases (PAPs) are ubiquitous binuclear metal-containing acid hydrolases characterised by their acidic pH optima and their intense purple colour due to a TyrO-to-FeIII charge-transfer transition. The amino acid residues coordinating the metal ions are conserved in all PAPs. Active PAPs contain an FeIII ion coordinated to Tyr O, a His N, and an Asp O2, in addition to a divalent metal ion (Fe, Zn, or Mn) coordinated by a His N, a His N, and an Asn O. A hydroxide ion and an Asp O2 bridge the two metal ions [ PUBMED:12440878 ]. These enzymes share a high degree of homology within their N-termini [ PUBMED:10510276 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan E-set (CL0159), which has the following description:

This clan includes a diverse range of domains that have an Ig-like fold and appear to be distantly related to each other. The clan includes: PKD domains, cadherins and several families of bacterial Ig-like domains as well as viral tail fibre proteins. it also includes several Fibronectin type III domain-containing families.

The clan contains the following 238 members:

A2M A2M_BRD A2M_recep AA9 Adeno_GP19K AlcCBM31 Alpha-amylase_N Alpha_adaptinC2 Alpha_E2_glycop Anth_Ig Arch_flagellin aRib Arylsulfotran_N ASF1_hist_chap ATG19 BACON BACON_2 BatD BIg21 Big_1 Big_10 Big_11 Big_12 Big_13 Big_2 Big_3 Big_3_2 Big_3_3 Big_3_4 Big_3_5 Big_4 Big_5 Big_6 Big_7 Big_8 Big_9 Bile_Hydr_Trans BiPBP_C bMG1 bMG10 bMG3 bMG5 bMG6 BslA BsuPI Cadherin Cadherin-like Cadherin_2 Cadherin_3 Cadherin_4 Cadherin_5 Cadherin_pro CagX Calx-beta Candida_ALS_N CARDB CBM39 CBM_X2 CD45 CelD_N Ceramidse_alk_C CHB_HEX_C CHB_HEX_C_1 ChitinaseA_N ChiW_Ig_like Chlam_OMP6 CHU_C Coatamer_beta_C COP-gamma_platf CopC CshA_repeat Cyc-maltodext_N Cytomega_US3 DsbC DUF11 DUF1410 DUF1425 DUF1929 DUF2271 DUF3244 DUF3327 DUF3416 DUF3458 DUF3501 DUF3823_C DUF3859 DUF4165 DUF4179 DUF4426 DUF4469 DUF4625 DUF4879 DUF4959 DUF4981 DUF4982 DUF4998 DUF5001 DUF5008 DUF5011 DUF5065 DUF5115 DUF525 DUF5643 DUF6383 DUF916 EB_dh ECD EpoR_lig-bind ERAP1_C EstA_Ig_like Expansin_C Filamin FixG_C Flavi_glycop_C FlgD_ig fn3 Fn3-like fn3_2 fn3_4 fn3_5 fn3_6 FN3_7 Fn3_assoc fn3_PAP GBS_Bsp-like Glucodextran_B Glyco_hydro2_C5 Glyco_hydro_2 Gmad2 GMP_PDE_delta GPI-anchored Hanta_G1 He_PIG HECW_N HemeBinding_Shp Hemocyanin_C Herpes_BLLF1 HYR IFNGR1 Ig_GlcNase Ig_mannosidase IL12p40_C Il13Ra_Ig IL17R_fnIII_D1 IL17R_fnIII_D2 IL2RB_N1 IL3Ra_N IL4Ra_N IL6Ra-bind Inhibitor_I42 Inhibitor_I71 InlK_D3 Integrin_alpha2 Interfer-bind Invasin_D3 IRK_C IrmA Iron_transport LEA_2 Lep_receptor_Ig LIFR_N Lipase_bact_N LPMO_10 LRR_adjacent LTD Mannosidase_ig MetallophosC MG1 MG2 MG3 MG4 Mo-co_dimer N_BRCA1_IG Na_K-ATPase NEAT Neocarzinostat Neurexophilin NPCBM_assoc PapD_C PBP-Tp47_c Peptidase_C25_C Phlebo_G2_C PhoD_N PKD PKD_2 PKD_3 PKD_4 PKD_5 PKD_6 Por_Secre_tail Pox_vIL-18BP Psg1 PTP_tm Pur_ac_phosph_N Qn_am_d_aII Qn_am_d_aIII RabGGT_insert Reeler REJ RET_CLD1 RET_CLD3 RET_CLD4 RGI_lyase RHD_dimer Rho_GDI Rib RibLong SCAB-Ig SKICH SLAM SoxZ SprB SusE SVA SWM_repeat T2SS-T3SS_pil_N Tafi-CsgC TarS_C1 TcA_RBD TcfC TIG TIG_2 TIG_plexin TIG_SUH Tissue_fac Top6b_C Transglut_C Transglut_N TRAP_beta TraQ_transposon UL16 Velvet WIF Wzt_C Y_Y_Y YBD ZirS_C Zona_pellucida

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(225)
Full
(7620)
Representative proteomes UniProt
(18649)
RP15
(1044)
RP35
(3741)
RP55
(6680)
RP75
(9623)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(225)
Full
(7620)
Representative proteomes UniProt
(18649)
RP15
(1044)
RP35
(3741)
RP55
(6680)
RP75
(9623)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(225)
Full
(7620)
Representative proteomes UniProt
(18649)
RP15
(1044)
RP35
(3741)
RP55
(6680)
RP75
(9623)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: PDB:1kbp_A
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Punta M
Number in seed: 225
Number in full: 7620
Average length of the domain: 98.20 aa
Average identity of full alignment: 24 %
Average coverage of the sequence by the domain: 17.34 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 30.0 30.0
Trusted cut-off 30.0 30.0
Noise cut-off 29.9 29.9
Model length: 94
Family (HMM) version: 7
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Pur_ac_phosph_N domain has been found. There are 64 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0W5I6 View 3D Structure Click here
A0A0P0XPV5 View 3D Structure Click here
A0A0P0XZH6 View 3D Structure Click here
A0A0P0Y702 View 3D Structure Click here
A0A0R0H044 View 3D Structure Click here
A0A0R0HM85 View 3D Structure Click here
A0A0R0HQB8 View 3D Structure Click here
A0A0R0JHK6 View 3D Structure Click here
A0A1D6EDB5 View 3D Structure Click here
A0A1D6EVQ6 View 3D Structure Click here
A0A1D6G9W1 View 3D Structure Click here
A0A1D6G9W5 View 3D Structure Click here
A0A1D6HR96 View 3D Structure Click here
A0A1D6IWU3 View 3D Structure Click here
A0A1D6KE93 View 3D Structure Click here
A0A1D6KKC7 View 3D Structure Click here
A0A1D6LBV4 View 3D Structure Click here
A0A1D6PZG4 View 3D Structure Click here
A0A1D6QMD0 View 3D Structure Click here
A5D6U8 View 3D Structure Click here
B4F9L6 View 3D Structure Click here
B4FKP7 View 3D Structure Click here
B4FR72 View 3D Structure Click here
B6TKL3 View 3D Structure Click here
B7YZW3 View 3D Structure Click here
B9GEG4 View 3D Structure Click here
C0HHY2 View 3D Structure Click here
C0P5E1 View 3D Structure Click here
C6T9R4 View 3D Structure Click here
G0T427 View 3D Structure Click here
G0T428 View 3D Structure Click here
G0T433 View 3D Structure Click here
G0T437 View 3D Structure Click here
G5EE15 View 3D Structure Click here
G5EGR0 View 3D Structure Click here
H2FLJ4 View 3D Structure Click here
I1K0B0 View 3D Structure Click here
I1KC33 View 3D Structure Click here
I1KXK7 View 3D Structure Click here
I1L5N5 View 3D Structure Click here
I1LUX6 View 3D Structure Click here
I1LZT0 View 3D Structure Click here
I1M3C5 View 3D Structure Click here
I1MY91 View 3D Structure Click here
I1NAM1 View 3D Structure Click here
I4DHV7 View 3D Structure Click here
K7K7T8 View 3D Structure Click here
K7KG04 View 3D Structure Click here
K7KG05 View 3D Structure Click here
K7KSQ8 View 3D Structure Click here
K7LFF4 View 3D Structure Click here
K7LXJ7 View 3D Structure Click here
K7MRU1 View 3D Structure Click here
K7MW57 View 3D Structure Click here
K7MZ83 View 3D Structure Click here
K7TEL4 View 3D Structure Click here
K7TM89 View 3D Structure Click here
M0RCA8 View 3D Structure Click here
O23244 View 3D Structure Click here
O48840 View 3D Structure Click here
P9WL81 View 3D Structure Click here
Q09131 View 3D Structure Click here
Q0IMD7 View 3D Structure Click here
Q0IUK0 View 3D Structure Click here
Q0J0L3 View 3D Structure Click here
Q10I09 View 3D Structure Click here
Q10Q09 View 3D Structure Click here
Q19553 View 3D Structure Click here
Q2QLL6 View 3D Structure Click here
Q2QLL9 View 3D Structure Click here
Q2QN73 View 3D Structure Click here
Q2QXM4 View 3D Structure Click here
Q38924 View 3D Structure Click here
Q54BS2 View 3D Structure Click here
Q54NC3 View 3D Structure Click here
Q54SB4 View 3D Structure Click here
Q54TC4 View 3D Structure Click here
Q558S4 View 3D Structure Click here
Q55F12 View 3D Structure Click here
Q55F77 View 3D Structure Click here
Q5MAU8 View 3D Structure Click here
Q67WU6 View 3D Structure Click here
Q6TPH1 View 3D Structure Click here
Q6YGT9 View 3D Structure Click here
Q6ZCX8 View 3D Structure Click here
Q6ZI95 View 3D Structure Click here
Q6ZNF0 View 3D Structure Click here
Q7XVG3 View 3D Structure Click here
Q86IH2 View 3D Structure Click here
Q8BX37 View 3D Structure Click here
Q8H1R2 View 3D Structure Click here
Q8H5T7 View 3D Structure Click here
Q8LJ43 View 3D Structure Click here
Q8S2H5 View 3D Structure Click here
Q8S340 View 3D Structure Click here
Q93XG4 View 3D Structure Click here
Q949Y3 View 3D Structure Click here
Q9C510 View 3D Structure Click here
Q9C927 View 3D Structure Click here
Q9LJU7 View 3D Structure Click here
Q9LMG7 View 3D Structure Click here
Q9LMX4 View 3D Structure Click here
Q9LX83 View 3D Structure Click here
Q9LXI4 View 3D Structure Click here
Q9LXI7 View 3D Structure Click here
Q9NAM9 View 3D Structure Click here
Q9SFU3 View 3D Structure Click here
Q9SI18 View 3D Structure Click here
Q9SIV9 View 3D Structure Click here
Q9U309 View 3D Structure Click here
Q9ZQ81 View 3D Structure Click here
X2JB52 View 3D Structure Click here