# STOCKHOLM 1.0
#=GF ID   ACD
#=GF AC   PF16671.6
#=GF DE   Actin cross-linking domain
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF SE   PDB:4e1f
#=GF GA   27.00 27.00;
#=GF TC   57.20 56.00;
#=GF NC   20.50 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   22898822
#=GF RT   Crystal structure of the VgrG1 actin cross-linking domain of the
#=GF RT   Vibrio cholerae  type VI secretion system.
#=GF RA   Durand E, Derrez E, Audoly G, Spinelli S, Ortiz-Lombardia M,
#=GF RA   Raoult D, Cascales E, Cambillau C;
#=GF RL   J Biol Chem. 2012;287:38190-38199.
#=GF DR   INTERPRO; IPR032074;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in Vibrio cholerae RtxA toxin and VgrG1
#=GF CC   protein. This domain cross-links to G-actin leading to
#=GF CC   cytoskeletal changes [1].
#=GF SQ   5
#=GS MARTX_VIBCH/1986-2371       AC Q9KS12.2
#=GS VGRG1_VIBCH/726-1111        AC Q9KS45.1
#=GS VGRG1_VIBCH/726-1111        DR PDB; 4GQK A; 1-355;
#=GS A0A2G9DK76_9ACTN/2867-3239  AC A0A2G9DK76.1
#=GS A0KHZ7_AERHH/1942-2327      AC A0KHZ7.1
#=GS A0A1H9MRZ7_9PSEU/5-327      AC A0A1H9MRZ7.1
MARTX_VIBCH/1986-2371                  ....KSVPGFKSHFASTSIGIENELSGLVVVLPKNSAQTFGYVHDS.QGNPLFMLTKDMNQGGYSNPVGINDIQGVNNWQTHTIELVTYPSEISDTAAVESRKEAMLWLAKEFTDHINQSNHQSLPHLVSDDGRFTLVISNSKHLIAAGNGTSIDAQGKTIGMTPSGQQATMAISAKEFGT.SSSPEVRLLESAPWYQAGLRDEFLANAKNTTLDDPATAQNVYAYLTSVYSKTADLAKEYGIYINDWDPASEGFSPNAQGLTDPKVKNAWSILPRTKPVRMLELLSAEDSRYVRQQIAEKLKGTYSESLAKNVFEYFQYGGEVAGHGINNATTGSVQQPEPAILFEFRSVPSALSDFVPKTASTVKVDVKALDHFDSASRKAIITEVNALV...........
VGRG1_VIBCH/726-1111                   ....KATPDFPTHFPKSSIGIENELAGLVVAMPANSAQKFGYVKSA.QGDALFMLTKDMNQGSYQRPPSLQDGKNYQNWQTHTVELVSYPCEMDDKAAVETRKQAMLWLATHFTTHIDQSNHQPLAPIQSEDGRFVIEITNAKHVIAAGNGISAESQGQTITMTPSGQQATVGVAAKGFGT.SATPELRLLESAPWYQKSLKSQFASLTSAENLDDKELAANVFAYLTSIYLKTAELAKKFGIYINEWDPMSEQITPNANGLTDPKVKNAWEILPRTKPSKIVEILSKSDAKAVMKHIKPQLQSRYSESLSKNVFQYFQDGGEVAGHGINNATVGDKHSPELAILFEFRTVPNELQSYLPKTESTTKSEVKLLDQFDPMKRKTVIQQVESLV...........
#=GR VGRG1_VIBCH/726-1111        SS    ....XX------EESS-EEEEEEEEESEEEEE-TT--SEEEEEEET.T--EEEEEEEEEEEEE----GGG--S---TT-EEEEEEEEE--EETT-HHHHHHHHHHHHHHHHHHHHHHHHSTTB-----B-TTSSEEEEES--S-EEEETTS-SSS------EEEEEEEEEEEEEEGGGTTT.--SHHHHHHHT-TT--TTHHHHHHHHTSSS--TTHHHHHHHHHHHHHHHHHHHHHHHHHT--BTTB-GGGGT----SSSTTSHHHHHHHSEEE-S-GGGGGGGS-HHHHHHHHHTHHHHHHTTS-HHHHHHHHHHHHTT--SSSS---S-EEE-SSSEEEEEEEEESS--GGGGGGS----XXXXXXXXXXXXXXXXXXXXXXXXXXXXX...........
A0A2G9DK76_9ACTN/2867-3239             ..vv--APGFPSSFGSTSLGTESELSGFVVAVPQNADRTFAFVQRVdTGEPLVMVTKDMGQGAYGNPAKLAAAE-RGNWQTHTVELVTYPSRFGDEAALADRDGATRFLLDVFRDRLGTHNHAPLASLVSPDGQFRLQVTNDRHVIAAGRGMDLEEQP-SVSMPSGQQQATVGVRASELGApGSADSALLLDHAPWFRADFRQDEALRAVAATADAPERVENAYTYLKSVVSFLSDLVKKHDIPLGEYPG-------AGRALTHPQVKNDWKVLPRTRPNLILGTLSDHDRAL-TQRLLRETAPLGDETIWKEVRQYVMGGGAVAGHGIDKATIA----GEQALLFEFRELPDRLLPYVPREAAPTVAVSDPLAGLG-GRRIAVIREVNEF-v..........
A0KHZ7_AERHH/1942-2327                 ....KAVPEFSSHFDGSSIGIENELTGLVVALPKNSAQKFGYVHDA.AGNPLFMLTKDMNQGGYTNPAGISDVKGINQWQTHTIELVTYPSEMQDQQAVEARKEAMLWLAREFTQHISQTNHTRLSDLVSEDGRFTLVISNANHVIAAGNGAARDGQGQTIGMTPSGQQATVAVSAKAFGS.GSSQEIRLLESAPWYHPELKDLLLSNMANVQWEDAATAQNVFAYLTSIYGKTADLAREYGIHINDWDPLAEGITPNAQGLTDPKVKNAWEILPRTKPVAMLALLSAHDRKLVSEQILATLKSAYSPALAQNIYDYFKFGGEVAGHGINNATTGDSKHPEPAILFEFRQVPNELSQFVPKSESTARVEVKTLDQFDPVSRRTIVAAVNNLV...........
A0A1H9MRZ7_9PSEU/5-327                 dlsp-----YRSEFAGPSVGTEQELLGVRIGRKASGGSEIADVV-S.GGQVLVQITTDIGGGG-DAPFG---------YLGYTMEIKTSPTEVTDVAGWELRRGAIREVIAAIADMVLVK---GGSFTGGKLGAYDLVVHNGDHVVYGADTLST-------GVSGSSRHATFGLPFALLGT.EH---AALVSKAGWYE-DWSEEFDLIEGSSPWVDRDRSLRVYNYLRSVLTRLARLTSDYSLAVHDLYDL-KGFTGN---LYDSAIKNRWGVLPRTSPWVAIELLAKSDRERIRPTLLKCPSRVTDPVIWSAAVSHITQHRSLAGHTPKAPTYTEEELP--GTLFEFRT------------------------------------------gipfafkhafv
#=GC SS_cons                           ....XX------EESS-EEEEEEEEESEEEEE-TT--SEEEEEEET.T--EEEEEEEEEEEEE----GGG--S---TT-EEEEEEEEE--EETT-HHHHHHHHHHHHHHHHHHHHHHHHSTTB-----B-TTSSEEEEES--S-EEEETTS-SSS------EEEEEEEEEEEEEEGGGTTT.--SHHHHHHHT-TT--TTHHHHHHHHTSSS--TTHHHHHHHHHHHHHHHHHHHHHHHHHT--BTTB-GGGGT----SSSTTSHHHHHHHSEEE-S-GGGGGGGS-HHHHHHHHHTHHHHHHTTS-HHHHHHHHHHHHTT--SSSS---S-EEE-SSSEEEEEEEEESS--GGGGGGS----XXXXXXXXXXXXXXXXXXXXXXXXXXXXX...........
#=GC seq_cons                          ....KusPsFsSHFuuoSIGIENELoGLVVAlPpNSAQcFGYV+cu.sGsPLFMLTKDMNQGGYsNPsGlsDscshsNWQTHTlELVTYPSEhsDpAAVEsRKpAMLWLAccFTDHIsQoNHpsLusLVS-DGRFsLVIoNu+HVIAAGNGhSt-uQGpTIGMTPSGQQATVGVuAKtFGT.uSosElRLLESAPWYcs-L+--FsupsuusshDDs-pApNVYAYLTSVYoKTADLAK-YGIaINDWDPhuEGhTPNApGLTDPKVKNAWcILPRTKPsthLELLSccDR+hVpppILcpLpusYSEoLuKNVapYFptGGEVAGHGINNATsG-pcpPE.AILFEFRoVPscLpsaVPKotSTs+s-VKsLDpFDsspR+slIppVNsLV...........
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